1. LOGO NONI V TC DNG SINH HC CA NONI

2. LOGO NI DUNG: Phn m u: Dch bnh mn tnh khng ly v Vaccine d phng Phn I : Cy Nhu v lch s s dng cc sn phm t Nhu Phn II : Cc nghin cu v Nhu. Phn III: Thnh phn ha hc. Phn IV : Tc dng sinh hc. Phn V : Cc sn phm mi ca Noni 3. LOGO Phn m u: Cn thy triu dch bnh mn tnh khng ly v Vaccine d phng 4. LOGO 1. Sc khe l g? Theo WHO: Sc khe l tnh trng: Khng c bnh tt Thoi mi v th cht Thoi mi v tm thn Thoi mi v x hi. 5. LOGO Sc khe v bnh tt 1. Tnh trng lnh ln v cu trc v chc nng ca t bo c th 2. Gi vng cn bng ni mi 3. Thch nghi vi s thay i mi trng 1.Tn thng cu trc v chc nng ca t bo c th 2. Ri lon cn bng ni mi 3. Gim kh nng thch nghi vi mi trng Sc khe Bnh tt 6. LOGO Sc khe l ti sn qu gi nht: - Ca mi ngi - Ca ton x hi Fontenelle: Sc khe l ca ci qu gi nht trn i m ch khi mt n i ta mi thy tic. iu 10 trong 14 iu rn ca Pht: Ti sn ln nht ca i ngi l sc khe. 7. LOGO Ni kinh hong (Thi Xun-Thu-Chin-Quc): Thnh nhn khng tr bnh ri, m tr bnh cha n, khng tr ci lon n m tr ci lon cha n. Kht mi ung, i mi n, mt mi ngh, m mi khm cha bnh Tt c u l mun! Tin bc l ca con, a v l tm thi, V vang l qu kh, Sc khe l ca mnh!. 8. LOGO 1 0 0 0 0 00 0 0 0 0 ... V C T N X V HV TY HB DL ... Sc khe Tiu ch cuc sng Sc khe l g? Khng c bnh tt Thoi mi y Th cht Tm thn X hi Quan im chm sc bo v SK. Chm sc bo v khi cn ang khe Do chnh mnh thc hin 9. LOGO Ngi dt: ch bnh m au mi i khm m au mi i cha Ngi ngu: Gy bnh Ht thuc Ung ru qu nhiu n ung v Li vn ng Ngi khn: Phng bnh Chm sc bn thn Chm sc sc khe Chm sc cuc sng 3 loi ngi TPCN 10. LOGO www.themegallery.com THC PHM Cung cp cht dinh dng Cht dinh dng i th: m ng M Cht dinh dng vi th: (vi cht dinh dng) Vitamin Nguyn t vi lng Hot cht sinh hc Cu trc c th Chc nng hot ng Nng lng hot ng 11. LOGO www.themegallery.com c im ca vi cht dinh dng 1 L nhng cht khng thay th c 2 Cn thit cho c th: Qu trnh trao i cht Tng trng v pht trin Bo v, chng li bnh tt v yu t bt li Duy tr cc chc nng 3 C th khng t tng hp v d tr c. Phi tip nhn hng ngy qua con ng n ung 12. LOGOCNH + th ha Thay i phng thc lm vic Thay i li sng li sinh hot Thay i cch tiu dng thc phm Thay i mi trng Hu qu 1. t vn ng th lc (70-80%) 2. S dng TP ch bin sn 3. Tng cn, bo ph 4. Stress 5. nhim mi trng 6. Di truyn 1. Tng cc gc t do 2. Thiu ht vi cht, vitamin, khong cht, hot cht sinh hc 1. Tn thng cu trc, chc nng 2. RL cn bng ni mi 3. Gim kh nng thch nghi Cn thy triu dch bnh mn tnh khng ly gia tng 13. LOGO6 c im tiu dng thc phm6 c im tiu dng thc phm Tnh ton cuTnh ton cu Pht tn cc miPht tn cc mi nguy ATTPnguy ATTP n ungn ung ngoi gia nhngoi gia nh TP km chtTP km cht lnglng TP nhimTP nhim TP giTP gi S dng TPS dng TP CN-CB-BQCN-CB-BQ TP nhimTP nhim Cht bo qunCht bo qun Thiu htThiu ht vitamin,vitamin, cht khong,cht khong, HCSH, cht xHCSH, cht x Thay iThay i trong SXTPtrong SXTP HCBVTVHCBVTV Thuc th yThuc th y Phn bnPhn bn ha hcha hc Nc tiNc ti Cng nghCng ngh CBTPCBTP Thit b myThit b my mcmc Ha cht,Ha cht, ph giaph gia Chui cung cpChui cung cp TP ko diTP ko di c imc im s dngs dng TP n ngayTP n ngay TP t ng vtTP t ng vt Giu bo, giuGiu bo, giu nng lngnng lng Khu phn n hng ngyKhu phn n hng ngy nhim nhim Thiu htThiu ht TngTng RL cu trc chc nng RL cn bng ni mi RL cu trc chc nng RL cn bng ni mi Gim kh nng thch nghiGim kh nng thch nghi Cn thy triu dch bnh mn tnh khng lyCn thy triu dch bnh mn tnh khng ly VitaminVitamin Cht khongCht khong HCSHHCSH Cht xCht x Ha chtHa cht Sinh hcSinh hc L hcL hc 14. LOGONan iNan i vi cht dinh dngvi cht dinh dng 1 t ngi thiu vi cht dinh dng1 t ngi thiu vi cht dinh dng 2 t ngi c nguy c thiu2 t ngi c nguy c thiu 1,6 t ngi gim kh nng lao ng do thiu mu thiu st1,6 t ngi gim kh nng lao ng do thiu mu thiu st 350.000 tr em b m lo do thiu Vitamin A350.000 tr em b m lo do thiu Vitamin A 1,1 triu tr em 0,30mg/ml, cn Noni cc ni khc ch t < 0,15mg/ml IRIDOIDS 62. LOGO Rosa Tundis; Monica R.Loizzo; Federca Menichini; Giancarlo A.statti; Francesco Department of Pharmaceutical Sciences Faculty of Pharmacy Nutrition and Health Science University of Calabria 87036 1 Rende (CS)) Italy. Tng hp cc cng trnh nghin cu v Iridoids ca 141 tc gi giai on 1986 - 2007 TC DNG SINH HC CA IRIDOIDS: 63. LOGO 1. Tc dng bo v t bo thn kinh: IRIDOIDS Catalpol Tng Synaptophysin Kch thch PKC (Protein Kinase C) GAP 43 Phn hy ROS v FR c ch to TNF - c ch LPS (Lipopoly- Saccarid) Lm chm to FR Bo v t bo thn kinh Lm chm qu trnh lo ha Ngn cn suy gim tr nh (Alzheimer) Gim t l thoi ha TBTK Bo v - phc hi TB tn thng 64. LOGO Ung th l bnh ca TB vi 3 c trng: 1. Sinh sn t bo v hn (c th mt kim sot) 2. Xm ln ph hoi cc t chc xung quanh. 