· Yoshida S, Tamiya-Koizumi, K. Disruption of phospholipase C 4 gene modulates the liver ......

64
6 1 1 2 Shigeru Nakashima Yoshiko Banno Shin-ichiro Hayashi 3 1 . , , , , , , , , 4 , 2007 2 , . , 2008 155161 3 , , . , 2008 4649 1 Yamada Y, Banno Y, Yoshida H, Kikuchi R, Akao Y, Murate T, Nozawa Y. Catalytic inactivation of human phospholipase D2 by a naturally occurring Gly901Asp mutation. Arch Med Res. 2006;37:696-699. IF 1.772 2 Akao Y, Banno Y, Nakagawa Y, Hasegawa N, Kim TJ, Murate T, Igarashi Y, Nozawa Y. High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation. Biochem Biophys Res Commun. 2006;342:1284-1290. IF 2.749 3 Morita M, Banno Y, Dohjima T, Nozawa S, Fushimi K, Fan DG, Ohno T, Miyazawa K, Liu N, Shimizu K. -Calpain is involved in the regulation of TNF--induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line. Biochem Biophys Res Commun. 2006;343:937-942. IF 2.749 4 Ohguchi K, Banno Y, Akao Y, Nozawa Y. Involvement of phospholipase D1 in collagen type I production of human dermal fibroblasts. Biochem Biophys Res Commun. 2006;348:1398-1402. IF 2.749 5 Akutagawa A, Fukami K, Banno Y, Takenawa T, Kannagi R, Yokoyama Y, Oda K, Nagino M, Nimura Y, Yoshida S, Tamiya-Koizumi, K. Disruption of phospholipase C4 gene modulates the liver

Transcript of  · Yoshida S, Tamiya-Koizumi, K. Disruption of phospholipase C 4 gene modulates the liver ......

6X ��?@

�!"��#$%

Y1Z[\]^!_

1X���`a DR��ÞêJ2­ëì3ÄÃWKLU��*+}���-.}��íî�§¨"OïìJð¶·ñ2

wí­ì���ñòwÄëKóghdijoT�íï=ôgh�3õ�()Ø7X�<ñöKWíW�

3ÇÄ��ñ`÷ÄëKó��@ø3ÇÄêö3ÇÄ*+Þ��0Þ�­®ñù÷ÄÃWó­®gh=ê

î�UW�\ñú¾ÕûüQVWý3­��>�þ�íî����C=êî�UW�\ñ�(VWý3­

¥¦��/UÂí­Wó�K��0�ìUËÌ�UÂÃÄ���ô|`�=�Wó�þ�¹�ËÌ÷°

�ù�vÕ��0�*+ËÌ����ñ|LÄÃWó�K�a��U@VW\íYU�/UÕW�

0d�gh�÷°Ø7X�<3Ë�¥¦UÂÃÄô��1��µñ� ÄÃWó�0êV�Ä����Ë

Ì­�ÐVWKL��£íDfBC=�¥��\U��<Ör��£í��íW���3Â=�Wó-Ð

���/èYéW3�j���=��0�p��U�£íno#ñ�1ÇÄv¥��gíÒÓvwñ

`÷ÄÃWó�ìU�ô��Â�0Þ=�W8Y�0�p��Ò�UÂÃÄô��ñì�ÇKó

2Xbc �³� ��³� ���

��� � �O�# ����

Shigeru Nakashima Yoshiko Banno Shin-ichiro Hayashi

3X��Fd�ef Ü !"!

1! ��� �. ]�#�, $%&�, 'E(), +*(+, ,-.�, ]/01, 2fõ3, 4%56, Ef�7=���X1 � 48, 9:�9:���J;2007��

2! ����, <=>��?@A�=. ����0�����/ gh�/!��0��B�0����CéwDEFûbÊ�D, 9:��G/H I!�ÜÆ8�; 2008��155J161�

3! ��� �, KOL3��MNO, $%P�=. ghd�ZQïoTÒ��Ûè"#�'� �R8, 9:��}��H;2008��46J49�

Ü S"! íÇ

©è !"! íÇ

©è S"! íÇ

Ï !"! íÇ

Ï S"!

1! Yamada Y, Banno Y, Yoshida H, Kikuchi R, Akao Y, Murate T, Nozawa Y. Catalytic inactivation of human phospholipase D2 by a naturally occurring Gly901Asp mutation. Arch Med Res. 2006;37:696-699. IF 1.772

2! Akao Y, Banno Y, Nakagawa Y, Hasegawa N, Kim TJ, Murate T, Igarashi Y, Nozawa Y. High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation. Biochem Biophys Res Commun. 2006;342:1284-1290. IF 2.749

3! Morita M, Banno Y, Dohjima T, Nozawa S, Fushimi K, Fan DG, Ohno T, Miyazawa K, Liu N, Shimizu K. �-Calpain is involved in the regulation of TNF-�-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line. Biochem Biophys Res Commun. 2006;343:937-942. IF 2.749

4! Ohguchi K, Banno Y, Akao Y, Nozawa Y. Involvement of phospholipase D1 in collagen type I production of human dermal fibroblasts. Biochem Biophys Res Commun. 2006;348:1398-1402. IF 2.749

5! Akutagawa A, Fukami K, Banno Y, Takenawa T, Kannagi R, Yokoyama Y, Oda K, Nagino M, Nimura Y, Yoshida S, Tamiya-Koizumi, K. Disruption of phospholipase C�4 gene modulates the liver

regeneration in cooperation with nuclear protein kinase C. J Biochem. 2006;140:619-625. IF 2.020 6! Raymond MN, Bole-Feysot F, Banno Y, Tanfin Z, Robin P. Endothelin-1 inhibits apoptosis through a

sphingosine kinase 1-dependent mechanism in uterine leiomyoma ELT3 cells. Endocrinology. 2006;147:5873-5882. IF 5.045

7! Sobue S, Iwasaki T, Sugisaki C, Nagata A, Kikuchi R, Murakami M, Takagi A, Kojima T, Banno Y, Akao Y, Nozawa Y, Kannagi R, Suzuki M, Abe A, Naoe T, Murate T. Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes. Leuchemia. 2006;20:2042-2046. IF 6.612

8! Ryu J, Kim HJ, Chang EJ, Huang H, Banno Y, Kim HH. Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. EMBO J. 2006;25:5840-5851. IF 8.662

9! Masuda H, Kalka C, Takahashi T, Yoshida M, Wada M, Kobori M, Itoh R, Iwaguro H, Eguchi M, Iwami Y, Tanaka R, Nakagawa Y, Sugimoto A, Ninomiya S, Hayashi S, Kato S, Asahara T. Estrogen-mediated endothelial progenitor cell biology and kinetics for physiological postnatal vasculogenesis. Circ Res. 2007;101:598-606. IF 9.721

10! You F, Osawa Y, Hayashi S, Nakashima S. Immediate early gene IEX-1 induces astrocytic differentiation of U87-MG human glioma cells. J Cell Biochem. 2007;100:256-265. IF 3.409

11! Leiber D, Banno Y, Tanfin Z. Exogenous sphingosine-1 phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms. Am J Physiol Cell Physiol. 2007;292:C240-C250. IF 4.230

12! Jung ID, Lee JS, Kim YJ, Jeong YI, Lee CM, Baumruker T, Billlich A, Banno Y, Lee MG, Ahn SC, Park WS, Han J, Park YM. Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells. Int Immunol. 2007;19:411-426. IF 3.290

13! Mizoguchi H, Yamada K, Niwa M, Mouri A, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y, Nabeshima T. Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9 deficient mice. J Neurochem. 2007;100:1579-1588. IF 4.451

14! Kikuchi R, Murakami M, Sobue S, Iwasaki T, Hagiwara K, Takagi A, Kojima T, Asano H, Suzuki M, Banno Y, Nozawa Y, Murate T. Ewing’s sarcoma fusion protein, EWS/Fli-1and Fli-1 protein induce PLD-2 but not PLD-1 gene expression by binding to an ETS domain of 5’ promoter. Oncogene 2007;26:1802-1810. IF 6.440

15! Kikuchi R, Sobue S, Murakami M, Ito H, Kimura A, Iwasaki T, Shibayama S, Takagi A, Kojima T, Suzuki M, Banno Y, Nozawa Y, Murrate T. The regulatory mechanism of Vitamine D3 induced increase of PLD1 transcription of a human keratinocyte cell line, HaCaT. FEBS Lett. 2007;581:1800-1804. IF 3.263

16! Mizoguchi H, Yamada K, Mouri A, Niwa M, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y, Nabeshima T. Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implications for dopamine receptor down-regulation and dopamine release. J Neurochem. 2007;102:1548-1560. IF 4.451

17! Murakami M, Ichihara M, Sobue S, Kikuchi R, Ito H, Kimura A, Iwasaki T, Takagi A, Kojima T, Takahashi M, Suzuki M, Banno Y, Nozawa Y, Murate T. RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis. J Neurochem. 2007;102:1585-1594. IF 4.451

18! Fushimi K, Nakashima S, You F, Takigawa M, Shimizu K. Prostaglandin E2 downregulates TNF-�-induced production of matrix metalloproteinase-1 in HCS-2/8 chondrocytes by inhibiting Raf-1/MEK/ERK cascade through EP4 prostanoid receptor activation. J Cell Biochem. 2007;100:783-793. IF 3.409

19! Yamashita K, Kotani Y, Nakajima Y, Shimozawa M, Yoshimura S, Nakashima S, Iwama T, Hara H. Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitoro and in vivo by acting directly on neurons. Brain Res. 2007;1154:215-224. IF 2.212

20! Banno Y, Nemoto S, Murakami M, Kimura M, Ueno, Y, Ohguchi K, Hara A, Okano Y, Kitade Y, Onozuka M, Murate T, Nozawa Y. Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway. J Neurochem. 2008;104:1372-1386. IF 4.451

21! Sobue S, Nemoto S, Murakami M, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Nakamura M, Ito Y, Suzuki M, Banno Y, Nozawa Y, Murate T. Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat -Relevance as a marker for daunorubicin sensitivity of leukemia cells. Int J Hematol. 2008;87:266-275. IF 1.491

22! Sobue S, Murakami M, Banno Y, Ito Y, Kimura A, Furuhata A, Gao S, Takagi A, Kojima T, Suzuki M, Akao Y, Nozawa Y, Murate T. V-src oncogene increases sphingosine kinase 1 expression through its mRNA stabilization -Alteration of AU-rich element binding proteins. Oncogene. 2008;27:6023-6033. IF 6.440

23! Niinomi K, Banno Y, Iida H, Dohi S. Nicorandil, an adenosine triphosphate-sensitive potassium channel opener, inhibits muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinases in PC12 cells. Anesth Analg. 2008;107:1892-1898. IF 2.214

24! Soeda A, Inagaki A, Oka N, Ikegame Y, Aoki H, Yoshimura S, Nakashima S, Kunisada T, Iwama T. Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells.

J Biol Chem. 2008;283:10958-10966. IF 5.581

4X��ghiOj 1Zklmno 1! ��ræ���O�#;����T��¹DU��(C)(2);\¢�YVWXrsYZUÕWgh[\�]�()Ò�vé;¿� 17J18�z;3,600^_(2,000�1,600^_)

2! ��ræ������;úû]�]����Þ������`� �!�KL�¶·X±;`a�0d�Fbp'c#��1vÕ��/ÉÊ;¿� 17�z;1,000^_

3! ��ræ��d� ef;úû]�]����Þ������`� �!�KL�¶·X±;gUZ8�W�gh�õ3"��\סòÒ��vé;¿� 17�z;500^_

4! ��ræ������;úû]�`�+T ��!;�0d�high�aj�0ê�"�()vÕ��/ÉÊ;¿� 18�z;1,200^_

5! ��ræ������;úû]�]����Þ������`� �!�KL�¶·X± "OñýkKj���!;���3*+l���+ÇÃ�/f�ìpUmwKDR�� ���Uvw

WËÌngh�"�()ñoÇK*+�0Ap�/f�§Ð;¿� 18�z;1,000^_ 6! ��ræ��d� ef;úû]�]����Þ������`� �!�KL�¶·X±;qYghUvwWî�UW�\3�WU¢rÙW�ñ;Y\;¿� 18�z;200^_

7! ��ræ��h�st;úû]�]����Þ������`� �!�KL�¶·X±;qYghUvwW�WU¢rÙWüQ3�ZQïoTÒ�;¿� 18�z;500^_

8! ��ræ������;úû]�`�+T ��!��0*+ma EphrinB 8qYÎñuÊÇKîï��×�W���'vévÕ��/ÉÊ;¿� 19�z;1,130^_

9! ��ræ��=�v (wxy]����), ��"z���O�#;����T��¹DU��(C)(2)�{-., *+l��=�\¢�YV�Y9QW|�p'b��vw3�'=�Q_;¿� 18J19�z;4,050^_(2,200�1,850^_)

10! ��ræ���O�#;úû]�`�+T ��!�}~«���`WXUÕWn�Ò�3��í;ÏWUvwWP��§Ð;¿� 19�z;1,130^_

11! ��ræ����� �;úû]�]����Þ������`� �!�KL�¶·X±�W�ËÌ+dÑ�Þngh3*+�Øc#ñÊÃK+ÇÃ*+���/f�ìp;¿� 19�z;100^_

12! ��ræ����� � (úû]�È��), ��"z���O�#;����T��¹DU��(C)(2)�+����] RhoGEF3�ÒmÊVWÐ"#��13Ë��ÒÓ�vé;¿� 20J22�z;4,200^_(1,400�1,400�1,400^_)

13! ��ræ����� � (úû]�È��), ��"z���O�#;����T��¹F1��ôGéY�´Xý��Â�G ×´ïñ:�+���ÐG�NX�ZQï�]RhoGEF��ÒÓvw;¿� 20J21�z;5,200^_(2,600�2,600^_)

14! ��ræ���=�� úûk�]�!, ��"z���O�#;��ST�GÒ��W�p�st���WXØéÙ��¡´\UÕW��/fñ×��W7W�Z�3Z�;¿� 20�z;2,000^_

15! ��ræ������;úû]�`�+T ��!��0*+ma EphrinB 8qYÎñuÊÇKîï��×�W���'vévÕ��/ÉÊ;¿� 20�z;1,060^_

16! ��ræ������;úû]�]����Þ������`� �!�KL�¶·X±:���-.UvwW8Y�0+�Ø7X�<vévÕ�8Y�0ñéW�¡U3ÇK�/ÉÊ;¿� 20�z;500^_

17! ��ræ����+�, "z������;úû]�]����Þ������`� �!�KL�¶·X±�ANGPT13ËÌnghñuÊÇK����0��U@VW+ÇÃ�/f�ìp;¿� 20�z;500^_

2Zpq�� íÇ

3Zr��� 1! ����������0d��UvwW PDE3�°« ��\é�Wï!���;¿� 19�z;

1,000^_�]��k I! 2! �O�#���vÕ���gh�è;�Îa'U�VW��;¿� 20�z;500^_�[WèW I!

5Xes�tuvwOj 1! �����Alzheimer ���éY�´, Amyloid-� (A�-40)��0��°mÊ;-.<ì�� WO2006/05977!

6Xx?@ 1Zxyz ��� �� 1! Áf��IÂL2��´(�'4) 2! Áf��I� �����"#Î���8LIO2(�¿� 19� 8 ) 3! � 20¡-.���"#Î�IL¢£�|O2IO2(�¿� 18� 6 ) �O�#� 1! Áf��I��¶�nX(¿� 18� 9 �¿� 20� 8 )

2Zx{| íÇ

3Z}~� íÇ

7Xx��$�����������%� ��� �� 1! úûy�¤¥�/è�QW(¿� 18� 1 , úû, &�) 2! úûy�¤¥�/è�QW(¿� 19� 1 , úû, &�) 3! úûy�¤¥�/è�QW(¿� 19� 9 , úû, &�) 4! úûy�¤¥�/è�QW(¿� 20� 9 , úû, &�)

�O�#� 1! �¦¡\¢�YVí;ÏW(STC)��I(¿� 18� 5 , §#, ¨�) 2! � 2¡\¢�YVí;ÏW(STC)��I(¿� 19� 5 , §#, ¨�) 3! � 3¡\¢�YVí;ÏW(STC)��I(¿� 20� 7 , §#, ¨�)

8X}�>�p�Oj íÇ

9X�x?@ ��� �� 1! TIMA Foundation (Liechtenstein) Adviser (�'4) �O�#� 1! Áf�T�G����TO2I�ðO2(¿� 19�z) �� ���� 1! ÁfÐ�8I\�W�δéW(©ª¶�)(¿� 19� 10 �'4)

10X^�� 1! �O�#�\¢�YVWXrsYZUÕWgh[\�]�()Ò��vé�¿� 17 �zJ18 �z����T��¹DU��(C)(2)���µjÊÜ(2007� 5 )

11X^� �O�#� 1! gh�õn�Ò�ñ«W�úû+¬(2007� 3  13Á)

12XTUVW Âà ��UÂÃÄê(ë�3K�Y�³W�¥^��=�Õ¥ôXUý­®¥�믮3ÂÃ�3W��

ñ�PÇÄëKóô�°Ç=pæ=ëW���µô±»²¥��1��µñ� Wý3­=ëK3³�ó

'5�´ÅY�Ë�@É� DRÞ"Ojk�´Å=�W]���§ãê�º��A�_P��bcUÕ¥�V�Vµ¨3í÷

Kó�A��]ª¶��êÁfiÐ�´Å=ô�W­�·®í@�­í�3íw3¸�·¹�ç>��

/Ð(��ÃÄêç>]��DR����êJ�ðUº»�¼Òñ½kW=�¾�ó"O¿À�ÁÂ3

ÇÄ��ê�½ëïw�Ã�3�§¨"O3�j���­Ä¹�V�V�£UíW3³®3Wópe

�ÅÆíÇ����ñ§ãVWQÈ=ô��"O�ÄÅ=íû�����iÐ=·®U¤¥ËÉ�ë´

Å=�¥�\7;W�¡���ÔêyûÂÃ=ëWóý3ïìêM"O­ÄÊ�U��±{ñd}Uî

ÏWïÇ��TU����£�vôǾ�ñËÌÇÄÃûý3­�£UíW=�¾�ó�����

iÐ=���Ð(�·®í�ZÍ­Ç�3Wó���ñ¦ÄÃW3��ÞUôïï®ìÎbt���

UGÈñÏ�íÃô�­®[ÇÄÃWÕ�U³®3WóÐÃIñ�lÇÄô�å�­��ìíÃÇ��

±�{3ÇÄÂÃ�3Wý3Ê}UêÑ¥GÈñÏ�Î�Ò3ïÓÇ3Ã�Ô�­ Õì3íÃ�­

®[ÇÄÃWÕ�U³®3Wó]�4�Êh�}Ö�WÃê�×��ñ믮3ØÙÇÄÃïíw3¸�

���4�12ñÃûì[�ÇÄô�fÚUÛÜðí½ëñÇÄû3W��ñ�ÄW�êÑ¥�Ý=ë

íÃ�=êíÃï3Ã�¼Ò ñÃû ÕÄÃWó

Ĺ�ÆÇ gh�3õ�()Ò�vÕ�gh�"�Ø7X�<�véê�­®��/�ËÌ������D

R3í¥ÞW��=�Wó�K��0ê���ËÌ�ßàUáïâíÃ�£í£Z=�¥�Ë����

�êÐ�ÒÓßàUÙ:ÇÄÃWóý�ã��íW�êV�Ä�§¨"OUôjkÇK´Å=�¥�

Ĺf�§¨Þ"OñêÕL3VWj���Ò�3��;ñÕ¥�äåLÄ�ý3ì���ñ�ìU|

LÄÃëKÃ3#kÄÃWóý3ì�����ìíWpÆñLæÇ��/ÉÊ�DR��3íWý3ñ

��3ÇKÃó

Y2Z!"20!_

1X���`a 1!�NX�y��$3ÒÓU�VWÎ���ð�� �\U��<Uòû��àáêô�NX�Örý3ôÔ®3ÄÃW­�noij�çèUÕ÷Ä�NX

­ª��3ÄË�ÒÓñpéVW�=U��NXêy��$ñ��ÇK¹U��æ�íçè¹Aê

post translational modification!ñ2wWó»�W�NX��=îïë�Y"#ñìUÇÄ���æ�íçè¹Aê­îïë�Y��ÒÓ�K3k¸8qYÎ:ªÓíîUî�Õ�ííîñïVï3Ã

÷K��ñ`Ã���3���UÂÃÄ��ÇÄÃWó 2!�NX�á�òÎ�b�ð�Ð���"#Ø7X�< �NX�ÐÐ�$ [Y¢ñØW��Y!b�UòcVW��3ÇÄ�îï��×�W���8�Y�

­ó��3ÄÃWóË�F,3ÇÄ�F1��NX­�ÃÖÑïï÷Äb�íð�Ðñ��ÇÄËÌdU

ôõÇ�4�gh�ÒÓb�ñëKV�=�ý3ì���ñ©öÇÄô[Y¢ñØW��Y�ý3Ü®=

ÃWó �÷ 1!���U��ÇÄ�î�Õ�íøùÔú@=�NX�b�íð�ЭpVWï��WÃêð�Ðpñ¦ûUêî�Õ�UÇKìÕÃï�Ĺô�����NXýñ@ø3ÇÄ��ñ|LW¥1

=�Wó 3!Ðdü�\UV\3VΡ´\Éý Ðê��æ�í}�Ûþ£cUÕ÷Ä��æ�í\UV\ñ2eÇÄÃWó3ûUü�\UV\ê�

��~�U�°U��ÇÄÃWó ��îïë�YêÐd=ô÷3ô±�U]4VW��� SHD�²�NX=�gh}ü����ÒÓñ²ÇÄÃWógh}��3ûUt�ÑdU]4VWîïë�Y�ü���5'ñ�1VWý3UÕ

÷Ä�¿ÐiÐ3ÇÄ�VΡ´\Éý�Ø7X�<�véU¤¥Ë®=ÃWó 4!�NX3 "#Ñ�ÒmÊ�"#Ø7X�< êÐ�� 60�ñ�LW"#��=���æ�íÐy"#UË�`a��ñµ¶ÇÄÃWóNMR

3Ã�����UÕ÷Ä��NX±�� "#���að�a�Ví®¯�NX� "#Ñ�ÒmÊ­Z

Æ�3�f��ÄÅê�ìKUô"#�gh×ØWÙYZfý§Ð�DR3í¥ÞW�Ó­«��3Ä

ÃWó

2Xbc �³� ��� ���

�0�� ��Ö+ =EL�

Seiichi Era Tomoyoshi Terada Koichi Murayama

3X��Fd�ef Ü !"!

