12th FRONTIERS IN IMMUNOLOGY RESEARCH NETWORK (FIRN) INTERNATIONAL CONFERENCE

Vienna, Austria Fleming’s Selection Hotel Wien, July 1-4, 2019

SUBJECT CATEGORIES (scroll down)

SCHEDULE (scroll down)

INSTRUCTIONS TO PROGRAM PARTICIPANTS (scroll down)

PROGRAM SESSIONS, OBSERVERS & RECOMMENDED ACTIVITIES, (scroll down)

SUBJECT CATEGORIES

• Allergy and immunopathology

• Antigen presentation

• Autoimmunity

• B cells

• Cellular immunology

• Cytokines, chemokines, inflammation

• Dendritic cells

• Diabetes

• Imaging at the molecular, cellular or animal level

• Immune responses to infectious diseases

• Immunogenetics and gene discovery

• Immunotherapy

• Innate immunity

• In silico modelling

• Knockout and knock-in studies

• Lymphocyte activation and homing

• Lymphocyte differentiation and migration

• Mechanisms of cell death

• Molecular immunology

• Mucosal immunology SIG

• NK cells

• NKT and T regulatory cells

• Plasmon resonance

• Protein crystallography

• Science communication - BD award session

• Signal transduction

• Stem cells

• T cell biology

• The immune response to viral infections

• The MHC and its interactions

• Tolerance

• Transplantation

• Tumour immunology

• Vaccine development

• Veterinary immunology SIG

12th Frontiers in Immunology Research Network (FIRN) International Conference Vienna, Austria, July 1-4, 2019

SCHEDULE OF MEETINGS & ACTIVITIES (subject to change) * *Excursions at extra cost

Sunday, JUNE 30, 2019

Pre-Conference Recommended Excursion: Town of Mödling

Registration: 5:00 PM – 6:00 PM

Monday, JULY 1, 2019

Registration & Sessions (9:00 AM – 1:30 PM) Welcome Reception with Working Lunch (1:30 PM – 3:30 PM)

Half-Day Recommended Excursion (after sessions): Vienna Sightseeing

Tuesday, JULY 2, 2019

Registration & Sessions (9:00 AM – 1:30 PM) Working Lunch (1:30 PM – 3:30 PM)

Half-Day Recommended Excursion (after sessions): Bratislava, Slovak Republic

Wednesday, JULY 3, 2019

Registration & Sessions (9:00 AM – 1:30 PM)

Working Lunch (1:30 PM – 3:30 PM)

Half-Day Recommended Excursion (after sessions): Schönbrunn Palace

Thursday, JULY 4, 2019

Registration & Sessions (9:00 AM – 10:00 AM)

Half-Day Recommended Excursion (after sessions): Town of Sopron, Hungary

Friday, JULY 5, 2019

Post-Conference Day-Long Recommended Excursion: Budapest, Hungary

INSTRUCTIONS TO PROGRAM PARTICIPANTS

(a) ORAL PRESENTATIONS:

Sessions, Time Allocations and Breaks: Eight sessions and three working lunches all together (over 20 hours of continuing education / training):

• two sessions each up to 180 minutes long inclusive of breaks; • three sessions, scheduled as invited or featured, each up to 75 minutes long; • three sessions each up to 90 minutes long; and • three working lunches, each up to 120 minutes long.

Session Moderators: Assume overall responsibility for your session. Try to contact the session participants before the meeting. Inform them that the presentation room will be equipped with power point capability. Ask them if they have any special needs relating to their presentation and, in collaboration with the registration desk, try to satisfy those needs. Arrive at the session room 10 minutes in advance and make sure that it is in order and properly equipped. Welcome and introduce the participants. Start the session on time and adhere to the time schedule. Moderate the open discussion to the best of your ability. Presenters: Each presenter should take no more than 40 minutes (or 60 minutes if invited or featured); any remaining time should be devoted to questions from the audience. Stay within the allotted time even though it may not be enough! Be well prepared. Please do not just read your paper. Your presentation of main points, methods, and conclusions should lead to a fruitful discussion during and after the session. The presentation room will be equipped with screens and power point capability (computer and projector). For Power Point presentations, please feel free to bring your own equipment and all necessary cables and transformers required by standards in Austria. If the session's moderator is absent, the last presenter listed should take on the role of the moderator.

