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Analytical Chemistry: Volume 80, Issue 21 (ACS Publications)

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Table of Contents

Larger Cover November 1, 2008Volume 80, Issue 21Pages 7903-8353

In this issue:

● Editorial●

● Research Profile●

● Feature● Accelerated Articles


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● Articles● Technical Notes● Correspondence● Correction

About the Cover: Art director Julie Farrar’s depiction of the principle behind a size exclusion redox-labeled immunoassay. The article is by Umesh Lad, Santosh Khokhar, and Girish M. Kale. View the article.

indicates the article is freely available through sponsorship by the author or related funding agency. More about this program.

Select All For Selected Articles:

Editorial

The Proteomic Revolution Has Changed the Capabilities of Analytical Chemistry

Catherine Fenselaup 7903 Publication Date (Web): October 31, 2008 (Editorial)DOI: 10.1021/ac802043cAbstract

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A mass spectrometer in every hand

Jennifer Griffithsp 7904 Publication Date (Web): October 4, 2008 (Research Profile)


http://dx.doi.org/10.1021/ac801500thttp://pubs.acs.org/page/policy/authorchoice/index.htmlhttp://pubs.acs.org/doi/abs/10.1021/ac802043chttp://pubs.acs.org/doi/abs/10.1021/ac802043chttp://pubs.acs.org/doi/abs/10.1021/ac802043chttp://pubs.acs.org/doi/full/10.1021/ac802043chttp://pubs.acs.org/doi/full/10.1021/ac802043chttp://pubs.acs.org/doi/pdf/10.1021/ac802043chttp://pubs.acs.org/doi/pdf/10.1021/ac802043chttp://pubs.acs.org/doi/pdfplus/10.1021/ac802043chttp://pubs.acs.org/doi/pdfplus/10.1021/ac802043chttp://pubs.acs.org/doi/abs/10.1021/ac8019027


DOI: 10.1021/ac8019027Abstract

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Research Profile

Microsized “giant” drives new rapid-screening device

Joe Alperp 7905 Publication Date (Web): October 10, 2008 (Research Profile)DOI: 10.1021/ac801967kAbstract

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The dawn of dairy

Rajendrani Mukhopadhyaypp 7906–7907 Publication Date (Web): October 2, 2008 (AC Detective)DOI: 10.1021/ac801789kAbstract

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http://pubs.acs.org/doi/abs/10.1021/ac8019027http://pubs.acs.org/doi/full/10.1021/ac8019027http://pubs.acs.org/doi/full/10.1021/ac8019027http://pubs.acs.org/doi/pdf/10.1021/ac8019027http://pubs.acs.org/doi/pdf/10.1021/ac8019027http://pubs.acs.org/doi/pdfplus/10.1021/ac8019027http://pubs.acs.org/doi/pdfplus/10.1021/ac8019027http://pubs.acs.org/doi/abs/10.1021/ac801967khttp://pubs.acs.org/doi/abs/10.1021/ac801967khttp://pubs.acs.org/doi/full/10.1021/ac801967khttp://pubs.acs.org/doi/full/10.1021/ac801967khttp://pubs.acs.org/doi/pdf/10.1021/ac801967khttp://pubs.acs.org/doi/pdf/10.1021/ac801967khttp://pubs.acs.org/doi/pdfplus/10.1021/ac801967khttp://pubs.acs.org/doi/pdfplus/10.1021/ac801967khttp://pubs.acs.org/doi/abs/10.1021/ac801789khttp://pubs.acs.org/doi/abs/10.1021/ac801789khttp://pubs.acs.org/doi/full/10.1021/ac801789khttp://pubs.acs.org/doi/full/10.1021/ac801789k




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A cool way to learn about climate change

Jeffrey Perkelpp 7908–7909 Publication Date (Web): October 31, 2008 (AC Detective)DOI: 10.1021/ac801861uAbstract

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Feature

Electrochemical Creatinine Biosensors

Umesh Lad, Santosh Khokhar and Girish M. Kalepp 7910–7917 Publication Date (Web): October 31, 2008 (Feature)DOI: 10.1021/ac801500tAbstract

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http://pubs.acs.org/doi/pdf/10.1021/ac801789khttp://pubs.acs.org/doi/pdf/10.1021/ac801789khttp://pubs.acs.org/doi/pdfplus/10.1021/ac801789khttp://pubs.acs.org/doi/pdfplus/10.1021/ac801789khttp://pubs.acs.org/doi/abs/10.1021/ac801861uhttp://pubs.acs.org/doi/abs/10.1021/ac801861uhttp://pubs.acs.org/doi/full/10.1021/ac801861uhttp://pubs.acs.org/doi/full/10.1021/ac801861uhttp://pubs.acs.org/doi/pdf/10.1021/ac801861uhttp://pubs.acs.org/doi/pdf/10.1021/ac801861uhttp://pubs.acs.org/doi/abs/10.1021/ac801500thttp://pubs.acs.org/doi/abs/10.1021/ac801500thttp://pubs.acs.org/doi/full/10.1021/ac801500thttp://pubs.acs.org/doi/full/10.1021/ac801500thttp://pubs.acs.org/doi/pdf/10.1021/ac801500thttp://pubs.acs.org/doi/pdf/10.1021/ac801500thttp://pubs.acs.org/doi/pdfplus/10.1021/ac801500thttp://pubs.acs.org/doi/pdfplus/10.1021/ac801500t


IMS/MS: its time has come

Rajendrani Mukhopadhyaypp 7918–7920 Publication Date (Web): October 31, 2008 (Product Review)DOI: 10.1021/ac8018608Abstract

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Accelerated Articles

C60 Secondary Ion Mass Spectrometry with a Hybrid-

Quadrupole Orthogonal Time-of-Flight Mass Spectrometer

Anthony Carado†, M. K. Passarelli†, Joseph Kozole†, J. E. Wingate‡, Nicholas Winograd*† and A. V. Loboda‡ pp 7921–7929 Publication Date (Web): October 10, 2008 (Accelerated Article)DOI: 10.1021/ac801712sAbstract