1! �0���Áf��I��O2I=,� CBTE©MCQUÕW��´Å��9:�"��;2006�. 2! �0�����éY�´X ��îïë�Y�´;\éW��!�ÁfV��ÙW�I=, V��ÙWÉW

é�YÎë¡´, 9:��\;2006��392J394� 3! $%����EL ��0���!�"1�#ÒÓ$@UÕW�% albumin���¾�$@—ßà&wì

3�'(�)*�4�+�� é� ,A�#3¢8W;Ù7ï � 9 ��9:�9:��H;2008 ��149J153.

4! �-./��E0é��EL �123#��E�4�g563��0���789:��#;i��UvwWü�\UV\�îïë�Yü���'ñP�3ÇKZÍ�)*�4�+�� é� ,A�#3¢8

W;Ù7ï � 9��9:�9:��H;2008��154J158. Ü S"! íÇ

©è !"!

1! <=t >, �0��, ¿�P�, =�Kv, M?@A, å8�7, 8f B��'ø3y"#C¿ÐDúµ excluded volume effect!Jy"#`�Ì» E!Áf��Fâ 2006�;68G�4J14�

2! <=t >, �0��, ¿�P�, =�Kv, M?@A, å8�7, 8f B��'ø3y"#C¿ÐDúµ excluded volume effect!Jy"#`�Ì» H!Áf��Fâ 2006�;68G�47J57�

3! �0���MN��UvwWü�I���Iîïë�Y�la F�—��îïë�YñJWKE�LÅ!��ØÂÃ3�/� 2007�;24G�139J143�

4! �0���ÐÞ� ��!ÖÑJy"#]4@=��!�ÁM�â� 2008�;28G�1J9� 5! �@N��, =EL¶, O���, Pª±<�EQ}��×ØWÙYZfvÕ�VWRWëVW´SÍY"

�fUÕWT«��U#�"VÂÃ�¢rW<í¡´Ùó�Y� 2008�;24G�1587J1595�� ©è S"! íÇ

Ï !"!

1! Ä*� ���0���WfXé�Y«Ã�ªoUvwWZ�[\#]¤�íî������ 2007 �;53G�40J41�

2! $%���)%^#��EL ��5_ `�aÏb6�cfvd��0���!�"1�#ÒÓ÷°UÕW�%îïë�Y����¾�$@3Ë�Òe�ã]�#;iì3ßà��&wì�'(�Á#Iâ�2008� 50G�513J520�

Ï S"!

1! Suda K, Kato J, Nozawa M, Komabayashi T, Imai H, Era S. ANP content in rat myocardium during and after swimming. Adv Exerc Sports Physiol. 2006;12:121-125.

2! Negawa T, Murayama K, Ozaki Y, Hayashi T, Era S. Near-infrared spectroscopy study of heat-induced gelation and hydration of bovine serum albumin in aqueous solution. ITE Lett Batt New Tech Med. 2006;7:42-48.

3! Murayama K, Tomida M, Ootake Y, Mizuno T, Ishimaru J. Principal discriminant variate analysis for diagnosis of temporomandibular joint disorders using capillary near-infrared spectroscopy of one drop of human temporomandibular joint synovial fluid. ITE Lett Batt New Tech Med. 2006;7:49-52.

4! Murayama K, Tomida M, Hayashi M, Kawakami Y. Abnormal crystal growth of rat teeth by excessive gamma knife irradiation of brain: microscope ATR/FT-IR spectroscopy study. ITE Lett Batt New Tech Med. 2006;7:84-86.

5! Tomida M, Hayashi M, Kawakami Y, Katayama Y, Kouyama N, Murayama K, Ando H, Asanuma N. The sensitivity of the rat sciatic nerve after gamma knife irradiation. ITE Lett Batt New Tech Med. 2006;7:87-91.

6! Terawaki H, Matsuyama Y, Era S, Matsuo N, Ikeda M, Ogura M, Yokoyama K, Yamamoto T, Hosoya T, Nakayama M. Elevated oxidative stress measured as albumin redox state in continuous ambulatory peritoneal dialysis patients correlates with small uraemic solutes. Nephrol Dial Transpl. 2007;22:968. IF 3.154

7! Terawaki H, Nakayama K, Matsuyama Y, Nakayama M, Sato T, Hosoya T, Era S, Ito S. Dialyzable uremic solutes contribute to enhanced oxidation of serum albumin in regular hemodialysis patients. Blood Purif. 2007;25:274-279. IF 1.493

8! Fukushima H, Miwa Y, Shiraki M, Gomi I, Toda K, Kuriyama S, Nakamura H, Wakahara T, Era S, Moriwaki H. Oral branched-chain amino acid supplementation improves the oxidized/reduced albumin ratio in patients with liver cirrhosis. Hepatol Res. 2007;37:765-770. IF 1.255

9! Terada T, Murayama K, Ra C. Structural study of mutated FcfRI g chain ITAM by circular dichroism spectroscopy. ITE Lett Batt New Tech Med. 2007;8:65-68.

10! Terada T, Murayama K, Ra C. Structural study of FcfRI g chain polymorphism by circular dichroism spectroscopy. ITE Lett Batt New Tech Med. 2007;8:84-87.

11! Bo Y, Murayama, K, Yan, H. Study of thermal dynamics of defatted bovine serum albumin in D2O solution by Fourier transform infrared spectra and evolving factor analysis. Appl Spectrosc. 2007; 61:921-927. IF 1.531

12! Matsushima S, Nishiofuku H, Iwata H, Era S, Inaba Y, Kinosada Y. Equivalent cross-relaxation rate imaging of axillary lymph nodes in breast cancer. J Magn Reson Imaging. 2008;27:1278-1283. IF 2.209

13! Era S, Matsuyama Y, Terada T, Minami T. Heterogeneity of the redox state of commercial human serum albumin products. FEBS J. 2008;275:209. IF 3.396

14! Iwai I, Ikuta K, Murayama K, Hirao T. Change in optical properties of stratum corneum induced by protein carbonylation in vitro. Int J Cosmet Sci. 2008;30:41-46.

4X��ghiOj 1Zklmno 1! ��ræ��!�"1, ��"z���0��;Ûþ�ãiÒ���¹���õöíîU�VW©ªð��;¿� 18�z;4,000^_

2! ��ræ��!�"1���"z���0��;Ûþh��T��¹��¹���õöíîU�VW©ª��;¿� 19�z;4,000^_

3! ��ræ����Ö+;"���h����T��¹Ç���(B)�yi! IgE2eÐ �j�ÒÓvw3�ZQïoT�vé;¿� 18J19�z;3,400^_(2,100�1,300^_)

4! ��ræ���0�����"z����� k�3�1ãl;"���h����T��¹DU��(C)(2)�MjmfUÕWÐËÌ�lZÆ�KL�"#×ØWÙYZ�ìp3§¨ÉÊ;¿�

19J20�z;3,570^_(2,470�1,100^_)

2Zpq�� íÇ

3Zr��� 1! �0���Z�[\#ñgUUn´ÇK.�}ü�mÊ�r1 ¥&bt!;¿� 18 �z;220 ^_�op[\Èq I!

2! �0���gUU@VWZ�[\#�}ü�úµ�ZÍ fbt!;¿� 18 �z;220 ^_�op[\Èq I!

5Xes�tuvwOj 1! �0���r�ks�?-Ov�ü�Iîïë�Y$@« pé!;¿� 18�z 2! �0���3�1ãl���� k������MR tNUÕWM�(aúµf3úµ'¨^ñuÊÇK�lb��·�ZÆf pé!;¿� 19�z

6Xx?@ 1Zxyz �0��� 1! Áf��IÂL2(�'4) 2! Áf�'��I�X(�'4) 3! Áf�'��IÂL2(�'4) 4! ÁfMjm��IrL2(�'4)

2Zx{| íÇ

3Z}~� íÇ

7Xx��$�����������%� �0��� 1! � 34¡ÁfMjm��I]I(2006� 9 �Âû¸, ��%¨ôÐËÌ��!ÖÑJy"#]4@=��!ý¨�)

2! � 51¡95�×ãõ�I©I(2008� 9 �úû�F^%¨ô"#Vvï=#kW����'� �"#���¦ïK�#k>�ý¨�)

8X}�>�p�Oj 1! �0���Ð�È��Y�ÙÍ<v\U8 Wòî³WÎ(¿� 20�z)

9X�x?@ íÇ

10X^�� íÇ

11X^� 1! �0���3�1ãl��� k��������­®���l� Gl�=¥wpØ�xy+¬(2007� 5  1Á)

12XTUVW Âà h��hÀ�UvwW��±{U'(VW3�Ä¡�±{U�ÇÄêz�{m­¦ì3WóÇïÇô'

5�´ÅYýU÷|ÇÄÃW}ÇÃ56��=�~�ð}�p¹��Þ�pé�F�Æ��ô`÷Äë

Äv¥�Ë3ì�Y=©ªVW3�Î�Î�ÂÃ=�¾�ïó '5�´ÅY�Ë�@É� ¿� 16 ��]�fJ���U��d�XiUÕ÷ÄÚ�"O���³�\U 1 ­ù2�3K�� 4

�­+bÇÄÃWó�������3X­ý3�=Ê�U£��3W'4��Ý2»�¤�ðí°í�

4��³ 1��� 1!êÚ�"O�Ĺ�pÆU]ëíëVW93íW=�¾�óË�búðí@É�ô}ÇÃ�=��d}=�j���3Ã�ïK¯=²ÒðU���ý3UÕ÷Ä�¥�÷ÄÃûÕ¥u

êíÃÕ�U³®3Wó Ĺ�ÆÇ �÷�´ÅêBUÚ�"O��"OUë÷KF�í56=êíÃóvS�ê�ê¥Jðp��§ã­

®PïÂ7Y¢ï«3í¾�­�Ë3ôb'=ëíÃ�=�3¸�Ĺ�ÆÇê'5Ê�U�V�V}

ÇÃô�3íW=�¾�ó �

Y3Z�0�&!_

1X���`a k��ð�f�ghÎ�ð�fvÕ�"#Î�ð�fñÊÃ��ñ`Ã�rs�����¥�a

��¥����Þ����'�véñkÇÄgUU²Êí+Kí�kñ�PÇ��ñ`÷ÄÃWó 1!NÀ��'UvwW$"#�\UV\�NX����vé Ð�\UV\ÉýUvÃÄ��ð��ñz�3#kì3ÄÃW\UV\�NXUó�Ç,�=ô"#

�­ 10-30kDa�$"#�$"#��ÒÓñvwÇÄÃWó\UV\�NX low-molecular-weight heat shock protein!�¢r�8W��=�HSP203 �B´8\é8Y­�d�ghd�óá�Y3ÇÄ�ÒÓÊ}U\UV\ÉýU.Ç�gh}U���3�t�ÒÓñ�(VWý3ñpØÇ�Ë�`�CñØ

ÆÇKóKE�HSP27�8Yü���zvÕ� HSP20�©p'�­gU�gh~UvwW TNM\íWÙ3���VWý3ñØÆÇ��~��'UvÃÄ$"#� HSP­~gh�[\()Ò�U�´ÇÄÃWý3ñÏÇKó�K,�t�ïì��U"qñ HSP27�8Yü�­()ÇÄÃWý3ñéìï3ÇÄÃWó'4�$"#�\UV\�NX HSP27�HSP20��B´8\é8Y!�ghd þ�gh�*+gh��t���~gh��~gh!�gh}=�ÒÓ����ZÍñ`÷ÄÃWó 2!þ�gh�*+gh��gh��gh�ghdijoTÒ��vé ºr�ØghvÕ��Éï´�WY�ghñÊÃÄ�gh[\c#� ×U7×Y�àï�Y�NÀ�

�`ÎX�ghdijoTÒ�UÂÃÄZÍñ`÷ÄÃWógh�[\�"��õ�Ø7X�<�Ë

�()vwW��ñvwÇ�þ��¥���¥�a��¥�®�¥����~��~�]�~��'

�véñs¦ÄÃWó�ìU�ý3ì��U�Ê�3ÄÃWNÀ�kÎ�+KímÊ�vwvÕ�mÊÒ

��ZÍñ`÷ÄÃWó 3!rs�� ����þ��¥�!vÕ�a��¥UvwW�t�ÒÓ�l�3üp�3WNÀ��'��vé ���íî�rs��ê���¥ ����!�*+���÷°íî� 2�ð���üp¾­yû��

t�ÒÓ�l�3��¥�M��÷°3��Ìñ��ÇÄÃWóKE�þ��¥��/k3ÇÄ�Ê�3

ÄÃW SERM ��Â=�W;�9�¢ÓY­Ë�!mÊ3ÇÄ�t�ð�Óñ�|�âWý3ñéìï3ÇÄÃWó'4�rs�� ����þ��¥�!vÕ�a��¥UvwW�t��ÒÓvÕ��t

�ghdijoTÒ��vwñ`÷ÄÃWó 4!î�UW�\p'Òe�vé3Ë�¥¦f�§Ð NÀ���U�î�UW�\UvwWghõ­åû�´ÇÄÃWý3­éìï3í÷ÄëÄÃWó\Q

²����Í\UvwW����� 0U3ôí�5¡*+ghõ�Éï�¢£*+ghõ�Éï��W

Ãê¤�¥ghõ�Éï�ñP�U�Ë�p'Ò��véíì�U¥¦f�«�ñ`÷ÄÃWó

2Xbc �³� �³(u�)� ���

t2� A ¦§s/ çÐK�

Osamu Kozawa Masayuki Niwa Seiji Adachi

3X��Fd�ef Ü !"! íÇ

Ü S"! íÇ

©è !"!

1! y*� ¨�,� Q�� ©,� È�� ªo,� t2� A.� $"#�\UV\éY�´X3ñ«�V�Y�HSP273�0¿¬­,� Áfk��Fâ� 2006�;128G�141�145.

2! t2� A.� ��0maÎX3ÇÄ�ñ«�V�Y�Ë�mÊÒe,� ��� 2008�;57G�S77�S85. ©è S"! íÇ

Ï S"!

1! Hanai Y, Tokuda H, Takai S, Harada A, Ohta T, Kozawa O. Minodronate suppresses prostaglandin F2�-induced vascular endothelial growth factor synthesis in osteoblasts. Horm Metab Res.

2006;38:152-158. IF 2.254 2! Hanai Y, Tokuda H, Ishisaki A, Matsushima-Nishiwaki R, Nakamura N, Yoshida M, Takai S, Ohta T,

Kozawa O. Involvement of p44/p42 MAP kinase in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblast-like MC3T3-E1 cells. Mol Cell Endocrinol. 2006;251:42-48. IF 2.971

3! Takai S, Tokuda H, Matsushima-Nishiwaki R, Hanai Y, Kato K, Kozawa O. Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. J Cell Biochem. 2006;98:1249-1256. IF 3.381

4! Takai S, Tokuda H, Yoshida M, Yasuda E, Matsushima-Nishiwaki R, Harada A, Kato K, Kozawa O. Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily. Prostaglandins Leukot Essent Fatty Acids. 2006;75:61-67. IF 2.000

5! Nakajima K, Suga H, Matsuno H, Ishisaki A, Hirade K, Kozawa O. Differential roles of MAP kinases in atorvastatin-induced VEGF release in cardiac myocytes. Life Sci. 2006;79:1214-1220. IF 2.257

6! Hara A, Niwa M, Kumada M, Aoki H, Kunisada T, Oyama T, Yamamoto T, Kozawa O, Mori H. Intraocular injection of folate antagonist, methotrexate induces neuronal differentiation of embryonic stem cells transplanted in the adult mouse retina. Brain Res. 2006;1058:33-42. IF 2.218

7! Takai S, Tokuda H, Hanai Y, Kozawa O. Phosphatidylinositol 3-kinase/Akt plays a part in tumor-necrosis factor-�-induced interleukin-6 synthesis in osteoblasts. Horm Metab Res. 2006;38;563-569. IF 2.254

8! Tanabe K, Tokuda H, Takai S, Matsushima-Nishiwaki R, Hanai Y, Hirade K, Katagiri Y, Dohi S, Kozawa O. Modulation by the steroid/thyroid hormone superfamily of TGF-�-stimulated VEGF release from vascular smooth muscle cells. J Cell Biochem. 2006;99:187-195. IF 3.381

9! Hara A, Niwa M, Aoki H, Kumada M, Kunisada T, Oyama T, Yamamoto T, Kozawa O, Mori H. A new model of retinal photoreceptor cell degeneration by a chemical hypoxia-mimicking agent, cobalt chloride. Brain Res. 2006;1109:192-200. IF 2.218

10! Hanai Y, Tokuda H, Ohta T, Matsushima-Nishiwaki R, Takai S, Kozawa O. Phosphatidylinositol 3-kinase/Akt auto-regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts. J Cell Biochem. 2006;99:1564-1571. IF 3.381

11! Niwa M, Hotta K, Hara A, Hirade K, Ito H, Kato K, Kozawa O. TNF-� decreases HSP 27 in human blood mononuclear cells: involvement of protein kinase C. Life Sci. 2006;80:181-186. IF 2.257

12! Hanai Y, Tokuda H, Yasuda E, Noda T, Ohta T, Takai S, Kozawa O. Up-regulation by zinc of FGF-2-induced VEGF release through enhancing p44/p42 MAP kinase activation in osteoblasts. Life Sci. 2006;80:230-234. IF 2.257