3. Di cn n ni khc. 2. Tc dng chng ung th: 65. LOGOC ch gy ung th: Phng x Ha cht Virus Gc t do Thuc l Vim mn tnh .............. t bin gen Sai hng ADN Phn chia t bo v t chc TB non, khng bit ha, khng thc hin c chc nng T bo qui, d sn, lon sn Pht trin v hn (Bt t) Xm ln, chn p cc m xung quanh Di cn ti cc m xa Trnh c Apoptosis (cht theo chng trnh) Khng vi cc yu t chng tng sinh 66. LOGO 1.1.Ch n:Ch n: 27% K v lin quan n n27% K v lin quan n n cht bo (cht bo ( 40% Calo t cht bo)40% Calo t cht bo) n nhiu tht : nguy c ln 2 lnn nhiu tht : nguy c ln 2 ln 2. Bo ph2. Bo ph Bo: Estrogen muBo: Estrogen mu TB m: c th sx EstrogenTB m: c th sx Estrogen nhy cm Knhy cm K Bo sau mn kinh: 50% nguy cBo sau mn kinh: 50% nguy c Bo+cao: nguy cBo+cao: nguy c 30% K v: do bo ph30% K v: do bo ph 4. Phi nhim tia x4. Phi nhim tia x 5. HCBVTV v thuc th y5. HCBVTV v thuc th y Di truyn:Di truyn: M+D b K,M+D b K, n gi nguy c 50%n gi nguy c 50% 7. Ru:7. Ru: nguy cnguy c Mi trng:Mi trng: nhim: HC, VL nhim: HC, VL AS t nhin (khng toAS t nhin (khng to c Vitamin D v Melatonin)c Vitamin D v Melatonin) 8 nguy c Ung th v8 nguy c Ung th v 3. Hormone:3. Hormone: N tr v sp mn kinh: nguy c caoN tr v sp mn kinh: nguy c cao Chu k KN >40 nm: nguy c caoChu k KN >40 nm: nguy c cao Thai u sau 30: nguy c caoThai u sau 30: nguy c cao Thi gian gia thai u & KN u : nguy c caoThi gian gia thai u & KN u : nguy c cao Khng sinh : nguy cKhng sinh : nguy c Ung th vUng th v nguy cnguy c 67. LOGO 1. Cm gic:1. Cm gic: au khi c ngau khi c ng au c nhau c nh au khi s, nau khi s, n 2. Nhn:2. Nhn: Mu scMu sc Hnh dngHnh dng S cn iS cn i Da nhn nhm,Da nhn nhm, co koco ko Chy dch, muChy dch, mu 3. S:3. S: U, ccU, cc Di ngDi ng n c chy dch,n c chy dch, mumu Khm chuyn khoa xc nhKhm chuyn khoa xc nh Gim st du hiu sm ung th v. 68. LOGOnh sngnh sng Bng tiBng ti (ng)(ng) Mt triMt tri Nhn toNhn to Tuyn tngTuyn tng Tuyn ynTuyn yn To MelatoninTo Melatonin To GHTo GH DaDa To Vit.DTo Vit.D Khng to Vit.DKhng to Vit.D Ung thUng th Vit.DVit.D MelatoninMelatonin TPCNTPCN Pht trinPht trin (ln)(ln) (+)(+) (+)(+) (+)(+) (+)(+)(+)(+) (+)(+) (+)(+) (-)(-) (-)(-) (-)(-) (-)(-) (-)(-) (+)(+) (+)(+) (-)(-) 69. LOGONguyn tc c bn D phng ung th Trnh xa tc nhn gy ung th Thay i li sng Ch n ung - TPCN Can thip y khoa (Ha d phng, iu tr tin c tnh .... ) 70. LOGO TNJ c ch C0X2 (Cyclo Oxygenase) c ch sx TNF (Tumor Necrosis Factor ) Cht gy K ni sinh Chng vim Ngn chn pht trin K 71. LOGO TNJ Chng oxy ha (mnh gp 2,8 ln so vi Vitamin C) Chng t bin gen Trnh h hng ADN Phng chng K Kch thch pt tuyn c Kch thch sn xut TB T Nng cao h thng min dch 72. LOGO Irdoids Aucubin Geniposide c ch hnh thnh khi u Chng t bin Catalpol c ch ADN polymerase c ch tng trng, pht trin Hapagide 8 - Acetylhapagide Tarennoside Genipin Paederoside c ch KN virus Chng t bin TB Chng ung th 73. LOGO Iridoid no c trong Noni Hai iridoid quan trng l: Deacetylasperulosidic acid (DAA) Asperulosidic acid (AA) 74. LOGO Cu trc Ha Hc ca DAA 75. LOGOV d v Hot tnh Sinh Hc ca Noni TAHITIAN NONI Juice bo v DNA cc i tng nghin cuTAHITIAN NONI Juice bo v DNA cc i tng nghin cu Iridoids ca Noni lm gim s tn thng DNA trong ng nghim 100%Iridoids ca Noni lm gim s tn thng DNA trong ng nghim 100% T n th ng DNA b i 4NQO T n th ng DNA b i 4NQO NoniNoni T n th ng DNA b tri t tiu b i Iridoid T n th ng DNA b tri t tiu b i Iridoid Data to be published in February 2011 issue of Food Research International 76. LOGO Bo v DNA ngi nghin thuc l nng 77. LOGO 78. LOGO 1 Gim tc dng ph ca Tia x v Ha tr liu: -Bun nn -Rng tc -Mt mi -Mt ngon ming 2 C hot cht chng li chnh ung th (DAA, AA) - H tr cng Ty y tn cng K 3 Nng H thng min dch v h tr chng cc bnh: + Do ha tr lm sp . + Do bn thn K lm suy yu. 3 Li ch sn phm Noni vi ung th3 Li ch sn phm Noni vi ung th3 Li ch sn phm Noni vi ung th3 Li ch sn phm Noni vi ung th 79. LOGO Min dch = kh nng khng ca c th chng li cc tc nhn gy bnh khng c hiu khng khng c hiu Hng ro bo v c th Da Nim mc M hi Dch nhy Thc bo KT khng c hiu: -Lysin -Leukin KT dch th KT c nh (KT trung gan TB) Globulin min dch IgG IgA IgM IgD IgE Lin kt cht ch trn mt t bo sx ra KT (TBT) Cng vi TB ti kt hp vi KN KN 3. Chng vim, tng cng min dch: 80. LOGO Tn cng TK t do a Merkel Tiu th Pacini Tiu th Meissner Tn cng TK chn lng Biu b Trung b H b mTiu th Ruffini Thn lng Tiu th Kraus Tiu th Golgi-Mazzoni Si ChollagenSi Chollagen Si chunSi chun Si vngSi vng Dy thn kinhDy thn kinh Si c trnSi c trn 1.1. Cm gic s m, t p, ng chm:Cm gic s m, t p, ng chm: Tiu th Meissner: s m tinh tTiu th Meissner: s m tinh t Tiu th Pacini: T p nngTiu th Pacini: T p nng a Merkel: s m sua Merkel: s m su 2. Cm gic t - p su:2. Cm gic t - p su: Tiu th GolgiTiu th Golgi Tiu th MazzoniTiu th Mazzoni 3. Cm gic nng, lnh:3. Cm gic nng, lnh: Tiu th Ruffini: cm gic nngTiu th Ruffini: cm gic nng Tiu th Krause: cm gic lnhTiu th Krause: cm gic lnh 4. Cm gic au:4. Cm gic au: tn cng thn kinh t dotn cng thn kinh t do S CU TO V CC RECEPTOR CM GIC CA DAS CU TO V CC RECEPTOR CM GIC CA DA 81. LOGO Iridods Aucubin Geniposide c ch TNJ - c ch Interleukin ( IL 6) Verproside Catalposide Monotropein Verminoside Genipin Oleuropeoside Ligustroside Scrovalentinoside Scropolioside Catalpol Gim au Gim ph n c ch iNOS, LPS c ch COX-2 (Cyclooxygenase 2) Gim phn ng qu mn Kch thch TB T Kch thch i thc bo Chng vim tng cng min dch 82. LOGO P < 0.05P < 0.05 83. LOGO P < 0.05P < 0.05 84. LOGO Tc dng ln thoi ha t sng c Effect on Cervical Spondylosis 85. LOGO 90 ng i, 3 nhm, 1 thng V t l tr li u (VLTL) TNJ 15 mL 2 l n/ngy TNJ 15 mL 2 l n/ngy + VLTL Trial MethodTrial Method Phng php th nghimPhng php th nghim Trial MethodTrial Method Phng php th nghimPhng php th nghim 86. LOGO ResultsResults - Kt Qu- Kt QuResultsResults - Kt Qu- Kt Qu Pain intensity decreased significantly from moderate-severe range to none-moderate range in all three groups Cng au gim ng k t khong au trung bnh- khc lit n khong khng au- trung bnh c 3 nhm When TNJ combined with physical therapy, cervical pain eliminated in almost all subjects- Khi TNJ kt hp vi VLTL, au thoi ha t sng c b mt hu ht cc i tng 87. LOGO90 Day Osteoarthritis Trial90 Day Osteoarthritis Trial 90 Ngy Th Nghim Bnh Vim Xng Khp90 Ngy Th Nghim Bnh Vim Xng Khp 90 Day Osteoarthritis Trial90 Day Osteoarthritis Trial 90 Ngy Th Nghim Bnh Vim Xng Khp90 Ngy Th Nghim Bnh Vim Xng Khp University of Illinois i hc Illinois 82 adults completed the trial (male & female, age 40 to 75)- 82 ngi trng thnh tham gia th nghim (nam & n, 40-75 tui) Patients with osteoarthritis of hip or knee- Bnh nhn b vim xng khp hng v khp gi Safety measurements Ch s o an ton Improvements in Quality of Life and Pain scores Ch s ci thin cht lng cuc sng v ch s au 88. LOGO Results Results Kt QuKt QuResults Results Kt QuKt Qu Kidney and liver function tests remained normal- Chc nng ca thn v gan c duy tr mc bnh thng No adverse effects/symptoms Khng gy tc dng ph/ triu chng kh chu Improved quality of life Ci thin cht lng cuc sng Improved ability to complete physical tasks Nng cao kh nng hon thnh cc bi kim tra th lc Improved mood Ci thin tnh kh Etc. V.v. Decreased pain Gim au 89. LOGOPost-menopausal Women TrialPost-menopausal Women Trial Th nghim trn ph n mn kinhTh nghim trn ph n mn kinh Post-menopausal Women TrialPost-menopausal Women Trial Th nghim trn ph n mn kinhTh nghim trn ph n mn kinh 3 month pilot study Nghin cu trin khai trong 3 thng Placebo controlled Kim sot gi dc Quality of life measurements Ch s o cht lng cuc sng Hearing tests (measure of inner ear bone loss) Xt nghim nghe (o s mt xng tai trong) Urinary test for deoxypyridinoline (Dpd), a marker for