9. intermediate metabolism
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Transcript of 9. intermediate metabolism
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INTERMEDIATE METABOLISM
o Dif :o LINTASAN METABOLISME LINTASAN KATABOLIK LINTASAN ANABOLIK LINTASAN AMFIBOLIKo Kompetensi khusus :
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LINTASAN METABOLISME
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• IKHTISAR METABOLISME HASIL DIGESTI KH, LEMAK DAN PROTEIN
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KATABOLIK METABOLISME
o METABOLISME KARBOHIDRATo LINTASAN YG. DIGUNAKAN : GLIKOLISIS OKSIDASI PIRUVAT ----> ASETIL- Ko A TCA CYCLE GLIKOGENOLISIS HMP- shunt
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GLIKOLISIS• PENGERTIAN :• TEMPAT BELANGSUNG :• PADA KONTRAKSI OTOT ( AEROBIK/
ANAEROBIK )• ERITROSIT• KOMPETENSI KHUSUS :• PRASARAT :• KULIAH; DARAH, VIT, ENZIM & DIGESTI• TAHAP REAKSI :
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• TAHAP REAKSI, lintasan EMBDEN-MEYERHOF
( AEROBIK & ANAEROBIK )
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• TAHAP FOSFORILASI OKSIDATIF PD LINT. GLIKOLISIS.
(D. GLISERALDEHIDA. P---> 1,3 BIFOSF0GLISERAT)• ENZIM: Gliseraldehida 3. P. DH• Struktur :• Mengandung 4 rantai polipeptida• Mengandung gugus Sulfhidril ( - SH )• Satu terdapat pd sisi aktif
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• TAHAP REAKSI FOSFORILASI OKSIDATIF Gliseraldehida 3.P
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• LINT. GLIKOLISIS DLM. ERITROSIT• LINTASAN “ bypass” 2,3 bifosfogliserat
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• Oksidasi piruvat menjadi asetil-KoA dalam mitokondria. Enzim : kompleks piruvat dehidrogenase Tahap reaksi :
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GLYCOGENOLYSIS
o Diff :o Kompetensi khusus :• Mhs mampu menjelaskan tahap-tahap reaksi dalam glikogenolisis.
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o TAHAP-TAHAP REAKSI DALAM GLIKOGENOLISIS 1. Pemecahan fosforil pada ikatan (1-4) α glikogen
---> glukosa 1-P, oleh aktivitas fosforilase 2. Pemecahan ikatan (1-6)α secara hidrolisis oleh
Debranching enzyme spesifik (amilo 1,6-glukosidase)
o Rate limiting factor pada langkah yg dikatalisis oleh fosforilase.
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o LANGKAH-LANGKAH DLM GIKOGENOLISIS ENZIM YG BERPERAN :• Fosforilase, glukan transferase dan
debranching enzyme
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Jalan glikogenesis dan glikogenolisis dalam hati. Dua ikatan fosfat berenergi tinggi digunakan untuk penggabungan 1 molekul glukosa ke glikogen.
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Pengaturan fosforilase dalam otot
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HEXOSE MONOPHOSPHAT SHUNT
o Diff :o FUNGSI : PENYEDIA GULA RIBOSA FOSFAT, untuk sintesis
nukleotida dan asam nukleat. PENYEDIA NADPH+H+, untuk sintesis reduktif ekstra
mitokondria PENGHASIL CO2
o RINGKASAN REAKSI : 3 Gluk.6-P + 6 NADP+ ----> 2 Gluk 6-P + Gliseraldehid 3-P +
6 NADPH + 6H+ + 3CO2
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o TAHAP-TAHAP REAKSI PADA HMP-SHUNT
Fase oksidatif non reversible
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Fase non oksidatif reversible
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Peranan NADPH pada detoksikasi H2O2 dalam eritrosit
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TCA CYCLE
o PENDAHULUAN- DIF- KOMPETENSI KHUSUSo MAKNA- Jalur Metabolisme Bersama- Karbohidrat, Protein dan Lipida
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o JALUR UTAMA KATABOLISME PADA ORGANISME AEROBIK
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o TAHAP REAKSI
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o ENERGETIKA TCA CYCLE
Reaksi dikatalisis oleh Cara pembentukan PJumlah P
yang terbentuk
Isositrat dehidrogenaseOksidasi NADH pada rantai pernapasan
3
α-ketoglutarat dehirogenaseOksidasi NADH pada rantai pernapasan
3
Suksinat tiokinase Oksidasi pada tingkat substrat 1
Suksinat dehidrogenaseOksidasi FADH2 pada rantai pernapasan
2
Malat dehidrogenaseOksidasi NADH pada rantai pernapasan
3
Jumlah 12
Tabel pembentukan ikatan fosfat berenergi tinggi oleh siklus asam sitrat.
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o PERAN AMPHIBOLIK TCA CYCLE TRANSAMINASI
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SINTESIS ASAM LEMAK