13! Tokuda H, Takai S, Matsushima-Nishiwaki R,Akamatsu S, Hanai Y, Hosoi T, Harada A, Ohta T, Kozawa O. (-)-Epigallocatechin gallate enhances prostaglandin F2�-induced VEGF synthesis via up-regulating SAPK/JNK activation in osteoblasts. J Cell Biochem. 2007;100:1146-1153. IF 3.381

14! Takai S, Tokuda H, Hanai Y, Kozawa O. Limitation by p70 S6 Kinase of PDGF-BB-induced IL-6 synthesis in osteoblast-like MC3T3-E1 cells. Metabolism. 2007;56:476-483. IF 2.647

15! Takai S, Tokuda H, Hanai Y, Kozawa O. Activation of phosphatidylinositol 3-kinase/Akt limitsFGF-2-induced VEGF release in osteoblasts. Mol Cell Endocrinol. 2007;267:46-54. IF 2.971

16! Takai S, Tokuda H, Hanai Y, Harada A, Yasuda E, Matsushima-Nishiwaki R, Kato H, Ogura S, Ohta T, Kozawa O. Negative regulation by p70 S6 kinase of FGF-2-stimulated VEGF release through stress-activated/c-JunN-terminal kinase in osteoblasts. J Bone Miner Res. 2007;22:337-346. IF 6.004

17! Takai S, Nagaki M, Imao M, Kimura K, Kozawa O, Moriwaki H. Intrinsic resistance to TNF-�-induced hepatocyte apoptosis in ICR mice correlates with expression of a short form of c-FLIP. Lab Invest. 2007;87:572-581. IF 4.479

18! Noda T, Kumada T, Takai S, Matsushima-Nishiwaki R, Yoshimi N, Yasuda E, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A, Kozawa O. Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma. Oncol Rep. 2007;17:1309-1314. IF 1.597

19! Tokuda H, Takai S, Hanai Y, Matsushima-Nishiwaki R, Hosoi T, Harada A, Ohta T, Kozawa O. (-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation. FEBS Lett. 2007;581:1311-1316. IF 3.263

20! Ochiai S, Sekiguchi S, Hayashi A, Shimadzu M, Ishiko H, Matsushima-Nishiwaki R, Kozawa O, Yasuda M, Duguchi T. Decreased affinity of mosaic-structure recombinant penicillin-bindingprotein 2 for oral cephalosporins in Neisseria gonorrhoeae. J Antimicrob. 2007;60:54-60. IF 4.038

21! Takai S, Matsushima-Nishiwaki R, Tokuda H, Yasuda E, Toyoda H, Kaneoka Y, Yamaguchi A, Kumada T, Kozawa O. Protein kinase C ® regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma. Life Sci. 2007;81:585-591. IF 2.257

22! Tokuda H, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Doi T, Harada A, Takai S, Kozawa O. Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts. Biochem Biophys Res Commun. 2007;362:799-804. IF 2.749

23! Yamauchi J, Takai S, Matsushima-Nishiwaki R, Hanai Y, Doi T, Kato H, Ogura S, Kato K, Tokuda H, Kozawa O. (-)-Epigallocatechin gallate inhibits prostaglandin D2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts. Prostaglandins Leukot Essent Fatty

Acids. 2007;77:173-179. IF 2.000 24! Tokuda H, Takai S, Hanai Y, Harada A, Matsushima-Nishiwaki R, Akamatsu S, Ohta T, and Kozawa O.

Platelet-derived growth factor-BB amplifies PGF2�-induced VEGF synthesis in osteoblasts: function of phosphatidylinositol 3-kinase. Prostaglandins Leukot Essent Fatty Acids. 2007;77:187-193. IF 2.000

25! Tokuda H, Takai S, Hanai Y, Harada A, Matsushima-Nishiwaki R, Kato H, Ogura S, Kozawa O. Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts. J Bone Miner Metab. 2008;26:335-341. IF 1.425

26! Tokuda H, Takai S, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Harada A, Hosoi T, Ohta T, Kozawa O. (-)-Epigallocatechin gallate inhibits basic fibroblast growth factor-induced interleukin-6 synthesis in osteoblasts. Horm Metab Res. 2008;40:674-678. IF 2.254

27! Takai S, Hanai Y, Matushima-Nishiwaki R, Minamitani C, Otsuka T, Tokuda H, Kozawa O. p70 S6 kinase negatively regulates FGF-2-stimulated IL-6 synthesis in osteoblasts: function at a point downstream from protein kinase C. J Endocrinol. 2008;197:131-137. IF 2.636

28! Hayashi K, Takai S, Matsushima-Nishiwaki R, Hanai Y, Kato K, Tokuda H, Kozawa O. (-)-Epigallocatechin gallate reduces transforming growth factor �-stimulated HSP27 induction through the suppression of stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts. Life Sci. 2008;82:1012-1017. IF 2.257

29! Tanabe K, Takai S, Matsushima-Nishiwaki R, Kato K, Dohi S, Kozawa O. �2 Adrenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells. J Neurochem. 2008;106:519-528. IF 4.451

30! Kato H, Takai S, Matushima-Nishiwaki R, Adachi S, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Doi T, Ogura S, Kozawa O. HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion. Arch Biochem Biophys. 2008;475:80-86. IF 2.578

31! Matsushima-Nishiwaki R, Takai S, Adachi S, Minamitani C, Yasuda E, Noda T, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A, Kumada T, Kozawa O. Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular-signal-regulated kinase. J Biol Chem. 2008;283:18852-18860. IF 5.581

32! Minamitani C, Otsuka T, Takai S, Matsushima-Nishiwaki R, Adachi S, Hanai Y, Mizutani J, Tokuda H, Kozawa O. Involvement of Rho-kinase in prostaglandin F2�-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. Mol Cell Endocrinol. 2008;291:27-32. IF 2.971

33! Adachi S, Nagao T, To S, Joe AK, Shimizu M, Matsushima-Nishiwaki R, Kozawa O, Moriwaki H, Maxfield FR, Weinstein IB. (-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells. Carcinogenesis. 2008;29:1986-1993. IF 5.406

34! Minamitani C, Takai S, Matsushima-Nishiwaki R, Hanai Y, Otsuka T, Kozawa O, Tokuda H. A case of raloxifene-induced acceleration of platelet aggregation. Internal Med. 2008;47;1523-1528.

35! Takai S, Matsushima-Nishiwaki R, Adachi S, Natsume H, Minamitani C, Mizutani J, Otsuka T, Tokuda H, Kozawa O. (-)-Epigallocatechin gallate reduces platelet-derived growth factor-BB-stimulated interleukin-6 synthesis in osteoblasts: suppression of SAPK/JNK. Mediators Inflamm. 2008;2008:291808. IF 1.162

36! Tokuda H, Takai S, Matsushima-Nishiwaki R, Hanai Y, Adachi S, Minamitani C, Mizutani J, Otsuka T, Kozawa O. Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts. Prostaglandins Leukot Essent Fatty Acids. 2008;79:41-46. IF 2.000

4X��ghiOj 1Zklmno 1! ��ræ��Q�� ©, ��"z��t2� A, ¯°A±;������¹DU��(C)(2)�±T��­��¹���8�É8YZUvwW¤øÞc#���3§¨ðQ_;¿� 17J18 �z;3,800^_(2,700�1,100^_)

2! ��ræ��t2� A, ��"z��y*¨�, ²��6;úû]�`�+T(��)������UvwWt�����|Òe�vé3�/ê�ÉÊ;¿� 18�z;1,200^_

3! ��ræ��²��6, ��"z��t2� A;³Ö#�J���������#¥�|ÆU@VW�t�ÒÓ()�íîU�VW��;¿� 18�z;100^_

4! ��ræ��y*¨�, ��"z��t2� A;J�fJ����8I��¹�þ���UvwW7í9Y���U�VW��;¿� 18�z;500^_

5! ��ræ��t2� A, ��"z��y*¨�, ²��6;"���h������¹DU��(C)(2)�þrsUvwWЦ)Ò��"#DU�vw�\UV\�NX�ÒÓvw;¿� 19 �J20�z;3,500^_(2,200�1,300^_)

6! ��ræ��y*¨�;"���h������¹Ç���(B)�$"#�\UV\�NXñ�ð3ÇK+Kí~�/f���;¿� 19J20�z;3,300^_(2,000�1,300^_)

7! ��ræ��²��6, ��"z��´*µ¶;J�fJ����8I��¹�þ��UvwWWnt/g-catenin�ZQïoT+·���U�VW��;¿� 19�;��T 500^_

8! ��ræ��y*¨�;� 25¡����5}1���¹�gh÷° Tgh�ÒÓAêUÕW+Kí~��/f�ìp;¿� 19�z;2,000^_

9!��ræ��t2� A, ��"z��y*¨�, ²��6;úû]�`�+T(��)������UvwWt�����|Òe�vé3�/ê�ÉÊ;¿� 18�z;120^_

10! ��ræ��²��6, ��"z��t2� A;³Ö#�J���������#¥�|ÆU@VW�t�ÒÓ()�íîU�VW��;¿� 18�z;10^_

11! ��ræ��y*¨�, ��"z��t2� A;J�fJ����8I��¹�þ���UvwW7í9Y���U�VW��;¿� 18�z;50^_

12! ��ræ��²��6, ��"z��t2� A;"���h������¹DU��(C)(2)������UvwW�����|Òe�vé3¸¹í�t�ð�Ó�Z�f�§Ð;¿� 20J22 �z;3,700^_(1,500�1,100�1,100^_)

13! ��ræ��Q�� ©, ��"z��t2� A;"���h������¹DU��(C)(2)���0ÞUvwWb]º»U@VW\UV\Éý�"#DU�vw;¿� 20J22�z;3,500^_(1,500�1,000�1,000^_)

14! ��ræ����Ot#, ��"z��t2� A;"���h������¹DU��(C)(2)��¼*+ÞUvwW*+ã�mÊ�"#DU�vw;¿� 20J22 �z;3,600 ^_(1,900�1,000�70^_)

15! ��ræ�� 5� ½, ��"z��t2� A, ¾5^¿, D�À3;wxy¶Ð]�F^��¸ÁT�ÂÃ�ö�" 7í9Y!�þ��¥¦úµU�VW��;¿� 20�z;70^_

16! ��ræ��t2� A, ��"z��çÐK�;J�fJ����8I��¹�þ���UvwWЦ)Ò����U�VW��;¿� 20�z;50^_

17! ��ræ��çÐK�;"���h������¹Ç���(B)�WX;¢Uñ�ð3ÇK EGCGUÕW]�~¥¦���;¿� 20J21�z;3,100^_(1,600�1,500^_)

2Zpq�� 1! t2� A, tÄ����t�UvwWîYòU�Y�YÅ�}��mÊ�"#Òe�vw;¿� 18J19�z;1,000^_�ZLBvW8YZ(I)

3Zr��� íÇ

5Xes�tuvwOj íÇ

6Xx?@ 1Zxyz t2� A� 1! Áfd"q�IrL2(�'4) 2! Áfk��IÂL2(�'4)

¦§s/� 1! Áfk��IÂL2(�'4) 2! ÁfÆ¥���IÂL2(�'4) 3! Áf§¨k��IÂL2(�'4)

2Zx{| íÇ

3Z}~� íÇ

7Xx��$�����������%� t2� A� 1! � 55¡Áf����I(¿� 20� 6 , ÇÈ, ��%¨ô��0mÊÎX3ÇÄ�ñ«�V�Y�Ë�mÊÒeý¨�)

8X}�>�p�Oj íÇ

9X�x?@ íÇ

10X^�� 1! t2� A, ,É� é�no#�¡´îÍU�Í\ñÊÃKþrsUvwW¤øÞc#�"#DU�vw�¿� 16�zJ17�z����T��¹DU��(C)(2)���µjÊÜ(2006� 3 )

2! Q�� ©, t2� A, ¯°A±�±T��­��¹���8�É8YZUvwW¤øÞ�Ê���3§¨ðQ_�¿� 17�zJ18�z����T��¹DU��(C)(2)���µjÊÜ(2007� 3 )

11X^� íÇ

12XTUVW Âà ý���Ñ�S"Ï Ë"3ÇÄ�îÍU�¡Uê 36 j=�÷KóË"�X3ÇÄ��Â�P�=

�W×Y�´U¢r´éW�¿ÀÌê 2.807 =�Wóý�ÍYïì�­�­îÍU�¡U�ÎXÏñ� Wý3­Ð£3³®3Wó�>, ÑUôpublish or perishý3î3WÕ�UÃïíW dataôKÒðU9òY3ÇKÏ Ë"3ÇÄÆVý3ê��U]�íý3=�Wý3êÃ��=ôíÃóý�Dfð

ÓÔ=�WîÍU�¡U�“�”�ÍYïìôî¡��âÄÃëKÃó

'5�´ÅY�Ë�@É� h¡�� 6 �UôÜÃKÕ�U, Kô�£íYê, ÁÀ���ñ�ÕU|LÄû3W^kíJ���

Þ=�Wó�ê¥, ��ñÖ`ÇÄÃû�=, ý��YU×ï÷ÄÃW3Ã÷ÄôbÔ=êíÃóý�JK¯��ïì, cd�z������­�J=ô��=ëWÕ�ÁÂÇÄÃëKÃó

Ĺ�ÆÇ '4�Ç|LÄÃW���µïì, cd²ú=Èiík«ñìpVWý3 �k!ñ�PÇ�ÃÂ�

Áï���®U��ÇKÃ3#kÄÃWó

Y4Z�2�!_

1X���`a oö�lm�ÒmÊU�VW�� ��ÒI­�W3lmêoöUíîñïÇ, oöêlmUíîñïVó¹�ê, �­�ÐVWïØï�S1£c3íWóh�ê, ���UÙ:VWóÚ�Ý=ê, ­Ùl�¤m=�WÚÛmñÊÃÄlm­oöUïVíîñ, "#Î�ð, ghÎ�ðUvwÇÄÃWó�K, ÚÛm­"qÇ, oöêíîñ´kW�`ÎX�no#È�ðíª�ñ`÷ÄÃWó Ê@, ���µñÜÐðU÷|VWó ÚÛm�+Ýmê, ­ÙghdUº4Ç, ­Ùghñlb�âWó­Ùghê, lbñº4¿GUëÞ�âWKLUghX�ß ñ`�­, ÚÛm��=ô T.pseudospiralis3ܸ3WN� �=ê, ý�ß ­výìÎ, º4�3K­ÙghiЭlbVWó­Ùgh�lbUàÃ, í;×Ugh­"á[\Ç, ­ÙghU"�ÇÕ�3VW­, ÚÛmê­Ùg�ê�"�ñ��Î, ÚÛm��Ø�3CâÎ�ãLñVWghUlb�âWóý3­, x1ðUäå��3ÇÄÖì3ÄÃK'ø=�W­, Ë��gí��ñf��Ý­éìïUÇKó �ìU, ý�­Ùgh�lbUà�p'no#UÂÃÄó�Ç, ­ÙpU�´VWc# MyoD,

myogenin, MRF4��añéìïUÇKó�K, å#��Uà�­Ùgh�î�UW�\U�´VWc#��1ñ`÷KóÚÛm� cDNA;×ë;8Wñm�Ç, ²Êíá�é×Î�no#ñ�ÀU´�WXYZ=ëKóË��Uê, +ÇÃé×����íîW|�°«���íîW|, �´�¢rWÙ�æ�çc#ô�¥, '4, ���F�¤Þ, �KêF�Æ��=�Wó

2Xbc �³� ��³� ���

yc^� �Oè éR0

Yuzo Takahashi Isao Nagano ZhiLiang Wu

3X��Fd�ef Ü !"!

1! yc^�= �ÀÁ3Nêã]�KL�ë˦�wxy���H;2006�� 2! yc^�, �*u"=�ræ�Z�Ì�¦ïKJì� �X¡´Ì�íîÌJ[ï 38�9:��}��H;

2006�788J789� 3! �O� è, yc^�, ?�Ë/, �� 0ð�gU­ëñWKL�Ð�Çû¦, wxy���H�29J47, 67

J86, 2007�� 4! �O� è, yc^�, ?�Ë/, �� 0ð�gU­ëñWKL�Ð�Çû¦�2 8, wxy���H�2008

�� Ü S"!

1! Suzuki Y, Niwa M, Shibata T, Takahashi Y, Chirasak K, Ariyawardana A, Ramesh JC, Evans P. Tan O-S, Problem-based Learning in eLearning Breakthroughs. Singapore: Thomson; 2006:131-146.

2! Nagano I, Takahashi Y. Parasitic Zoonoses in Asian-Pacific Regions 2006. Nagoya: Sankeisha; 2006.

©è !"! 1! ò�!d, ,�T7.� ���, d"q��UÕWóôõ,� f��� 2006�;12G�17J21� 2! yc^�, �õ<ã���:VW��YñÊÃK�����b.�+ÇÃ�����03W, � 23 ¡��

��è�QW3³W´��¡��÷£, 2007�51J63�

©è S"! 1! Wu Z, Sofronic-Milosavljevic L, Nagano I, Takahashi Y. Trichinella spiralis: Nurse cell formation

with emphasis on analogy to muscle cell repair. Parasite and Vectors. 2008;27:1-8. 2! Takahashi Y. Problem-Based Learning and Task-based Learning: A practical Synthesis. Kaoshiung

Medical Journal. 2008;24:S31-S34. 3! Nagano I, Wu Z, Takahashi Y. Functional genes and proteins of Trichinella spp. Parasitol Res.

2008;104:197-207.

Ï !"! 1! yc^��¸h�����+ÇÃam¦J´ÅÐöIí:UW8îïJ, ����^÷� ����NÜ

2006�8� 2006�;56J59. 2! yc^����Ò�d���ìpËÌ, ����^÷� ����NÜ 2006�8� 2006�; 110J113�

3! yc^����:VW��Y����UQ4VWUÚK÷Ä, �Éïø��:VW��Y������Ij� 2007�;1G�47J60�

4! yc^�ì�����/ijñ��UuÊVWUÚK÷Ä�q×Î;×YO2Iù, ����Fâ 2007�;38G�173J177�

5! AL#,� yc^�. ��:VW��Yñ�/ÀILUuÊVWKL����m�, �Éïø��:VW��Y� ������Ij� 2008�;2G�37J40.

6! AL#,� yc^�.� ��:VW��Yñ�/�����m¥UÂÃÄ, �Éïø��:VW��Y������Ij� 2008�;2G�41J43.

7! AL#, yc^�.� ��:VW��Y=\í¡�î¡�ÇÂÂ���/ÀIL���m�, �Éïø��:VW��Y������Ij 2008�;2G�44J50.

8! $%ö/, ¦§s/, yc^�.� í:U8îï3��:VW��Y��ñE-learning=`��\í<���UÂÃÄ, �Éïø��:VW��Y������Ij 2008�;2G�51J56.

Ï S"!

1! Wu Z, Nagano I, Boonmars T & Takahashi Y. Involvement of the c-Ski oncoprotein in cell cycle arrest and transformation during nurse cell formation after Trichinella spiralis infection. Int J Parasitol. 2006;36:1159-1166. IF 3.392

2! Nagano I, Wu Z, Boonmars T. & Takahashi Y. Molecular cloning and characterization of an Rcd1-like protein in excretory-secretory products of Trichinella pseudospiralis. Parasitology. 2006;133:785-792. IF 2.081

3! Pei F, Nagano I, Wu Z, Takahashi Y. Preparation of a recombinant cysteine proteinase of Clonorchis sinensis and its applied study for immunodiagnosis of Clonorchiasis. Parsitic Zoonoses in Asian-Pacific Regions. 2006;9:40-53.

