IV) Female Reproductive System A) Basic Anatomy. IV) Female Reproductive System A) Basic Anatomy.
8. Female Anatomy
Transcript of 8. Female Anatomy
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FemaleFemaleReproductiveReproductive
AnatomyAnatomy
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Ovary - Primary Organ
Ovary - Gross anatomyOvary - Gross anatomy–– usually pairedusually paired–– may be solid or hollowmay be solid or hollow–– size can vary greatly depending onsize can vary greatly depending on
species and stage of reproductivespecies and stage of reproductiveactivityactivity
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Gross Anatomy - Mammal
HumanHuman
Paired, solidPaired, solidSize changes littleSize changes little
with reproductivewith reproductiveactivityactivity–– 'Blisters on the surface''Blisters on the surface'
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Gross Anatomy - Reptile
AlligatorAlligator
1 cm1 cm
20 cm20 cm
Paired, solid ovaryPaired, solid ovaryEnlarged dramaticallyEnlarged dramatically
with reproductivewith reproductiveactivityactivity
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Gross Anatomy - Fish
PerchPerch20 cm20 cm
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Ovarian Histology serosaserosa - outer covering of- outer covering of
tough connective tissuetough connective tissue
germinal epitheliumgerminal epithelium - -single layer of cells oncesingle layer of cells oncethought to produce thethought to produce thegerm cells - thus its namegerm cells - thus its name
ovarianovarian stroma stroma or cortexor cortex- contains follicles and- contains follicles andscar tissue, some bloodscar tissue, some bloodvesselsvessels
ovarianovarian hylus hylus or medullaor medulla - -contains blood vessels,contains blood vessels,nerves, lymphnerves, lymph
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Ovarian Follicle folliclefollicle - composite structure - composite structure
that will produce maturethat will produce mature oocyte oocyte
–– primordial follicle - germ cellprimordial follicle - germ cell((oocyteoocyte) with a single layer) with a single layerofof mesodermal mesodermal cells aroundcells arounditit
–– as development of follicleas development of follicleprogresses,progresses, oocyte oocyte willwillobtain a obtain a ‘‘halohalo’’ of cells and of cells andmembranes that are distinct:membranes that are distinct:
1.1. zona pellucide zona pellucide (ZP)(ZP)
2.2. granulosa granulosa ((GrGr))
3. theca3. theca interna interna andandexterna externa (TI & TE)(TI & TE)
OocyteOocyte
TI & TETI & TE
GrGr
ZPZP
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Germ Cells Division and Follicle Formation
from Makabe and van Blerkom, 2006
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Summary:The follicle is the functional unit of the ovary.
One female gamete, the oocyte is contained in each follicle.
The granulosa cells produce hormones (estrogen and inhibin) that provide ‘status’signals to the pituitary and brain about follicle development.
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Human Ovary
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Corpora Lutea (CL) remnant of ovulatedremnant of ovulated
folliclefollicle–– following ovulationfollowing ovulation
theca and theca and granulosagranulosacells remain in ovarycells remain in ovary
–– these cells these cells luteinizeluteinizeand produceand produceprogesteroneprogesterone
–– will remain will remain ‘‘activeactive’’ for a for aspecies specific periodspecies specific periodof time and thenof time and thenundergoundergo luteolysis luteolysis - -lutealluteal death death
ff
ff
clcl
clcl
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AtresiaAtresia
Atretic Atretic follicles - folliclesfollicles - folliclesundergoing death = undergoing death = atresiaatresia
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Human OvaryHuman Ovary at 5 months in at 5 months in utero utero - ovary has- ovary has
>3,500,000 germ cells>3,500,000 germ cells–– they then begin to die -they then begin to die - atresia atresia
at birth each ovary has 400,000 germat birth each ovary has 400,000 germcellscells–– all she will have for rest of lifeall she will have for rest of life
at puberty = 83,000/ovaryat puberty = 83,000/ovary
at 35at 35 yrs = 30,000 folliclesyrs = 30,000 follicles
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Mouse - Follicle Number
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Oogonial Oogonial NestsNestsOogonial Oogonial NestsNests
–– some species (adults) retain clumps ofsome species (adults) retain clumps ofoogonia oogonia that undergo mitosis to generatethat undergo mitosis to generatenew follicles.new follicles.
–– Not found in mammals or birdsNot found in mammals or birds
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P. gracilis
I. whitei
Fish Ovary - Histology
• Hollow, fused• Ovulation
toward thecentral cavity
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I. whitei
Fish Ovary - Germinal Epithelium
• Germ cells (oogonia) lie below surface ofovarian epithelium
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Follicles at various stages
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I whitei
What is this?What is this?
Ovary of viviparous fish withOvary of viviparous fish withdeveloping embryos in it!developing embryos in it!