(b) POSTER PRESENTATIONS:

• Displays and presentations have been scheduled to take place daily. Please search in the Program to find out

when you present and be prepared to display prior to your presentation. After your presentation, please remove all materials that relate to your poster.

• Posters should be prepared on heavy paper (preferably laminated), plastic, foam or other that can readily be

displayed and not exceed 3ft x 4ft (36 x 48 inches). Please note that FIRN would not provide any construction materials for, or electricity to, the posters.

• Posters should easily read from 2-3 feet away. Text should be limited to the core ideas and presented in a

font size that allows one to read it with ease. Experienced poster presenters suggest 3-6 graphics to mix in with your text to make the posters more engaging. Bring with you and make available five or more copies of your abstract and/or manuscript.

12th Frontiers in Immunology Research Network (FIRN) International Conference

Vienna, Austria, July 1-4, 2019

Fleming’s Selection Hotel

CONFERENCE PROGRAM

Sessions

&

Social Activities

FRONTIERS IN IMMUNOLOGY

RESEARCH NETWORK

Sunday, June 30, 2019

Registration: 5:00 PM – 6:00 PM

Pre-Conference Recommended Excursion: Town of Mödling

Registration: 5:00 PM – 6:00 PM

Monday, July 1, 2019

Registration & Sessions (9:00 AM – 1:30 PM)

Welcome Reception with Working Lunch – Bio Clusters (1:30 PM – 3:30 PM)

Monday, July 1, 2019

Session 1: 10:15 AM – 11:45 AM, FIRN Conference Room

MODERATOR:

Myungsoo Joo

Division of Applied Medicine

School of Korean Medicine, Pusan National University

Yangsan 50612, Korea

Evaluation of the anti-leukemic effects of a combination of neuroleptic drugs

and tyrosine kinase inhibitors in Chronic Myeloid Leukemia (CML)

C. Aussel1, 2, L. Bonhomme-Faivre1,2, P. Hugues1, A. Bennaceur-Griscelli1,3,4,5, A. Turhan1,3,4,5

1 INSERM 935 : SFR André Lwoff, University Paris Sud,

Paul Brousse Hospital, Villejuif, France APHP

2 Department of Pharmacy, Paul Brousse Hospital, Villejuif France APHP 3 Department of Hematology, Paul Brousse Hospital, Villejuif, France APHP

4 National Pluripotent Stem Cell Infrastructure INGESTEM,

University Paris Sud, Inserm, Paris, France

5 Department of Hematology Bicêtre Hospital, Kremlin-Bicêtre, France APHP

Session 1 continued next page:

Session 1 continued from previous page:

Restored Epithelial Gap Closure Capacity in Sera from Diabetic

Patients by Introduction of Alpha1-Antitrypsin

Melody Zaknoun1, Ronen Schuster1, Rotem Tzur2,

Eldad Silbertein2 and Eli C. Lewis1

1Department of Clinical Biochemistry & Pharmacology, Faculty of Health

Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel and

2Department of Plastic Surgery, Soroka University Medical Center,

Be'er Sheva, Israel

Break (15 minutes)

Monday, July 1, 2019

Session 2: 12:00 Noon – 1:15 PM, FIRN Conference Room

MODERATOR:

Eli C. Lewis

Department of Clinical Biochemistry &

Pharmacology Faculty of Health Sciences

Ben-Gurion University of the Negev Beer-Sheva, Israel

FEATURED TALK

Nivolumab-induced pneumonitis and cardiopathy in

a patient with relapsed Hodgkin’s lymphoma

S.C Misra1, 2, A. Santagostino1, G. Dine3, L. Bonhomme-Faivre4

1 Department of Hematology, Troyes Hospital, Troyes France

2 Department of Hematology, Saint-Antoine Hospital, Paris France APHP

3 Biotechnological Institute, Troyes France 4 Department of Pharmacy, Paul Brousse Hospital, Villejuif France APHP

Welcome Reception with Working Lunch – Bio Clusters (1:30 PM – 3:30 PM)