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http://pubs.acs.org/doi/abs/10.1021/ac8018608http://pubs.acs.org/doi/abs/10.1021/ac8018608http://pubs.acs.org/doi/full/10.1021/ac8018608http://pubs.acs.org/doi/full/10.1021/ac8018608http://pubs.acs.org/doi/pdf/10.1021/ac8018608http://pubs.acs.org/doi/pdf/10.1021/ac8018608http://pubs.acs.org/doi/pdfplus/10.1021/ac8018608http://pubs.acs.org/doi/pdfplus/10.1021/ac8018608http://pubs.acs.org/doi/abs/10.1021/ac801712shttp://pubs.acs.org/doi/abs/10.1021/ac801712shttp://pubs.acs.org/doi/abs/10.1021/ac801712shttp://pubs.acs.org/doi/full/10.1021/ac801712shttp://pubs.acs.org/doi/full/10.1021/ac801712shttp://pubs.acs.org/doi/pdf/10.1021/ac801712shttp://pubs.acs.org/doi/pdf/10.1021/ac801712shttp://pubs.acs.org/doi/pdfplus/10.1021/ac801712shttp://pubs.acs.org/doi/pdfplus/10.1021/ac801712s


Articles

Giant Magnetoresistance Sensors. 1. Internally Calibrated Readout of Scanned Magnetic Arrays

John Nordling, Rachel L. Millen, Heather A. Bullen† and Marc D. Porter*Mark Tondra‡Michael C. Grangerpp 7930–7939 Publication Date (Web): October 1, 2008 (Article)DOI: 10.1021/ac8009577Abstract

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Giant Magenetoresistive Sensors. 2. Detection of Biorecognition Events at Self-Referencing and Magnetically Tagged Arrays

Rachel L. Millen, John Nordling, Heather A. Bullen† and Marc D. Porter*Mark Tondra‡Michael C. Grangerpp 7940–7946 Publication Date (Web): October 1, 2008 (Article)DOI: 10.1021/ac800967tAbstract

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http://pubs.acs.org/doi/abs/10.1021/ac8009577http://pubs.acs.org/doi/abs/10.1021/ac8009577http://pubs.acs.org/doi/abs/10.1021/ac8009577http://pubs.acs.org/doi/full/10.1021/ac8009577http://pubs.acs.org/doi/full/10.1021/ac8009577http://pubs.acs.org/doi/pdf/10.1021/ac8009577http://pubs.acs.org/doi/pdf/10.1021/ac8009577http://pubs.acs.org/doi/pdfplus/10.1021/ac8009577http://pubs.acs.org/doi/pdfplus/10.1021/ac8009577http://pubs.acs.org/doi/abs/10.1021/ac800967thttp://pubs.acs.org/doi/abs/10.1021/ac800967thttp://pubs.acs.org/doi/abs/10.1021/ac800967thttp://pubs.acs.org/doi/abs/10.1021/ac800967thttp://pubs.acs.org/doi/full/10.1021/ac800967thttp://pubs.acs.org/doi/full/10.1021/ac800967thttp://pubs.acs.org/doi/pdf/10.1021/ac800967thttp://pubs.acs.org/doi/pdf/10.1021/ac800967thttp://pubs.acs.org/doi/pdfplus/10.1021/ac800967thttp://pubs.acs.org/doi/pdfplus/10.1021/ac800967t


Theoretical Analysis of Microscopic Ohmic Drop Effects on Steady-State and Transient Voltammetry at the Disk Microelectrode: A Quasi-Conformal Mapping Modeling and Simulation

Christian Amatore*†, Alexander Oleinick†‡ and Irina Svir*†‡ pp 7947–7956 Publication Date (Web): October 1, 2008 (Article)DOI: 10.1021/ac8010268Abstract

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Capacitive and Solution Resistance Effects on Voltammetric Responses of a Thin Redox Layer Attached to Disk Microelectrodes

Christian Amatore†, Alexander Oleinick†‡ and Irina Svir*†‡ pp 7957–7963 Publication Date (Web): October 1, 2008 (Article)DOI: 10.1021/ac8012972Abstract

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http://pubs.acs.org/doi/abs/10.1021/ac8010268http://pubs.acs.org/doi/abs/10.1021/ac8010268http://pubs.acs.org/doi/abs/10.1021/ac8010268http://pubs.acs.org/doi/abs/10.1021/ac8010268http://pubs.acs.org/doi/abs/10.1021/ac8010268http://pubs.acs.org/doi/full/10.1021/ac8010268http://pubs.acs.org/doi/full/10.1021/ac8010268http://pubs.acs.org/doi/pdf/10.1021/ac8010268http://pubs.acs.org/doi/pdf/10.1021/ac8010268http://pubs.acs.org/doi/pdfplus/10.1021/ac8010268http://pubs.acs.org/doi/pdfplus/10.1021/ac8010268http://pubs.acs.org/doi/abs/10.1021/ac8012972http://pubs.acs.org/doi/abs/10.1021/ac8012972http://pubs.acs.org/doi/abs/10.1021/ac8012972http://pubs.acs.org/doi/abs/10.1021/ac8012972http://pubs.acs.org/doi/full/10.1021/ac8012972http://pubs.acs.org/doi/full/10.1021/ac8012972http://pubs.acs.org/doi/pdf/10.1021/ac8012972http://pubs.acs.org/doi/pdf/10.1021/ac8012972http://pubs.acs.org/doi/pdfplus/10.1021/ac8012972http://pubs.acs.org/doi/pdfplus/10.1021/ac8012972


Oxidation of Ethyl Ether on Borate Glass: Chemiluminescence, Mechanism, and Development of a Sensitive Gas Sensor

Jing Hu†, Kailai Xu†, Yunzhen Jia†, Yi Lv*†, Yubao Li‡ and Xiandeng Hou*†‡pp 7964–7969 Publication Date (Web): October 8, 2008 (Article)DOI: 10.1021/ac800748mAbstract | Supporting Info

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A 200-Antibody Microarray Biochip for Environmental Monitoring: Searching for Universal Microbial Biomarkers through Immunoprofiling

Luis A. Rivas†, Miriam Garc a-Villadangos†, Mercedes Moreno-Paz†, Patricia Cruz-Gil†, Javier Gmez-Elvira‡ and V ctor Parro*†

pp 7970–7979 Publication Date (Web): October 7, 2008 (Article)DOI: 10.1021/ac8008093

