A Critical Analysis of Rheumatic Fever Prevention Protocol ... annie judkins.pdf · A Critical...
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Walking the Tightrope
A Critical Analysis of Rheumatic Fever Prevention Protocol
A Balancing Act In a High Risk Community
Ora Toa Poriua
Annie Judkins
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Keep antibiotics working
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Post Code Penicillin
Colour Code Cefalexin
Area Code Amoxil
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Rheumatic fever rapid response service reporting
Capital and Coast DHB
1 Total number of eligible (Māori, Pacific, NZDep quintile 5) 4-19 year olds (index case only) presenting to rapid response service
2 Total number of eligible 4-19 year olds given antibiotics the same day assessed
3Percentage of eligible (M, P, Q5) 4-19 year olds given antibiotics the same day assessed
4Total number given oral amoxicillin once daily
5 Total number given intramuscular single dose benzathine benzylpenicillin
6 Total number given twice daily oral erythromycin
7 Total number given other antibiotics
8Percentage given appropriate antibiotics
1
Eligible household contacts (3-35 years old with a sore throat)
9 Total number of eligible household contacts (3-35 years old with a sore throat) assessed
10 Total number of eligible household contacts given antibiotics the same day assessed
11 Percentage of eligible household contacts given antibiotics the same day assessed
12Total number given oral amoxicillin once daily
13 Total number given intramuscular single dose benzathine benzylpenicillin
14 Total number given twice daily oral erythromycin
15 Total number given other antibiotics
16Percentage given appropriate antibiotics
1
1 Appropriate antibiotics for high risk population with a sore throat are: Amoxicillin once daily, one dose of intramuscular benzathine benzylpenicillin, twice daily erythromycin
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18%
4%
78%
828 Throat Swabs in 2 years
GAS Pos
Gp C&G
GAS Neg
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0
10
20
30
40
50
60
70
80
Throat Swabs by Month and Results
Number of Swabs
GAS Pos
Gp C&G
GAS Neg
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0
10
20
30
40
50
60
70
Jul-17 Aug-17 Sep-17 Oct-17 Nov-17 Dec-17 Jan-18 Feb-18 Mar-18 Apr-18 May-18 Jun-18
Throat Swab Result and Treatment as per Guidelines
Number GAS Pos
No GAS Pos treated as per Guidelines
Number GAS Neg
Neg Swabs Given Abs
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402
251
62% GAS Negative Swabs treated with ABs
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Email from MOH RF Group 3 days ago
“…As with Q2 it appears there have low numbers of eligible individuals presenting to the sore throat management services and also given same day antibiotics. Can you advise what more is being done to promote awareness of sore throat management services and ensuring appropriate antibiotics are being given…”
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2016 = 10 cases, 7<16 & 3 adults
2017 = 9 cases, 6 <16 & 3 adults
Year to date = 8 cases, 4<16 & 4 adults
RF in Wellington 2016 -> now
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It is used to measure the Minimum Inhibitory Concentration [MIC] of an antimicrobial agent, which is the lowest concentration of antimicrobial agent which will inhibit the growth of microbes.
MIC
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Penicillins need to have the MIC above 40-60% of the time to be effective
3-4 times daily to maintain this MIC level
Amoxicillin once daily does not achieve this!
MIC
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What does a 32 kg 4 year old girl have in common with antibiotic metabolisation with a 102 kg 18 year man?
32 kg
Question?
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Bacterial Adaptation
Antibiotic Resistance
People NOT presenting when there is a true risk
Losing Trusting Relationship
What are the risks?
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CVR
Smoking Status Recording
Institutionalised Racism
Crap Housing and Poverty
EBM
Challenge Everything
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Advocate for your Patients
Prescribe Antibiotics thoughtfully
We are only here for a short time, but our actions could affect generations.
Do Your Best
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Antimicrobial Resistance (AMR):A heads up on the threat
Speakers: David Holland on behalf of Infection Services, CMH and HARCBryan BettyAnnie Judkins
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Several major reports in recent years and media interest…
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antibiotic resistance potentially threatens the safety and efficacy of surgical procedures and chemotherapy
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Released August 2017 on MoH website
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Development of AMR:
• Darwinian Evolution
• Selective pressure
• Survival of the fittest spread
Resistantbacterial spread
Antibiotic effectiveness
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The hammer: Antibiotic prescribing
In NZ about 85-90% human antibiotics prescribed in the communityand 10-15% in hospitalInappropriate antibiotic prescribing approximately 50% in both settings
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The anvil: Spread of resistant organisms
• Locally generated
• Introduction from elsewhere ‘pre-prepared’
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An outbreak of Carbapenem-Resistant Organisms in Burns Patients in a
critical care complex.