bone turnover- Xt nghim nc tiu ch s deoxypyridinoline (Dpd), dng nh gi chuyn ha xng. 90. LOGO Results-Results- Kt QuKt QuResults-Results- Kt QuKt Qu Improved quality of life scores- Ci thin ch s nh gi cht lng cuc sng Hearing loss was slowed, compared to placebo group Mt kh nng nghe b chm li, so snh vi l i chng Slight increase in Dpd in TNJ group, suggesting bone remodeling Tng nh Dpd trong nhm TNJ, chng t c s t chc li xng 91. LOGOHigh Light of IIRS 2012High Light of IIRS 2012 im Ni bt ca IIRS 2012im Ni bt ca IIRS 2012 High Light of IIRS 2012High Light of IIRS 2012 im Ni bt ca IIRS 2012im Ni bt ca IIRS 2012 International Iridoids Research Symposia of 2012 was held at Morinda Bioactives Inc. Headquarter, Utah Hi Ngh Nghin Cu Iridoids Quc T nm 2012 c din ra ti tr s chnh ca Morinda Bioactives Inc, Utah. Researchers and doctors from 6 countries, south Korea, India, Germany, US, China, and Russia, are toxicologist, pharmacologist, food scientist, plant chemist, etc. Cc nh nghin cu v cc bc s t 6 quc gia, Hn Quc, n , c, M, Trung Quc, Nga, l cc chuyn gia c cht, nh dc hc, nh khoa hc thc phm, nh ha hc thc vt, 92. LOGOHigh Light of IIRS 2012High Light of IIRS 2012 im ni bt ca IIRS 2012im ni bt ca IIRS 2012 High Light of IIRS 2012High Light of IIRS 2012 im ni bt ca IIRS 2012im ni bt ca IIRS 2012 Research reports at the symposia included: Bo co ca cc nghin cu ti hi ngh bao gm: Iridoids are found in over 900 plants and their health benefits are studied widely - Iridoids c tm thy hn 900 loi cy, cc li ch v sc khe ca chng ang c nghin cu rng ri Iridoids major benefits are anti-oxidant, anti- inflammatory, anti-cancer, anti-bacteria, anti-diabetic, immune enhancement, sedation, etc. - Cc cng dng chnh ca Iridoids l chng oxy ha, chng vim, chng ung th, khng vi khun, chng i tho ng, tng cng h min dch, gim au,. Research done on Max showed that the iridoids in Max were more effective in treating type 2 diabetic rats- Nghin cu thc hin vi SP Max cho thy iridoids trong Max c hiu qu hn khi iu tr chut i tho ng tup 2 93. LOGOHigh Light of IIRS 2012High Light of IIRS 2012 im ni bt ca IIRS 2012im ni bt ca IIRS 2012 High Light of IIRS 2012High Light of IIRS 2012 im ni bt ca IIRS 2012im ni bt ca IIRS 2012 Rats were more calm after taking Max - Chut u n nh hn sau khi dng Max Max may delay the development of late stage of type 2 diabetic syndrome - Max c th tr hon s tin trin hi chng i tho ng tup 2 giai on mun. 94. LOGO 4. Chng oxy ha: 95. LOGO S : THUYT GC T DO (FREE RADICAL THEORY OF AGING) Hng ro Bo vAO FR -Nguyn t -Phn t -Ion e l i, vng ngoi 1. H thng men 2. Vitamin: A, E, C, B 3. Cht khong 4. Hot cht sinh ha: (ch, u tng, rau-c-qu, du gan c) 5. Cht mu thc vt (Flavonoid) 1. H hp 2. nhim MT 3. Bc x mt tri 4. Bc x ion 5. Thuc 6. Chuyn ha FR mi Phn ng lo ha dy chuyn Kh nng oxy ha cao Phn t acid bo Phn t Protein Vitamin Gen TB no TB vng mc VXM Bin i cu trc c ch H men K Parkinson M 7. Vi khun 8. Virus 9. KST 10. M thc phm 11. Cc tn thng 12. Stress. 96. LOGO 96 Gc t do Gc t do Qu trnh oxi ha to ra nng lng v cc gc t do Ty th 97. LOGO 97 Cc gc t do gy ra mt mi e da ti sc khe ca chng ta Gc t doNguy h i t i DNA Nguy h i t i m Nguy h i t i tim m ch Lo ha Ung th 98. LOGO Iridoids Picroside I Kutkoside Oleuropein Aucubin Phn gii cc gc do Thu dn cc FR Chng sn sinh FR Chng oxy ha 99. LOGO Trc th nghim Nhm Placebo Nhm ung TNJ Chn i tng: 30 ngi tui t 18-55 Sc kho tt Ht thuc l mi ngy 1 bao, 1 nm 30 ngi tui t 18-55 Sc kho tt Ht thuc l 1 bao/d, 1 nm Xt nghim trc: SAR (Superoxide Anion Redical) LPO (Lipid Peroxide) 0,21 0,17 mol/ml 0,59 0,21 mol/ml 0,23 0,18 mol/ml 0,59 0,45 mol/ml Liu lng ung Ung 2 ounces/l x 2l/dung dch gi tr Thi gian 30 ngy Ung 2 ounces TNJ x 2 l/d Thi gian: 30 ngy Kt qu nghin cu tc dng chng oxy ho ca TNJ (M.Y Wans, A.Cheerva, C.Su, J.Jensen, D.Nowicki, G.Anderson, S. Jensen, J. W.Fritz) (2001 2002) 100. LOGO Kt qu: Sau th nghim Nhm placebo Nhm ung TNJ Cm quan 95% thy khng c s thay i. 5% c thy kho mt cht 75% thy kho hn, tnh to,ng tt. 15% khng mun ht thuc na Xt nghim: SAR LPO 0,23 