Abstract | Supporting Info

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http://pubs.acs.org/doi/abs/10.1021/ac800748mhttp://pubs.acs.org/doi/abs/10.1021/ac800748mhttp://pubs.acs.org/doi/abs/10.1021/ac800748mhttp://pubs.acs.org/doi/suppl/10.1021/ac800748mhttp://pubs.acs.org/doi/full/10.1021/ac800748mhttp://pubs.acs.org/doi/full/10.1021/ac800748mhttp://pubs.acs.org/doi/pdf/10.1021/ac800748mhttp://pubs.acs.org/doi/pdf/10.1021/ac800748mhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800748mhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800748mhttp://pubs.acs.org/doi/abs/10.1021/ac8008093http://pubs.acs.org/doi/abs/10.1021/ac8008093http://pubs.acs.org/doi/abs/10.1021/ac8008093http://pubs.acs.org/doi/abs/10.1021/ac8008093http://pubs.acs.org/doi/suppl/10.1021/ac8008093http://pubs.acs.org/doi/full/10.1021/ac8008093http://pubs.acs.org/doi/full/10.1021/ac8008093http://pubs.acs.org/doi/pdf/10.1021/ac8008093http://pubs.acs.org/doi/pdf/10.1021/ac8008093http://pubs.acs.org/doi/pdfplus/10.1021/ac8008093http://pubs.acs.org/doi/pdfplus/10.1021/ac8008093


Micropatterned Fluid Lipid Bilayer Arrays Created Using a Continuous Flow Microspotter

Kathryn A. Smith†, Bruce K. Gale‡ and John C. Conboy*†pp 7980–7987 Publication Date (Web): October 8, 2008 (Article)DOI: 10.1021/ac800860uAbstract

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Simultaneous Nanoplasmonic and Quartz Crystal Microbalance Sensing: Analysis of Biomolecular Conformational Changes and Quantification of the Bound Molecular Mass

Magnus P. Jonsson*†, Peter J nsson and Fredrik H k*†pp 7988–7995 Publication Date (Web): October 4, 2008 (Article)DOI: 10.1021/ac8008753Abstract

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http://pubs.acs.org/doi/abs/10.1021/ac800860uhttp://pubs.acs.org/doi/abs/10.1021/ac800860uhttp://pubs.acs.org/doi/abs/10.1021/ac800860uhttp://pubs.acs.org/doi/full/10.1021/ac800860uhttp://pubs.acs.org/doi/full/10.1021/ac800860uhttp://pubs.acs.org/doi/pdf/10.1021/ac800860uhttp://pubs.acs.org/doi/pdf/10.1021/ac800860uhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800860uhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800860uhttp://pubs.acs.org/doi/abs/10.1021/ac8008753http://pubs.acs.org/doi/abs/10.1021/ac8008753http://pubs.acs.org/doi/abs/10.1021/ac8008753http://pubs.acs.org/doi/abs/10.1021/ac8008753http://pubs.acs.org/doi/full/10.1021/ac8008753http://pubs.acs.org/doi/full/10.1021/ac8008753http://pubs.acs.org/doi/pdf/10.1021/ac8008753http://pubs.acs.org/doi/pdf/10.1021/ac8008753http://pubs.acs.org/doi/pdfplus/10.1021/ac8008753http://pubs.acs.org/doi/pdfplus/10.1021/ac8008753


Self-Assembly of Quantum Dots and Carbon Nanotubes for Ultrasensitive DNA and Antigen Detection

Daxiang Cui*†‡, Bifeng Pan†, Hong Zhang‡, Feng Gao†, Rina Wu§, Jingping Wang‡, Rong He† and Toru Asahi‡ pp 7996–8001 Publication Date (Web): September 25, 2008 (Article)DOI: 10.1021/ac800992mAbstract | Supporting Info

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Time-Dependent Profiling of Metabolites from Snf1 Mutant and Wild Type Yeast Cells

Elizabeth M. Humston†, Kenneth M. Dombek‡, Jamin C. Hoggard†, Elton T. Young‡ and Robert E. Synovec*†pp 8002–8011 Publication Date (Web): October 1, 2008 (Article)DOI: 10.1021/ac800998jAbstract | Supporting Info

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Infrared Reflectance−Absorbance Spectroscopy of Thin Films


http://pubs.acs.org/doi/abs/10.1021/ac800992mhttp://pubs.acs.org/doi/abs/10.1021/ac800992mhttp://pubs.acs.org/doi/abs/10.1021/ac800992mhttp://pubs.acs.org/doi/suppl/10.1021/ac800992mhttp://pubs.acs.org/doi/full/10.1021/ac800992mhttp://pubs.acs.org/doi/full/10.1021/ac800992mhttp://pubs.acs.org/doi/pdf/10.1021/ac800992mhttp://pubs.acs.org/doi/pdf/10.1021/ac800992mhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800992mhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800992mhttp://pubs.acs.org/doi/abs/10.1021/ac800998jhttp://pubs.acs.org/doi/abs/10.1021/ac800998jhttp://pubs.acs.org/doi/abs/10.1021/ac800998jhttp://pubs.acs.org/doi/suppl/10.1021/ac800998jhttp://pubs.acs.org/doi/full/10.1021/ac800998jhttp://pubs.acs.org/doi/full/10.1021/ac800998jhttp://pubs.acs.org/doi/pdf/10.1021/ac800998jhttp://pubs.acs.org/doi/pdf/10.1021/ac800998jhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800998jhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800998jhttp://pubs.acs.org/doi/abs/10.1021/ac801019r


Formed by Forced Dewetting of Solid−Fluid Interfaces

Shinobu Tsuruta Heier†, Kevin E. Johnson‡, Anoma Mudalige, Domenic J. Tiani§, Vanessa R. Reid and Jeanne E. Pemberton*pp 8012–8019 Publication Date (Web): October 1, 2008 (Article)DOI: 10.1021/ac801019rAbstract | Supporting Info

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Direct Electrochemistry of Laccase Immobilized on Au Nanoparticles Encapsulated-Dendrimer Bonded Conducting Polymer: Application for a Catechin Sensor

Md. Aminur Rahman, Hui-Bog Noh and Yoon-Bo Shim*pp 8020–8027 Publication Date (Web): October 8, 2008 (Article)DOI: 10.1021/ac801033sAbstract