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Index Patient (A)
• 68 Male
• Sailor
• Boat explosion –burns
– 85% TBSA superficial –deep
• Transferred for further specialized burn care from overseas hospital
On admission:
Strict infection control and isolationFashioned a treatment
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Quick primer of Carbapenems
• Beta-lactams (kind of)• Extremely broad spectrum• Extensive evidence of efficacy
& safety• Tolerated in severe penicillin
allergy• 1st-line treatment for serious
infections with multi-resistant GNBs eg ESBLs (extended spectrum beta-lactamase producers)
e.g.• Meropenem• Imipenem• Ertapenem
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Carbapenemase-Producing Enterobacteriaceae (CPE)
• Enterobacteriaceae• Plasmid-mediated enzyme
producers– Spreads very easily– Linked with multiple other
resistances
• ‘Super-ESBL’ organisms that are resistant to their primary treatment
→ Major clinical & public health concern
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ESBL CPE
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Quick guide to CRO terminology
Enterobacteriaceae:– E.coli– Klebsiella
pneumoniae– Proteus– Enterobacter
cloacae– Citrobacter– Serratia marcescens– Morganella
morganii– Providencia– Salmonella,
Yersinia, Shigella, and many others…
CROCarbapenem Resistant Organism
CRECarbapenem Resistant
Enterobacteriaceae
*CPE*Carbapenemase Producing
Enterobacteriaceae
NDM KPCOxa-48
Etc…
[other]
[other]
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Great concern: Limited rx options = poor outcomes
Colistin
Tigecycline
Fosfomycin
Ceftazidime-avibactam
Ceftolozane-tazobactam
• Colonisation– Asymptomatic, but can
transmit– Community spread is
known
• Infection– Just like any other GNB
infection…– …except limited treatment
options– High mortality &
morbidity (~50% from bacteraemia)
• Healthcare costs• ?Impact on elective
treatments
‘Typical’ E.coli ‘Wild-type’ ESBL CPE
Amoxicillin
Augmentin
Cefuroxime
Ceftriaxone
Co-trimoxazole
Ciprofloxacin
Gentamicin
Amikacin
Carbapenems
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Patient B (27 Dec)SITE: CVL later in blood culture
Cross-Transmission!
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Timeline of Burns patients in ICU & OT: A tale of two transmissions
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
WEEK
7FNZer. Flame injury 40%
68MSailor. Not NZ. Burned in boat explosion. Transfer from overseas hospital. 85% supfl
*
58FNZer45% TBSA (33% full thickness)
* * *Admission 27 DecBacteraemic
Vascularcatheter tip then tissues and blood cultures P. stuartii
Very Stormy course, several postive blood cultures, tissue culturesTransmission of resistance element to other organisms. Given
novel antibiotic regimen
2 February: tissues P. stuartii
and K pneumoniae NDM and BCIschaemic bowel
*
admission 11 DecBlood cultures positive on admission carbapenem resistant P. stuartii
Admitted 17 Jan*
discharged 23 April
PATIENT A
PATIENT B
PATIENT C
Multiple tissue and blood cultures positiveFive different CRO
Prolonged bacteraemia with CRO and Candida
eventually recovered and discharged home with support
IC discussions/investigations/interventions
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Patient C (2 Feb)
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So what can we do?
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How is it spread?
CRO will not jump, skip, hop or fly!
Contact with infected/colonised people, mostly via:
Hands
Shared Equipment
Environmental/surfaces
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Timeline of Burns patients in ICU & OT: A tale of two transmissions
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
WEEK
7FNZer. Flame injury 40%
68MSailor. Not NZ. Burned in boat explosion. Transfer from overseas hospital. 85% supfl
*
58FNZer45% TBSA (33% full thickness)
* * *Admission 27 DecBacteraemic
Vascularcatheter tip then tissues and blood cultures P. stuartii
Very Stormy course, several postive blood cultures, tissue culturesTransmission of resistance element to other organisms. Given
novel antibiotic regimen
2 February: tissues P. stuartii
and K pneumoniae NDM and BCIschaemic bowel
*
admission 11 DecBlood cultures positive on admission carbapenem resistant P. stuartii
Admitted 17 Jan*
discharged 23 April
PATIENT A
PATIENT B
PATIENT C
Multiple tissue and blood cultures positiveFive different CRO
Prolonged bacteraemia with CRO and Candida
eventually recovered and discharged home with support
Multiple multi-team IC discussions/investigations/interventions
OUTBREAK declared
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Finding a Source…….
