Adaltis company presentation 2011

IVD SYSTEMS & AUTOMATED CLINICAL DIAGNOSTIC ANALYZERS

2Apr 8, 2023 Adaltis S.r.l.

Adaltis is an international in-vitro diagnostic company

headquartered in Guidonia (Rome), Italy.

Adaltis develops, manufactures and markets in-vitro diagnostic systems and reagent products

to detect viral infections, diagnose immune system diseases

and measure human hormone responses.


Personal Lab™ 2-plate automated micro plate analyzerPersonal Lab Clia 2-plate automated micro plate analyzer Elisa / Clia NexGen Four™ 4-plate automated micro plate analyzer Eclectica™ v4 a compact random access analyzer for immunoassay and clinical chemistryPChem range clinical chemistry systems Instruments and reagents

All our instruments manufactured with excellent performance, with dedicated support for application and technical service.

More than 10-thousands of instruments installed world-wide.

ADALTIS is an ISO 9001 and ISO 13485 certified and all our products are IVD-CE marked.


Adaltis automated analyzers are ideal for small to mid-sized laboratories and include:


ReagentsReagents

Our reagents include the: EIAgen-ELISA and ELISA CLIA microplate kits for Infectious diseases

HepatitisSerologyToRCH RetrovirusTumor Autoimmunity, Immunoassays, Clinical Chemistry and Controls

Adaltis provides dedicated customized services for your Antibody production and Antibody supply.

Our team dedicated to customer satisfaction and will dothe utmost to respond quickly to your needs..

We look forward to an exciting and jointly

profitable future with partners like you.

For more information, you may contact us directly or visit our new website at

www.adaltis.net / www.adaltis.com


Apr 8, 2023 Adaltis S.r.l. 7

PERSONAL LAB™PERSONAL LAB™FULLY AUTOMATED FULLY AUTOMATED

2 MICROPLATE ANALYZER2 MICROPLATE ANALYZER

InstrumentsInstruments

PERSONAL LAB™PERSONAL LAB™

The new Personal Lab (Plab) is an integration between our extensive expertise gathered from thousands of manufactured instruments.

The new Plab is innovative in hardware and software while combining state of the art Italian design. The New Personal Lab is a compact desktop analyzer, noiseless and reliable. It is designed to simultaneously process two microplates with multiple assays per plate. New, easy to use interface software enables you to program almost all the protocols of microELISA assays currently available on the market.

FULLY AUTOMATED 2 MICROPLATE ANALYZERFULLY AUTOMATED 2 MICROPLATE ANALYZER



Each compact workstation consist of:

Sample Station Samples can be identified by reading bar-code

Plate Housing The plate housing is designed for simultaneous processing two microplates. The plate holders are able to do vertical shaking with definable intensity/period The plates are placed into two independent chambers that are programmable

for the temperature.




One robotics arm operated by stepper motor, controlled by optic/mechanic sensors Automatic tip change system and the self-cleaning of the metal needle, with a wash volume Programmable by the user, guarantee the absence of interferences due to carry over. The instrument is equipped with -PLS- pneumatic level sensor (patented) and a capacity sensor

(for the metal needle). The polymeric tip is equipped with a coagulate detection system. In the event of insufficient liquids, the instrument alerts with acoustic / optic alarm. The New Personal Lab performs automatic pre-dilution of samples, standards and controls.

Pipetting StationPipetting Station




Washing StationWashing Station



The washing station has a 16-channel wash head. Eight channels dedicated to the wash solution

and eight channels are dedicated to aspiration. Cycles, volume and number of washes, are easily programmable

by the operator and three wash buffers can be loaded on board at the same time.

Washing volume: programmable from 100 to 2000 ml.Number of cycles: from 1 to 9; Soak time: programmable from 1 sec to 3 minutes.Pressure: programmable.

Each protocol can be programmed by the operator with several washes different in terms of cycle, volume, soak time and pressure.


The reading station has a programmable photometer Suitable for reading, with single, double or triple ray. (Vertical reading) In the case of triple ray (over-range reading), the instrument automatically converts the absorbance values detected at the different wavelengths.

Filter set provided: 405 , 450, 492, 550 and 620 nm.Optional filters: customized available in the range 400-700 nm, up to a maximum of 8 filters.

Reading StationReading Station

The loading area is easily accessible for easy and simple loading activity of reagents, samples and polymeric tips.

The reagents and samples rack are easily removable in order to quickly store the reagents in a refrigerator.




It is possible to program and store almost unlimited number of protocols arranged on a panel drawn up by the user according to his needs.

Execution is possible as individual test or by panel,

at random and/or in batches.