Monday, July 1, 2019

Half-Day Recommended Excursion (after sessions): Vienna Sightseeing

Tuesday, July 2, 2019

Registration & Sessions (9:00 AM – 1:30 PM)

Working Lunch – Journals & Editorial Policies (1:30 PM – 3:30 PM)

Tuesday, July 2, 2019

Session 3: 9:00 AM – 12:00 Noon, FIRN Conference Room

MODERATOR:

Mughis Uddin Ahmed

Ex. Professor of Pathology Karachi Medical &

Dental College and Abbasi Shaheed Hospital, Karachi-Pakistan.

Now Consultant and Head of Microbiology & Serology (Immunology),

King Abdulaziz Hospital (MNGHA) & KSAU, Al-Ahsa, Eastern Region-KSA

Structure-Function Aspects of Alpha1-Antitrypsin:

Novel Insights and Improved Formulations

Yotam Lior1, Maria Jatcevich1, Marianna Zaretsky 2,

David E Ochayon1, Ronen Schuster1, Amir Aharoni2 and Eli C. Lewis1

1Department of Clinical Biochemistry & Pharmacology, Faculty of Health Sciences,

Ben-Gurion University of the Negev, Be'er Sheva, Israel and 2Department of Life Sciences, Ben-Gurion University of the Negev and

National Institute for Biotechnology, Be'er Sheva, Israel

Session 3 continued to next page:

Session 3 continued from previous page:

Goat as prototype of Sterile Inflammation and

Inflammasome-Associated Diseases

Borros Arneth

Institute of Laboratory Medicine and Pathobiochemistry,

Molecular Diagnostics, Hospital of the Universities Giessen and Marburg UKGM

Justus Liebig University Giessen, Germany

Break (15 minutes)

Reduction of autophagy by Alisol B acetate is associated with

the amelioration of chronic obstructive pulmonary disease in mice

Kyun Ha Kim, Ji Yeon Lee, Min Jung Kwun,

and Myungsoo Joo*

Division of Applied Medicine, School of Korean Medicine,

Pusan National University, Yangsan 50612, Korea

Targeting neuroimmune semaphorin 4A signaling

pathways in allergic asthma

Svetlana P Chapoval*, Xiulan Qi, Amit Golding,

Andrew F Neuwald and Achsah D Keegan

University of Maryland School of Medicine,

Baltimore, MD 21201, USA

Tuesday, July 2, 2019

Session 4: 12:15 PM – 1:30 PM, FIRN Conference Room

MODERATOR:

David W. Scott

Department of Medicine, Uniformed Services University Bethesda, MD 20814, USA

INVITED SPEAKER

L. Courtney Smith is a professor in the Department of Biological Sciences at George Washington

University (GWU) where she teaches undergraduate and graduate level Immunology courses. She

initiated her research on marine invertebrate immunology at UCLA (PhD, 1985) with an investigation

of allograft rejection in sponges. As a postdoc at Caltech, she developed the sea urchin immunology

research program, identified its complement system (Smith et al., 2001, Immunol Rev 180:16), and

moved the program to GWU in 1995. Since then, she has focused on the SpTransformer gene family

(formerly Sp185/333) and focuses on the complexities of gene family diversification (Smith, 2012, Front

Immunol 3:70) and the anti-pathogen functions of the SpTransformer proteins (Smith and Lun, 2917,

Front Immunol 8:725).