4! Wu Z, Nagano I, Boonmars T, Takahashi Y. Thermally induced and developmentally regulated expression of a small heat shock protein in Trichinella spiralis. Parasitol Res. 2007;101:201-212. IF 1.512

5! Wu Z, Snabel V, Pozio E, Hurnikova Z, Nareaho A, Nagano I, Takahashi Y. Genetic relationships among Trichinella pseudospiralis isolates from Australian, Nearctic, and Palearctic regions. Parasitol Res. 2007;101:1567-1573. IF 1.512

6! Yoshikawa H, Wu Z, Howe J, Hashimoto T, Geok-Choo N, Tan KSW. Ultrastructural and Phylogenetic Studies on Blastocystis Isolates from Cockroaches. J Eukaryot Microbiol. 2007;54:33-37. IF 2.288

7! Li LH, Zhou XN, Du ZW, Wang XZ, Wang LB, Jiang JY, Yoshikawa H, Steinmann P, Utzinger J, Wu Z, Chen JX, Chen SH, Zhang L. Molecular epidemiology of human Blastocystis in a village in Yunnan province, China. Parasitol Int. 2007;56:281-286. IF 1.776

8! Li LH, Zhang XP, Lu S, Zhang L, Yoshikawa H, Wu Z, Steinmann P, Utzinger J, Tong XM, Chen SH, Zhou XN. Cross-sectional surveys and subtype classification of human Blastocystis isolates from four epidemiological settings in China. Parasitol Res. 2007;102:83-90. IF 1.512

9! Nagano, I, Wu, Z, Takahashi, Y.: Species-specific antibody responses to the recombinant 53-kilodalton excretory and secretory proteins in mice infected with Trichinella spp. Clin Vaccine Immunol. 2008;15:468-473.

10! Wu Z, Nagano I, Takahashi Y. Candidate genes responsible for common and different pathologies of infected muscle tissues between Trichinella spiralis and T. pseudospiralis infection. Parasitol Int. 2008;57:368-378. IF 1.776

4X��ghiOj 1Zklmno 1! ��ræ���O� è, ��"z��é� R0, ú� 3û, ü� ri, í Q� �WY, òS;�ëWY�W\�¿!��J�� îÙîçá�Y�T������Ým é×�Ým!Ëýk�N}

ÏñÊÃK�-vÕ�é×-dUvwW��F f�§Ð;2006�z;1988^_ 2! ��ræ��é� R0, ��"z���O� è;"���h������¹DU��(C)(2)�ÚÛm �UÕWoö­Ùghlb�no#p'a'�vw3Ë�"#Ò��vé;¿� 17J18 �z;3500^_ 2,100�1,400^_!

3! ��ræ���Oè, úû]�`���T(��);ÚÛm+d)þ��c# Rcd1­­Ùgh"�üQUïVíî�"#Î�ðvw;¿� 19�z;1,130^_

4! ��ræ���Oè, ��"z���ç3±, xE�#, éR0;úû]�]����Þ���, ±"Oj���;�k;×ë;8W3ÇÄ�l¤mñÊÃK+��`ÎX�«�;¿� 19 �z;800^_

5! ��ræ���Oè, ��"z��éR0;������¹DU��(C)(2)�ÚÛm+d)þ��c# Rcd1 ­­Ùgh"�üQUïVíî�"#Î�ðvw;¿� 20J22 �z;3,960 ^_(1,560�1, 500�900^_)

6! ��ræ��é� R0;¿!��J�}-J67���é×�Ým �UÕW�0~p�"#Ò

�;¿� 20�;2000^_

2Zpq�� 1! yc^��$º»g�T¶·������\í<�ìp� �/�����Ù¡U;¿� 18�z;

36, 943^_�J�fJúûü��ìpJ� 2! �Oè�úû]�����UvwW{��/STijU�VW×Y¢ñW<Î[YèYUÊÉÙéï[YíY��ìp;¿� 17J18�z;3,000^_(1,500�1,500^_)�²ëIHØÉ�7ï³

3! yc^��$º»g�T¶·������\í<�ìp;¿� 19 �z;25,520 ^_�çá��ST¨�X±T��¹�Öð´;\éW��X±�úûü��ìpJ�

4! yc^��$º»g�T¶·������\í<�ìp� �/�����Ù¡U;¿� 20�z;25,555^_�J�fJúûü��ìpJ�

3Zr��� íÇ

5Xes�tuvwOj 1! �O� è, yc^�, é� R0�ÚÛm�NFbð}Ï;vÕ��}ÏñuÊÇKÚÛm ��Z�f(F�);¿� 20�z�òÆ��

2! yc^�������$Ð;¿� 20�z(F�Æ��) 3! yc^��Ða�'tN;¿� 20�z(F�Æ��) 4! yc^��¡�|��\í<;¿� 20�z(F�Æ��) 5! yc^��F����Xé8YZtN;¿� 20�z(F�Æ��) 6! yc^���/Ê çèæÏ�\í<;¿� 20�z(F�Æ��)

6Xx?@ 1Zxyz yc^�� 1! Áf�����IÂL2(�'4) 2! Áflm�IÂL2(�'4) 3! Áf§¨lm�IÂL2(�'4) 4! Áf²aÎ�InX(�'4) 5! International Commission on Trichinellosis: active member(�'4) 6! �Éïø��:VW��Y�����II�(¿� 18�z�'4) 7! §¨[WòYZ��I!I�(¿� 18�z�'4) 8! Áf�/�³�\í<�I�X(¿� 20�z�'4) �Oè� 1! Áflm�IÂL2(�'4) 2! Áf �¥�IÂL2(�'4)

2Zx{| yc^�� 1! The Ninth Asian-Pacific Congress for Parasitic Zoonoses(¿� 18� 8 , úû)

3Z}~� yc^�� 1! Parasitology : Editorial Board(2007��'4) 2! Parasites & Vectors BioMed Central, Editatorial Board(�'4)

7Xx��$�, ��������, %� yc^�� 1! 6th Asia-Pacific Conference on Problem-Based Learning(¿� 18� 5 , 9:, ôNeeds of a set of

guiding questions to facilitate student’s scientific mindý¨�)

2! � 38¡Áf�����I(¿� 18� 7 , �0, ôÕ¥0Ã����UmwÄ�+Kí�Y�reflection�CNFwý&�)

3! �Éïø��:VW��Y������I(¿� 18� 8 , ô�Éïø��:VW��Y������I��Æý¨�)

4! � 8 ¡Áf ��/�I�T�I(¿� 18 � 10  , úû, ô�/�X��Z���Uê�­Ð£ï�ý¨�)

5! ��:VW��Y���b.�iJð�/ñbâ=ëW�/J���ñ�PÇÄJ� ¿� 18�z"���h�/J GP �Y�ÙÍ<(¿� 18 � 11  , 9:, ô��:VW��Yñ����U�ÐÂ�UVWKL�È7ý¨�)

6! KMU International conference and workshop on PBL 2008.(¿� 20 �, 6Ý%¨, Attractive scenario writing for PBL¨�)

7! � 28¡Áf�/ij��ª]I(6Ý%¨ ��:VW��Yñ����UQ4 ¨�)

8X}�>�p�Oj íÇ

9X�x?@ íÇ

10X^�� 1! yc^��[î�789:;<@ÉI���b?���ìp3��¿� 17�z����T��¹b{jÊÜ� DU��(B)(2006�)

2! �O� è��Ým é×�Ým!Ëýk�N}ÏñÊÃK�-vÕ�é×-dUvwW��F f�§Ð�¿� 18�z¿!��J�îÙîçá�Y�T����jÊÜ(2007� 5 )

3! é� R0, �O� è�ÚÛm �UÕWoö­Ùghlb�no#p'a'�vw3Ë�"#Ò��vé�¿� 17�zJ18�z"���h������¹jÊÜ(2007� 5 )

11X^� 1! yc^�����Ù¡U� �3ºL�®���+¬+¬(2006� 1  1Á) 2! yc^�����Ù¡U� �3ºL�®�xy+¬(2006� 5  2Á) 3! yc^�����Ù¡U� �3ºL�®�wxyíV�\W�WX:W\(2006� 5 ) 4! yc^�����Ù¡U� �3ºL�®��Á¢� NEWS(2006� 5 ) 5! yc^�����Ù¡U� �3ºL�®��Á¢�(2006� 5 ) 6! yc^�����Ù¡U� �3ºL�®��:íV��;\³Y(2006� 5 ) 7! yc^��èï¢ �WU�[WòYZ�×Yé�:W� � 2 ¡�JAMIC JOURNAL vol.26

No.6(2006� 6 ) 8! yc^���3ºL�®�úû¢�X:W\(2006� 6 ) 9! yc^��i-ñ×�´;\éW«��úû�]��Ùí�¡´{��/´;\éW�Bionics(2006� 7 )

10! yc^�����Ù¡U� �3ºL�®�95íV�\W�WX:W\(2006� 7 ) 11! yc^�����Ù¡U� �3ºL�®�¢ÙíV�\W�WX:W\(2006� 8  1Á) 12! �Oè, yc^��7WÙY�×´�[×ï�å� ����×Î�(� úû]­pØ�Áåȱ+¬

(2006� 11  11Á) 13! yc^����:VW��Y��ê, 'r����UpØ�3K+]�=�Wó�JMA�²ÙØYU

V�:Wvol.12 No.11(2006� 11 ) 14! yc^��l�� ������´ÅvSU��:VW��Y�`Êñô�Éïø��:VW��Y

������IýpçU.ÇÄ� å��!+¬(2006� 12  4Á) 15! �Oè, yc^��CMC=­®[\�(�Áåȱ+¬(2006� 12  14Á) 16! yc^���/b?Ê���Ù¡Uìp�xy+¬(2007� 6  15Á) 17! yc^�, �Oè�CMC�Áåȱ+¬(2007� 2  6Á) 18! yc^����:VW��Y�����Ùó�¡´ÙóWQï(2007� 3 ) 19! �Oè�"Z#ß7WÙY�×´�[×ï, N��gh[\ñ�(��Á+¬(2008� 3  12Á) 20! �Oè�lm3JÑ�jñ«W�úû+¬(2008� 8  5Á)

21! �Oè�CMC 7WÙY�×´�[×ï!, N���/Uúµ, ­®gh�[\�(�Áåȱ+¬(2008� 3  31Á)

22! yc^��ñWòóï���wxyíV�j«(2008� 2  15Á) 23! yc^��]�pvYòóW�±� ØÉ�7ï³��Á+¬(2008� 4  12Á) 24! yc^��ñWòóï���ã!ñlkWÁfJ 100w�íV�9:(2008� 10  17Á) 25! yc^��ñWòóï��� ���Ù¡U� �3ºL�®��Á+¬(2008� 12  4Á) 26! yc^��ñWòóï��� vêÕ�Áf�NHKíV�(2008� 11  14Á)

12XTUVW Âà ÚÛm� ���UÂÃÄ"#Î�ðUvwñ|LÄÃWóË��µê, ßû5}UÖì3ÚÛm

¥�"O=êéìïU�×�Xîðí��ñµKÇÄÃWóúû]�dU�÷Äê, lm �¥�[Y ïéYU±Pñz÷ÄÃWó°íÃJ»í­ì, lm�I�]�ê�$Ûzê]ëÃó

'5�´ÅY�Ë�@É� ���=DR��ñRVÇ�êù°ÇÄÃWólm��"OêFU ÇÃóý3­K]�´Å=�

¥, @É�ê%ÇÃó

Ĺ�ÆÇ ÚÛm¥� �����U�ÇÄê, �­Ù�ËÌ��ïìiÜ�&Éêvw��Yñ(Ç, ý�

"O=ôã!�8WÎ�ñ�PVó

Y5Z��e2!_

1X���`a nop"O����ðêÑñno3p��YïìvéÇ��ìUË3ñ���vé3F �/U

ÉÊVWý3�vÕ�ý��ðñÖ`=ëWJ�ñ��VWý3=�Wó ��'=ê�îVï(W�{)��;i¥�{)rsb��~�gU�p�"��*+íîUÂ

ÃÄ�l�ð�*�ðí idea3 strategyñi�ÇÄ�"#no�ðïÂ�$Î�ðUvwÇÄÃWó E��no��êF ��/�¦=íû�7ÍYè8YZ�×Y¢ñW<Î[YèYU���ð�î�

HIð �WUñ�LK©ªð¢ñ�Wî¡���£­+¸3ÄÃWó���µ�ÉÊ3ÇÄf�Uv

ÃÄô�no�F/­í�3�1�ðí¥ì7Y¢rVY\ñì,Ç�Õ¥0Ãno�F/ñ�PÇÄ`

aÇÄÃWóË�deêöU���vÕ�´;×�YUU@VWijµ¶�7ÍYè8YZ>?�ZÍ�

§¨noU�VWK+ÖØ��ÄÅUÂÃÄ�ijQØ/ý�§¨M����ê�@Éíî=�Wó �K�2003�UêÁfJ�no�I+(zUÕW�AP1ñ�ÞÇKó2004�5Õ¥+KUnop

"O3ÇÄ*ÐÇK�ñÒIU��ìU�-UÁLÄÃWógU�Æh��no�p��ƹ�

���pTUvwW�ðïÂ�ð5'ñ@ø3ÇÄÃWó DR��UvÃÄ�.Âï�"OU/Wý3UÕ¥�AåÃ��­|Lì3ÄÃWóîVï(W���

;i�rsb��M"O=.Âï�����cno#­Ú%&=ã!U{iw´�WXYZ�3�ã!ñ

8WÎVW�µ­.Âô0Æ�3�+¬1���'=ô¤¥� ì3ÄÃWóMíW�UjkVWý3ê�

M"O�����c3�'�vé=�¥�Ë��µñF ��/�¥Ö�¥¦U2ÉÇÄÃûý3=�Wó

�ìUý3ìñkÕÄ�gU�no�p����pT�+KívéUÂí ÄÃWó>fËðUê�Á

�§¨��ïìgYU3pe­Þì3�no#�ð�fUåk���ê��$Î��Q4 21 ã3I�\U��<3ÇÄ��$Î�� structure biological medicine �E8UÕW!ñÇÄÃWó��<no#b�ïì�ÏÙÓ²í�´\�no#p'b�ñ+ÄéY�´ÐÐ�$�b�3ÒÓb�3���ñ

vwÇ�F ��/ê�ÉÊñ|LÄÃWóã!ðïÂl�ðí�µ­�Ý�3ÄÃWóý3ì��µê

.Âï�]I~ªð��T�ÞU'3ÄÃWó ���[�����&Pr�����

1Z� ¡¢£ 3îUÏW îVï(W!��(Þ��cno#ñã!=ºLÄéìïUÇ Lancet 1996 ��

BBRC1999�UòÃÄ, JACI 2003�!�IgE ��(Þ IL-12�IL-12Vè�éW�Kê IL-18�IL-18Vè�éW�IFN��ZQ8YZ��£ñÏÇKó�ý3ì��µñô3UÇÄã!U{iwÄ�¤¥¦��§£Y� ¡¢£Z¨��"m¦!©ª¥�4�ìU�ý3ñô3U� ¡¢£Y��§£Z��

�"«¬­®�ñìpÇ�F�º»�=�W 2007�2008 �!ó5gU IL-18 �éY�´ÐÐ�$ñã!U{iwÄvéÇYNature structure biology¯ 2003Z�Ë�§¨ÉÊ3ÇÄ�$"#�kñ|LÄÃWó6no#ij3}îVï(Wkúµïì¿^��/�Ví®¯�îîVï(W��WSWØ×Î�/�§Ð

ñ|L“0¶78�íW;WØ×Î�/0�f�KL��9ë”ñã!=ºLÄm�ÇKó:no#p'�RNA��è¡�YZFU RNA editing3 alternative splicing­îVï(Wp¥U�®÷ÄÃWý3ñã!=ºLÄvéÇKó;×ÎîVï(W�}ÏFb�p'Ò��vé�KL�Tgh´�WY�sÐUã!=ºLÄ�èÇ�îVï(Wp¥UvwW HLA�á�òÎ�TghVè�éW�Fb3:ªñÐÐ�$ïìvéÇÄÃWó PNAS 2008u!<ý��µUDFÃÄ�++���=eñüQVW�/f§Ð�KL“×�Ä�V×Þ�ìp”��ÙÓ´U­'4|`ÇÄÃWó>Ûþ3no#UÕWîVï(Wp¥�"#no�ðvé 21ã3I�\U��<3ÇÄ�nno#'�� genetic ecological medicine -E8UÕW!ó?zl�UÕ¥�NF-kappaB�ÒÓ­l�Ç� ×U7×Y �éWY­l�VWý3ñéìïUÇKó�ìU@Á8�<��Yïì��3ÐdÖÕno#3���ñZÍÇÄÃWóAÀô��

Þ3��3���ñ«�Ç�/ìpUÂí WKLU�Toll like receptor TLR!vÕ�Ë��ZQïoTÞ�MyD88"#íî�"#vÕ�Ë3ì�:ªBCñéìïUÇ��ÖUË3ì�no#�ðéY�´�$�ðb�ñéìïUÇÄÃWóD\UV\3îVï(Wp¥�"#no�ðvé�Í×ï\ �U

ÕWîVï(Wp¥�î;9ÎYü7\�WÎ�ÂÃ3�WSWØ×Î�/�X�yà QOLÂÃæ�m��EF���ÙÓ´U�FACS ñÊÃKÀô��Þn� T gh�vw3�Þ��Þ Th1�Th2 îYñ;Y\�vé3ÉÊíîóGÊ����ÙÓ´UU�ÇÄÊ@�]I~ªð}�p¹ñ�Þ=ëKó "���h����Tíîê^H�I! 1. J"���hy���ÞK"���hyz{|�/ìp+Tô���îVï(W���céY�´

XÐÐ�$UDFÃK�$Î�ð�kUÕW�/f�§Ðý��ræ�� E8Ùb� ��8Â�� å8

\���a�>±��fLÀ�@2M`�¹#À3�å?XL��*N#�O��7�$%4"�N_0

P� ¿� 13J15�! 2. JPQ½h����T��¹K��îVï(W��¥¦��/��X±ôîVï(W����/

&É¥�c#�§Ð�íW;Ø×Î�/f�§ÐU�VW��ýö����� E8� Ùb� R2� �

*� N#Sï ¿� 16J21�! 3. JÎÞ ±�Æ�KL�b"OTª��¶·X±Kb"OTª��ìpIô×ÎîVï(W@�

×Þ�DR��UDFûl�ð��ý��ræ�� E8Ùb� R2� ¹#À3Sï ¿� 17�Õ¥ 5�Ñ!� 2Z°±²³´µ¶·P DNA¸¹

IgG ë´;\áU¥��c3íWno#b�ñã!U{iwéìïUÇK J Clin Invest �JACI !ó��GÐ^�no�Cñ3Wy IgM¥����cUÂÃÄô AID� dominant negativeúµUÕWý3ñã!=ºLÄéìïUÇK (JACI 2003�)ó'(ðVz�yÃ��;i¥=�W IgAáU¥UÂÃÄvwñ`ÃË� B gh�"�÷°�CñéìïUÇKó�ìU�fW 2 ì����Z�ë8Y�jno#�áU}ÞñjÊÇKóyp~3��;iñÏV Bloom¥��� Ataxia-telangiectasia��cno# BLM 3 ATM �ÒÓ3�$�vwñkÇÄgh±��DNA Ap��ZQïoTUÂëvéÇp~Ò��véñ`÷ÄÃW Blood ,CEI, PNAS u!ó�ìU±XíÀô��;i¥�ÀÁÆ¥����c�'vé3�/ìpUõ�ÇKó 3Zº»¼½¾¿À· �UYÐrsb�¥�FU ´�Xï-CoA:3-�Uü CoA U;Y\¢Ó;W|(SCOT)3 � �Uò�;W|áU¥�YZF �no#F UvÃÄê�ã!�ïì��Yñ�wÄvwñ`÷ÄÃWóý3�=

±û�no#lb3Ë�F,ñéìïUÇÄëKóñ]`ñôÂ¥I���Uò�;W|áU¥�SCOTáU¥�1Iì3�§¨��ZÃUÂÃÄôéìïUÇÄÃWó¢�Y;YÎ�ZïW�3�j���=�gU�ghXò�;W|3�U[YÎ8îîèUîèòï-CoAò�;W|� 3��$ñS1Ç��ìUî��ül�­�NU´kWíîUÂÃÄ�vwñ|LÄÃW��[]�3�j���=�W�ü

�ü�Þb�¥��Nno#vwô`÷Ä�µ­ÆÄëÄÃWó 4Z��²ÁÂÃÄ· no<[±�¥UÂÃÄ·�F �"#�'vw��/fìpU¤¥Ë®=ÃWóFU<[±�¥\