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Electrochemical Biosensor for Detection of BCR/ABL Fusion Gene Using Locked Nucleic Acids on 4-Aminobenzenesulfonic


http://pubs.acs.org/doi/abs/10.1021/ac801019rhttp://pubs.acs.org/doi/abs/10.1021/ac801019rhttp://pubs.acs.org/doi/suppl/10.1021/ac801019rhttp://pubs.acs.org/doi/full/10.1021/ac801019rhttp://pubs.acs.org/doi/full/10.1021/ac801019rhttp://pubs.acs.org/doi/pdf/10.1021/ac801019rhttp://pubs.acs.org/doi/pdf/10.1021/ac801019rhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801019rhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801019rhttp://pubs.acs.org/doi/abs/10.1021/ac801033shttp://pubs.acs.org/doi/abs/10.1021/ac801033shttp://pubs.acs.org/doi/abs/10.1021/ac801033shttp://pubs.acs.org/doi/abs/10.1021/ac801033shttp://pubs.acs.org/doi/full/10.1021/ac801033shttp://pubs.acs.org/doi/full/10.1021/ac801033shttp://pubs.acs.org/doi/pdf/10.1021/ac801033shttp://pubs.acs.org/doi/pdf/10.1021/ac801033shttp://pubs.acs.org/doi/pdfplus/10.1021/ac801033shttp://pubs.acs.org/doi/pdfplus/10.1021/ac801033shttp://pubs.acs.org/doi/abs/10.1021/ac801040ehttp://pubs.acs.org/doi/abs/10.1021/ac801040e


Acid-Modified Glassy Carbon Electrode

Jinghua Chen†‡, Jing Zhang†§, Kun Wang‡, Xinhua Lin‡, Liying Huang†‡ and Guonan Chen*†pp 8028–8034 Publication Date (Web): September 25, 2008 (Article)DOI: 10.1021/ac801040eAbstract | Supporting Info

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Selective Electrochemical Sensing of Glycated Hemoglobin (HbA1c) on Thiophene-3-Boronic Acid Self-Assembled

Monolayer Covered Gold Electrodes

Jin-Young Park†, Byoung-Yong Chang†, Hakhyun Nam‡ and Su-Moon Park*†pp 8035–8044 Publication Date (Web): October 1, 2008 (Article)DOI: 10.1021/ac8010439Abstract

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Microscale LC-MS-NMR Platform Applied to the Identification of Active Cyanobacterial Metabolites


http://pubs.acs.org/doi/abs/10.1021/ac801040ehttp://pubs.acs.org/doi/abs/10.1021/ac801040ehttp://pubs.acs.org/doi/suppl/10.1021/ac801040ehttp://pubs.acs.org/doi/full/10.1021/ac801040ehttp://pubs.acs.org/doi/full/10.1021/ac801040ehttp://pubs.acs.org/doi/pdf/10.1021/ac801040ehttp://pubs.acs.org/doi/pdf/10.1021/ac801040ehttp://pubs.acs.org/doi/pdfplus/10.1021/ac801040ehttp://pubs.acs.org/doi/pdfplus/10.1021/ac801040ehttp://pubs.acs.org/doi/abs/10.1021/ac8010439http://pubs.acs.org/doi/abs/10.1021/ac8010439http://pubs.acs.org/doi/abs/10.1021/ac8010439http://pubs.acs.org/doi/abs/10.1021/ac8010439http://pubs.acs.org/doi/full/10.1021/ac8010439http://pubs.acs.org/doi/full/10.1021/ac8010439http://pubs.acs.org/doi/pdf/10.1021/ac8010439http://pubs.acs.org/doi/pdf/10.1021/ac8010439http://pubs.acs.org/doi/pdfplus/10.1021/ac8010439http://pubs.acs.org/doi/pdfplus/10.1021/ac8010439http://pubs.acs.org/doi/abs/10.1021/ac801049khttp://pubs.acs.org/doi/abs/10.1021/ac801049k


Yiqing Lin†, Susan Schiavo†, Jimmy Orjala‡, Paul Vouros† and Roger Kautz*†pp 8045–8054 Publication Date (Web): October 4, 2008 (Article)DOI: 10.1021/ac801049kAbstract

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Versatile Online−Offline Engine for Automated Acquisition of High-Resolution Tandem Mass Spectra

Craig D. Wenger, Michael T. Boyne, , Jonathan T. Ferguson, Dana E. Robinson and Neil L. Kelleher*pp 8055–8063 Publication Date (Web): October 8, 2008 (Article)DOI: 10.1021/ac8010704Abstract | Supporting Info

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In Situ Amplified Electrochemical Immunoassay for Carcinoembryonic Antigen Using Horseradish Peroxidase-Encapsulated Nanogold Hollow Microspheres as Labels

Dianping Tang*† and Jingjing Ren


http://pubs.acs.org/doi/abs/10.1021/ac801049khttp://pubs.acs.org/doi/full/10.1021/ac801049khttp://pubs.acs.org/doi/full/10.1021/ac801049khttp://pubs.acs.org/doi/pdf/10.1021/ac801049khttp://pubs.acs.org/doi/pdf/10.1021/ac801049khttp://pubs.acs.org/doi/pdfplus/10.1021/ac801049khttp://pubs.acs.org/doi/pdfplus/10.1021/ac801049khttp://pubs.acs.org/doi/abs/10.1021/ac8010704http://pubs.acs.org/doi/abs/10.1021/ac8010704http://pubs.acs.org/doi/abs/10.1021/ac8010704http://pubs.acs.org/doi/suppl/10.1021/ac8010704http://pubs.acs.org/doi/full/10.1021/ac8010704http://pubs.acs.org/doi/full/10.1021/ac8010704http://pubs.acs.org/doi/pdf/10.1021/ac8010704http://pubs.acs.org/doi/pdf/10.1021/ac8010704http://pubs.acs.org/doi/pdfplus/10.1021/ac8010704http://pubs.acs.org/doi/pdfplus/10.1021/ac8010704http://pubs.acs.org/doi/abs/10.1021/ac801091jhttp://pubs.acs.org/doi/abs/10.1021/ac801091jhttp://pubs.acs.org/doi/abs/10.1021/ac801091j


pp 8064–8070 Publication Date (Web): September 25, 2008 (Article)DOI: 10.1021/ac801091jAbstract

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Open Bridge-Structured Gold Nanoparticle Array for Label-Free DNA Detection

Shiho Tokonami, Hiroshi Shiigi* and Tsutomu Nagaokapp 8071–8075 Publication Date (Web): October 7, 2008 (Article)DOI: 10.1021/ac801088uAbstract

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Equivalence of the Different Cm- and Cs-Term Expressions

