A Bacteria in the Gut may Predict Type 1 Diabetes
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Transcript of A Bacteria in the Gut may Predict Type 1 Diabetes
A Bacteria in the Gut may Predict Type 1 Diabetes
Ningwen Tai, Associate Research ScientistYale Diabetes Center
Heart and blood vessel diseaseNerve damageKidney damageEye damageFoot damagePregnancy problem
Diabetes complications
Type 1 diabetes (T1D)
Healthy
Insulin
Glucose
Diabetic
Immune cells
Pancreas
islet
XXX
5 million Americans are expected to have type 1 diabetes by 2050, including nearly 600,000 youth.
Prevalence of type 1 diabetes
The percentage of newly diagnosed cases of T1D rose 21.2% from 2001-2009
American Diabetes Association 2016
Less than 50% of identical twins develop type 1 diabetes
One twin develops diabetes while the other does not.
HealthyDiabetic
Different gut bacteria composition between diabetic patients and healthy controls
Gut bacteria
NOD - mouse model of human T1D
GUTBACTERIA
TYPE 1 DIABETES
Type 1 diabetesAutoimmune
response
Environment(bacteria,
virus)
Genetics(Genes)
Genetic and environmental factors contribute to T1D development
Less Fusobacteria
Mimic peptide
Mimic peptide
Immune cells
Preliminary study: mouse
Lower diabetes incidence
Higher diabetes incidence
More Fusobacteria
Research plans -
1. Collection of human oral and fecal samples from diabetic, high-risk and healthy individuals
2. Measurement of Fusobacteria in the collected samples by two different methods - sequencing and qPCR
3. Data analysis and evaluation
Research goal
To prove the increase of Fusobacteria is associated with human diabetes development and provide a better knowledge for early disease intervention.
1. Prevention: to find specific treatment for eliminating diabetes inducing bacteria in order to better prevent from diabetes development in high-risk individuals
2. Cure: to modify diabetes inducing bacteria and replace with “good” bacteria to treat diabetic patients
Future applications