AI���=ê�-.��ÙÓ´U�©]ðÐ�=��vw��/fìpñ`÷Äv¥�HI�Àô^n��YZ�a/f�<[±�¥i_�·��\\´8WXYZ�\í<�ìpôuâÄ�vYòóW�±

3�j���ô|LÄÃWó 5ZÅ¡Æ­�Ç£Á� {)áï�9�«W<rsb�¥��c3�/UÂÃÄ��ñ|LÄv¥�áï�9�«W<áU¥

�+��cno# PEX16,19,13,3,26 ��1�?z 2'ø�pØ�+Kí�ü�YZáU¥�pØ�!#NXÙ\U�¢�W�þ`(a�MÀUÂÃÄã!ñ8WÎVW�µñ� ÄÃWóno#F 3Ç

Ä PEX10no#� 2bDác�PEX16no#b��PEX26no#b�íîñF ÇKSï���UFbíì3ÇÄ�Zellweger¥���§¨�ñdÇALDPno#ñ�É large deletionìñF ÇKó�K�áï�9�«W<áU¥�?z 2UÂÃÄêéY�´ÐÐ�$vw�¥I?z 2�Éï�Í

\�m�íîñ`Ã�f¥��'vé3�/f�ìpU¤¥Ë®=ÃWó�>=�áï�9�«W<�*

+pb�UvwW��UÂÃÄ���ËÌ��ð�fñÊÃÄvw�=�Wó 6ZÈ�ÉÊËÌ�#ÍÎ tu������NX�ÐÐ�$vwUDFÃK�'vw��/f�ìpíîñ`�”�$��”�§Ðñ�PÇ�$"#8qYÎ\´8WXYZ��NVvï=��NÈ�ðî��WòUÕW�/f�ìpU

�YñNÃÄ��ñ|LÄÃWó�K�Àô��ïì�Þ��UeW+·U�´VW�IL-18�IL-1�� Toll-like Receptor�UÐfí"#=�W�ZQïoTîS�éW�Nñ��UÇK�$�ð��ñ|LÄÃWóKE��µ��Â3ÇÄ�±��¯MjmfUÄS1ÇKgU IL-18ÐÐ�$ñô3U�lbÐvwñ`Ã�×YéW�×9YUvwW+ÇÃ:ªBC�véUe÷Kó

2Xbc �³(u�)� �³(u�)�

E8Ùb O��7

Naomi Kondo Kazuo Kuwata

3X ��Fd�ef tu�'��J� �¦)èYéW�I

4X ��ghiOj tu�'��J� �¦)èYéW�I

5X es�tuvwOj tu�'��J� �¦)èYéW�I

6X x?@ tu�'��J� �¦)èYéW�I

7X x��$�����������%� tu�'��J� �¦)èYéW�I

8X }�>�p�Oj tu�'��J� �¦)èYéW�I

9X �x?@ tu�'��J� �¦)èYéW�I

10X^�� tu�'��J� �¦)èYéW�I

11X^� tu�'��J� �¦)èYéW�I

12XTUVW Âà ©ªðUêË3í¥�ÂÃê=ëWóĹô9ëòë���µ3±{�gíWßà�m�­Ç�3Wó

'5�´ÅY�Ë�@� tu�'�3j�ÇÄÃWóiàáñ7ñWVWtu��§¨ïì®ëÆWh´3íW��iÄUõ

�VWý3굨=�W­�îVï(W����rsUåkÄÛþ� �3no#�Õ�í+Kí��

ÙÓ´UñЯ� Ä|LÄÃWó

Ĺ�ÆÇ '4�íW�3>m�gíWab3i]ó�ìU�ý3ì��µñ�/UÙ°ðUÉÊVW U;

Y\VW��Qï8 Wò!ó

Y6ZÏ!н¾�&!_

1X���`a ÁfJ� 2I���ê'(ð�âI=×Y\8Y"q;iñF,3VW�=��d"qÒÓ3��VW

d"q�\í<ñ©ªðU�vÇ�ÁfJUF²��� 2ñ�LWójk3ÇÄ���p¥�l�n

o#ñ"#no�ðU�1VWý3UÕ÷Ä�����p¥Ò��vé3m�ÐX�no#F f�ìp

ñ�PVó�K����F/��ðêªu¥�¥¦U�W�=�NÀ�rsb��a���gt�0�

l��'vé3�/f�ìpô�ÖU�|VWó �>�2I���ê`?���ræ��=�W�=�×?��Á��ÜÐ`a�\UV\Éýíî�

n���ñçáöÐUbcVWý3UÕ÷Ä�¿À�ÐXñ#~ÇK�WSWØ×Îðí`PQf�ì

pô�OUNûó

2Xbc �³� �³(u�)� ��³� ��³(u�)� ��³(u�)� %�� %�(u�)� §¨%�� §¨%�� ��� �2� �2�

n�� o Efp+t åqr² $%À± s_Ld t�uv wÀ%"6 _çx� b5�+t y�zd {Ø|} ~5yR

Jun Takeda Mayumi Yamamoto Yoshinori Kano Eiji Suzuki Yukio Horikawa Tetsuya Suwa Akihiko Sasaki Shin-ichi Kawachi Mayumi Enya Takuo Hirota Nobutoshi Fushimi Takashi Shibuya

3X��Fd�ef Ü !"!

1! �� �P�!#JîïÎ\í�Yb�¥� ÏpîïÎ\í�Y¥vÕ����� 11�HSD2áU¥(AME¥��)J�?� �!=�Áf§¨^÷� +àá^¥���8W�� 1 G�]��Áf§¨H;2006 ��651J654�

2! Efp+t��E�� õöF ����� �¥�ì£� �/�r�(z�9óY�\;×¢�õö0��úû�úûü]�ãõ0���I=;2006��8J11�89J92�111J113�

3! wÀ%"6�s_Ld�n�� o��rsJMODY(1-6I)� �?� �!=�Áf§¨^÷� +àá^¥���8W�� 3G�]��Áf§¨H;2006��54J57�

4! ��>t�s_Ld�ØéÙ8¡´�YÎ�W<p¥£c3ÇÄ�d�°��W�ghÒÓb�JW�gh�"��[\�ïï®Wc#� ChREBP. �?� �!=�Áf§¨[å� 64G�]��Áf§¨H;2006��249J253�

5! $%À±�DR=�PWVñÖW� ���ÒÓ÷°3 PWV�@�ÚÛ3 PWV��Y��Yë¡´� PWVñÖW� PWV=FW� 9:��EÜ�;2006��132J138�

6! s_Ld�b5�+t��� 2no#vé�'5� W�� v$=.� Áf§¨+Ör�����(1);2008��387J392�

7! b5�+t, s_Ld����3 NASH-C.� W�������°�jknoZcUÂÃÄ �Ïu�=.�NASH F/� �}��H;2008��98J103�

8! s_Ld, b5�+t. TCF7L2no#� W�� v$=.� Áf§¨�2008��678J683. 9! $%À±�C���������'�F ��|�� �����Z���|�� ������Z� �1

f� §¨ðQ_� ÂÃf l�Z�� MRA� Áf§¨� � 66G� [å� 4� +Ör������ 2G�]��Áf§¨H;2008��546J550�

Ü S"! íÇ

©è !"!

1! $%À±�y��3�0���Medical View Point� 2006�;27G�2� 2! n�� o����3×Y\8Y�}ñLûWUÏ¡´\�Medical View Point� 2006�;27G�1� 3! s_Ld����3×Y\8Y�}ñLûWUÏ¡´\J×Y\8Y�}3noZc�Medical View

Point� 2006�;27G�4� 4! n�� o����J��÷°�¥¦ñ��U�MEDICAMENT NEWS� 2006�;1858G�14J16�

5! b5�+t�s_Ld���p'no#���¢r×8YZ���<��� 2006�;5G�521J525� 6! Efp+t��Q�������'3¥¦�����I­Õ¥� 2006�;50G�35J41� 7! n�� o�+��/kUÕW��0��Kh¤��;´í�\� 2006�;23G�335J340� 8! wOÑ.v�y�zd�=�� ���� �P�ÏpîïÎ\í�Y¥�����JApparent

Mineralocorticoid Excess¥���Áfd��IFâ� 2006�;95G�50J55� 9! n�� o�����kÎ�/�[��úûü��I��Fâ� 2006�;19G�69J72�

10! Efp+t�úûü�vwW���@��¤¥Ë¦UÂÃÄJ�����²WÙØYUñ��U�úûü��I��Fâ� 2006�;19G�63J68�

11! b5�+t�s_Ld��� �P�n�� o�Ç�p¥����UvwWno#\´8WXYZ�úûü��I��� Fâ� 2006�;20G�29J31�

12! Efp+t�n�� o�3�1ãl�iÒN�ÀÁ���1��ÉWéñúû]�����#7ïí�=HÊ�âWs¦�Q&A=®ïWô°�3���ý� 2006�;5G�47J51�

13! KÈM��n�� o�Efp+t�×Y\8Y�Èi0�Ð([\ñ�ð3ÇK�d�EÜ�m�3Ë�ÂÃ��;´í�\� 2006�;23G�464J468�

14! n�� o�`y� 4��¢R3�������WX0�3a��� Medical View Point� 2006 �;27G�5J6�

15! n�� o�Áf���8I3êî®í�Ð�Jô¢£�ýñoÇK+ÇÃô�F��;ý�ïK¯�úûü��Ij� 2006�;660G�18J19�

16! wOÑ.v�n�� o�SHP3�WXrs�d"q������ 2006�;23G�52J56� 17! n�� o�ÇÃ���âRmñ�ÃÄ�úûü��Ij� 2006�;661G�25J26� 18! _çx��n�� o�ØéÙ8¡´�YÎ�W<�ö£�'3Ë�0�JØéÙ8¡´�YÎ�W<Uv

wW����{m�Áf§¨([å)� 2006�;64G�445J448� 19! �� �P�E��#�y�zd�=�� ��t�uv��²;�[ïò[×Î�"#no��d"q��

���� 2006�;23G�643J647� 20! Efp+t� �¥3]�ãõ0��i-]�ãõ0�8I95���ç>�IjÊÜ¿� 17�z� 2006

�;31J34� 21! n�� o��� �P�]��±��� x��-� ��New Evidence for EVENT REDUCTION in

Hypertensive Patients K+� ASCOT stïì�¤�/UvwWvW\k3ÇÄ�î<�ÙÏY�²ÊñZ�VW� Medical Tribune� 2006�;1J4�

22! y�zd�=�� ��wOÑ.v�t�uv��� �P�n�� o��îïÎ\í�Y¥�Ã�� C���ñ�É�>kê�®3ÄÃíÃï���/�� 2006�;40G�893J894�

23! )�=����M�u�f±�#��� s�¡�A¶�n�� o�Efp+t�úû]�UvwW¢£@��²ú�ZÍJX[òY�¡ò��¤¥µ¶ñs¦Ä�Campus Health� 2006�;43G�160�

24! f±�#�)�=����M�u���s�¡�A¶�¦��s�¯*�§�¨�X/�n�� o�Efp+t�]����õF:µ�ZÍ�Campus Health� 2006�;43G�211�

25! �M�u�)�=���f±�#���s�¡�A¶�n�� o�Efp+t�]��©��b'n�J0�PQÐ(U�VWZÍ�Campus Health� 2006�;43G�238�

26! ��s�ò_Lã�f±�#�)�=����M�u�a%Ë"�n�� o�Efp+t�UPI3 GHQ60��Ön�:µÕ¥� �õön�UvwW UPI²Ê�ZÍ�Campus Health� 2006�;43G�269�

27! $%À±�����´�îY(���W�Z��F f�|�� MjmfUÕW+ÇÃF f� Áf§¨� 2006�;64G�2062J2068�

28! $%À±�Technics Guide MjmñÊÃK¢¡U��U[ïUÕW���ç�l�·�pØ� Diabetes Journal� 2006�;35G�31J35�

29! wOÑ.v�y�zd�=�� ���� �P�d"qy�¤¥� F 3�/�|�� Apparent Mineralocorticoid Excess¥���Áfd��IFâ� 2006�;95G�662J667�

30! �� �P�îïÎ\í�Y7\�WÎ3no#±I�����ª¦� 2007�;221�709J715� 31! �� �P�Cushing¥���Year Note ^÷� 2007�;589J593� 32! ��>t, s_Ld. 7ï�×Y 10, 7;W8� �����DR3§¨�� 2007�;319J322. 33! b5�+t, s_Ld, n�� o. SHP3�WXU�VWrsb�, K+��� 2007�;62G�63J68� 34! $%À±�`aÚÛ÷°U@VW+ÇÃî��Wò� Diabetes In The News(DITN)� 2007�;353G�

8� 35! $%À±������UvwW`aÚÛ÷°U@VW+ÇÃî��Wò�Angiology Frontier� 2007�;

6� 36! Efp+t�3�1ãl�y�ÙÓ. �/ñlkW IT��Ø8¡U��/�ð%��²ÙØYU��Uv

wW IT`Ê��Ó� +�/� 2007��54J57�� 37! �� �P.� JAC 2007�ñ�¥«÷ÄWKE�îïÎ\í�Y���amñ«WWMedical tribune, 2008

��82J83� 38! Efp+t�b5�+t�s_Ld�n�� o�úû¶UvwW���F/�b'n�� úûü��I�

�Fâ� 2008�;21G�89J94���39! s_Ld.� ����+ÇÃnoZc� Diabetes Frontier 2008�;19G�441J452� �40! �M�u� )�=��� ��s� n�� o� Efp+t.� �]�ñ@øUbcÇK©�b'n�� �

×ãõ��� 2008�;50G�264� 41! Efp+t�_Ƭ6�­5�À#�n�� o�®fN7�3�1ãl¯�úûü��I�F�;�\í<Uv

wW����F�; �WU�\í<�sm� °�3���� 2008�;7G�556J561��42! $%À±����3`aÚÛ÷°��1�j� 2008�;172G�12J17�� ©è S"!

1! Horikawa Y. Calpain-10(NIDDM1) as a susceptibility gene for common type 2 diabetes. Endocr. J. 2007;53:567-576.

2! Iizuka K, Horikawa Y. ChREBP: A glucose-activated transcription factor involved in the development of metabolic syndrome Endocr. J .2008;55:617-624.

Ï !"!

1! ��s�Efp+t�]�`3ØYéï¢ï\ �WUJ2005 �úû]�1�õöF Ö UPI n�Õ¥#��°±�*ãõr�� 2006�;42G�47J52�

2! _çx��n�� o�}îVï(W«�uÊ=² �U�èÇK³ÖIiÜ×Y\8YîVï(W� 1ì����� 2006�;9G�441J444�

3! Efp+t�çá�/�;3`PQ�o4�d"q������ 2006�;24G�32J37� 4! Efp+t�)�=����M�u���s�¡�A¶�wc"´�¦��s�¯*�§�¨�X/�

n�� o�úû]�U��õöF ñbcÇÄ�Campus Health� 2006�;44G�109J114� 5! Efp+t�çá�/�;3`PQ�o4�d"q������ 2007�;24G�32J37� 6! Efp+t�)�=����M�u���s�¡�A¶�wc"´�¦��s�¯*�§�¨�X/�

n�� o�úû]���õöF ñbcÇÄ�Campus Health 2007�;24G�109J114� 7! Efp+t�n�� o�3�1ãl�SMBGÉWé��#7ïí�=�HÊê�ÀÁ���1��ÉWé

ñ�#7ïí�=HÊ�âWs¦UÂÃÄ�kÄû­�Ã�°�3���� 2007�;6G�475J477� 8! f±�#�wc"´�)�=����M�u�µ*W¥#���s�¦�`s�¯*�§�¨�X/�

n�� o�Efp+t�]�UvwW���õö5'3`?�3���UÂÃÄ��×ãõ��� 2007�;49G�112J116�

9! �� �P�E�|#�y�zd�_çx��wÀ%"6�t�uv�n�� o�×b 2no#��¤�2007�;14G�958J962�dh'¶£U�VW¤÷wÀ÷Cn��¶£��� 2007�;1G�10J15�

10! Efp+t���s�n�� o�·%¢R7�]����%2i2Uc`ÇK¸çdh'¶£U�VW¤÷wÀ÷Cn��¶£��� 2007�;1G�10J15�

11! Efp+t���s�n�� o�·%¢R7�]�%2�¢£�ñ@øUbcÇK¢£�b'n�J¸çdi'¶£c` 2�ñ+bÇÄ�+�/� 2007�;1G�18J23�

12! µ*W¥#, ��s, wc"´, )�=��, �M�u, n�� o, Efp+t. õöF �X�m�ñ�PÇÄW��2F�çz�ÍYïìW, Campus Health� 2007�;1G�125�

13! wc"´���s�)�=����M�u�µ*W¥#�n�� o�Efp+t. ��%2i2Uc`ÇK�d¶£�îY�WUn��¸çd¶£bc 2 �ñ+bÇÄW, Campus Health� 2007 �;44G�149�

14! ��s, ò_Lã, f±�#�)�=��, �M�u�µ*W¥#, n�� o, Efp+t. �`=�Lì3Wãõ0�èYéW� WØYéï¹ï\ �WU���U�VWZÍ�, Campus Health� 2007�;44G�196�

15! ò_Lã, ��s, _��#, _�N#, wc"´, )�=��, �M�u, n�� o, Efp+t.�UPIÞY3`?�n����UÂÃÄ, Campus Health� 2007�.;44G�198�

Ï S"!