Used in Liquid Chromatography and a Geometrical Model Uniting Them

Gert Desmet* and Ken Broeckhovenpp 8076–8088 Publication Date (Web): September 27, 2008 (Article)


http://pubs.acs.org/doi/abs/10.1021/ac801091jhttp://pubs.acs.org/doi/full/10.1021/ac801091jhttp://pubs.acs.org/doi/full/10.1021/ac801091jhttp://pubs.acs.org/doi/pdf/10.1021/ac801091jhttp://pubs.acs.org/doi/pdf/10.1021/ac801091jhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801091jhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801091jhttp://pubs.acs.org/doi/abs/10.1021/ac801088uhttp://pubs.acs.org/doi/abs/10.1021/ac801088uhttp://pubs.acs.org/doi/abs/10.1021/ac801088uhttp://pubs.acs.org/doi/full/10.1021/ac801088uhttp://pubs.acs.org/doi/full/10.1021/ac801088uhttp://pubs.acs.org/doi/pdf/10.1021/ac801088uhttp://pubs.acs.org/doi/pdf/10.1021/ac801088uhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801088uhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801088uhttp://pubs.acs.org/doi/abs/10.1021/ac8011363http://pubs.acs.org/doi/abs/10.1021/ac8011363http://pubs.acs.org/doi/abs/10.1021/ac8011363


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Analytical Utility of Small Neutral Losses from Reduced Species in Electron Capture Dissociation Studied Using SwedECD Database

Maria F lth†, Mikhail M. Savitski‡, Michael L. Nielsen‡, Frank Kjeldsen‡, Per E. Andren† and Roman A. Zubarev*‡ pp 8089–8094 Publication Date (Web): October 7, 2008 (Article)DOI: 10.1021/ac800944uAbstract

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Solution Titration by Wall Deprotonation during Capillary Filling of Silicon Oxide Nanochannels

Kjeld G. H. Janssen*†, Hanh T. Hoang‡, Jan Floris‡, Jeroen de Vries‡, Niels R. Tas‡, Jan C. T. Eijkel‡ and Thomas Hankemeier*† pp 8095–8101 Publication Date (Web): October 1, 2008 (Article)


http://pubs.acs.org/doi/abs/10.1021/ac8011363http://pubs.acs.org/doi/suppl/10.1021/ac8011363http://pubs.acs.org/doi/full/10.1021/ac8011363http://pubs.acs.org/doi/full/10.1021/ac8011363http://pubs.acs.org/doi/pdf/10.1021/ac8011363http://pubs.acs.org/doi/pdf/10.1021/ac8011363http://pubs.acs.org/doi/pdfplus/10.1021/ac8011363http://pubs.acs.org/doi/pdfplus/10.1021/ac8011363http://pubs.acs.org/doi/abs/10.1021/ac800944uhttp://pubs.acs.org/doi/abs/10.1021/ac800944uhttp://pubs.acs.org/doi/abs/10.1021/ac800944uhttp://pubs.acs.org/doi/abs/10.1021/ac800944uhttp://pubs.acs.org/doi/full/10.1021/ac800944uhttp://pubs.acs.org/doi/full/10.1021/ac800944uhttp://pubs.acs.org/doi/pdf/10.1021/ac800944uhttp://pubs.acs.org/doi/pdf/10.1021/ac800944uhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800944uhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800944uhttp://pubs.acs.org/doi/abs/10.1021/ac800603mhttp://pubs.acs.org/doi/abs/10.1021/ac800603m


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Electrochemically Modulated Liquid−Liquid Extraction of Ionized Drugs under Physiological Conditions

Courtney J. Collins, Alfonso Berduque and Damien W. M. Arrigan*pp 8102–8108 Publication Date (Web): October 9, 2008 (Article)DOI: 10.1021/ac800646bAbstract

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Rotational Hydrodynamic Diffusion System To Study Mass Transport Across Boundaries

Sai Sree Mamidi, Bo Meas and Tarek R. Farhat*pp 8109–8114 Publication Date (Web): October 10, 2008 (Article)DOI: 10.1021/ac800889dAbstract

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Subpicogram per Milliliter Determination of the Tobacco-Specific Carcinogen Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in Human Urine Using Liquid Chromatography−Tandem Mass Spectrometry

Peyton Jacob, *†, Christopher Havel†, Do-Hoon Lee‡, Lisa Yu†, Mark D. Eisner§ and Neal L. Benowitz†pp 8115–8121 Publication Date (Web): October 8, 2008 (Article)DOI: 10.1021/ac8009005Abstract

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Dependence of Effective Peak Capacity in Comprehensive Two-Dimensional Separations on the Distribution of Peak Capacity between the Two Dimensions

Joe M. Davis*Dwight R. StollPeter W. Carrpp 8122–8134 Publication Date (Web): October 8, 2008 (Article)DOI: 10.1021/ac800933zAbstract


http://pubs.acs.org/doi/pdf/10.1021/ac800889dhttp://pubs.acs.org/doi/pdf/10.1021/ac800889dhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800889dhttp://pubs.acs.org/doi/pdfplus/10.1021/ac800889dhttp://pubs.acs.org/doi/abs/10.1021/ac8009005http://pubs.acs.org/doi/abs/10.1021/ac8009005http://pubs.acs.org/doi/abs/10.1021/ac8009005http://pubs.acs.org/doi/abs/10.1021/ac8009005http://pubs.acs.org/doi/abs/10.1021/ac8009005http://pubs.acs.org/doi/full/10.1021/ac8009005http://pubs.acs.org/doi/full/10.1021/ac8009005http://pubs.acs.org/doi/pdf/10.1021/ac8009005http://pubs.acs.org/doi/pdf/10.1021/ac8009005http://pubs.acs.org/doi/pdfplus/10.1021/ac8009005http://pubs.acs.org/doi/pdfplus/10.1021/ac8009005http://pubs.acs.org/doi/abs/10.1021/ac800933zhttp://pubs.acs.org/doi/abs/10.1021/ac800933zhttp://pubs.acs.org/doi/abs/10.1021/ac800933zhttp://pubs.acs.org/doi/abs/10.1021/ac800933z


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First Evidence for Occurrence of Hydroxylated Human Metabolites of Diclofenac and Aceclofenac in Wastewater Using QqLIT-MS and QqTOF-MS

Sandra P rez*† and Dami Barcel †‡pp 8135–8145 Publication Date (Web): September 26, 2008 (Article)DOI: 10.1021/ac801167wAbstract | Supporting Info

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Prediction of Sublayer Depth in Turbid Media Using Spatially Offset Raman Spectroscopy