0,15mol/ml 0,58 0,22 mol/ml ( P > 0,05 ) 0,17 0,10 mol/ml (Gim 27%) 0,45 0,02 mol/ml (Gim 23%) ( P < 0,05) Kt lun TNJ kh c SAR v LPO 101. LOGO Cc vn thng gp lin quan ti h tun hon Tch t Cholesterol/triglyceride Cao huyt p Va x ng mch Stress Mu km lu thng Bnh tim mch 5. Tc dng ln h tim mch: 102. LOGO 1. Ch n 2. Ht thuc l 3. Gc t do 4. Cc bnh mn tnh 5. Mi trng 6. t vn ng 7. Ung nhiu ROH 8. Lo ha 9. Gii Chng tc 10. Di truyn Nguy c tim mch 103. LOGO Hu qu ca cc yu t nguy c Bnh mch vnh Va x ng mch -Cht t ngt -Ri lon nhp T vong -Tng HA. -i tho ng -RL m mu -Bo ph, qu cn -Lm dng R0H -Ht thuc l -t vn ng -HC-X Yu t nguy c tim mch Suy tim giai on cui Nhi mu c tim Ri lon chc nng 104. LOGO 5.1 Tc dng lm gim huyt p: Irodoids NoNi Oleacin Angiotensinogen Angiotensin Th cm th AT1 Th cm th AT2 Co mch Tng huyt p Renin ACE + (-) Lin kt 105. LOGO S trung bnh huyt p trc nghin cu 144 83 Bnh Th ng1 20 Bnh Th ng 80 Huyt p tm thu Huyt p tm trng 106. LOGO S trung bnh huy t p sau nghin c u Huy t p Tm Thu Huy t p Tm Tr ng 132 78 Bnh Th ng 120 Bnh Th ng 80 107. LOGOSN PHM NONI H TR PHNG CHNG BNH TIM MCH (Dr. Anne Hirazumi Kim -1997) NONI (TNJ) Scopoletine Gin mch H huyt p H tr lm khe mnh h thng tim + mch Duy tr gii hn cholesterol mc bnh thng 108. LOGO Kch thch c th sn xut Nitric Oxyde (NO) NONI (TNJ) Gin mch Mch n hi hn Gim HA 109. LOGOGii Nobel Y hc nm 1998 Mt trong nhng khm ph quan trng nht ca lch s y khoa tim mch. Nitric oxit, NO nh l mt phn t tn hiu trong h thng tim mch NO = yu t gin mch c ngun gc t ni mc hay EDRF C th dng kh Nitric oxit lm cho mch mu gin ra v m rng 110. LOGO Trong c th chng ta oxit nit c hnh thnh t L-arginine. Kh ny c i sng rt ngn v thc hin nhiu chc nng sinh l bao gm: To tr nh Dn truyn thn kinh c ch khi u Kh nng min dch Chc nng h hp Chc nng tim mch Oxit Nit trong c th chng ta. 111. LOGO NO cung cp 13 li ch sau: 1) Tng lu lng mu bng cch lm gin cc mch mu. 2) Gi mch mu mm do v n hi. 3) Ngn chn cht bo d tha bm vo thnh mch 4) c ch s dy ln ca thnh mch nh c ch s tng trng bt thng ca c mch mu. 112. LOGO 5) Lm gim cc c hi co tht mch mu 6) C th gip ngn chn v o ngc x va ng mch. 7) Cha cc triu chng au tht lng v au chn. 8) C th lm i mi nng lng dn n i sng tnh dc c ci thin. 9) iu ha cc emzyme oxy ha trong t bo. 10) Ngn chn qu trnh oxy ha. 113. LOGO 11) Ngn chn s gn kt ca cc t bo mu vo thnh mch bng cch gim s kt dnh ca cc lp ni mc t ngn chn c s gn kt cc t bo bch cu. 12) Chng cc bnh v mch mu, bnh ng mch vnh v t qu 13) Lm chm tng trng mng bm v ngn chn x va ng mch. 114. LOGO 5.2 Gim LDL: Geniposidic acid Scandoside Feretoside 10 0 methyl benzoylscandoside ester Oldenlandoside III Asperulosidic acid (AA) Deacetylasperulosidic acid (DAA) c ch LDL 115. LOGO 5.3 . Gim tnh thm thnh mch: Catalpol Methylcatalpol Gim tnh thm thnh mch 116. LOGO 117. LOGO 118. LOGOTPCN h tr gim nguy c t qu, suy vnh v nhi muTPCN h tr gim nguy c t qu, suy vnh v nhi mu Thoi ha Protein Methionin Vitamin B12Vitamin B12 TPCN Vitamin B6 Axit Folic Homocysteine (BT: 5 - 10 mol/L) Nguy c tim mch t qu Nhi mu Alzheimer i ni mmch Tng kt dch tiu cu Bin i yu t mu CystathioninCystathionin Cystein Homocystin Bi xut qua thn Homocystin niu Suy vnh L ln tui gi + + No ni+ 119. LOGO TPCN h tr gim Cholesterol & bnh timmchTPCN h tr gim Cholesterol & bnh timmch Tng ngng t tiu cu Kch thch tng sinh c trn thnh mch Thc y x va ng mch To TB bt do i thc bo bt gi mng cht bo hp lng mch Thc n ng vt: no, tim, bu dc, lng trng mn, ngt Du m rn B sa ton phn Axit bo no LDL NONI MUFA PUFA Cholesterol t chc Cholesterol mu Cholesterol gan (thoi ha) HDL Axit bo khng no Ch n nhiu rau, tri cy n phm thc vt TPCN Noni Gim Cholesterol Gim nguy c MV (CHD) Gim x va ng mch Tng CholesterolTng Cholesterol Tng nguy c MV (CHD)Tng nguy c MV (CHD) Tng XVMTng XVM (-) (+) (+) (+) (+) (+) (+) Vn chuyn Vn chuyn Ghi ch: CHD (Coronary Heart Disease): Bnh ng mch vnh 120. LOGO Homocysteine HDL 10-16 % 121. LOGO 5.4. Tc dng chun ha 122. LOGO 6. Tc dng h ng huyt: Iridoids Oleuropein Chng oxy ha Tng dung np Glucose Scropolioside D2 Harpagoside 8-0-Acethylharpagide