1 Wang haitao March 14 2011. Loss of one type of sensory input can cause improved functionality of...
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Transcript of 1 Wang haitao March 14 2011. Loss of one type of sensory input can cause improved functionality of...
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• Loss of one type of sensory input can cause improved functionality of other sensory systems. Whereas this form of plasticity, cross-modal plasticity, is well established, the molecular and cellular mechanisms underlying it are still unclear.
• blind individuals compensate their lack of visual input by responding to somatosensory or auditory input with improved sensitivity and accuracy. The brain can adapt to sensory deprivation in one modality (e.g., visual cortex) by increasing plasticity and retuning neuronal circuits in other remaining modalities.
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Methods
• In vitro whole cell recording
• Infection of Neocortical Neurons In Vivo
• In Vivo Microdialysis
• In Vivo Extracellular Recording
• Biochemical Analysis
• Immunohistochemistry
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VD Drives GluR1 into Layer 4 to Layer 2/3 Synapses of the Barrel Cortex in Juvenile Rats
GFP-GluR1
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• Visual deprivation (VD) drives AMPA receptors into synapses in the rat barrel cortex
• Seoronin mediates VD-induced facilitation of synaptic AMPA receptor delivery
• VD increases activation of ERK and increase of phosphorylation of GluR1 at Ser845
• VD sharpens the map in the barrel cortex