N. A. Macleod*†, A. Goodship‡, A. W. Parker† and P. Matousek*†pp 8146–8152 Publication Date (Web): September 12, 2008 (Article)DOI: 10.1021/ac801219aAbstract

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Liquid Chromatography of Theta-Shaped and Three-Armed Star Poly(tetrahydrofuran)s: Theory and Experimental Evidence of Topological Separation

Andrey V. Vakhrushev†, Alexei A. Gorbunov*†, Yasuyuki Tezuka*‡, Akiko Tsuchitani‡ and Hideaki Oike‡§pp 8153–8162 Publication Date (Web): October 1, 2008 (Article)DOI: 10.1021/ac801229fAbstract

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Speciation Analysis of Gadolinium-Based MRI Contrast Agents in Blood Plasma by Hydrophilic Interaction Chromatography/Electrospray Mass Spectrometry

Jens K nnemeyer†, Lydia Terborg†, Sascha Nowak†, Andy Scheffer†, Lena Telgmann†, Faruk Tokmak‡, Andreas G nsel§, Gerhard Wiesm ller§, Stephan Reichelt and Uwe Karst*† pp 8163–8170 Publication Date (Web): September 27, 2008 (Article)DOI: 10.1021/ac801264jAbstract

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Development of a Proton-Transfer Reaction-Linear Ion Trap Mass Spectrometer for Quantitative Determination of Volatile Organic Compounds

Levi H. Mielke†, David E. Erickson†, Scott A. McLuckey†, Markus M ller‡, Armin Wisthaler‡, Armin Hansel‡ and Paul B. Shepson*†§pp 8171–8177 Publication Date (Web): October 8, 2008 (Article)DOI: 10.1021/ac801328dAbstract | Supporting Info

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Multiplex Mass Spectrometric Genotyping of Single Nucleotide Polymorphisms Employing Pyrrolidinyl Peptide Nucleic Acid in Combination with Ion-Exchange Capture

Boonjira Boontha†, Jeerawat Nakkuntod‡, Nattiya Hirankarn§, Piyasak Chaumpluk and Tirayut Vilaivan*† pp 8178–8186 Publication Date (Web): September 27, 2008 (Article)DOI: 10.1021/ac801336qAbstract | Supporting Info


http://pubs.acs.org/doi/pdf/10.1021/ac801264jhttp://pubs.acs.org/doi/pdf/10.1021/ac801264jhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801264jhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801264jhttp://pubs.acs.org/doi/abs/10.1021/ac801328dhttp://pubs.acs.org/doi/abs/10.1021/ac801328dhttp://pubs.acs.org/doi/abs/10.1021/ac801328dhttp://pubs.acs.org/doi/abs/10.1021/ac801328dhttp://pubs.acs.org/doi/suppl/10.1021/ac801328dhttp://pubs.acs.org/doi/full/10.1021/ac801328dhttp://pubs.acs.org/doi/full/10.1021/ac801328dhttp://pubs.acs.org/doi/pdf/10.1021/ac801328dhttp://pubs.acs.org/doi/pdf/10.1021/ac801328dhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801328dhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801328dhttp://pubs.acs.org/doi/abs/10.1021/ac801336qhttp://pubs.acs.org/doi/abs/10.1021/ac801336qhttp://pubs.acs.org/doi/abs/10.1021/ac801336qhttp://pubs.acs.org/doi/abs/10.1021/ac801336qhttp://pubs.acs.org/doi/suppl/10.1021/ac801336q


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Global Detection and Identification of Nontarget Components from Herbal Preparations by Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry and a Strategy

Haiping Hao†, Nan Cui†, Guangji Wang*†, Binren Xiang‡, Yan Liang†, Xiangyang Xu§, Hui Zhang§, Jun Yang§, Chaonan Zheng†, Liang Wu†, Ping Gong† and Wei Wang† pp 8187–8194 Publication Date (Web): September 17, 2008 (Article)DOI: 10.1021/ac801356sAbstract | Supporting Info

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Assay for Glucosamine 6-Phosphate Using a Ligand-Activated Ribozyme with Fluorescence Resonance Energy Transfer or CE-Laser-Induced Fluorescence Detection

Jennifer R. W. Furchak†, Peilin Yang, Colin Jennings, Nils G. Walter* and Robert T. Kennedy*pp 8195–8201 Publication Date (Web): October 9, 2008 (Article)DOI: 10.1021/ac801410kAbstract


http://pubs.acs.org/doi/full/10.1021/ac801336qhttp://pubs.acs.org/doi/full/10.1021/ac801336qhttp://pubs.acs.org/doi/pdf/10.1021/ac801336qhttp://pubs.acs.org/doi/pdf/10.1021/ac801336qhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801336qhttp://pubs.acs.org/doi/pdfplus/10.1021/ac801336qhttp://pubs.acs.org/doi/abs/10.1021/ac801356shttp://pubs.acs.org/doi/abs/10.1021/ac801356shttp://pubs.acs.org/doi/abs/10.1021/ac801356shttp://pubs.acs.org/doi/abs/10.1021/ac801356shttp://pubs.acs.org/doi/suppl/10.1021/ac801356shttp://pubs.acs.org/doi/full/10.1021/ac801356shttp://pubs.acs.org/doi/full/10.1021/ac801356shttp://pubs.acs.org/doi/pdf/10.1021/ac801356shttp://pubs.acs.org/doi/pdf/10.1021/ac801356shttp://pubs.acs.org/doi/pdfplus/10.1021/ac801356shttp://pubs.acs.org/doi/pdfplus/10.1021/ac801356shttp://pubs.acs.org/doi/abs/10.1021/ac801410khttp://pubs.acs.org/doi/abs/10.1021/ac801410khttp://pubs.acs.org/doi/abs/10.1021/ac801410khttp://pubs.acs.org/doi/abs/10.1021/ac801410k


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Determination of Polycyclic Aromatic Hydrocarbons in Drinking Water Samples by Solid-Phase Nanoextraction and High-Performance Liquid Chromatography

Huiyong Wang and Andres D. Campiglia*pp 8202–8209 Publication Date (Web): October 4, 2008 (Article)DOI: 10.1021/ac8014824Abstract

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Direct Analysis of Fatty Acid Vapors in Breath by Electrospray Ionization and Atmospheric Pressure Ionization-Mass Spectrometry

Pablo Mart nez-Lozano†‡ and Juan Fern ndez de la Mora*§ pp 8210–8215 Publication Date (Web): September 26, 2008 (Article)DOI: 10.1021/ac801185eAbstract