Deacethylasperulosidic acid (DAA) Gim Glucose mu 123. LOGO NONI H TR PHNG CHNG TIU NG T bo b tn thng Nc p tri nhu -Proxeronine -Proxeroninase Proxeronie Proxeroninase Proxeroninase Proxeronine Xeronine RUT GI -Tng hp thu cc cht dd vo t bo -Tng hp thu cc cht khc: hormone, men, serotonin. -T sa cha v t ti to Qu nhu 124. LOGO 7. Tc dng khng vi sinh vt: Khng VSV Hot cht thuc Iridoids Loi vi sinh vt Khng vi khun Isoplumericin Plumericin Galioside Gardenoside Gentiopicroside Staph.aureus Bacillces cereus B. Subtilis E.coli Klebsiella pheumoniae Pseudomonas aerugenosa Enterobacter cloacae Khng virus Arbortristoside A,C Acibin Oleuropein Lucidumoside Oleuropein Virus vim no c ch virus vim gan B Virus ho hp c ch HIV Khng k sinh trng Plumericin Isoplumericin Epoxygaertnroside Methoxygaertnroside Mt s Iridoids khc Leishmaial v Mollusicicidal Amip KSTSR (Plasmodium falciparum) 125. LOGO 8. Cc tc dng khc ca Iridoids: Iridoids Lm lnh vt thng, kch thch sn xut collagen Tng bi tit mt Chng d ng Chng trm cm, ri lon tm thn ph n mn kinh 126. LOGO Tnh thch nghi v cht thch nghi 127. LOGOTnh hnh lnh ln ca c th v: cu trc, chc nng t t bo - c quan - c th Sc khe (1) 1 Kh nng iu ha gi cn bng ni mi2 3 Thch nghi vi s thay i ca hon cnh Bnh tt (1000 bnh) 1 Ri lon tn thng cu trc, chc nng t mc t bo c quan c th 2 Mt cn bng ni mi 2 Gim kh nng thch nghi vi ngoi cnh 128. LOGO Stress: 1. Trng thi cng thng ca c th 2. Di tc dng ca cc tc nhn tn cng (stressor) 3. Biu hin bng mt phc hp cc phn ng khng c hiu (Hi chng thch ng chung) 129. LOGO Cc stressor: 1. C hc 2. L hc 3. Ha hc 4. Sinh hc V d: Chn thng Nhim khun Qu lnh Ng c Gy m Bng Xc ng Mt mi qu 130. LOGO Hi chng thch ng: 3 giai on Giai on bo ng Do t ngt c th tm thi b sc. Ngay sau huy ng cc bin php chng li 1. Pha sc (Di ha u th) Gim trng lc c Gim HA Gim thn nhit Gim Glucose huyt C c mu Tng tnh thm mao mch Tn thng lot (d dy) .... 2. Pha chng sc (Tng tit ACTH v Corticosteroid) Tng trng lc c Tng HA Tng Glucose huyt Giai on khng + Biu hin: ph i v thng thn, hot ha qu trnh ng ha, tng tn to Glucose + ngha bo v giai on ny: gip cho c th sng st c qua stress + a s stress dng li giai on ny. Nu stress qu nng, qu di, phn ng thch nghi ri lon giai on III Giai on suy kit Cn kit cc ngun d tr vt cht v chc nng Teo v xut huyt v thng thn Gim chuyn ha protein I II III 131. LOGO ngha ca Stress Hu qu ca stress ph thuc vo tng quan gia: Cng v thi gian ca Stress v kh nng thch nghi bo v ca c th Giai on II: cn c tng cng, duy tr, h tr gip c th vt qua tc ng xu ca stress Vai tr cc cht Adaptogen (TPCN). Cc stress yu, ngn hn,c th thng xuyn tri qua, c tc dng tng cng kh nng khng khng c hiu ca c th nh l mt s rn luyn 132. LOGO + Tnh thch nghi: Kh nng thch nghi (iu chnh v thay i) vi mi trng bn ngoi (cn gi l s iu bnh Homoestasis) + Cht thch nghi: (Adaptogen): kh nng gip c th thch nghi vi s thay i ca mi trng. + C ch tc dng: Tng cng h ni tit (quan trng l tuyn yn thng thn) H thn kinh H min dch Adaptogen (cht thch nghi): 133. LOGO CC TUYN NI TIT Hypothalamus Tuyn c Tinh hon (Nam) Tuyn thng thn Bung trng (N) Tuyn ty Tuyn gip v cn gip Tuyn tng Tuyn yn 134. LOGO C quan ch Tc dng sinh hc v iu ha chc nng chuyn ha ca c th: Phn ng ha hc t bo Vn chuyn vt cht qua mng t bo S bi tit:men, sa, dch .... S pht trin ca t bo v m Hot ng ca tim, HA, thn, tiu ha, h sinh sn ... Gan: chuyn ha Thn: o thi Bi tit Tuyn ni tit Hormone Mu 135. LOGOH thng ni tit Vng di i [Hypothalamus] ADH (Vasopressin) Oxytoxin Hormone gii phng Hormone c ch Tuyn yn: GH, ACTH, TSH, FSH, LH, Prolactin. Tuyn gip T3, T4, Calcitonin. Cn gip: PTH Ty ni tit Isulin, Glucagon V thng thn Cortisol, Aldosteron Ty thng thn Adrenalin, Noradrenalin Bung trng Estrogen, Progesteron Tinh hon Testosteron, Inhibin Rau thai HCG, Estrogen, Progesteron, HCS, Relaxin 136. LOGO Hng tnh ni mi = Duy tr s sng Dch ni TBDch ni TB T boT bo Dch ngoi boDch ngoi bo (Ni mi)(Ni mi) Hng tnh ni mi:Hng tnh ni mi: pH, nng ion, axit aminpH, nng ion, axit amin OO22, CO, CO22, Glucose, axit bo, Glucose, axit bo H thng tip nhnH thng tip nhn cht dinh dng, tiu hacht dinh dng, tiu ha v chuyn ha cht dinhv chuyn ha cht dinh dngdng H tiu haH tiu ha H h hpH h hp GanGan C ....C .... H thng vn chuynH thng vn chuyn cht dinh dngcht dinh dng MuMu Bch huytBch huyt Dch kDch k H thng bi tit ccH thng bi tit cc sn phm chuyn hasn phm chuyn ha H tiu haH tiu ha H h hpH h hp H tit niuH tit niu Da ...Da ... 