Aging Process of Polyamidoamine Dendrimers: Effect of pH ...
Aging Process
Transcript of Aging Process
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I am 60 years old, but I want to be always young in heart and healthy. Physiclly, mentally, social living inthe meaningful condition for waiting the hopeful something for tomorrow
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SCIENCE :SCIENCE : 1. THEORITICAL SCIENCE1. THEORITICAL SCIENCE a. Nomothetic theoritical sciencea. Nomothetic theoritical science b. Descriptive theoritical scienceb. Descriptive theoritical science 2. APPLIED SCIENCE2. APPLIED SCIENCE a. Normative applied sciencea. Normative applied science b. Teleologic applied scienceb. Teleologic applied science c. Comprehensive applied sciencec. Comprehensive applied science d. Finalistic applied scienced. Finalistic applied science e. Complementary sciencee. Complementary science 3. PROFESSIONALISM3. PROFESSIONALISM a. Subjective cummulative value baseda. Subjective cummulative value based b. market oriented basedb. market oriented based c. divergensive mechanismc. divergensive mechanism d. competition and survivald. competition and survival
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Clinical Interventional Clinical Interventional Radiology and the Aging Radiology and the Aging
ProcessProcessSoetjiptoSoetjiptoMei 1996Mei 1996
( Department of Radiology, School of ( Department of Radiology, School of Medicine, UNS University / dr Muwardi Medicine, UNS University / dr Muwardi
Teaching HospitalTeaching HospitalSurakarta )Surakarta )
Presented in national congress of Radiology 1996Presented in national congress of Radiology 1996
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The medicine postulation :The medicine postulation :
1. BIO-ORGANIC POSTULATION 1. BIO-ORGANIC POSTULATION Until 1950Until 1950 2. BIOCELLULAR POSTULATION2. BIOCELLULAR POSTULATION Until 2000Until 2000 After all, it was still to be primadona in After all, it was still to be primadona in Indonesia now adaysIndonesia now adays 3, BIOM OLECULAR POSTULATION3, BIOM OLECULAR POSTULATION in the beginning of the third in the beginning of the third mellinneummellinneum
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Bio-organic postulateFunctional equilibrium
Interdependency
Feedback mechanism
organon
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C-DNA
nucleus
150.000
Endothermicbiochemistry
Mt-DNA
BIOMOLECULARY POSTULATEExothermic biochemistry
1. oxidant2. Energy
No repairy Mt-DNA
Decreasing energy
1. Aging process2. Mets3. Auto-immune disease4. Functional disbalancing5. Apoptosis
The cell
17.p.23
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The information The information revolutionrevolution
1. The human development index 1. The human development index 2. Biocellular to biomolecular postulate2. Biocellular to biomolecular postulate3. How to win the competition 3. How to win the competition 4. How to have the safety, the security 4. How to have the safety, the security and the prosperity of the applied and the prosperity of the applied
science and its professionalismscience and its professionalism
The philosophy of existentialism inThe philosophy of existentialism in applied science is one of the manyapplied science is one of the many ways to solve ways to solve
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How is about Radiology in the How is about Radiology in the effort to overcome effort to overcome the challenging future ?the challenging future ? depending upon Tdepending upon T 1 modality vs multiple modality 1 modality vs multiple modality
SWOTSWOT One of the many ways is the matters One of the many ways is the matters of meaning given by the Radiologist of meaning given by the Radiologist in the Clinical Interventional in the Clinical Interventional RadiologyRadiology
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C-DNA
nucleus
150.000
Endothermicbiochemistry
Mt-DNA
Exothermic biochemistry
1. oxidant2. Energy
No repairy Mt-DNA
Decreasing energy