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Digitized Molecular Diagnostics: Reading Disk-Based Bioassays with Standard Computer Drives

Yunchao Li, Lily M. L. Ou and Hua-Zhong Yu*pp 8216–8223 Publication Date (Web): September 26, 2008 (Article)DOI: 10.1021/ac8012434Abstract | Supporting Info

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In Situ Fabrication of Ionic Polyacrylamide-Based Preconcentrator on a Simple Poly(methyl methacrylate) Microfluidic Chip for Capillary Electrophoresis of Anionic Compounds

Sachio Yamamoto, Shingo Hirakawa and Shigeo Suzuki*pp 8224–8230 Publication Date (Web): October 8, 2008 (Article)DOI: 10.1021/ac801245nAbstract

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Sampling and Electrophoretic Analysis of Segmented Flow Streams Using Virtual Walls in a Microfluidic Device

Gregory T. Roman†‡, Meng Wang†, Kristin N. Shultz†, Colin Jennings† and Robert T. Kennedy*†§ pp 8231–8238 Publication Date (Web): October 3, 2008 (Article)DOI: 10.1021/ac801317tAbstract

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Disposable Magnetic DNA Sensors for the Determination at the Attomolar Level of a Specific Enterobacteriaceae Family Gene

scar A. Loaiza†, Susana Campuzano†, Mar a Pedrero†, M. Isabel Pividori‡, Pedro Garc a§ and Jos M. Pingarr n*† pp 8239–8245 Publication Date (Web): October 7, 2008 (Article)DOI: 10.1021/ac801319bAbstract

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Metalation States versus Enzyme Activities of Cu, Zn-Superoxide Dismutase Probed by Electrospray Ionization Mass Spectrometry

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Following the Biocatalytic Activities of Glucose Oxidase by Electrochemically Cross-Linked Enzyme−Pt Nanoparticles Composite Electrodes

Lily Bahshi†, Marco Frasconi‡, Ran Tel-Vered†, Omer Yehezkeli† and Itamar Willner*†pp 8253–8259 Publication Date (Web): October 8, 2008 (Article)DOI: 10.1021/ac801398mAbstract | Supporting Info

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Azamacrocycle Activated Quantum Dot for Zinc Ion Detection

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Identification of Cell Surface Markers to Differentiate Rat Endothelial and Fibroblast Cells Using Lectin Arrays and LC−ESI-MS/MS

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Chemometrics-Assisted Excitation−Emission Fluorescence Spectroscopy on Nylon Membranes. Simultaneous Determination of Benzo[a]pyrene and Dibenz[a,h]anthracene at Parts-Per-Trillion Levels in the Presence of the Remaining EPA PAH Priority Pollutants As Interferences

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Electroosmotic Flow-Based Pump for Liquid Chromatography on a Planar Microchip

Joseph F. Borowsky†, Braden C. Giordano‡, Qin Lu†, Alex Terray† and Greg E. Collins*†pp 8287–8292 Publication Date (Web): October 7, 2008 (Article)DOI: 10.1021/ac801497rAbstract

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Continuous Time-of-Flight Ion Imaging: Application to Fragmentation

Oh Kyu Yoon, Matthew D. Robbins, Ignacio A. Zuleta, Griffin K. Barbula and Richard N. Zare*pp 8299–8307 Publication Date (Web): October 7, 2008 (Article)DOI: 10.1021/ac801512nAbstract

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Laser Ablation Coupled to a Flowing Atmospheric Pressure Afterglow for Ambient Mass Spectral Imaging


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Enzyme Kinetics by Directly Imaging a Porous Silicon Microfluidic Reactor Using Desorption/Ionization on Silicon Mass Spectrometry

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Electronic Referencing Techniques for Quantitative NMR: Pitfalls and How To Avoid Them Using Amplitude-Corrected Referencing through Signal Injection


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Knut Mehr, Boban John, David Russell and Daina Avizonis*pp 8320–8323 Publication Date (Web): October 10, 2008 (Technical Note)DOI: 10.1021/ac800865cAbstract | Supporting Info

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Mass Spectrometry Analysis of Phosphopeptides after Peptide Carboxy Group Derivatization

Yawei Xu, Lijuan Zhang, Haojie Lu* and Pengyuan Yangpp 8324–8328 Publication Date (Web): September 27, 2008 (Technical Note)DOI: 10.1021/ac801220cAbstract | Supporting Info

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Surface Plasmon Resonance Assay for Chloramphenicol

Jing Yuan†‡, Richard Oliver†, Marie-Isabel Aguilar‡ and Yinqiu Wu*† pp 8329–8333 Publication Date (Web): October 7, 2008 (Technical Note)DOI: 10.1021/ac801301pAbstract | Supporting Info


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Simple Coupling of Gas Chromatography to Electrospray Ionization Mass Spectrometry

Nina Brenner, Markus Haapala, Katariina Vuorensola and Risto Kostiainen*pp 8334–8339 Publication Date (Web): October 7, 2008 (Technical Note)DOI: 10.1021/ac801406tAbstract

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Identification of Recombinant Equine Growth Hormone in Horse Plasma by LC−MS/MS: A Confirmatory Analysis in Doping Control

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In Situ Measurements of Aggregation and Disaggregation of Cu(II) Complex at Liquid/Liquid Interface

Hitoshi Watarai* and Hiroko Oyamapp 8348–8352 Publication Date (Web): October 10, 2008 (Correspondence)DOI: 10.1021/ac8008719Abstract

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Complications in the Assignment of 14 and 28 Da Mass Shift Detected by Mass Spectrometry as in Vivo Methylation from Endogenous Proteins

Sung Yun Jung, Yehua Li, Yi Wang, Yue Chen, Xian-De Liu, N. Tony Eissa, Yingming Zhao and Jun Qinp 8353 Publication Date (Web): October 8, 2008 (Addition/Correction)DOI: 10.1021/ac801953e


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1H NMR and UPLC-MSE Statistical Heterospectroscopy: Characterization of Drug Metabolites (Xenometabolome) in Epidemiological Studies

Derek J. Crockford, Anthony D. Maher, Kourosh R. Ahmadi, Amy Barrett, Robert S. Plumb, Ian D. Wilson and Jeremy K. Nicholsonp 8353 Publication Date (Web): October 4, 2008 (Addition/Correction)DOI: 10.1021/ac801996wAbstract

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Analytical Chemistry is published by the American Chemical Society. 1155Sixteenth Street N.W., Washington, DC 20036

AC Detective

A cool way to learn about climate changeJeffrey Perkel

Anal. Chem., 2008, 80 (21), 7908-7909• DOI: 10.1021/ac801861u • Publication Date (Web): 31 October 2008

Downloaded from http://pubs.acs.org on April 9, 2009

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Analytical Chemistry is published by the American Chemical Society. 1155Sixteenth Street N.W., Washington, DC 20036

http://pubs.acs.org/doi/full/10.1021/ac801861u

A cool way to learn about climatechangeExamination of ice cores reveals weather conditions of the past.

