01.16.09: The Digestive Tract Ecosystem
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Transcript of 01.16.09: The Digestive Tract Ecosystem
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Author(s): Gerald Abrams, M.D., 2009
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OUR MICROBIAL FRIENDS
The Digestive Tract Ecosystem
Gerald D. Abrams
Winter, 2009
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G.D. Abrams, University of Michigan Medical School
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Department of Pathology, University of Michigan
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Department of Pathology, University of Michigan
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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Ilya Mechnikov
Wikimedia Commons
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DEFENSIVE FUNCTIONS OF THE MICROBIAL FLORA
• PROVIDES “COLONIZATION RESISTANCE”
• STRENGTHENS MUCOSAL BARRIER
• STIMULATES IMMUNE SYSTEM
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METABOLIC FUNCTIONS OF THE MICROBIAL FLORA
- ENZYMES PRODUCED
- VITAMINS PRODUCED
- SECRETIONS, FOODSTUFFS, DRUGS PROCESSED
- GI LINING CELLS NOURISHED
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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Department of Pathology, University of Michigan
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G.D. Abrams, University of Michigan Medical School
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Department of Pathology, University of Michigan
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PROBIOTIC
• A preparation containing live micro-organisms that can enter the GI ecosystem and produce positive health effects.
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PROBIOTIC
• A preparation containing live micro-organisms which, upon ingestion in sufficient numbers, exert health benefits beyond basic nutrition.
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PREBIOTIC
A substance or preparation which stimulates the growth of a potentially beneficial micro-organism(probiotic)
SYNBIOTIC A mixture of probiotic and prebiotic.
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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G.D. Abrams, University of Michigan Medical School
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PROBIOTIC CAVEATS
• FEW CLINICALLY PROVEN EFFECTS • STRAIN SELECTION PROBLEMATIC • PREPARATION QUALITY VARIABLE • SAFETY ISSUES REMAIN
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Additional Source Information for more information see: http://open.umich.edu/wiki/CitationPolicy
Slide 4: G.D. Abrams, University of Michigan Medical School Slide 5: Department of Pathology, University of Michigan Slide 6: Department of Pathology, University of Michigan Slide 7: G.D. Abrams, University of Michigan Medical School Slide 8: G.D. Abrams, University of Michigan Medical School Slide 9: G.D. Abrams, University of Michigan Medical School Slide 10: G.D. Abrams, University of Michigan Medical School Slide 11: G.D. Abrams, University of Michigan Medical School Slide 12: G.D. Abrams, University of Michigan Medical School Slide 13: G.D. Abrams, University of Michigan Medical School Slide 14: G.D. Abrams, University of Michigan Medical School Slide 15: G.D. Abrams, University of Michigan Medical School Slide 16: G.D. Abrams, University of Michigan Medical School Slide 17: G.D. Abrams, University of Michigan Medical School Slide 18: G.D. Abrams, University of Michigan Medical School Slide 19: Wikimedia Commons, http://commons.wikimedia.org/wiki/File:Ilya_Mechnikov_(Nobel_1908).png Slide 22: G.D. Abrams, University of Michigan Medical School Slide 23: G.D. Abrams, University of Michigan Medical School Slide 24: G.D. Abrams, University of Michigan Medical School Slide 25: G.D. Abrams, University of Michigan Medical School Slide 26: G.D. Abrams, University of Michigan Medical School Slide 27: G.D. Abrams, University of Michigan Medical School Slide 28: G.D. Abrams, University of Michigan Medical School Slide 29: G.D. Abrams, University of Michigan Medical School Slide 30: G.D. Abrams, University of Michigan Medical School Slide 31: Department of Pathology, University of Michigan Slide 32: Department of Pathology, University of Michigan Slide 33: Department of Pathology, University of Michigan Slide 37: G.D. Abrams, University of Michigan Medical School , CC:BY-NC-SA, http://creativecommons.org/licenses/by-nc-sa/3.0/ Slide 38: G.D. Abrams, University of Michigan Medical School Slide 39: G.D. Abrams, University of Michigan Medical School Slide 40: G.D. Abrams, University of Michigan Medical School Slide 41: G.D. Abrams, University of Michigan Medical School Slide 42: G.D. Abrams, University of Michigan Medical School Slide 43: G.D. Abrams, University of Michigan Medical School