The Personal Lab can be used to carry out both qualitative and quantitative analysis, with suitable quality control operations.

SOFTWARE CHARACTERISTICSSOFTWARE CHARACTERISTICS




SOFTWARE CHARACTERISTICS

The new user friendly Open Lab™ software guarantees extremely easy programming.

‘Open Lab’ uses templates that can be completed quickly and intuitively.

The software is enabeling the instrument to be an ‘open system’.




FULLY AUTOMATED FULLY AUTOMATED 2 MICROPLATE ANALYZER ELISA / CLIA2 MICROPLATE ANALYZER ELISA / CLIA

NEWNEW


Adaltis proudly presents:It’s new and innovative PERSONAL LAB CLIA The first 2-plates fully automated analyser for

microELISA CLIA assays & microELISA assays in the same platform

It’s a new concept: Instrument N-Plab CLIA & the new CLIA microplate line

FULLY AUTOMATED 2 MICROPLATE ANALYZER ELISA / CLIAFULLY AUTOMATED 2 MICROPLATE ANALYZER ELISA / CLIA


NEWNEW

The N-Plab CLIA is the first instrument that can combine 2 different detection systems for microplates: Spectrophotometer Luminometer

open system performing 2 microplates with multiple assays per plate.

The Chemiluminescence Immunoassay (CLIA) detection using microplate luminometers that provides a sensitive, high throughput, an economical alternative to conventional colorimetric

methodologies Quicker results, better performance



NEWNEW



The CLIA microplate line will include the below panels: ToRCH Tumor Markers Thyroid Autoimmunity Fertility & Prenatal

New plate gripper mechanism New plate gripper mechanism under the XYZ-armunder the XYZ-arm

Advantage of the luminometer Large measuring range (Dynamic Range) Better discrimination Low background (high signal to noise ratio) No protein quenching problem as in fluorescence Higher Linearity

Steroids Growth Deficiency Cardiac Markers Diabetes Infectious Diseases Anemia

NEWNEW


Fully Automated 4 microplate analyzer.


NEXGEN FOUR fully Automated 4 microplate analyzer.

The NEXGEN FOUR is a fully automated four plate ELISA processer able to perform parallel tests and multiple assays per plate. The instrument managed by one internal and one external computer, integrates on board: one sample carousel, two independent pipetting robotic arms, four separate incubators, two independent photometers two washing stations which allow the processing of up to four microplates simultaneously.


The NEXGEN FOUR is operated by the OpenLab™ proprietary software suite based on Microsoft software. Multitasking capabilities and front loading of samples allow random access in the microplate format as well.



The NEXGEN FOUR is an open system equipped with: Touch screen for a simple and quick programming Laboratory Information System (LIS Connection) Liquid level sensor with clot and bubble detection Plastic and metal tips Bar Code reader identification Remote trouble shooting by modem

The NEXGEN FOUR has the CE-Marked and can be pre-programmed with validate EIAgen assays for a complete range of blood screening test. NEXGEN FOUR Is the right companion for the laboratories.



ReagentsReagents

Microplate Assays menuMicroplate Assays menu

Autoimmunity Hepatitis Retroviruses Mononucleosis Syphilis Torch Hormones and Tumor Markers Virology and Infectious Diseases Chronic Gastric Diseases



Random Access AnalyzerRandom Access Analyzer


For Immuno-Assay and Clinical Chemistry Eclectica™ is the first compact random access system for Immuno-Assay and Clinical Chemistry. Dramatically simplify routine testing by combining Immunoassay and Clinical Chemistry in a single workstation.




Eclectica™ is a bench top analyser, consisting of two carousels, for samples and reagents, both equipped with barcode reader.

All steps, from primary tube to the printing of the results, are controlled through dedicated software.

The flat touch-screen color monitor along with the separate provides the user with a fast interface with the Eclectica.

Eclectica™ can be connected with a Laboratory Information

System (LIS) to directly download and upload data.





The dedicated panel of reagents are bar-coded and include enzyme immunoassay, turbidimetry and clinical chemistry tests.

Adaltis reagents are specifically developed for Eclectica™,

ensuring consistently high quality, as well as analytical system performance.

The optimization and the stability of reagents provide

the user with convenient packaging and user friendly systems.

Eclectica Clinical ChemistryEclectica Clinical Chemistry

Proteins Kidney Profile Liver Profile Lipid Profile Cholesterol Profile

Random Access Assays menu

Eclectica Plasma Proteins*Eclectica Plasma Proteins*

Immunoglobulins Glycoproteins Light chains Reumatoid Factor ASO

* available end 2012

Eclectica ImmunoassaysEclectica Immunoassays

Anemia Metabolism Fertility / Pregnancy Diabetes Thyroid Function Tumor Markers Other Reagents


The New User Interface SoftwareThe New User Interface Software

New Easy User Interface (EUI): You can easily navigate the modules through the links and configure your instrument.