Consult an almanac and you can findout what the weather was like inyour hometown on any date from thepast few decades. Patrik Kaufmann,though, takes a somewhatlonger-range viewOabout800,000 years longer. Kauf-mann, of the University of Bern(Switzerland), along with col-leagues at the British AntarcticSurvey, the University ofCopenhagen, and the AlfredWegener Institute for Polar andMarine Research (Germany),analyzes ice cores from Green-land and Antarctica to read theatmospheric conditions abovethe Northern and Southernoceans long before recordedhistory began.

Just as tree rings can revealnot only a tree’s age but also itsgrowth conditions, ice coresrecord the meteorological story of thetime when their frozen layers were de-posited. As snow or ice falls to theground and compacts, it retains thetrace elements, particulates, and gasesthat permeate it. By peeling back thoselayers and reading their chemical com-position, researchers can begin to piecetogether the ambient conditions thatoccurred during the layers’ creation.

“In Antarctica, we have just a con-tinuing layering [of ice] over severalhundred thousand years of climate,”explains Kaufmann. “The temperatureon the plateau on Antarctica was neverabove 0 °C, so we have a continuousarchive.” The European Project for IceCoring in Antarctica’s Dome C core,which has a record of �800,000 years, isone such archive (Nature 2004, 429,623�628); another is the 123,000-year-old core drilled by the North GreenlandIce Core Project.

Many chemical components of theice core help tell its climatological story:sodium ion content, for instance, revealsthe extent of sea-ice coverage; NH4� in

Greenland cores indicates forest fires inNorth America; dust from Antarcticcores recalls the atmospheric moisturelevel in the Patagonia region of SouthAmerica; SO42� content indicates bio-chemical activity in the Southern Ocean,a possible surrogate for the carbon cycle;and total air content (TAC) is linked tolocal insolationOthat is, how much solarenergy is hitting the earth. The methodKaufmann and his colleagues use to mapthese chemical changes over time iscalled continuous flow analysis (CFA),in which an ice core is melted steadilyand analyzed continuously in a series ofparallel absorbance and fluorescencechambers.

Every graduate student’snightmareKaufmann recently obtained his Ph.D.,but he was a new master’s candidate inBern when he made his first foray to

Antarctica with his lab’s battle-testedCFA system. Flush with data, he re-turned to EuropeObut unfortunately,the hardware did not. Sometime after

the equipment wasloaded into a cargo con-tainer for transport andbefore the container wasopened back in Europe,the CFA equipment, plusall the team’s spare parts,disappeared.

“When my professortold me, ‘Hey, Patrik, thecargo container is empty,everything disappeared,’it was like a bad joke,”Kaufmann recalls.

But it was no joke. Itwas time to start over.After securing funds fromthe Swiss National Sci-ence Foundation, Kauf-

mann, who has an undergraduate degreein physics as well as experience as anelectrical engineer; Urs Federer, anothergraduate student on the project; and ateam of mechanics and electrical engi-neers set out to build a next-generationCFA device that would re-create theoriginal system and even improve on it.

Three ideas were key. The first wasmaking the system easier to deploy inthe field. The original design wasshipped in piecesOvalves, tubes, detec-tors, and so onOand assembled on-site.Not only was this troublesome, it madesystem calibration and troubleshootingdifficult, Kaufmann says.

The new system is modular, withthree preassembled, rack-mountedunitsOfor melting, distribution, andanalysisOthat need only be connectedto get the system up and running. Ac-cording to Kaufmann, this developmentmakes field analysis of the ice core more

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A CFA system prototype without temperature stabilization inside a tent atKohnen Station in Antarctica.

1 0 . 1 0 2 1 / A C 8 0 1 8 6 1 U 2 0 0 8 A M E R I C A N C H E M I C A L S O C I E T Y7908 A N A L Y T I C A L C H E M I S T R Y / N O V E M B E R 1 , 2 0 0 8Published on Web 10/31/2008

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productive. “In the old system, they didabout 25 m per day, and now we domore than 30 m per day,” he says. Everylittle bit helps when the core is 3300 mlong.

A second improvement is the numberof analytical channels. The current sys-tem has 11: the 8 the system originallyhad (Na�, Ca2�, NH4�, NO3�, SO42�,H2O2, HCHO, and electrolytical con-ductivity), plus 3 others that are new(TAC, dust, and total organic carbon).At the moment, the TAC channel re-ports only the volume of air trapped inthe ice, but the team is developing waysto analyze that airOfor instance, to

quantify the concentration of gases suchas methane.

A final improvement is the ability tocontrol the temperature of each mea-surement module individually (the pre-vious system had no temperature con-trol). “That seems a bit like a not-so-important thing, but it makes a hugedifference if you measure at different,stabilized temperatures,” says Kauf-mann. For instance, while Na� analysisperforms optimally at 16 °C, NO3�

analysis works best at 22 °C.In a recent report in Environmental

Science & Technology (2008, DOI10.1021/es8007722), Kaufmann and

colleagues applied their system to apiece of Greenland ice deposited�10,000 years ago, demonstrating thatall 11 channels could function in paral-lel. The resolution was so high, the re-searchers found they literally couldcount ice layers, just as with annual treerings. It was an “essential proof of per-formance,” he says. Now Kaufmann andcolleagues want to apply their CFA sys-tem to the deeper past to examine theclimatology and glaciology of the Ant-arctic circa 800,000 years B.C.E. “It iskind of a big puzzle,” he says.

—Jeffrey Perkel

7909N O V E M B E R 1 , 2 0 0 8 / A N A L Y T I C A L C H E M I S T R Y

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acs.orgAnalytical Chemistry: Volume 80, Issue 21 (ACS Publications)http://pubs.acs.org/doi/pdfplus/10.1021/ac801861u

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