Working Lunch – Journals & Editorial Policies (1:30 PM – 3:30 PM)

The SpTransformer system and robust innate immunity in sea urchins

L. Courtney Smith

Department of Biological Sciences

George Washington University Washington DC, USA

Tuesday, July 2, 2019

Half-Day Recommended Excursion (after sessions): Bratislava, Slovak Republic

Wednesday, July 3, 2019

Registration & Sessions (9:00 AM – 1:30 PM)

Working Lunch – Education Issues (1:30 PM – 3:30 PM)

Session 5: 9:00 AM – 12:00 Noon, FIRN Conference Room

MODERATOR:

Borros Arneth

Institute of Laboratory Medicine and Pathobiochemistry,

Molecular Diagnostics, Hospital of the Universities Giessen and Marburg UKGM

Justus Liebig University Giessen, Germany

Clostridium Difficile

PCR (Polymerase Chain Reaction) Laboratory Diagnosis of

Clostridium difficile associated diarrhea at our

hospital in Al-Ahsa Eastern Region of KSA

Mughis Uddin Ahmed

Ex. Professor of Pathology Karachi Medical & Dental College and

Abbasi Shaheed Hospital, Karachi-Pakistan.

Now, Consultant and Head of Microbiology & Serology (Immunology), King Abdulaziz

Hospital (MNGHA) & KSAU, Al-Ahsa, Eastern Region-KSA

Session 5 continued to next page:

Session 5 continued from previous page:

Harnessing Directed Evolution for Enhancing Desired

Attributes in Alpha1-Antitrypsin

Yotam Lior1, Maria Jatcevich1, Marianna Zaretsky2, David E Ochayon1,

Boris Baranovski1, Ronen Schuster1, Amir Aharoni2 and Eli C. Lewis1

1Department of Clinical Biochemistry & Pharmacology, Faculty of Health Sciences, Ben-

Gurion University of the Negev, Be'er Sheva, Israel and 2Department of Life Sciences, Ben-Gurion University of the Negev and National Institute for

Biotechnology, Be'er Sheva, Israel

Break (15 minutes)

Desensitization of the Gi-Coupled Adenosine A1 receptor in severe trauma induces immunosuppression, a possible mechanism to

minimize the risk from autoimmune diseases

Reut Riff1, Yosef Haviv2, Cidio Chaimovitz2 and Amos Douvdevani1,2.

1Clinical Biochemistry and Pharmacology and 2Nephrology Departments, Soroka University Medical

Center and Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Session 5 continued to next page:

Session 5 continued from previous page:

Roundtable I:

MODERATOR: Borros Arneth

Institute of Laboratory Medicine and Pathobiochemistry Molecular Diagnostics, Hospital of the Universities Giessen and Marburg UKGM, Justus Liebig

University Giessen, Germany

Theme: Macrophage Activation Syndrome

MAS / Hemophagocytic Lymphohistiocytosis HLH (i) Invited Participants (alphabetically by last name): L. Bonhomme-Faivre Department of Pharmacy, Paul Brousse Hospital, Villejuif, France APHP

Eli C. Lewis Department of Clinical Biochemistry & Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev Beer-Sheva, Israel

Yotam Lior Department of Clinical Biochemistry & Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel

David W. Scott Department of Medicine, Uniformed Services University, Bethesda, MD 20814, USA

_______________________

(i) References (next page):

(2018) Colin Casault et al., Case Report: Secondary Hemophagocytic Lymphohistiocytosis: A Challenging Diagnosis in a Patient with Autoimmune Hepatitis. Hindawi Case Reports in Critical Care, Volume 2019, Article ID 3580796, 4 pages. https://doi.org/10.1155/2019/3580796

(2019) Crayne CB et al., The Immunology of Macrophage Activation Syndrome. Front. Immunol. 10:119. https://doi.org/10.3389/fimmu.2019.00119

(2019) Guido A. Gualdoni et al., Prevalence and Outcome of Secondary Hemophagocytic Lymphohistiocytosis Among SIRS Patients: Results from a Prospective Cohort Study. Journal of Clinical Medicine, 8, 541. https://doi.org/10.3390/jcm8040541

Wednesday, July 3, 2019

Session 6: 12:15 PM – 1:30 PM, FIRN Conference Room

MODERATOR:

L. Courtney Smith

Department of Biological Sciences

George Washington University Washington DC, USA

FEATURED TALK

Engineering antigen-expressing T cells to modulate adverse immune responses

David W. Scott1, Maha Abdeladhim1, Aihong Zhang1,

Jeong Heon Yoon1, Kalpana Parvathaneni1, Laura Kropp2, Yong Chan Kim1, and Edward Mitre2