137. LOGO iu ha chc nngiu ha chc nng ng thn kinhng thn kinh ng th dchng th dch Phn xPhn x khngkhng iu kiniu kin Phn xPhn x cc iu kiniu kin Cung phn x:Cung phn x: 1.1. Th cm thTh cm th 2.2. ng dn truyn hng tmng dn truyn hng tm 3.3. Trung tm TKTrung tm TK 4.4. ng dn truyn ly tmng dn truyn ly tm 5.5. C quan p ng: cC quan p ng: c (co gin)(co gin) 1.1. Nng cc cht kh:Nng cc cht kh: O2, CO2O2, CO2 2. Cc ion trong mu:2. Cc ion trong mu: KK++ ,, NaNa++ , Ca, Ca++++ , Mg, Mg++++ , Fe, Fe++++ ,, ClCl-- , HCO3, HCO3-- .......... 3. Hormone3. Hormone 4. C quan p ng:4. C quan p ng: cc (co gin)(co gin) RECEPTORRECEPTOR Hng tnh ni miHng tnh ni mi Duy tr s sngDuy tr s sng 138. LOGO c im ca Adaptogen Khng c hi: An ton cho ngi dng Khng c hiu: ph tc dng rng, tng cng h thng khng khng c hiu trong c th Chun ha (Normalizing): c tc dng chun ha, lp li s cn bng trong c th Gip c th thch nghi vi nhng thay i ca mi trng bn ngoi thng qua tng sc khng (ni tit, TK, min dch) chng li cc tc nhn l hc, sinh hc, ha hc 139. LOGO C th 1. Gi lnh ln cu trc - chc nng; t bo c quan c th 2. iu ha gi cn bng ni mi 3. Thch nghi vi thay i hon cnh Adaptogen Ngoicnh C hc L hc Ha hc Sinh hc 140. LOGO Noni = Adaptogen Khng c hi: 50-80ml c c/kg: cha thy du hiu ng c Irdoids: tc dng khng c hiu, ph tc dng rng: Bo v TK Chng khi u Khng vim Chng oxy ha Li ch tim mch Bo v gan Gim ng huyt Chng st, ho, vt thng Khng sinh iu ha min dch H HA Chng RL da Tc dng chun ha: Gim cholesterol xung mc sinh l Khng lm gim thp hn mc gii hn 141. LOGO 1. Tng kh nng khng ca c th chng li tc hi, tc nhn ca mi trng (tc nhn ha hc, sinh hc v vt l) 2. Duy tr cn bng trong c th - Lm gim hoc gii hn n mc sinh l ca c th. - Chun ha (bnh n, cn bng) cc gii hn sinh l. 3. Thch nghi vi s thay i ca mi trng. Khng c vi c th. Noni l 1 Adaptogen (cht thch nghi): 142. LOGO 1. Phun ln l du: Qu nhiu hn Qu ln hn Qu ngt hn 2. B sung vo thc n ca b: B tng trng nhanh hn Khe mnh hn 3. Vi ngi: Tng cng h min dch Bo v gan Bo v ADN Cng c h khp Tng lc v tng sc bn Duy tr mc HA bnh thng Duy tr mc Cholesterol bnh thng Nghin cu v tnh thch nghi ca Noni: 143. LOGO 9. Tc dng chng Glycate ha 144. LOGOTHUYT GLYCOSYL HATHUYT GLYCOSYL HA Sn phm Glycate ha bn vngSn phm Glycate ha bn vng Advanced Glycation End ProductsAdvanced Glycation End Products AGEsAGEs nh ngha:nh ngha: AGEs l cc phn t c to thnh do s kt hp ca cc phn tAGEs l cc phn t c to thnh do s kt hp ca cc phn t ng d vi cc phn t Proteine, Lipide, acid Nucleic. l tnh trng sinh l t nhinng d vi cc phn t Proteine, Lipide, acid Nucleic. l tnh trng sinh l t nhin dn ti lm tng cc bin chng v nguy c bnh tt, tng tc lo ha trong c th.dn ti lm tng cc bin chng v nguy c bnh tt, tng tc lo ha trong c th. OO = C -= C - HH HH - C - C OO -- HH HO - C - HHO - C - H H - C OHH - C OH HO - C HHO - C H H - C OHH - C OH HH ++ HH HH N - RN - R D Glucose m vngD Glucose m vng ++ Hp cht nhmHp cht nhm AminoAmino Bn vngBn vng Pht quangPht quang AGEAGE 145. LOGONGUN GC AGENGUN GC AGE Ngoi sinhNgoi sinh TP x lTP x l nhit caonhit cao TP thm, ngon,TP thm, ngon, mi v, mu scmi v, mu sc hp dnhp dn ngng ProteineProteine AGEAGE Ni sinhNi sinh Qu trnh trao i chtQu trnh trao i cht Qu trnh lo haQu trnh lo ha StressStress Bnh ttBnh tt Thng tnThng tn Thiu ngThiu ng Li sng khng lnh mnhLi sng khng lnh mnh (ROH, thuc l )(ROH, thuc l ) nh sng mt trinh sng mt tri GenGen Yu t tng sinh AGEYu t tng sinh AGE ++ Tng xc tcTng xc tc 146. LOGO AA AGE ngoi sinhAGE ngoi sinh TP chin, rn, tht nng, quay, g nng,TP chin, rn, tht nng, quay, g nng, quay BBQ, khoai ty rn, tht c hun khi,quay BBQ, khoai ty rn, tht c hun khi, TP n ngayTP n ngay Advanced GlycationAdvanced Glycation End ProductsEnd Products Proteins, lipidsProteins, lipids Nucleic acidsNucleic acids GlucoseGlucose AGE