All
patients
in ICUAll
patients
in OR4
All have
the same
consulting
team
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Current state of play…..
• Continue to define and refine
• No single source identified (as often the case in literature)
• Vigilance over the next several months
• Audits/projects for hand hygiene compliance and environmental cleaning commenced
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What's happening globally and in NZ?
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Global carbapenem resistance:Dark is bad
The Lancet Infectious Diseases 2013
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Arcilla, M. S. et al. Import and spread of extended-spectrum beta-lactamase-
producing Enterobacteriaceae by international travellers (COMBAT study): a
prospective, multicentre cohort study. Lancet Infect Dis 17, 78-85,
doi:10.1016/S1473-3099(16)30319-X (2017).
Fournier, S. et al. J Travel Med 19, 320-323, doi:10.1111/j.1708-8305.2012.00641.x (2012).
Global resistance and risk :travellers can acquire
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Increase in resistance may be rapid
Italy moved from green to red in 10 years
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CPE in NZ 2009-2017
Source: ESR surveillance
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Counties Manukau ESBL and CRO timeline
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200
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CRO
ESBL
CROs: Note scale but alsoonly about 15ys behind ESBLs.
Outbreak studies of CRO bacteraemia havereported mortality rates of 40-60%
*
*
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Summary: coming to a MSU near you
• Antimicrobial Resistance produced by antibiotics; need to use judiciously
• Once develop, resistant organisms (local or introduced) can spread rapidly compounding problem
• Control strategies for community as well as hospital will be very important. National Guidelines
• Take home: If you come across one – call for help!
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Acknowledgements& Questions
• Infection Control Team
• ICU staff
• Operating Theatre staff
• Management& Incident Control team
• Infectious Diseases
• Microbiology
• Pharmacy
• Special Thanks to Rachael Hart and Christopher Hopkins for some slides
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Keep antibiotics working
Winter 2018
Bryan Betty, Deputy Medical Director
GP Cannons Creek East Porirua
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Our objective
“…to secure for eligible people in need of pharmaceuticals,
the best health outcomes that are reasonably achievable
from pharmaceutical treatment and from within the amount
of funding provided.”
• New Zealand Public Health and Disability Act 2000
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PHARMAC’s role
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Our consumption is high
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Prescribing by seasons – what’s driving prescribing behavior?
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Drivers for antibiotics
• Psychology/neuroscience - humans make EMOTIONAL decisions
• Higher the emotions = more irrational the behaviour
• If we understand behavioural drivers, we can change behaviour
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Core health emotion
The core emotion associated with health is anxiety
Anxiety:
• roadblocks our ability to hear
• hinders our ability to understand and accept messages
• creates irrational behavior
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Consumers attitudes to health and antibiotics
• Need for speed – fix me fast, fix me now (it’s about fixing, not recovery)
• Drugs and technology will do this
• Antibiotics are more like panadol than a significant medicine
• Lack of shared understanding with my Health Professional around when antibiotics are necessary
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Prescribers’ views and experiences
• I may give backpocket prescriptions if patients
demand antibiotics
• I feel pressure to prescribe, even if that’s
unnecessary, because I don’t want patients to get sicker
• I’m aware of the dangers of antibiotic resistance, but it’s a bigger problem overseas than in NZ
• I’m aware that my peers and I may overprescribe antibiotics
• I’m not always able to discuss antibiotic resistance with patients
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CONSUMERS
• Understand value of
antibiotics
• Some awareness of antibiotic
resistance, but don’t feel it’s
important to me
• Want a quick fix
• View antibiotics as a safe,
quick-fix treatment
PRESCRIBERS
• Aware of antibiotic
resistance, but don’t feel it’s
something I can influence
• Lack of time or narrative to
change expectation for an
antibiotic prescription
• Therefore, I prescribe
antibiotics
Current behavior dynamic
These are behaviors we need to disrupt
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CONSUMERS
• Awareness and understanding
of antibiotic resistance
• Advocates for the message -
help ‘spread’ the idea
• Balanced view of antibiotic
use
PRESCRIBERS
• Motivated to help spread
information about antibiotic
resistance
• Reduce prescribing antibiotics
This is an idea that can be spread
The behaviour dynamic we want
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Example of Facebook posts
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Resources for primary care
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How to print or order campaign resources
• Visit www.pharmac.govt.nz and search “Keep antibiotics working”
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Questions