1Department of Medicine and 2Department of Microbiology, Uniformed Services University, Bethesda, MD 20814, USA

Working Lunch – Education Issues (1:30 PM – 3:30 PM)

Wednesday, July 3, 2019

Half-Day Recommended Excursion (after sessions): Schönbrunn Palace

Thursday, July 4, 2019

Registration & Sessions (9:00 AM – 12:00 Noon)

Session 7: 9:00 AM – 10:30 AM, FIRN Conference Room

Roundtable II:

MODERATOR: Eli C. Lewis Ben-Gurion University of the Negev, Be’er Sheva, Israel

Theme: Recombinant proteins in modern medicine - why do some end up going back to the drawing board? (ii)

Invited Participants (alphabetically by last name):

Mughis Uddin Ahmed King Abdulaziz Hospital & KSAU, Al-Ahsa, Eastern Region-KSA Borros Arneth Universities Giessen and Marburg UKGM, Justus Liebig Univ. Giessen, Germany Svetlana P Chapoval University of Maryland School of Medicine, Baltimore, MD 21201, USA Myungsoo Joo School of Korean Medicine, Pusan National University, Yangsan 50612, Korea Yotam Lior Ben-Gurion University of the Negev, Be’er Sheva, Israel Reut Riff Ben-Gurion University of the Negev, Be’er-Sheva, Israel L. Courtney Smith Department of Biological Sciences, George Washington Univ., Washington DC, USA _______________________________________________ (ii) References: (2018) Justin Bryan Goh et al., Impact of host cell line choice on glycan profile, Critical Reviews in Biotechnology, 38:6, 851-867, https://doi.org/10.1080/07388551.2017.1416577 (1992) A. Carver, et al., Expression of alpha1 human antitrypsin in transgenic sheep, Cytotechnology 9: 77-84 <https://www.dropbox.com/s/ln9tfgddkqofd0f/3%20Human%20AAT%20in%20sheep.pdf?dl=0>

Session 8: 10:30 AM – 12:00 Noon, FIRN Conference Room

Roundtable III:

MODERATOR: Eli C. Lewis Ben-Gurion University of the Negev, Be’er Sheva, Israel

Theme: Recombinant proteins in modern medicine - Can ex-vivo gene manipulation circumvent expressional discrepancies between species? (iii)

Invited Participants (alphabetically by last name):

Mughis Uddin Ahmed King Abdulaziz Hospital & KSAU, Al-Ahsa, Eastern Region-KSA Borros Arneth Universities Giessen and Marburg UKGM, Justus Liebig Univ. Giessen, Germany Svetlana P Chapoval University of Maryland School of Medicine, Baltimore, MD 21201, USA Myungsoo Joo School of Korean Medicine, Pusan National University, Yangsan 50612, Korea Yotam Lior Ben-Gurion University of the Negev, Be’er Sheva, Israel Reut Riff

Ben-Gurion University of the Negev, Be’er-Sheva, Israel L. Courtney Smith Department of Biological Sciences, George Washington Univ., Washington DC, USA _____________________________________________ (iii) References:

(2019) Thomas Amanna, et al., Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1

esterase inhibitor with fully humanized N-glycosylation profiles, Metabolic Engineering, Volume 52, March,

Pages 143-152, https://doi.org/10.1016/j.ymben.2018.11.014

(2016) Wolfgang Landgraf et al., Recombinant Human Insulins – Clinical Efficacy and Safety in Diabetes Therapy, European Endocrinology, 2016; 12(1):12–7, http://doi.org/10.17925/EE.2016.12.01.12

Thursday, July 4, 2019

Half-Day Recommended Excursion (after sessions): Town of Sopron, Hungary

Friday, July 5, 2019

Full-Day Recommended Excursion: Budapest, Hungary

The End!

See you next year!

13th Frontiers in Immunology Research Network International Conference!

July 11-14, 2020

Rome, Italy

Best Western Plus Hotel Universo