ni sinhAGE ni sinh Bin i chuyn ha GlucoseBin i chuyn ha Glucose (ng mu cao, khng Insulin,(ng mu cao, khng Insulin, i tho ng )i tho ng ) AlzheimerAlzheimer c nhn mtc nhn mt Thoi ha hong imThoi ha hong im Cao HACao HA Bnh tim mchBnh tim mch Bnh mch ngoi viBnh mch ngoi vi t qut qu Thiu muThiu mu Bnh thn mn tnhBnh thn mn tnh Suy thnSuy thn Long xngLong xng Gy xngGy xng trng lc ctrng lc c ssinh linh l REDUCEDREDUCED LONGEVITYLONGEVITY 147. LOGOC ch tc ng ca AGEC ch tc ng ca AGE GlycosylGlycosyl ProteineProteine++ Khng cn EnzymeKhng cn Enzyme Tng theo tui thTng theo tui th Gn kt vi TB vGn kt vi TB v m lnh qua RAGEm lnh qua RAGE Tn thng, suy chc nngTn thng, suy chc nng To cc Proteine kmTo cc Proteine km hoc mt chc nnghoc mt chc nng (c 30.000 loi Protein)(c 30.000 loi Protein) Oxy haOxy ha vimvim Chc nng PrteineChc nng Prteine 1. Cu trc (cu trc c, da,1. Cu trc (cu trc c, da, gn tt c t chc c th)gn tt c t chc c th) 2. iu ha cn bng ni mi2. iu ha cn bng ni mi 3. Vn chuyn3. Vn chuyn 4. Bo v4. Bo v 5. To nng lng5. To nng lng Bnh mn tnhBnh mn tnh 148. LOGO BNH C XNG KHP A.G.E.s l nguyn nhn hoc tng nng nhiu bnh SINH DC-TIT NIU BNH NHN KHOABNH NHN KHOA Bnh vng mc tiu ng Thoi ha im vng Glaucoma Chng vin thi ESRD/ gcui / Lc phc mc Bnh thntiu ng THNTHN Lo ha da Bnh tiu ng au thn kinh X cng b Hn ch Vn ng chung S tng trng khi u CC BNH KHC Ri lon cng dng Tc nghn ng niu BNH TMCHBNH TMCH Bnh suy tim X va ng mch Ni mng Ri lon Cao huyt p tm thu Bnh mch mu ngoi bin Tng huyt png mch phi Bnh mch vnh Chng rung tm nh BNH NG HHPBNH NG HHP Vim khp dng thp Vim khp mn tnh a thot v Xng vt gy Cc bnh rng ming Chng long xng X ha phi Bnh kh ph thng H THN KINH TWH THN KINH TW Stroke/ t qu/Tai bin mch mu no Bnh Alzheimer Amyotrophic/x cng ng vin 149. LOGO Kim sot AGEsKim sot AGEs 11 Kim sot AGE ngoi sinh:Kim sot AGE ngoi sinh: ch n ung hn ch AGEch n ung hn ch AGE 22 Kim sot AGE ni sinh:Kim sot AGE ni sinh: chng Glycat hachng Glycat ha 11 Hn ch to thnh AGEHn ch to thnh AGE 22 Ph v lin kt phn tPh v lin kt phn t 33 Tng o thiTng o thi TPCN:TPCN: Hot cht dc tho: Iridoids, Flavonoids .Hot cht dc tho: Iridoids, Flavonoids . Hot cht t hoa qu.Hot cht t hoa qu. Vn ngVn ng Ung ncUng nc 150. LOGO Phn V: Cc sn phm mi ca Noni 151. LOGO Bao b: bng nhm Dung tch: 750 ml c im: - Nh hn, d mang theo - D vn chuyn, thun tin - Khng v - C th ti ch, ti s dng - t cht thi rn. 152. LOGOSN PHM MI Thrive Adaptogenics MAX 120 mg iridois / 60 ml SP Noni Vit qut Chit xut l liu Sn th Nht Bn Sn th Chu u 153. LOGO 1. Bo v c th khi tn thng do gc t do 2. Chng lo ha 3. Ci thin chc nng tun hon v tim. To lu thng mch mu tt. 4. Chng vim. 5. Tng cng kh nng min dch. 6. Tng cng chc nng no. 7. Tng sc bn b v do dai . 8. Gim cholesterol, Triglycerid v LDL, tng HDL. SN PHM MI Thrive Adaptogenics MAX 154. LOGO Thnh phn: - Nc p nguyn cht qu Noni vng Polynesia. - Nc p nguyn cht l Noni Hm lng: 72mg Iridoid/60 ml sn phm Cng dng: Cung cp Iridoid c tc dng: - Tng sc khng - Trung ha gc t do - Gim cholesterol - H tr tim mch Tahitian Noni Pure (Nguyn cht) 155. LOGO Thnh phn: - Nc p nguyn cht qu Noni vng Polynesia - Qu nho v vit qut Hm lng: 30mg Iridoid/60ml sn phm Cng dng: Cung cp Iridoids c tc dng: - Tng sc khng - Trung ha gc t do - Gim cholesterol - H tr h tim mch - Tng cng sc khe Tahitian Noni PureTahitian Noni Original (Noni nguyn gc) 156. LOGO Thnh phn: - Nc p nguyn cht qu Noni vng Polynesia. - L liu, qu vit qut Hm lng: 60 mg Iridoid / 60ml sn phm. Cng dng: - Tng sc khng - Gim cholesterol - H tr h tim mch - Tng cng sc khe Tahitian Noni Extra (vt tri) 157. LOGOTahitian Noni Family Hng v xoi chanh ty Thnh phn: - Nc p nguyn cht qu Noni vng Polynesia. - Qu chanh ty, qu to, qu xoi Hm lng: 15 mg Iridoid / 60ml sn phm. Cng dng: - Tng sc khng - Trung ha gc t do - Gim cholesterol - H tr h tim mch - Tng cng sc khe 158. LOGOTahitian Noni Family Hng v nho Thnh phn: - Nc p nguyn cht qu Noni vng Polynesia. - Nc p qu nho Hm lng: 15 mg Iridoid / 60ml sn phm. Cng dng: - Tng sc khng - Trung ha gc t do - Gim cholesterol - H tr h tim mch - Tng cng sc khe 159. LOGO