1! Yoshimura T, Suzuki E , Egawa K, Nishio Y, Maegawa H, Morikawa S, Inubushi T, Hisatomi A, Fujimoto K, Kashiwagi K. Low blood flow estimates in lower-leg arteries predict cardiovascular event in Japanese patients with type 2 diabetes with normal ankle-brachial indexes. Diabetes Care. 2006;29:1884-1890. IF 7.071

2! Isomura Y, Mune T, Morita H, Suwa T, Takeda N, Yamamoto Y, Takeda J. Physiologic role of 11g-hydroxysteroid dehydrogenase type 2 in kidney. Metabolism. 2006;55:1352-1357. IF 2.143

3! Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, Nanjo K, Mori H, Kasuga M, Hara K, Kadowaki T, Tanizawa Y, Oka Y, Iwami Y, Ohgawara H, Yamada Y, Seino Y, Yano H, Cox NJ, Seino S. Association studies of variants in the genes involved in pancreatic g-cell function in type 2 diabetes in Japanese. Diabetes. 2006;55:2379-2386. IF 8.848

4! Gu N, Adachi T, Matsunaga T, Takeda J, Tsujimoto G, Ishihara A, Yasuda K, Tsuda K. Mutant HNF-1 ºand mutant HNF-1 g�identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells. Biochem Biophys Res Commun. 2006;346:1016-1023. IF 2.904

5! Gu N, Adachi T, Takeda J, Aoki N, Tsujimoto G, Ishihara A, Yasuda K, Tsuda K. Surrase-isomaltase gene expression is inhibited by mutant hepatocyte nuclear factor (HNF)-1 ºand mutant HNF-1 g�in Caco-2 cells. J Nutr Sci Vitaminol. 2006;52:105-112. IF 0.784

6! Moro H, Sato H, Ida I, Oshima A, Sakurai N, Shihara N, Horikawa Y, Mikuni M. Effect� SKF-38393, a dopamine D1 receptor agonist on expression of amphetamine-induced behavioral sensitization and expression of immediate early gene are in prefrontal cortex of rats. Pharmacol Biochem Behav. 2007;87:56-64. IF 2.092

7! Hamaguchi M, Kojima T, Takeda N, Nagata C, Takeda J, Sarui H, Kawahito Y, Yoshida N, Suetsugu A, Kato T, Okuda J, Ida K, Yoshokawa T. Nomalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol. 2007;13:1579-1584. IF 3.318

8! Yamada Y, Sekihara H, Omura M, Yanase T, Takayanagi R, Mune T, Yasuda K, Ishizuka T, Ueshiba H, Miyachi Y, Iwasaki T, Nakajima A, Nawata H. Changes in serum sex hormone profiles after short-term low-dose administration of dehydroepiandrosterone (DHEA)to young and elderlypersons. Endocr J. 2007;54:153-162. IF 1.140

9! Ishizuka T, Miura A, Kajita K, Matsumoto M, Sugiyama C, Matsubara K, Ikeda T, Mori I, Morita H, Uno Y, Mune T, Kanoh Y, Ishizawa M. Effect of dehydroepiandrosterone on insulin sensitivity in Otsuka Long-Evans Tokushima-fatty rats. Acta Diabetol. 2007;44:219-226. IF 1.676

10! Oda N, Imamura S, Fujita T, Inagaki K, Kakizawa H, Hayakawa N, Suzuki A, Takeda J, Horikawa Y, Itoh M. The ratio of leptin / adiponectin can be used as an index of insulin resistance. Metabolism. 2008;57:268-273. IF 2.647

11! Miyake K, Horikawa Y, Hara K, Yasuda K, Osawa H, Furuta H, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, Makino H, Nanjo K, Kadowaki K, Kasuga M. Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. J Hum Genet. 2008;53:174-180. IF 2.275

12! Zenibayashi M, Miyake K, Horikawa Y, Hirota Y, Teranishi T, Kouyama K, Sakaguchi K, Takeda J, Kasuga M. Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population. Endocr J. 2008;55:699-707. IF 1.572

13! Horikawa Y, Miyake K, Yasuda K, Enya M, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, Kasuga M. Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J Clin Endocrinol Metab. 2008;93:3136-3141. IF 5.493

14! Sato H, Horikawa Y, Iizuka K, Sakurai N, Tanaka T, Shihara N, Ohshima A, Takeda J, Mikuni M. Large-scale analysis of glucocorticoid target genes in rat hypothalamus. J Neurochem. 2008;106:805-814. IF 4.451

15! Enya M, Horikawa Y, Kuroda E, Yonemaru K, Tonooka N, Tomura H, Oda N, Shihara N, Iizuka K, Saibara T, Takeda J. Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients. Hum Mutat. 2008;29:E271-E277. IF 6.273

16! Hirota T, Suzuki E, Ito I, Ishiyama M, Goto S, Horikawa Y, Asano T, Kanematsu M, Hoshi H, Takeda J. Coronary artery calcification, arterial stiffness and renal insufficiency associate with serum levels of tumor necrosis factor-alpha in Japanese type 2 diabetic patients. Diabetes Res Clin Pract. 2008;82:58-65. IF 1.823

17! Iizuka K, Horikawa Y. Regulation of lipogenesis via BHLHB2/DEC1 and ChREBP feedback looping¯Biochem Biophys Res Commun. 2008;374:95-100. IF 2.749¯

18! Okauchi Y, Iwahashi H, Okita K, Yuan M, Matsuda M, Tanaka T, Miyagawa J, Funahashi T, Horikawa

Y, Shimomura I, Yamagata K. PGC-1� Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men. Endocr J. 2008;55:991-997. IF 1.572

19! Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maed E, Shin HD , Cho YM, Park KS, Lee HK, Ng MCY, Ma RCW, So WY, Chan JCN, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M.A multistage genome-wide association study identifies SNPs in KCNQ1 associated with susceptibility to type 2 diabetes mellitus¯Nat Genet. 2008;40:1092-1097. IF 25.556

20! Tokunaga A, Horikawa Y, Fukuda-Akita E, Okita K, Iwahashi H, Shimomura I, Takeda J, Yamagata K. A common polymorphism in the P2 promoter of hepatocyte nuclear factor-4ºgene is associated with an index of the early-phase insulin secretion in Japanese subjects with type 2 diabetes. Endocr J. 2008;55:999-1004. IF 1.572

21! Sasaki A, Horikawa Y, Suwa T, Enya M, Kawachi S, Takeda J. Case report of familial Carney complex due to novel frameshift mutation c.597del C (p.Phe200LeufsX6) in PRKAR1A. Mol Genet Metab. 2008;95:182-187. IF 2.550

22! Kajita K, Mune T, Ikeda T, Matsumoto M, Uno Y, Sugiyama C, Matsubara K, Morita H Takemura M, Seishima M, Takeda J, Ishizuka T. Effect of fasting on PPAR� and AMPK activity in adipocytes. Diabetes Res Clin Pract. 2008;81:144-149. IF 1.823

4X��ghiOj 1Zklmno 1! ��ræ��n�� o;��ST�GX±��jkð�$�� (CREST)�)þn�Þ�"#vxUÕW���Zc�«�;¿� 14J19 �z;455,970 ^_(52,000�106,200�107,500�107,270�83,000^_)

2! ��ræ��n�� o;"���h��TF1àá���Fbðno#�p'n�»U¼Yñ/÷K���no#�«�;¿� 17J20�z;21,000^_(5,900�5,400�5,700�4,000^_)

3! ��ræ���ÆL7���"z��n�� o;+¬ ±hçá+[Y«W�î<X±�yú¾�¡´SÍYÒÓñ²VW siRNA�$f�ìp3`Ê;¿� 17J18�z;8,000^_(4,000�4,000^_)

4! ��ræ��s_Ld;PQ½hgU��<���/��X±�7ï�×Y 10��"#ñÊÃK 2I���no#F f3+��/f�ìp;¿� 16J18�z;107,379^_(41,550�37,868�27,961^_)

5! ��ræ��s_Ld;+¬ ±h��<�kå½�¶·ñ×�DUSTìpT��ªÎ�ñ`ÊÇKÎ�\í<()DUSTìp;¿� 18J20�z;193,000^_(85,000�68,000�40, 000^_)

6! ��ræ��s_Ld;úû]�`�+T�+���"qéY�´3���]�0¥�8Y´;¿� 18�z;1,200^_

7! ��ræ��b5�+t;úû]�`�+T�×Y\8Y"q�(no#ïì¦K+� 2 I��� 2no#��Þ;¿� 18�z;1,200^_

8! ��ræ��s_Ld;iÁf[WgW8I����¹�+�[WgW¾Æ�"UÕW×Y\8Y"q`�Ò��vé;¿� 19�z;1,300^_

9! ��ræ��s_Ld;úû]�`�+T(��)��×Y\8Y´8î;Y\`�3Ã�+� 2I����/@��§Ð;¿� 19�z;600^_

10! ��ræ��n�� o;PQ½����T��¹;�kDU�|��X±�ÐW�ù°c#ñÊÃK 2I�����/;¿� 19J20�z;97,167^_(50,326�46,841^_)

11! ��ræ��_çx�;úû]�`�+T(��)�)þc# HNF-1º3 HNF-1g��ðno#�¢¿ðvwUÕWÒÓÀb�vé;¿� 19�z;1,130^_

12! ��ræ���� �P;PQ½����T��¹� ¨���rÁ��X±�!#àï�Y b�U�VWn���;¿� 19�z;500^_

13! ��ræ��n�� o;PQ½����T��¹;ÚÛ����`?��@�©ª��X±�ÚÛ�8\´3��Ó÷°�úµðíõF�W7W�«�;¿� 20�z;18,945^_

14! ��ræ��n�� o;Áf�T�GI����T��¹Â����ô��ÒÓU��VW�×´�"#��13ÒÓvw;¿� 20�z;1,900^_

2Zpq�� 1! n�� o�×Y\8Y�Ê�� 2 I�����ñ@ø3ÇK��0Þ×vYUp8\´U�VWZÍ;¿� 19J22�z;1,500^_� �¢��îvYí�\ICIH

2! n�� o�V��WÎYÃjóÊ 100� �Ê�{n�;¿� 19J20�z;315^_� 3! n�� o�ô\éW�\Tý²°Xø�gn�;¿� 19�z;21^_� 4! n�� o��7ïÉ�\T� F1�Ê�{n�����ÊÖ�����0×vYUU�VWn�;¿� 18J21�z;252^_

5! n�� o�«ñ�WUF1�Ê�{n�����ÊU�VWn��(��U[Wï No.A6291023;¿� 20J25�z;189^_

6! g:W�U�W�F1�Ê�{n���J��àï�Y"q;i¥(�¥UëW);¿� 20J21 �z;126^_

7! î´í<;F1�Ê�{n�(iìn�)��8Í�ò�±��U`añ²VWÇ�óp��Æ�;¿� 20J25�z;94,500^_��}�kICIH

8! î´í<;F1�Ê�{n�(��¢ñ�Wî¡�n�)��8Í�ò;¿� 20J25�z;31,500^_��}�kICIH

3Zr��� íÇ

5Xes�tuvwOj íÇ

6Xx?@ 1Zxyz n�� o� 1! Áfd��IÂL2(�'4) 2! Áf����I,X�ÂL2(�'4) 3! Áf���ªu¥�IÂL2(�'4) 4! Áf���ÄÅ�I�X�ÂL2(�'4) 5! Áf�'�Ø�IÂL2(�'4) 6! Áfd"q�IrL2(�'4) 7! Áf����IÂL2(�'4) 8! Áf�����I�X(�'4) 9! ÁfJ�no�IÂL2(�'4)

�� �P� 1! Áfd"q�IrL2(�'4) 2! Áf\í�×Îàï�Y�IÂL2(�'4) 3! Áf��0d"qrs�IÂL2(�'4) s_Ld� 1! Áf�'�IÂL2(�'4) 2! Áf����IÂL2(�'4) 3! ÁfJ�no�IÂL2(�'4) 4! Áfd"q�IrL2(�'4) Efp+t� 1! Áf����IÂL2(�'4) 2! Áfd��I95ç>IÂL2(�'4) 3! Áfd"q�IrL2(�'4) 4! Áf§¨�Ø�IÂL2(�'4) 5! Áf�'�Ø�IÂL2(�'4) 6! ÁfÆ��I95¶����2(�'4) $%À±� 1! Áf����IÂL2(�'4)

2Zx{| íÇ

3Z}~� n�� o� 1! ÁfJ�no�I;=�O2(�'4) 2! Áfd��I�À"â=�O2(�'4)

7Xx��$�����������%� n�� o� 1! � 40¡�����|�(2006� 2 �¹Ç�F^%¨ô+��/kUÕW��0��Kh¤ý¨�) 2! 2006��;×�8�î�I(2006� 5 �wxy�F^%¨ô���3��0�8\´ý¨�) 3! � 27¡Áf°��I(2006� 10 �*­�F^%¨ô[�Yrs��ÁfJÐXý¨�) 4! � 43¡Áf�����IEÈç>I(2006� 11 �:ª�F^%¨ôÁfJ 2I���3��0×vYU8\´ý¨�)

5! ���ÉÊ��J�� 50 ¡�T%¨I(2006 � 11  �wxy�F^%¨ô���3��0×vYUý¨�)

6! � 6¡"#¥¦Ûþ����I(2006� 12 �:ª�F^%¨ô����ÁfJ�"#��ý¨�)

7! � 3¡<ì�Y�ÙÍ<ôíW;WØ×Î�/ñ�PÇK��<ij`ÊDUSTý(2007� 8 �9:�ô)þ²¡U³W´�"#vxUÕW���Zc��1ý¨�)

8! � 42¡�����|�(2008� 2 �y��F^%¨ô)þc#b�UÕW×Y\8Yª�"q÷°ý&�É�

9! � 23 ¡���ªu¥�I(2008 � 10  �9:�F^%¨ô2 I������UWéï8\´�²WÙØYUý&�É�

�� �P� 1! International Symposium The Kidney and Hypertension(2006� 10 �ÊË�F^% ô̈Common

genetic variation in the mineralocorticoid pathwayý¨�) 2! ISH Symposium for Aldosterone Hypertension(2006� 10 �9:�F^% ô̈Polymorphisms in

the aldosterone cascadeý¨�) 3! � 29¡EÈd"q3y�¤��I(2006� 11 �]��F^%¨ôRe-definition of 11gHSDsý¨�)

s_� Ld� 1! � 7¡�*ØéÙ8�<��I(2006� 6 �ÌÉ�6Ý%¨ô2I���3noZcý¨�) 2! ��]�%¨I(2006 � 6  ��-��hÍ�¶�6Ý%¨ô����no����+ÇÃÆìý¨�)

3! ��]�%¨I(2006� 6 ��-��hÍ�¶�6Ý%¨ôÁf�����/�'5ý¨�) 4! ��<�k¢ñW;<� 9¡�Y�ÙÍ<(2006� 11 �9:�6Ý%¨ôéY�´X�ÒmÊYUÕW 2I���no#��ï�véý¨�)

5! � 12¡�Y�ÙÍ<���(2008� 4 �9:�F^% ô̈�����"qéY�´(�\í�²´òY)3���]�0¥�8Y´ý¨�)

6! � 43¡no����I(2008� 11 �9:�F^%¨ô��� 2no#�1�'53Îd�ý¨�)

$%� À±� 1! � 3¡:ª`aÚÛ÷°ZÍI(2006� 2 �:ª�6Ý%¨ô���3a��ý¨�) 2! Management of PAD @��0�lU�VW�F�;(2006� 6 �úû�6Ý%¨ô�²ïÉ�\7¡��Y� �����UvwWMjmñÊÃK@��0vwý¨�)

Efp+t� 1! �W\c`³±yz�/[Y«W�î<(2006 � 2  �]��6Ý%¨ôòW<�/3�/�ÉïJ���F/�Éïý¨�)

2! � 70 ¡÷�ÁfÚÛ��I©I (2006 � 3  �wxy�6Ý%¨ô���3a��¥J¥¦��£Jý¨�)

3! i-]�ãõ0�8I� 95���ç>�I���I(2007� 7 , ¹Ç, ô9óY�\d¶£ 2�ñ+bÇÄW'53ÄÅ�ý%¨�Y�Ù\U)

8X}�>�p�Oj íÇ

9X�x?@ n�� o� 1! Áf§¨d��Iúûü!I�(�'4) 2! "���h��<²¡U³W´�|O2IO2(�'4) 3! i-]�ãõ0�8IÂL2(¿� 19�z) 4! Áf���8Iúûü¶��(�'4) 5! "���h��ST��TÏLI�ðO2(�'4) 6! úûü���@��|ÂLI!I�(�'4) 7! Áf���8I/ØPQO2IO2�(�'4)

s_� Ld� 1! úûçá�/�;��InX(�'4) 2! úûçá��I�;�\HIO2IO2(�'4) 3! úûü��I���@�O2IO2(�'4) 4! úûü��I���çá�;�\³W9YZZïW�O2�(�'4) 5! Áf���8Iúûü¶�rL2(�'4) Efp+t� 1! ��çá���8LIO2(�'4) 2! úûü�J�ZF0�PQ8LIÚÛ����O2I2(�'4) 3! úû`?��Ha/f��IãLJ(�'4) 4! úûüãõ�/�|8LIO2(¿� 20� 10 ) 5! úûü��I���@�O2IO2&�(�'4) 6! úû¶õö ±�G"�IO2(¿� 19� 8 �¿� 20� 3 ) 7! úûüãõ�/�|8LIO2�çáãõÕl�IO2(¿� 19� 11 �'4)

10X^�� 1! s_Ld�7ï�×Y 10 ��"#ñÊÃK 2 I���no#F f3+��/f�ìp�¿� 16�zJ18�zP����T��¹� ©]jÊÜ(2006� 1 )

2! �� �P�t�uv�=�� ��n�� o�Disabled-2 �!#�XUvwWÒÓ3!#Ð-=�p'�!#àï�Y b�U�VWn���� ¿� 17�z��jÊÜ�109J112(2006� 3 )

3! Efp+t�3�1ãl�$%ö/�y�ÙÓ��/ij0��\í<3F/�ÉïJ���J�/+IJ�������Z;<ìp��ÙÓ´U� yz�/��[Y«W�<�¿� 17�z+¬ ±hô�/+IJ���X±HIUÌW����Z;<ýb{jÊÜ�141J176(2006� 1 )

4! n�� o�ÐW�ù°c#ñÊÃK 2I�����/�¿� 19�zPQ½����T� �kDU�|��X±jÊÜ(2008� 4 )

5! n�� o���Fbðno#�p'n�»U¼Yñ/÷K���no#�«��¿� 19�z����T��¹� F1àájÊÜ(2008� 4 )

6! �� �P�CYP11B1 common variants 3æ'I����PQ½����T��¹� ¨���rÁ��X±� !#àï�Y b�U�VWn���R� ¿� 19�z��jÊÜ(2008� 3 )

7! s_Ld��ªÎ�ñ`ÊÇKÎ�\í<()DUSTìp�+¬ ±h��<�kå½�¶·ñ×�DUSTìpT� ¿� 19�z��jÊÜ

11X^� 1! �� �P�ô��Ýïì]�êÃ�ýZc±�kÕ¥0Ã`ñ�úû+¬(2006� 10 ) 2! $%À±�ô��Ýïì]�êÃ�ý`?���¥¦fñn��úû+¬(2007� 4 ) 3! Efp+t�úû]���¶· GP U"1�>õöñ�PÇK�õö¶·��Z;<��Á+¬(2007� 9 )

4! Efp+t�úû]���¶· GP U¼½�]�ê>õö�\éWUçY��Á+¬(2007 �10 )

5! Efp+t�úû]��>õöñ�PÇK�õö¶·��Z;<W>õö����|3õö¶·�ab��Á+¬(2007� 10 )

6! n�� o�����/�;ñ8WÎVWôúû�\í<ýñx¦vû�DITN(2008� 2 ) 7! s_Ld�ô��Ýïì]�êÃ�ý`?���/kñ���úû+¬(2008� 2 ) 8! n�� o�ÜEí�ô���ýñ�ÕU#kW��Á+¬(2008� 11 )

12XTUVW Âà ��U�ÇÄê�±cÔj���UÕ¥+ÇÃ���no# KCNQ1 Nature Genetics 2008�!í

îÃûÂï�l�no#ñ�1VWý3U�èÇK­�h 3 �U'ÇÄã!ñ8WÎVW��Ë"­ù÷Ký3ê&hY=�W S"Ï 22=!ó�>�2008� 3 U]I��=�W CREST ræ�n�o!­ÒÑÇK­�Ë�¹ñ�ÒVWïK¯= NEDO�� ræ�s_Ld!3 2Â�P�� ræ�n�o!�]Ip¹ñ�Þ=ëKý3êyÂÃUÌVWó

���U�VWHI`a3ÇÄê�ôúû�Éïý3ÇÄúûü���@��|8LI�öQð��ñ

µKÇÄÃWó`K3�8n=�¶Ó%&�Ëp9óYáWY3ÇÄ�ã!���ÉW`a úûÔ;

×Uî¡�íî!��/\é¡¢�A�¢£��/ØPQ�(z�Q4íî­bc�3Kó3�Ñ=�úû����çá�/U�VW� 40¡�%¨�Y­i-ïì�÷Ký3êÂÃUÌVWó

'5�´ÅY�Ë�@É� �����F/�HIU�ÝJ2­�ï3�Õ"í���3��ÖÑ­§ã=ëíï÷Ký3­´Å

Y=�÷Kó@�3ÇÄê�2009� 4 Õ¥�¡]����òW<ñÖÇÄúûòW<U,ªÇ��ìU]��� 1 w[2ñ¥1VWóbt��2�gíW§ã�KLU�}�p¹ñ�ìU�ÞVWÕ�ÁÂVWó

Ĺ�ÆÇ {ið=�Wô��U;Y\´8�UW<ýU�VW��<��ñ�|�âWó×Y\8Yª�3"

qU�VW+���`ÎX�ÒÓvéñkÕÄ����F 3�/ê�ÆìñÛWóÜÐðUê�

�d"q�FU��VW�Ó­�W�c#ñ�1ÇÄÃW�=����1F 3�/ÉÊñ�P

Vó�ÖU��� 2���no#±IñÊÃK��vwUÕW�m�ÐX� DNA F f�ìpñ�OUNûó5}�0â=��µpæ3F�¤ÞñÚ'�×T��3VWó çá����3ÇÄê�`K���I����Ð3��;�ô3U���ðí�'n����·�p

Ø3p¥¥¦�Ð(���çá=`Ê�3WkÎ/f�ìpíîñ�|ÇÄÃû¥1=�Wó

Y7Z���&!_

1X���`a Ú�ÝUvwWDR���§¨��êÃÎ3ô§¨UÐöÇ�ØLÄDRðí��­í�3�Ë��µ

êÐÎ�§¨U���3Wô�=�WóU;Y\VW��Qï8 Wò=ô�Wó�KË�de3�fê

�UbÙïì'4�^�UÐöÇÄ�cdñØÚkKØLÄÛXW´ííW�=�¥�ïÂ�f=�Wó

Æhtu��no�p��tu����pT3i§¨"OU®KW�ð5'�V�Äñ@ø3ÇÄ

ÃWó DR��UvÃÄê�.Âï�"OU/Wý3UÕ¥�AåÃ��­|Lì3ÄÃWóîVï(W��

�;i�rsb��M"O=.Âï�����cno#­Ú�Ý=ã!U{iw´�WXYZ�3�ã!

