2007 - Bacillus Anthracis
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Transcript of 2007 - Bacillus Anthracis
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Bacillus anthracis
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Bacillus anthracis- opšte osobine -
Gram pozitivan bacilraspored: pojedinačno i u parovima (u direktnom
preparatu) ili u lancima (na preparatu iz kulture)nepokretankapsula proteinskog sastava:
- polimer D-glutaminske aminokiseline- retko se uočava na preparatu iz kulture
sporogen: centralna spora koja ne deformiše telobacila
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Bacillus anthracis- faktori virulencije -
kapsulaspora
spora 92000×
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Bacillus anthracis- faktori virulencije -
egzotoksin (A-B toksin): 3 komponente
protektivni antigen (B):vezuje se za receptore na različitim ćelijama(mozak, srce, creva, pluća, pankreas, makrofagi...)
letalni faktor (A):metaloproteaza smrt ćelije (nedovoljno poznatmehanizam)
edem faktor (A):povećava koncentraciju cAMP edem
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Egzotoksin: A-B toksin PA: protektivni antigen = B
LF: letalni faktor = A
EF: edem faktor = A
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Bacillus anthracis- epidemiologija -
spore prisutne u zemljiod antraksa oboljevaju pre svegatravojedi
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Bacillus anthracis- epidemiologija -
www.belimantil.info
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Bacillus anthracis- epidemiologija -
www.belimantil.info
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Bacillus anthracis- bolesti -
kožni antraks - inokulacijaplućni antraks - inhalacijagastrointestinalni antraks - ingestija
spore uplućima
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svaki od 3 oblika antraksa možepreći u sepsu
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Kožni antraks
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Bacillus anthracis- bakteriološka dijagnostika -
uzorci: bris lezije na koži, sputum, stolica, krvdirektni preparat: Gram pozitivni bacili u lancima; možese uočiti kapsula, retko spora
kapsula
kapsula
kapsula
sputum krv
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Bacillus anthracis- bakteriološka dijagnostika -
izolacija: krvni agaridentifikacija:ispitivanje mikroskopskih osobina
preparat sa kulture:bacili u lancima,centralna sporakoja ne deformišetelo bacila
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Bacillus anthracis- bakteriološka dijagnostika -
ispitivanje kulturelnih osobinakrupne hrapave (R) kolonije bez hemolize
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Bacillus anthracis- bakteriološka dijagnostika -
ispitivanje fiziološko biohemijskih osobina- razlikovanje B. anthracis-a od drugih Bacillus-amolekularne metode (PCR)
test pokretljivosti
nepokretnaB. anthracis
pokretna
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Bacillus anthracis- prevencija i kontrola -
vakcinisanje životinja (živa atenuisana vakcina)
spaljivanje leševa životinjauginulih od antraksa
vakcinisanje ovaca 1882.
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Bacillus anthracis- prevencija i kontrola -
potpuna kontrola i eradikacijanije moguća zbog sporavakcine za humanu upotrebu (mrtvaceloćelijska, acelularni filtrat - protektivniantigen)
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Bacillus anthracis: biološko oružje
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