Poster Abstracts Friday, November 11, 2005 $487

1519 A randomized, open label, controlled trial of Celecoxib (CELEBREX) versus Naproxen Sodium in tile treatment of acute illigraine

Tan, H J 1, Loo, CY a, Shamsul, AS 1, Raymond AA a. z Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

Introduction: migraine is a common neurological condition resulting in considerable socJo-economic losses. Although the role of non-steroidal anti-inflammatory drugs (NSAIDs) in acute migraine is well estab- lished, gastric side effects are commonly reported with their use. The efficacy of the COX-2 inhibitors in acute migraine has not been established. We compared the efficacy of the COX-2 inhibitor celecoxib with naproxen sodium in the treatment of acute migraine. Methods: This was a randomized, open label, controlled trial involving 60 migraneurs recruited fi'om the neurology clinic, Hospital Universiti Kebangsaan Malaysia. They were randomised to receive either celecoxib 400 mg (in -- 30) or naproxen sodium 550 mg (n - 30). Following an episode of acute migraine, the patients took the respective medication and reported a reduction of headache intensity based on a visual analogue score (VAS) at 1 and 2 hours after the treatment. Any side effects of the medication were also recorded. Results: The mean VAS in the celecoxib group improved significantly from baseline (6.48 ± 1.53) to 1 hour (14.28 ± 2.11) and 2 hours (2.24 ± 2.57) (p < 0.0005). The mean VAS in the naproxen sodium group also improved significantly from baseline (17.30 ± 1.66) to 1 hour (4.81 ± 2.50) and 2 hours (12.63 ± 2.65) (p < 0.0005). However, there was no significant difference between the magnitudes of improvement between the treatment groups. The incidence of gastric disturbance was significantly higher in naproxen group. (p -- 0.029). Conclusion: Celecoxib was as effective as naproxen sodium in relieving headache in acute migraine but caused significantly less gastric disturbances.

1520 I.H.S. Criteria for primary chronic headache and Radiology finds

Luengo, A ~, Hernando, V1 Colas, J2. 1,Yaime Vera". Cvslada, University Hospital Princesa, Neurology. ~fadrid, Spain; 2Hospital "At Sra. Del Prado", Neurology. Tulavera de lu Reina. Toledo, Spain

Background: Analysing the reliability of 1988 International Headache Society criteria for primary chronic headache, confronting these, with the results of by the patients demanded radiology explorations, in our National Health Service universal and free. Method: Prospective and randomly study of patients with primary chronic headache (I.H.S. criteria 1988). Achieved in outpatient Neuro- logy services o f: Jaime Vera Co slada, Madrid; and Talavera de la Renia, Toledo (Spain). Patients selected two randomly days a week, during three months a year, eight consecutive years, ending at December, 21 of 2003. They demand a cranial-CT exploration by themselves, their relatives, or their primary care physician by judicial fear. Results: 992 patients were analysed (69,6% females, and 30,4% males). In simple without contrast cranial CT we found: three patients with pathology, an occipital vascular malformation, a cysticercus in subarachnoid space, and a lacunar infarct in caudate. The rest of the patients had 11,1% migraine without aura; 21,95"/o migraine with aura; 39,4% Tensional episodic headache; 26,9% Tensional chronic headache; 0,53% chrorfic hemicranea. Conclusion: In our study we found a negative predictive value of I.H.S. 1988 criteria for primary chronic headache near 0,99.

1521 Assay of Monoamino oxidase-B activity in platelets of patients with migraine headache

Maheshwari P K 1, Singh H 01, Agarwal A K 1, Khanna V K 2, Sharma S K 1, Pursnani M L 1, Singh J B 1. 1S N Medical College, Agra, India; :Industrial Toxicology and .Research Centre, Lucknow, India

Background: To assess the platelet MAO-B activity in patients of migraine headache during headache free period and it 's comparison to controls and correlation of platelet MAO-B activity with the age at onset of migraine and severity of migraine. Method: 60 patients of migraine headache were selected according to IHS criteria. Cases were further subgrouped according to age at onset of headache - Group I (n - 21) - (Age at onset of headache bet- weenl0-20 yrs); Group [[ (n - 23) - (Age at onset of headache between 20-30 yrs); Group HI 0 a -- 16) - (Age at onset of headache between 30-40 yrs); And according to severity of headache using headache index (R Shukla et al) :- Group I (n -- 15) - Mild headache; Group II 0 a - 21) - Moderate headache; Group IH 0 a - 24) - Severe headache; Controls (n - 25). Platelet MAO-B activity was measured fluoro- metrically with kynuramaine as substrate following the method of Suzuki et al. Results: Mean platelet MAO B activity in migraineurs during headache fi-ee period was 1.43 ± 0.31 in comparison to controls (1.37 ± 0.34) and the difference was statistically insignificant. (p > 0.05)

Mean platelet MAO-B activity in Group [, Group H and Group If[ were 1.49 ± 0.24, 1.48 ± 0.41, 1.30 ± 0.17) respectively. The difference was statistically insignificant. (p > 0.05), Mean platelet MAO-B activity in migraineurs with Mild, Moderate, and Severe headache were 1.36 ± 0.14, 1.51 ± 0.39 and 1.31 ± 0.21 respectively and the differences was statistically insigo_ificant.(p > 0.05) Conclusion: In migraineurs platelet MAO-B activity remains normal during headache free period and early age at onset of migraine and severity of migraine do not have significant effect on basal platelet MAO-B activity.

1522 The elitfical presentation and affeetive disorders in Burning Mouth SymIrome

Mijajlovic, M ~, Zidverc-Trajkovic, j1, Jankovic, Lj ~, Stanimirovic, D ~, Sternic, N 1 . 1Institute of Neurology, C[iniea! Center of Serbia, Belgrade; ~Sehoo[ of Dentistry, University of Be~erade, Serbia and Montenegro

Background: According to IHS classification, burrfing mouth syndrome (BMS) is intra oral b m ~ n g sensation without obvious cause. Diagnostic. criteria include the presence of burning oral sensation during the most period of day without obvious changes of oral mucosa. Local and systemic, causes have to be excluded. Subjective feeling of dry mouth, paraesthesias and taste changes could be associated symptoms. The BMS is of unknown aethiology. Method: We examined 61 patients fulfilled the diagnostic criteria for primary BMS. Patients were recruited at the Clinic for oral diseases of the School of Dentistry in Belgrade, between January and December 2004. We have tested clinical characteristics and affective disorders using standard tests for attxiety and depression. Results: The average age was 65.5 ± 11.2 years, with female:male ratio 2:l.The disorder lasted more than twelve months in 62.7% of patients. The burning sensations were distributed on the whole oral cavity in 39.2%, on tongue or lips in 29.4%, while in the other patients the sensation involved the specified part of oral cavity. High scores were obtained on Hamilton Depression Rating Scale (16.5 ± 4.5), Beck Depression Inventory (117.4 ± 8.2) and Hamilton Anxiety Rating Scale (20.6 ± 5.6). Conclusion: As the other chronic, pain conditions, BMS is strongly associated with amxiety and depression.

1523 Senlm magnesium levels in migraine - Clinical and Electrophysiological correlations

Mukherjee, S1 Bhattacharya, G 2, Mukhetjee, A ~, Chatterjee, G ~, Mukhetjee, A 3, Alam, M 1, Ghosh, S 4. ZDepartment of Neurology, Medical College, Kolkata, India; 2Department of Biochemistry,