ñ8WÎVW�µ­.Âô0Æ�3�+¬1���'=ô¤¥� ì3ÄÃWóMíW�UjkVWý3

ê�M"O�����c3�'�vé=�¥�Ë��µñF ��/�¥Ö�¥¦U2ÉÇÄÃûý3=

�Wó�ìUý3ìñkÕÄ�gU�no�p����pT�+KívéUÂí ÄÃWó>fËðU

ê�Á�§¨��ïìgYU3pe­Þì3�no#�ð�fUåk���ê��$Î��Q4 21ã3I�\U��<3ÇÄ��$Î�� structure biological medicine DE8UÕW!ñÇÄÃWó��<no#b�ïì�ÏÙÓ²í�´\�no#p'b�ñ+ÄéY�´ÐÐ�$�b�3ÒÓb�3�

��ñvwÇ�F ��/ê�ÉÊñ|LÄÃWóã!ðïÂl�ðí�µ­Þì3pæ�3ÄÃWó ý3ì��µê.Âï�]I~ªð��T�Þ��ÑË"©»� 100 =�Ë��¯-.âÜ|�À"

Ë"�Ñ� 30=U'3ÄÃWó 1!îVï(W 3îUÏW îVï(W!��(Þ��cno#ñã!=ºLÄéìïUÇ Lancet 1996 ��

BBRC1999�UòÃÄ, JACI 2003�!�IgE ��(Þ IL-12�IL-12Vè�éW�Kê IL-18�IL-18Vè�éW�IFNÝ�ZQ8YZ��£ñÏÇKó�ý3ì��µñô3UÇÄã!U{iwÄ�+KUîUÏW îVï(W!ñno#�ðU"�ÇKó4�ìU�ý3ñô3UîVï(W îUÏW!�

no#F 9¡UñìpÇ�F�º»�=�W 2007�2008 �!ó5gU IL-18 �éY�´ÐÐ�$ñã!U{iwÄvéÇ Nature structure biology� 2003!�Ë�§¨ÉÊ3ÇÄ�$"#�kñ|LÄÃWó6no#ij3}îVï(Wkúµïì¿^��/�Ví®¯�îîVï(W��WSWØ×Î�/

�§Ðñ|LÎ0¶78�íW;WØ×Î�/0�f�KL��9ëÏñã!=ºLÄm�ÇKó:n

o#p'�RNA��è¡�YZFU RNA editing3 alternative splicing­îVï(Wp¥U�®÷ÄÃWý3ñã!=ºLÄvéÇKó;×ÎîVï(W�}ÏFb�p'Ò��vé�KL�Tgh´�WY�sÐUã!=ºLÄ�èÇ�îVï(Wp¥UvwW HLA�á�òÎ�T ghVè�éW�Fb3:ªñÐÐ�$ïìvéÇÄÃWó PNAS 2008u!<ý��µUDFÃÄ�++���=eñüQVW�/f§Ð�KLÎ×�Ä�V×Þ�ìpÏ��ÙÓ´U­'4|`ÇÄÃWó>Ûþ3no#UÕ

WîVï(Wp¥�"#no�ðvé 21 ã3I�\U��<3ÇÄ�nno#'�� genetic ecological medicine -E8UÕW!ó?zl�UÕ¥�NF-kappaB�ÒÓ­l�Ç� ×U7×Y �éWY­l�VWý3ñéìïUÇKó�ìU@Á8�<��Yïì��3ÐdÖÕno#3���ñZ

ÍÇÄÃWóAÀô��Þ3��3���ñ«�Ç�/ìpUÂí WKLU�Toll like receptor TLR!vÕ�Ë��ZQïoTÞ�MyD88"#íî�"#vÕ�Ë3ì�:ªBCñéìïUÇ��ÖUË3ì�no#�ðéY�´�$�ðb�ñéìïUÇÄÃWóD\UV\3îVï(Wp¥�"#no�ð

vé�Í×ï\ �UÕWîVï(Wp¥�î;9ÎYü7\�WÎ�ÂÃ3�WSWØ×Î�/�X�

yà QOLÂÃæ�m��EF���ÙÓ´U�FACSñÊÃKÀô��Þn� Tgh�vw3�Þ��Þ Th1�Th2 îYñ;Y\�vé3ÉÊíîóGÊ����ÙÓ´UU�ÇÄÊ@�]I~ªð}�p¹ñ�Þ=ëKó "���h����Tíîê^H�I! 1. J"���hy���ÞK"���hyz{|�/ìp+Tô���îVï(W���céY�´

XÐÐ�$UDFÃK�$Î�ð�kUÕW�/f�§Ðý��ræ�� E8Ùb� ��8Â�� å8

\���a�>±��fLÀ�@2M`�¹#À3�å?XL��*N#�O��7�$%4"�N_0

P ¿� 13B15�! 2. JPQ½h����T��¹K��îVï(W��¥¦��/��X±ôîVï(W����/

&É¥�c#�§Ð�íW;Ø×Î�/f�§ÐU�VW��ýö����� E8� Ùb� R2� �

*� N#Sï ¿� 16B21�! 3. JÎÞ ±�Æ�KL�b"OTª��¶·X±Kb"OTª��ìpIô×ÎîVï(W@�

×Þ�DR��UDFûl�ð��ý��ræ�� E8Ùb� R2� ¹#À3Sï ¿�17�Õ¥5�Ñ!

2!{)��;i¥3 DNAAp IgG ë´;\áU¥��c3íWno#b�ñã!U{iwéìïUÇK J Clin Invest �

JACI!ó��GÐ^�no�Cñ3Wy IgM¥����cUÂÃÄô AID� dominant negativeúµUÕWý3ñã!=ºLÄéìïUÇK JACI 2003�!ó'(ðVz�yÃ��;i¥=�W IgAáU¥UÂÃÄvwñ`ÃË� B gh�"�÷°�CñéìïUÇKó�ìU�fW 2 ì����Z�ë8Y�jno#�áU}ÞñjÊÇKóyp~3��;iñÏV Bloom¥��� Ataxia-telangiectasia��cno# BLM 3 ATM �ÒÓ3�$�vwñkÇÄgh±��DNA Ap��ZQïoTUÂëvéÇp~Ò��véñ`÷ÄÃW Blood, CEI, PNAS u!ó�ìU±XíÀô��;i¥�ÀÁÆ¥����c�'vé3�/ìpUõ�ÇKó

3!²Òürsb�¥ �UYÐrsb�¥�FU ´�Xï-CoA:3-�Uü CoA U;Y\¢Ó;W| SCOT!3��Uò�

;W|áU¥�YZF �no#F UvÃÄê�ã!�ïì��Yñ�wÄvwñ`÷ÄÃWóý3�

=±û�no#lb3Ë�F,ñéìïUÇÄëKóñ]`ñôÂ¥I���Uò�;W|áU¥�SCOTáU¥�1Iì3�§¨��ZÃUÂÃÄôéìïUÇÄÃWó¢�Y;YÎ�ZïW�3�j���=�gU�ghXò�;W|3�U[YÎ8îîèUîèòï-CoAò�;W|� 3��$ñS1Ç��ìUî��ül�­�NU´kWíîUÂÃÄ�vwñ|LÄÃW��[]�3�j���=�W�ü

�ü�Þb�¥��Nno#vwô`÷Ä�µ­ÆÄëÄÃWó 4!no<[±�¥ no<[±�¥UÂÃÄ·�F �"#�'vw��/fìpU¤¥Ë®=ÃWóFU<[±�¥\

AI���=ê�-.��ÙÓ´U�©]ðÐ�=��vw��/fìpñ`÷Äv¥�HI�Àô^n��YZ�a/f�<[±�¥i_�·��\\´8WXYZ�\í<�ìpôuâÄ�vYòóW�±

3�j���ô|LÄÃWó 5!áï�9�«W<� {)áï�9�«W<rsb�¥��c3�/UÂÃÄ��ñ|LÄv¥�áï�9�«W<áU¥

�+��cno# PEX16,19,13,3,26 ��1�?z 2'ø�pØ�+Kí�ü�YZáU¥�pØ�!#NXÙ\U�¢�W�þ`(a�MÀUÂÃÄã!ñ8WÎVW�µñ� ÄÃWóno#F 3Ç

Ä PEX10no#� 2bDác�PEX16no#b��PEX26no#b�íîñF ÇKSï���UFbíì3ÇÄ�Zellweger¥���§¨�ñdÇALDPno#ñ�É large deletionìñF ÇKó�K�áï�9�«W<áU¥�?z 2UÂÃÄêéY�´ÐÐ�$vw�¥I?z 2�Éï�Í

\�m�íîñ`Ã�f¥��'vé3�/f�ìpU¤¥Ë®=ÃWó�>=�áï�9�«W<�*

+pb�UvwW��UÂÃÄ���ËÌ��ð�fñÊÃÄvw�=�Wó 6!éY�´ÐÐ�$vw tu������NX�ÐÐ�$vwUDFÃK�'vw��/f�ìpíîñ`�Ï�$��Ï�§

Ðñ�PÇ�$"#8qYÎ\´8WXYZ��NVvï=��NÈ�ðî��WòUÕW�/f�ìp

U�YñNÃÄ��ñ|LÄÃWó�K�Àô��ïì�Þ��UeW+·U�´VW�IL-18�IL-1�� Toll-like Receptor�UÐfí"#=�W�ZQïoTîS�éW�Nñ��UÇK�$�ð��ñ|LÄÃWóKE��µ��Â3ÇÄ�±��¯MjmfUÄS1ÇKgU IL-18 ÐÐ�$ñô3U�lbÐvwñ`Ã�×YéW�×9YUvwW+ÇÃ:ªBC�véUe÷Kó

7!'4j�=`®3ÄÃW��ÙÓ´U IL-18 3Ë�:ª"#�éY�´ÐÐ�$3ÒÓ� E8Ùb�å8\��!:ª]�� N_0P�

Ataxia-telangiectasia3 Bloom¥����'vw� E8Ùb!�W\U;8î� Queensland Institute of Medical Research Professor M. Lavin�tu0¶78� QOLÂà E8Ùb��*N#!¿EÞ���}îVï(Wk3no#U�VW��� E8Ùb��*N#!]ßkÞȱ�<[±�¥�YZ�

a/f�DRð��vÕ�§¨ÉÊ� E8Ùb�àáâ�!USA St.Louis University ��³� ­�}��¢£¤y 2���"#�'U�VW��� å?XL!�W\U;8î� Queensland Institute of Medical Research Professor M. Lavin�ò�;W|�N� 3��$3ÒÓU�VW��� å?XL!¢�Y;YÎ Oulu University Professor R.Wierenga�CoAU;Y\¢Ó;W|�N� 3��$3ÒÓU�VW��� å?XL!¢�Y;YÎ Oulu University Dr.P.Kursula�{)�UYÐrsb�¥U�VW��� å?XL!�;YS� Amsterdam Medical Center Professor RJA Wanders�{)�UYÐrsb�¥U�VW��� å?XL!USA Oregon Heath and University Professor M. Gibson�{)�UYÐrsb�¥U�VW��� å?XL!7QS� Ste-Justine Hospital, Montreal, Professor GA. Mitchell�Ûg�0iãHacn¥UvwW*+lÒ�ñvéVWKL�DRð��� àá���E8Ùb!USA St.Jude Childrens Research Hospital Associate member Peter J. McKinnon���

GÐäy IgE¥���Ïcno#�ZÍ� ¹#À3�E8Ùb!9:����]�]��� ��îVï(W� å2r`�ATM3 BLM�Iª� ¹#À3!�W\U;8î� Queensland Institute of Medical Research Professor M. Lavinó

8!+Kí��ÙÓ´U ¨�*+�� '`­æç¥íî!�F 3�/ìp ��/íî!,Ç���8Í�ò3À

Á������/ìp�noyp~�� P53áU�ATMáU�BLMáUíî!U@VWno#���/ìpíîUõ�ÇÄÃWó

2Xbc �³� �³(u�)� �³(u�)� %�� %�� %�� §¨%�� §¨%�� §¨%�� �2� �2� �2� �2� �2� �2� �2� �³(u�)�

E8Ùb å?XL ¹#À3 å8\�� �fLÀ �*N# àá�� è­«² ]�k1 _ft�# t�«7 )%3o ?�k` Oã�� ²Øu± é*À3 @2M`

Naomi Kondo Toshiyuki Fukao Hideo Kaneko Zenichiro Kato Takahide Teramoto Eiko Matsui Kenji Orii Michinori Funato Hidenori Ohnishi Minako Kawamoto Michio Ozeki Yusuke Aoki Hideyuki Morita Kazuo Kubota Tetsuji Tokumi Hideo Sasai Nobuyuki Shimozawa

3X��Fd�ef Ü !"!

1! E8Ùb�Oϳt�×ÎîVï(W�p¥Òe3�/�¥¦�78� n�_fM��êEo����D`�§5Ó3=�×ÞZ�38\´¡ë�KL�¦)ST�9:��W�<�WÆ8;2006��137J147�

2! E8Ùb�;éì��W5s��?ín�?_"y=�î^F ��9ëWôtu­®��9ëý¢�WòóWUÕ¥W�9:�§¨�k��8I;2006��50�

3! E8Ùb������?_"y�dE� ��Ï� ï�=��Etu��� � 68;9:���Ü�;2006��288J311�

4! E8Ùb�� 1.îUÏW��Æ�1_���@���'���c� 3,�c�Ef!ð�WOñ�=�îUÏW��ÆF/q×Î;×Y 2006�9:�8!�l;2006��4J6�

5! E8Ùb�îVï(W����Ob3�t�W6�Ï��o�ò*pó#=�NEWtu��� [ï� 28�9:�¾��;2006��286J304�

6! E8Ùb��*N#�Oϳt�� 6.îVï(W���Ef�7=�ñ×�vw�F ST�íW;WØ×Î�/ê�ÉÊ�9:��J�<�WÆ8;2006��138J144�

7! E8Ùb�îUÏW��Æ�ôÕõv=�tu���F �/DE� � 38�9:�9:��H;2006��258J259�

8! E8Ùb�{)��;i¥���Áf����I=�¿� 18�zhb{�AI"½[W\�9:�Áf����I;2006��1J27.

9! å?XL�²Òürsb�¥�]�n6�x_� ö�Ç�}��=�ÄÁ�tu�/P?� � 148�9:���Ü�;2006��168J169.

10! E8Ùb�Oϳt�I-B78��'3p¥Òe�6���VWno#ñLû÷Ä�]�� õ���M4!=��ÜÝ� common disease�F/� 0¶78�V�Ä�9:�"��;2007��62J66�

11! E8Ùb�§¨=Å���3�Ø� 5�îVï(W���K�� 4�¡�÷3�EÔ3��=��+§¨�Ø��9:���Ü�� 2007��362J368�

12! E8Ùb�� 1.� ×ÎîVï(W��'3¥5�ÁftuîVï(W�I=�îVï(W��F ��/q×Î;×Y�9:�8!�l;2007��317J322�

13! E8Ùb�\[YU�Wï�3KÝ4\í�×Î�ù�3�²�b. ÍË����²�t��3�1f"4� =��0¶78�Õ¥ÕÃ�/�KLUWPharmaco Kinetics, Pharmaco DynamicsïìØK78�/��#�9:��jHøùICIH;2007��98J99.

14! ]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��1J1855. 15! E8Ùb�tu����/©Ë�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008

��85J86. 16! E8Ùb�;éì�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��267J273. 17! E8Ùb���Ò�—Ц)Ò��]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;

2008��833J837. 18! E8Ùb���;i¥�"�3F �]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;

2008��837J850. 19! E8Ùb�Wiskott-Aldrich¥��(WAS)�]�n6�E8Ùb� ©=��tu�� 38�9:���Ü�;

2008��862J863. 20! E8Ùb�Ûg�0iãt�cn¥�Louis-Bar ¥���]�n6�E8Ùb� ©=��tu��� 3

8�9:���Ü�;2008��863J864. 21! E8Ùb�Nijmegen breakage¥���]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;

2008��864. 22! E8Ùb�ArtemisáU¥�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��

864. 23! E8Ùb�Bloom ¥���]�n6�E8Ùb� ©=��tu��� 3 8�9:���Ü�;2008 ��

864. 24! E8Ùb�DiGeorge¥���� 3�� 4úû¥���]�n6�E8Ùb� ©=��tu��� 38�9

:���Ü�;2008��864. 25! E8Ùb�îVï(W��'��c�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;

2008��925J928. 26! E8Ùb�îUÏW��Æ�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��

948J952. 27! å?XL�Ø�jî�ï - CoA² ZYZ(VLCAD)áU¥�]�n6�E8Ùb� ©=��9:���Ü

�;2008��475. 28! å?XL��j 3 -gÎ�9�î�ï CoA² ZYZ(LCHAD)áU¥3�©YZ(MTP)áU¥�]�n6�

E8Ùb� ©=��tu��� 38�9:���Ü�;2008��476. 29! å?XL�üj 3 -gÎ�9�î�ï CoA² ZYZ(SCHAD)áU¥�]�n6�E8Ùb� ©=��t

u��� 38�9:���Ü�;2008��477. 30! å?XL�2,4 -Ù��×ï- CoA��YZáU¥�]�n6�E8Ùb� ©=��tu��� 38�9:�

��Ü�;2008��478. 31! å?XL��jî�ï- CoA² ZYZ(MCAD)áU¥�]�n6�E8Ùb� ©=��tu��� 38�

9:���Ü�;2008��477. 32! å?XL�üjî�ï- CoA² ZYZ(SCAD)áU¥�]�n6�E8Ùb� ©=��tu��� 38�

9:���Ü�;2008��478. 33! ¹#À3�Chediak—Higashi¥���]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;

2008��865J866. 34! ¹#À3�Griscelli¥���]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��

866. 35! ¹#À3�X�j8Y�[\���]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;

2008��866J867. 36! ¹#À3�Ë�u���n�;i����]�n6�E8Ùb� ©=��tu��� 3 8�9:���Ü

�;2008��867. 37! ¹#À3�òp��;i¥� ©Ë�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;

2008��879J883. 38! ¹#À3�Behcet ��]�n6�E8Ùb� ©=��tu��� 3 8�9:���Ü�;2008 ��910

J912. 39! ¹#À3�Sjogren¥���]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��

912J913. 40! ¹#À3�ý£Æ�þý�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��1018

J1020. 41! �fLÀ�´8X7ï�\�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��

290J292 42! �*N#�®��©Æ( �¥��)�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;

2008��993. 43! �*N#�®�©�òÆ�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��

993J994. 44! �*N#��ò±�þ.��¹þ.�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;

2008��994. 45! �*N#��ò°](���ò�îÉ�×Î)�]�n6�E8Ùb� ©=��tu��� 3 8�9:��

�Ü�;2008��994J995. 46! �*N#�FpÑX�Æ�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��

1012J1014. 47! �*N#��¹�ÙÉ�W�\�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008

��1014J1015. 48! �*N#��h�N¥�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��1015

J1016. 49! �*N#�bX��Æ�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��1016