1. Aging process2. Mets3. Auto-immune disease4. Functionasl disbalancing5. Apoptosis
The cell
17.p.23
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LIFE IS INDEED THE BIOCHEMISTRY MECHANISM LIFE IS INDEED THE BIOCHEMISTRY MECHANISM PROCESSPROCESS
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Aging process is really a diseaseAging process is really a disease
1. The genetic Mt-DNA vs the c-DNA1. The genetic Mt-DNA vs the c-DNA 2. The target organ :2. The target organ : a. nutrition given cell ( 22.p.72 anda. nutrition given cell ( 22.p.72 and 22.p.92 genes) vs the endothelial22.p.92 genes) vs the endothelial responseresponse b. fibroprotein & collagen vs GAGb. fibroprotein & collagen vs GAG c. Auto-immune Ag formation.c. Auto-immune Ag formation. d. Metabolic syndrome&Organ dysfunctiond. Metabolic syndrome&Organ dysfunction 3. Ecosystem’s influenced variables ( oxydant, 3. Ecosystem’s influenced variables ( oxydant, foetal & inheritance program, nutrition, foetal & inheritance program, nutrition, life style / corpus amygdale )life style / corpus amygdale )
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THE CELL
22.P.7222.P.92
1.METALOPROTEINASE I a. Angiopoetin for capillary bed b. vasculopoetin for vascularity 2. METALOPROTEINASE II For nutritional cytocine3. METALOPROTEINASE III For extracellulary matrix (ECM) a. For the frame of ECM ( collagen, elastin, fibroprotein b. For the basic ontent of spaces inter the frame ( mucopolysacharide fluid ) c. For the substances supporting the living cell ( GAG, laminin, nutrition, mineral, aminoglican, hyalin, etc ) 4. METALOPROTEINASE IV For protocollagenase and proto stromelysin (active after contact with the proteinase enzym
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THE CELL
RECEPTOR c-AMP
RECEPTOR c-GMP
GAP-JUNCTION 200 ANGSTROM
THE ACTIN MECHNISM
THE INTEGRIN MECHANISM
THE ECM
THE INTERDEPENDENCY
THE COMPONENT
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ENDOTHELIAL DYSFUNCTION
Endothelin NO Adhesion mol
Prostacyclin
C-DNA
At-1R Ar-2R
C-Amp A-GmpCa+ Ca+Oligopeptide OligopeptideOligosachaeride Oligosacharide
Nutrition receptor
Endothelium
component
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The fourth fundamental physical law of nature : interdependency
cytokineNutrition for the cell
The vascular with its general nutritional substance
Endothel ia
The cell
22.p.72
At
t
At-1R At-2R
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nucleus
mitochondria
Extracellulary matrix
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Atheroscclerotic plaque
Ig-G anti CMV –
Ig-G anti Mitochondria +
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Double contour aortitis
Proteinuri 500 mg %
Creatinin 3,2 mg %
Ig-G antimitochondria +
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atheroma
double contour aortitis
HbA1c 10
Ig-G anti mitochondria +
Ig-G anti chlamydea +
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granulomatous
wall
atherosclerotic plaque
Cholesterol total 350 mg %LDL 250 mg %HDL 25 mg %uric acid 10 mg %tensi 180/60
atheroma
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atherosclerotic plaque dan atheroma
granulomatous wall
Kadar gula darah sewaktu 425mg % HBA1c 17 Chol:HDL=7 LDL:HDL=5Tensi 170/110 trombosit 400.000/cc, fibrinogen 450 mg / dl
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cephalgia khronik, badan lemah sekali, Hb 10 gr %, HBA1-c 8 HS-CRP 8 chol:HDL 7 LDL:HDL 4,5 Ig-G anti mitochondria – Endogenic anti-oksidan drop
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atheroma dan atherosclerotic plaque
Lemah sekali, sulit jalan, reflex pateler normal,anorexia Head Ct Scan : chronic ischemic brain HS-CRP 15, Ig-G anti mitochondria + HBA1-c 7,5 uric acid 8 mg % creatinin 1,3 mg %
chol : HDL 7, LDL : HDL 4,5
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granulomatous wall
kadar gula darah sewaktu 425 mg % Chol:HDL= 7 LDL:HDL 5
Ig-G anti CMV -. Ig-G anti chlamydea -
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I am satisfied, ….and Matur Nuwun