Easy Worklist Programming: Possibility to easy select samples and connect to the different assays, profiles and work lists




Step by step Worklist execution: the software checks what you need. You can choose the specific reagent lot. You can load a smart card directly.

Temporary results: you can have sample results even with an expired calibration curve and confirm them within 24 hrs.

New Warehouse module: Compact; many available queries; easy smart card loading

Compact maintenance module: All the maintenance steps in one menu.

► The software guides you to choose the right maintenance and or warehouse procedure





Random Access Analyzers Random Access Analyzers Dedicated ReagentsDedicated Reagents

Random Access Analyzers Dedicated ReagentsRandom Access Analyzers Dedicated Reagents


Fully-automated Clinical Chemistry Analyzers

Pchem 1 - Fully-automated Clinical Chemistry Analyzer up to 150 tests / hourPchem 2 - Fully-automated Clinical Chemistry Analyzer up to 240 tests / hourPchem 3 - Fully-automated Clinical Chemistry Analyzer up to 500 tests / hour



Pchem family of biochemistry analyzers offers cost-effective, highly reliable, testing for routine clinical chemistry, immunoturbidimetry, TDM, DoA and special application for wine and water analysis, for laboratories of all sizes.

Test can be initiated in random mode (patient by patient), in batch mode (test by test), in or STAT with equivalent tests per hour

Capable of completing from 120 to 300 photometric tests per hour and 180 to 500 tests per hour with ISE module on board, these automatic biochemical analyzers allow you to make treatment decisions sooner.

Low sample requirements - 2 microliters – reduce waste and costs without compromising accuracy. A wide range of automated processes make the test process fast and reliable.


2 Fully-automated Clinical Chemistry Analyzer up to 180 tests / hour

Fully-automated Clinical Chemistry Analyzer for Small Labs or as a system back-up Capable of up to 120 photometric tests per hour,up to 180 tests per hour with ISE module on board,

The best choice for smaller labs and doctors’ offices.

Only 83 cm in length, the unit fits easily into your laboratory bench.

An optional ISE module includes four electrodes (Na+, CL-, Li+, K+) plus 1 reference.

The ‘Pchem 1’ also supports mono, bi and triple reagent methods.



120 photometric tests per hour

up to 180 tests per hour with integrated ISE module

9 sample, calibrator and control positions

20 reagent positions refrigerated on board

up to 60 parameters on line

unlimited off line

80 on-board reusable cuvettes

with automatic washing station



Fully-automated Clinical Chemistry Analyzer Fully-automated Clinical Chemistry Analyzer for Small to Medium Labsfor Small to Medium Labs Capable of up to 160 photometric tests per hour, up to 250 tests per hour with ISE module on board Perfectly suited for small to medium sized labs or as a system back-up for large labs.

An optional ISE module includes four electrodes (Na+, CL-, Li+, K+) plus 1 reference.

‘Pchem 2’ supports mono, bi and triple reagent methods.



160 photometric tests per hour

up to 250 tests per hour with integrated ISE module.


up to 60 parameters on line, unlimited off line

50 sample positions

6 pediatric sample positions

18 calibrator positions

3 control positions



Fully-automated Fully-automated Clinical Chemistry Analyzer for Medium LabsClinical Chemistry Analyzer for Medium Labs

Capable of up to 300 photometric tests per hour, up to 500 tests per hour with ISE module on board Perfectly suited for medium sized labs or as a system back-up for large labs. An optional ISE module includes four electrodes (Na+, CL-, Li+, K+) plus 1 reference.

The ‘Pchem 3’ also supports mono, bi and triple reagent methods.



300 photometric tests per hour,

up to 500 tests per hour with integrated ISE module


up to 60 parameters on line, unlimited off line

50 sample positions

6 pediatric sample positions

18 calibrator positions

3 control positions



The Pchem family wants to simplify your routine work. Adaltis offers a complete CE marked reagent panel (mono or bi-reagent) ready to use. Positive identification of reagents gives the end user the assurance to work without compromises on quality.

Twenty-eight parameters for enzymes and substrates, with application on serum, plasma and urine, based on the most advanced research in clinical chemistry following international recommendations (IFCC).

Twenty-eight parameters for specific protein, with application on serum, plasma and urine, standardized with 5-point calibration curve. The Pchem family gives you the possibility to create special methods.



