1 Global New Employee Orientation Workshop Welcome.

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Global New Employee Orientation Workshop

Welcome

April 4,2000 Global New Employee Orientation Company ConfidentialCopyright © 2000 Eli A Pharmaceutical Company and Company

2Recruiting

InterviewingJob Offer and Acceptance

Receipt of Welcome Packet

New Employee Orientation Workshop

Intranet Orientation Site

On-the-job Experience and Training

Job-specific Training

On-going Networking and Social Events


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Workshop Agenda

Welcome

Participant Introductions

Document Completion

Benefits Information

A Pharmaceutical Company History Video


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Workshop Agenda (continued)

Company Overview

Red Book and Asset Protection

Performance Management/Career Development

Workshop Summary

Wrap-up and Evaluation


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Workshop Objectives

To let you know:

• What is expected of you

• How to add value to the company

• How to communicate with your colleagues

• How to integrate as team players

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Company Overview


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A Pharmaceutical Company’s Global Presence

• Employs more than 31,000 people

• Has Research and Development facilities in 9 countries

• Markets medicines in 179 countries

Around the world, A Pharmaceutical Company:

• Has Manufacturing facilities in 20 countries


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Our Three Core Values

Respect for people

Integrity

Thirst for excellence


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Our Mission

Enable people to live longer, healthier, more active lives

A Pharmaceutical Company is a research-based global company

Creates pharmaceutical-based health care solutions

That

To


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People

Scientific Innovation

Demand Realization

Shareholder Value

Our Four Corporate Objectives


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Our Organizational Structure

Policy Committee Charter

At the corporate level, approve and own:

• Performance targets

• Strategies

• Policies

Ensure compliance


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Policy Committee Activities:

Manage corporate strategy

Allocate resources

Manage corporate assets

Review investments

Review organizational policies


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Operations Committee Charter

Integrate strategies based on:

• Product

• Geography

• Function

Monitor corporate performance


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Operations Committee CharterIdentify and discuss corporate:

• Strategic issues

• Operational issues

• Opportunities

Provide for organizational learning


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Operations Committee Activities:

Review functional, product and geographic plans

Align plans with corporate goals and targets

Monitor corporate performance

Debate strategic issues

Review succession plans


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Global Pharmaceutical MarketEurope,

Middle Eastand Africa

31%

North America33%

Japan23%

Australia1%

Latin America

7%

Asia and Pacific5%

Sales: $134 Billion U.S. In 1999


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External Factors Affecting the Industry

Demographics

Government/Individual Spending

Disease Focus

Decision Maker/Influencer


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Internal Factors Affecting the Industry

Cost

Competition

Regulation

Product Risk


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Pharmaceutical Research Spending

Global (R&D) spending was $24 billion U.S. in 1999

R&D as a percentage of sales was 18 percent

Much higher than other industries:

• 6.4 percent in electronics

• 3.9 percent in aerospace


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Product Risk

10,000 Compounds

1,000 Show Promise

100 Are Tested

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Average cost to develop one drug:

$500 Million U.S.

To Market


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Product Life Cycle

15 years for R&Dand Product

Launch

Drug Discoveryand Development

5 Yearsto RecoverR&D costs

Launch

Generic Competition

Off Patent No Longer Manufactured

Patent Protection

20 years


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Drug Development Process

Commercialization

ProductsPrograms

Candidate Development

Hypothesis Generation

Projects


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Projects

• Target identification and validation

• Assay development

• Lead generation

Activities Goal

Testable,valuable hypothesis


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Candidate Development

• Lead optimization

• First human dose preparation

• Phase IA clinical trials

• Phase IB / II clinical trials

Goal

Proven or disproven hypothesis for given drug candidate

ActivitiesCandidate Development


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Commercialization

Commercialization

Products

• Phase III clinical trials

• Submission to regulatory agencies

• Global launch

• Global optimization

Goal

Successfulcommercial

product

Activities


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Quality, Speed, Value

• Quality: Working on the best opportunities

• Speed: Develop drugs in half the time

• Value: Double the products for every R&D dollar


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Targeted Research Categories

Cardiovascular

Central Nervous System

Endocrine

Infectious Diseases

Cancer


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Current Products

More muscle

• Increase the sales force

• Visit more decision makers more frequently

• Publish more articles

New indications

• Increase direct marketing

Novel delivery devices


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Product Development

New products

Product partnerships

• Research

• Launch

New combinations of existing products

• Depression

• Cancer

• Diabetes

• Sepsis


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Bulk Manufacturing

A Pharmaceutical Company’s Manufacturing Processes

Raw pharmaceutical materials are made intoactive drug compounds.

Raw pharmaceutical materials are made intoactive drug compounds.


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Formulation and Filling

Bulk Manufacturing


Compounds are processed for storage and proper dosage. This could include:

• Mixing inert substances into compounds

• Compressing dry compounds into tablets

• Filling capsules with dry compounds

• Filling vials with liquids

• Freeze-drying liquids for longer storage

Compounds are processed for storage and proper dosage. This could include:

• Mixing inert substances into compounds

• Compressing dry compounds into tablets

• Filling capsules with dry compounds

• Filling vials with liquids

• Freeze-drying liquids for longer storage


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Formulation and Filling

Bulk Manufacturing

Finishing (packaging)


Products are preparedfor distribution by:

• Putting them in containers

• Labeling the containers

• Inserting patient instructions

• Placing the containers in bulk packaging

Products are preparedfor distribution by:

• Putting them in containers

• Labeling the containers

• Inserting patient instructions

• Placing the containers in bulk packaging


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Introduction to Our Intranet

The Company Intranet

The Orientation Site links to:

• Employee benefits and services

• Corporate policies and procedures

• Functional business components

• A Pharmaceutical Company’s product portfolio

• Pharmaceutical industry overview

• Career development resources

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Global New Employee Orientation Workshop

Thank You

1 Global New Employee Orientation Workshop Welcome.

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