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Summary - Ovary
• Chondrichthyes- - paired, fused, solid• Osteichthyes
– Teleosts - paired, fused, hollow– Holostean - paired, separate, solid
• Amphibians - paired, separate, solid• Reptiles - paired, separate, solid (some ribbon)• Birds - paired, separate, solid• Mammals - paired, separate, solid
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Vertebrate Tree
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Tetrapod Tree
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Duct systemDuct system
all derived from theall derived from theembryonic embryonic Müllerian Müllerian ductduct
whole duct is termed whole duct is termed oviductoviductin comparative biologyin comparative biology–– in mammals - oviduct usually refers toin mammals - oviduct usually refers to
Fallopian tubeFallopian tube
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Female Tubular Structures
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Fallopian tube afterafter Fallopius Fallopius three regionsthree regions
–– infundibuluminfundibulum, , ampullaampulla, isthmus (& intramural region), isthmus (& intramural region) infundibuluminfundibulum - top thin walled region that- top thin walled region that
receives the eggreceives the egg–– opening isopening is ostiumostium–– finger-like projections arefinger-like projections are fimbriafimbria
ampullaampulla - ciliated for sperm and ova transport- ciliated for sperm and ova transport–– region where egg is fertilized in many speciregion where egg is fertilized in many specieess–– egg egg ‘‘whitewhite’’ or albumen is secreted or albumen is secreted
isthmusisthmus - - junction with uterusjunction with uterus–– usually usually aglandularaglandular–– Intramural regionIntramural region - region thru wall of uterus (mammals) - region thru wall of uterus (mammals)
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Fallopian Tube thin walled muscular tubethin walled muscular tube three layersthree layers
–– SerosaSerosa - outer connective tissue covering- outer connective tissue covering–– MyometriumMyometrium - thin layers of smooth muscle- thin layers of smooth muscle
Inner layer - circularInner layer - circular
Outer layer - longitudinalOuter layer - longitudinal
–– EndometriumEndometrium - layer(s) of epithelial cells- layer(s) of epithelial cells Can be 'thrown into folds'Can be 'thrown into folds'
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Mammalian Fallopian tube anatomy
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Mammalian Tube - Isthmusmyometriummyometrium
endometriumendometrium
inner layerinner layer
outer layerouter layer
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Reptilian Tube - IsthmusLamina Lamina propriapropria
(glandular)(glandular)
endometriumendometrium
EpitheliumEpithelium
MyometriumMyometrium
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Uterus thick walled muscular tubethick walled muscular tube three layersthree layers
–– serosaserosa, , myometriummyometrium, , endometriumendometrium
region for egg / embryo development inregion for egg / embryo development inviviparous speciesviviparous species
egg shell protein and calcium secreted inegg shell protein and calcium secreted inoviparous speciesoviparous species
structure and shape variable depending onstructure and shape variable depending onspecies and stage of reproductive activityspecies and stage of reproductive activity
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Human Uterine AnatomyHuman Uterine Anatomy
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Mammalian Uteri
A = A = Monotreme Monotreme (Echidna)(Echidna) B = B = MarsupialMarsupial (Opossum) (Opossum) C =C = Marsupial (Kangaroo)Marsupial (Kangaroo) D = D = Eutherian Eutherian (Rat)(Rat) E = E = Eutherian Eutherian (Cat)(Cat) F = F = Eutherian Eutherian (Pig)(Pig) G = G = Eutherian Eutherian (Woman)(Woman)
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Comparative Duct Systems
Derived fromDerived from Mullerian Mullerian ductduct May have one or two May have one or two ‘‘hornshorns’’
–– Most birds have oneMost birds have one
FunctionsFunctions–– Sperm transportSperm transport–– Egg shell/jelly productionEgg shell/jelly production–– Growth factor synthesisGrowth factor synthesis
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Alligator Uterus - Isthmus
Lamina Lamina propriapropria(glandular)(glandular)
endometriumendometrium
EpitheliumEpithelium
endometriumendometrium
Fiber RegionFiber Region Calcium RegionCalcium Region
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Cervix Highly muscular wallsHighly muscular walls Barrier to spermBarrier to sperm Functions to retain egg inFunctions to retain egg in
uterusuterus
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Vagina/Cloacacommunicates with outside andcommunicates with outside and
connects uterus via cervixconnects uterus via cervix receives sperm in internalreceives sperm in internal
fertilizersfertilizers in some - connects toin some - connects to cloacacloaca - -
common vestibule for urinary,common vestibule for urinary,digestive and reproductive systemsdigestive and reproductive systems
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VaginaVagina
Thick muscular wallsThick muscular walls Sperm transport andSperm transport and
selectionselection Embryologically Embryologically from twofrom two
originsorigins–– Mullerian Mullerian ductduct–– External genitaliaExternal genitalia
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Cloaca Common region into which theCommon region into which the
vagina and intestine openvagina and intestine open Latin for 'sewer'Latin for 'sewer' Common in birds, reptilesCommon in birds, reptiles