A user-friendly software interface means that lab personnel can be trained quickly and simplifies routine laboratory analysis procedures. A 24-month warranty provides you unlimited technical support and on-site service calls as needed to give you the certainty that your purchase is without compromises.


ReagentsReagents


The EIAgen microplate line

The EIAgen line is a complete range of Microplate assays able to satisfy the requirements of the most demanding laboratories.

Our wide offer of assays includes the following lines:

ToRCH Autoimmunity Gastric Function Hepatitis

The excellent quality of Adaltis products, outstanding performance and ease of use, make of the EIAgen line the best solution for every laboratory. The EIAgen line is completely automated on both NEXgen Four™ and Personal Lab™ instruments. All application protocols have been validated and approved. The kits use our TMB substrate, this world renowned component is ready to use and has long shelf life. Most assays includes reagents that are ready to use and with shelf life of at least 12 months or more.

NEWNEW

Retrovirus Syphilis Hormones / Tumor Markers Virology Mononucleosis

Custom Antibody Production ServicesCustom Antibody Production Services

Monoclonal antibodies purification methods: IgG purification by HPLC /FPLC and by affinity chromatography. Producing purified or not purified antibodies by using our cell lines.

Adaltis can provide purity antibodies on request.

Polyclonal antibodies purification methods: Ammonium sulphate precipitation.Protein A / G affinity purification.


Antibody/Protein / Peptide Conjugation with:

FITC (fluoroisotiocianate). Biotine Horseradish peroxidase (HRP). Alkaline phosphatase (ALP). Keyhole - Limpet - Hemocyanin (KLH). Bovine and human serum albumin (BSA and HSA).

Conjugation can be optimised by the following process: Customer conjugation requirements confirmation. Antibody/protein HPLC analysis. Conjugate preparation and purification.



IVD development and prototyping: From the R&D phase into pilot and full-scale production

Solid phases coating: Coating of microplates for ELISA applications. Magnetic particle preparation.

Reagents production and filling: From solution preparation to filling, capping and labeling

Packaging: Full service assembly and packaging for diagnostic products.



BLUE STARBLUE STAR

The Most Stabilized & Most Sensitive Single Solution substrate for ELISA assays TMB - 3,3’, 5,5’ TETRAMETHYLBENZIDINE

TMB solution is a chromogenic reagent for peroxidase, designed for ELISA techniques Manual or Automatic systems.

TMB (3,3´,5,5´-Tetramethylbenzidine) is a chromogen that yields a blue colour when oxidized, typically as a result of oxygen radicals produced by the hydrolysis of hydrogen peroxide by HRP.

For kinetic or non-stopped ELISA assays, the TMB chromogen has maximal with the addition of sulphuric or phosphoric acid with maximum absorbance at 370 nm and 650 nm. The colour then changes to yellow absorbance at 450 nm.


Adaltis is proud to present the:

The EIAgen HIV Total Screening Kit is a new screening assay for the simultaneous detection of HIV-1 antibodies, HIV-2 antibodies and HIV-p24 antigenin human serum or plasma.

The EIAgen HIV Total Screening is a 4th Generation assay, developed and evaluated in compliance with the new Common Technical Specifications 2009/886/EC (CTS) as required by the article 5 of the IVD Directive 98/79/EC.

Monoclonal antibodies against HIV p24 antigen Antigens HIV-1 gp41 and HIV-2 gp36 Recombinant antigens Synthetic Peptides


EIAgen Detect HIV 4 Total Screening KitEIAgen Detect HIV 4 Total Screening Kit

The EIAgen HIV Total Screening assay is the state of the art kit providing superior performances:Diagnostic Sensitivity 100%Diagnostic Specificity >99,7% The test procedure can be easily automated on most of the currently available microplate analyzers in the market.

The ease of use and the color monitoring reagents satisfy the requirement of laboratories that work under Good Laboratory Practice (GLP) and other quality management systems. They are an important contribution to your supervision of reliable test results.

The application protocols for our NexGen Four™ and new Personal Lab™ automated micro ELISA analyses will be available for a certified quality system in your laboratory.


EIAgen Detect HIV 4 Total Screening KitEIAgen Detect HIV 4 Total Screening Kit


The HIV p24 HIV p24 antigen is a protein produced by the virus immediately after infection, before the emergence of antibodies.

Early detection is critical for controlling viral spread and the EIAgen HIV Total Screening is a 4th generation kit that drastically reduces the detection windows.

The combination of Antibody/Antigen increases the sensitivity and decreases the risk of false negative results.


HIV Total Screening KitHIV Total Screening Kit


Adaltis company presentation 2011

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