J1017. 50! �*N#���þ¥(�þ.)�]�n6�E8Ùb� ©=��tu��� 38�9:���Ü�;2008��

1017J1018. 51! E8Ùb� u���[{Ö��/f ÍË�1f"4�t��3����²� =��78�[{�3Ë�@

É�;×¢ ×�Y\;2008��106J119.� 52! w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:;ØÙ7ï�:WH;2008

�� 53! E8Ùb�pì�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:�ØÙ7

ï�:WH;2008��70J73. 54! E8Ùb�p�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:�ØÙ7

ï�:WH;2008��93J94. 55! E8Ùb����w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:�ØÙ

7ï�:WH;2008��108J109. 56! E8Ùb���;i¥�"��w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���

9:�ØÙ7ï�:WH;2008��335J337. 57! E8Ùb�îVï(WF/�DRÖ��w�Ð�²���]2�%#�E8Ùb��=±� =�%_£t

u���9:�ØÙ7ï�:WH;2008��361J363. 58! E8Ùb�tu0¶78�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9

:�ØÙ7ï�:WH;2008��364J367. 59! E8Ùb�îVï(W�Æ�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���

9:�ØÙ7ï�:WH;2008��368. 60! å?XL�DNA�no#���<�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu�

��9:�ØÙ7ï�:WH;2008��181J184. 61! å?XL�no���"�3Vz�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu

���9:�ØÙ7ï�:WH;2008��185J187. 62! å?XL�B�no#��w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:�

ØÙ7ï�:JH;2008��188J190. 63! å?XL��Z ×´ïb�¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���

9:�ØÙ7ï�:JH;2008��221J222. 64! å?XL��rsb�¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:�

ØÙ7ï�:JH;2008��223J226. 65! å?XL��8ï�Yrsb�¥3�ï¢�8Yrsb�¥�w�Ð�²���]2�%#�E8Ùb�

�=±� =�%_£tu���9:�ØÙ7ï�:JH;2008��237J239. 66! å?XL�Ûg�0iãcn¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu�

��9:�ØÙ7ï�:JH;2008��355J356. 67! å?XL�Ë�u���b�¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���

9:�ØÙ7ï�:JH;2008��359J360. 68! ¹#À3���Ò��w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:;Ø

Ù7ï�:JH;2008��332J334. 69! ¹#À3��ª��;i¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9

:;ØÙ7ï�:JH;2008��338J339. 70! ¹#À3�X �j¤qY�Z�ë8Y�¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_

£tu���9:;ØÙ7ï�:JH;2008��343J344. 71! ¹#À3�"�;ÓI��;i¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu�

��9:;ØÙ7ï�:JH;2008��345J346. 72! ¹#À3�IgAá%¥�"½ð IgG ë´;\á%¥�w�Ð�²���]2�%#�E8Ùb��=±�

=�%_£tu���9:�ØÙ7ï�:JH;2008��347J348. 73! �*N#�Õ®��w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:�Ø

Ù7ï�:JH;2008��369J370. 74! �*N#�îUÏJ��Æ�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���

9:�ØÙ7ï�:JH;2008��371J373. 75! �*N#�Í×ï\ �¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9

:�ØÙ7ï�:JH;2008��398J400. 76! �*N#�g� �¥��×[�;���w�Ð�²���]2�%#�E8Ùb��=±� =�%_£

tu���9:�ØÙ7ï�:JH;2008��401J404. 77! �*N#����\Ï�¹Jé�´;�Ùî�8�¡òî �¥�w�Ð�²���]2�%#�E8Ù

b��=±� =�%_£tu���9:;ØÙ7ï�:JH�2008��405J406. 78! �*N#�æ4 �¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:;

ØÙ7ï�:JH;2008��409J410.

79! �*N#��C^ �¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:�ØÙ7ï�:JH;2008��411J413.

80! �*N#� �¥�w�Ð�²���]2�%#�E8Ùb��=±� =�%_£tu���9:�ØÙ7ï�:JH;2008��414J415.

81! è­«²�]��#��?#1�æ��b.�MFICU�Ð��u�X:îï�ØÉ�7Æ8� ]�;2008��368J374.

82! E8Ùb����îVï(J���K�� 4� ,A��@� ��E9�����@é�·_��#� =��§¨�Ø��/�bâ� �'^=�9:�¹ÏÆ8;2008��423J440.

83! E8Ùb�0¶78��?� �� ,A�$%ö/� =��Õû®ïW�'� 15 tu���9:�Áf�X+jH;2008��122J126.

84! E8Ùb�îUÏJ��Æ��?� �� ,A�$%ö/� =��Õû®ïW�'� 15 tu���9:�Áf�X+jH;2008��127J130.�

85! E8Ùb�����?� �� ,A�$%ö/� =��Õû®ïW�'� 15 tu���9:�Áf�X+jH;2008��131J132.�

86! è­«²�� 5.� b�"��0�3�N�MFICU(± ��/)�·8LI� =��MFICU�Ð��uICU�X:îï�9:�ØÉ�7Æ8;2008��368J374�

Ü S"!

1! Kondo N, Kato Z, Kaneko H, Fukao T, Matsui E, Aoki M. Molecular mechanisms of hygiene hypothesis. In: Holgate S, Marone G, Ring J, eds. Cellular and Molecular Targets in Allergy and Clinical Immunology. Gottingen: Hogrefe & Huber Publishers; 2007:36-37.

2! Matsuura N, Tada H, Nakamura Y, Uehara R, Kondo N, Yokota Y, Kaneko H, Fukushi M.Effects of Dioxins in Breast Milk on Thyroid Function in Infants Born in Japan. Maatoshi Morita M et.. Persistent Organic Pollutants(POPS) Research in Asia, Tsukuba, 2008:368-374.

©è !"!

1! E8Ùb��*N#�Oϳt�_f1�)%t�#��fLÀ�¹#À3�å?XL�å8\����*ót�+*vß�t2� ��%=� ��îVï(W���¥Ö�¥¦ê�Óï�ÁftuîVï(W

�Iâ� 2006�;20G�44J54. 2! E8Ùb�é§U1_�3K��;i¥-Wiskott-Aldrich¥���Ûg�0iãcn¥íî-�tu�F

/� 2006�;69G([å�)�257J259. 3! E8Ùb�Oϳt�tuîVï(W��UvwW QOL n��b.�îVï(W���� 2006 �;13

G�32J43. 4! E8Ùb�1.tuîVï(W3��no�—îVï(W��c���no#3no#�ð"��s¦W�

tu�§¨� 2006�;59([å�)�1209J1213. 5! mE²#��Ñ���²�06�78�#���fP3�5�2�P�E8Ùb�¨��t#�x�G��

pû�"�×ÎîVï(WF/q×Î;×Y�Áftu��Iâ� 2006�;110G�904J911. 6! E8Ùb�îVï(Wp¥ê¥Ö=ëW��Q&A=®ïWîVï(W��� 2006�;2G�318J320. 7! E8Ùb�tu0¶78�/�0�q×Î;×Y 2005 ñî�xÉï� � 6 .tu0¶78�¼äc

#3Ë�¥¦�ÁftuîVï(W�Iâ� 2006�;20G�233J237. 8! E8Ùb�×ÎîVï(WF/q×Î;×Y 2005 vè� � 3 .×ÎîVï(W��'�ÁftuîVï

(W�Iâ� 2006�;20G�238J239. 9! E8Ùb�r��´�Ataxia-telangiectasia�d"q¥��(� 2 8)Å�Áf§�� 2006 �;3 G�114

J118. 10! E8Ùb�Oϳt��Ýu�UvwWno�Ûþ£c3îVï(W���§¨���îVï(W�� 2006

�;46G�273J279� 11! E8Ùb�Ý4\í�×Îk��ê�íî—ëÉ«XÎÝ4�«ñ��U��Pharma Medica� 2006�;

24G�49J53. 12! a�>±�¹#À3�E8Ùb�Å.×ÎîVï(W��'�îVï(W���� 2006�;13G�22J28. 13! E8Ùb�KE�îVï(WF�q×Î;×Y�îVï(Wî� 2006�;35G�62J64� 14! E8Ùb�Oϳt�tu78���¥¦���¥¦���¥¦�'53´ÅY�§¨���îVï(W

�� 2006�;46G�501J508. 15! å?XL�E8Ùb�ó�V�ëîVï�Y3Ë��' ×��²[��3îVï(W�p¥�§¨���

îVï(W�� 2006�;46G�604J612. 16! E8Ùb�Oϳt, �*N#�no3îVï(W�ïì­���� 2006�;252G�24J28. 17! 78�#�E8Ùb�×ÎîVï(WF/q×Î;×Y 2005 vè� � 5 .� ×ÎîVï(W�F �Á

ftuîVï(W�Iâ� 2006�;20G�526J530. 18! @2M`�$%ö/�áï�9�«W<��®­-=�c­vé�3K{)rsb�¥�tu�F/� 2006

�;69G�1646J1652. 19! $%ö/�þ¥5=ØÂïW{)rsb�¥�Á�F/=�{)rsb�¥�tu�F/� 2006 �;69

G�1590J1594. 20! àáâ��å?XL�wÃ3®�Q�÷°ñòýV����/�0���×YU�²Òürsb�¥�t

ud�� 2006�;38G�452J454.

21! å?XL�tu���F �/DE� ataxia telangiectasia�tud�� 2006�;38G(§Ö[å�)�232J233.

22! �fLÀ�)%t�#��*N#�E8� ��_f1�¹#À3�å?XL�E8Ùb�RSÍ×ï\ �378p¥— �UÕW78�p¥�[{�Òe—, îVï(W���� 2006�;13G�1031J1037.

23! Ä* ��r!�"#�#f�3¦�¿�$#�%&�#�%=� ��t2� ���*ót�å?XL�r!'�àá÷7��uã�(=�ã���¥5�l�UÂÃÄ�ZÍ�ã�3ãõ� 2006 �;12 G�31J33.

24! r!� '�w�)u�)%3o�$%Ë#�+*vß�å?XL�E�+t#�%&�#��*+�×Y¢ï�YR�ªu¥5U@VWúµ�ZÍ��>3���îVï(W� 2006�;20G�44J53.

25! Kft,�WOñ��E8Ùb�&�IôîVï(W���p¥¥Ö3¥¦ê�Óï�ý�Q&A =®ïWîVï(W��� 2006�;2G�337J350.

26! E8Ùb��*N#�Oϳt�_f1�)%t�#��fLÀ�¹#À3�å?XL�0¶78�p¥¥¦�Áftu��IFâ� 2007�;111G�23J27�

27! E8Ùb�îUÏW��Æ�tud�� tu���F �/DE� � 38� 2007�;38G([å�)�258J259.

28! E8Ùb�78�íW;WØ×Î(¿^�)�/�'53cdê�î��Jò�International Review of Asthma� 2007�;9G�8J29.

29! E8Ùb�îVï(Wp¥UvwWno#3Ûþ�îVï(W� 2007�;56G�94J100� 30! E8Ùb�Q&A ´-¥UvwWÞG¥53iÜðí¥5ê�î�Õ�U@ÉÇKìÕÃ=Vï�Allergy

From the Nose to the Lung� 2007�;5G�17� 31! E8Ùb��*N#�)%t�#�+*vß�¹#À3�å?XL�Oϳt�Ûþ­ÐUïVíî�

ÁftuîVï(W�Iâ� 2007�;21G�92J95� 32! çÐ3��*�.��cf�±�E8Ùb�pû�"�?_"y��Ñ���tu0¶78�/�0�

q×Î;×Y 2005­�u78��/'�U´kKô�J� 15¡tu«îVï(W��I=�îY�WUn�:µÕ¥J�ÁftuîVï(W�Iâ� 2007�;21G�116J123.

33! E8Ùb�×ÎU@VW��Éý�b�3×ÎîVï(W�tud�� 2007�;39G�545J548. 34! E8Ùb�Oϳt�îQ¢�;9�W�tu�F/� 2007�;70G([å�)�111J112. 35! E8Ùb�no#F �/ª§¨� 2007�;56G�1883J1890. 36! E8Ùb�×ÎîVï(W��'��îVï(W� 2007�;56G�439J444. 37! E8Ùb� Q&AîUÏW��Æ�#¶­78UíìíÃKLUê� Answer�� Q&A=®ïWîVï

(W��� 2007�;3G�273J274� 38! E8Ùb�&�I tuîVï(W� QOLÂÃf3§¨UvwWQ_�Pediatric Allergy for Clinicians

2007�;3G�5J11� 39! å?XL��UYÐrsb�¥� FUîèUY�01¥3î^V�ë ´�XïJCoA�3J�Uü CoA

U;Y\¢Ó;J|áU¥ñ��U�Áftu��IFâ� 2007�;111G�727J739. 40! å?XL�á¡U��Ûþ3tuîVï(W�îVï(W�§¨� 2007�;356G�129J135. 41! $%Ë#�¹#À3�E8Ùb�IgA ë´;\(IgA1, IgA2)�F�§¨���îVï(W�� 2007�;

473G�652J657� 42! _f1�å?XL��*N#�_ft�#�¹#À3�E8Ùb�EF�ñÊÃKÆ[àWU��U

ÕWtuîVï(W���ÂÃ�îVï(W�§¨� 2007�;27G�77J82� 43! E8Ùb�×ÎîVï(W3Ë�@��±K¸� 2007�;71G�11J15. 44! E8Ùb�çá�/§ã�KL�2Â�pe)ý—úû]ôçá�/��èYéWý�ÔЗ�Áf�X

+j� 2007�;4364G�80J85� 45! E8Ùb�kÎîVï(W�F 3�/�tu�§¨� 2007�;60G�2319J2327� 46! E8Ùb�×Þ3îVï(W�FOODS & FOOD INGREDIENTS JOURNAL OF JAPAN� 2007�;212

G�997J1001� 47! E8Ùb��*N#��=�ï3�0¶78�uU@VWíW;WØ×Î�/�tu�� 2007 �;48

G�1981J1988. 48! E8Ùb�Уc3Ûþ£c3��®¥ïì��@�ñ#kW�Áf�X+j� 2008 �;4367 G�

49J50. 49! �*N#�_f1�å?XL�E8Ùb��Ýu����Éý�l43îVï(W��p¥�îVï

(W���� 2008�;15G�170J174.� � 50! E8Ùb�×ÞîVï(W3Ë��/jk�Milk Science� 2008�;56G�138J140� 51! E8Ùb��*N#��=�ï3�tu0¶78�íW;WØ×Î�/�78� 2008 �;21 G�40J

46. 52! ]�k1�å8\���5� ³6�%=� ��w�)u�²Øu±��¡!b��*N#�¹#À3�E

8Ùb�7?�J�N_0P�"#Î�ðî��Wò�×Y�´U� ILJ18��ZQïoTÞéY�´X�$vwUDFû�kê�î��Wò�ÁftuîVï(W�Iâ� 2008�;22G�63J70�

53! E8Ùb�í8îVï(W­[åÇK�ï�BIO INDUSTRY� 2008�;25G�7J14.� 54! E8Ùb�=�¹÷�ÁftuîVï(W�Iâ� 2008�;22G�464� 55! E8Ùb�1f"4�]�� õ�U�ïü\�;é\U9�� 78�/UvwW Th2 ×U7×Y�°k

�CNFw�PROGRESS IN MEDICINE� 2008�;28G�2167J2173.� 56! ¹#À3�E8Ùb�"�;ÓI��;i¥�îVï(W���� 2008�;15G�2J9.

57! r!� '�¹#À3�]�k1�:ÏLt#�E8Ùb�tu×Y¢ï�YRUvwW�*+�úµ3�/�"½UÂÃÄ�ZÍ��>3���îVï(W� 2008�;27G�22J33.

58! E8Ùb�QOLn�;��Ã>�Pediatric Allergy for Clinicians� 2008�;4G�31J35.� 59! å?XL�XhÉý� tu��UW�\�� Áf�X+j� 2008�;4329G�89J90� 60! ¹#À3�����b�UÕW��;i¥�ýý�="ï÷ÄÃW��;i¥���tu�F/� 2008

�;61G�1775J1782� 61! å?XL�IgG ë´;\áU¥3 IgAáU¥�tu��F/�KL��'��� 48� tud�� 2008

�;40G([å�)�1288J1293� 62! ¹#À3�Ataxia-telangiectasia 3Ë������tu��F/�KL��'��� 4 8� tud��

2008�;40G([å�)�1314J1317. ©è S"!

1! Matsui E, Kaneko H�Fukao T�Teramoto T�Kondo N. Tailor-made edicine and gene polymorphisms in bronchial asthma. Int Rev Asthma. 2006;8:64-72.

2! Shimozawa N. Molecular and clinical aspects of peroxisomal diseases. J Inher Metab Dis. 2007;30:193-197.

3! Kondo N�Munakata M�Rosenwasser LJ. Round table discussion�tailor-made(personalized)medicine for asthma-current situation and future vision�Int Rev Asthma. 2007;9:7-29.

4! Kondo N. Current position of Japanese and Chinese medicine in regard to tailor-made medicine -From the viewpoint of allergic disorders-. J Tradit Med. 2007;24:43-46.

5! Kondo N, Matsui E, Nishimura A. A genetic classification and a tailor-made medicine in allergic disorders. Korean J Asthma, Allergy and Clin Immunol. 2007;27:83-86.

6! Mukoyama T, Nishima S, Arita M, Ito S, Urisu A, Ebisawa M, Ogura H, Kohno Y, Kondo N, Shibata R, Hurusho M, Mayumi M, Morikawa A. Food Allergy Committee, Japanese Society of Pediatric Allergy and Clinical Immunology Guidelines for diagnosis and management of pediatric food allergy in Japan. Allergol Int. 2007;56:349-361.

7! Kondo N. From the Editorial Committee. Int Rev Asthma. 2008;10:4. 8! Kondo N, Hae Sim Park, Soo Jong Hong. Round Table Discussion-clinical application of molecular

genetics of allergy. Int Rev Asthma. 2008;10:5-21.

Ï !"! 1! �Ñ���ÉEL3�?_¦ë�<�!6�<Ï�t�?_"y�WOñ���=�X/�Õ>"#��

Ï3L�?� @�78�é���fP3�E8Ùb�pû�"�¿}}d�78�#�`y� A�²�0

6�x_ ö�BÉ3¿�tuîVï(W��UvwWîVï�Y m�i-n��ÁftuîVï(W�Iâ� 2006�;20G�109J118.

2! wÀ%��C�0#�E8Ùb���fP3�]Oã<D�îVï(W���·�o4(early intervention)�b.3ÂÃ�§¨���îVï(W�� 2006�;46G�3J20.

3! t�«7�N�"#�78Lt#��yE���%�F#�%�ks�E8!3���p�#�E�+v�82"t�G�:¯8Y��Æïì��Ð�ñp¥ÇKtuì�Áftu����IFâ� 2006�;25G�101J104.

4! �*N#�)%t�#�a�>±�r!� '�¹8åït�E8Ùb�QOL ÂÃ�bìHo�Pediatric Allergy for Clinicians� 2007;3G�25J29.

5! E8Ùb�¿EÞ����*N#��fLÀ�¹#À3�å?XL�àá���_ft�#�è­«²�]�k1�_f1�?�k`�%=��w�)u�²Øu±�s�.�IJß#�tu0¶78�u

3iKêã��� QOLn�;¸H[ï8 2008(GIFU)�îVï(W� 2008�;57G�1022J1033. 6! E8Ùb�tu�/(z=�'53´ÅY—]�tu��P��tu�F/ 2008�;71G�1879J1881. 7! ¿�$#�õ*��t�L_1#�r!�"#�%&�#�å?XL�È8�t#��2]M�t�«7�

r!'��uã�UvwW¥5Uª®âK���ZÍ�ã�3ãõ� 2008�;14G�46J49. 8! ?�k`�¹#À3�]�k1�E8���*N#�å?XL�E8Ùb���=eüQ�KL�×Îî

Vï(Wö£}ÏéY�´�DRðZÍ�ÁftuîVï(W�Iâ� 2008�;22G�233J238. 9! r!'�¹#À3�]�k1�:ÏLt#�E8Ùb�tu×Y¢ï�YRUvwW�*+�úµ3�/

�"½UÂÃÄ�ZÍ��>3���îVï(W� 2008�;27G�22J32� 10! )%3o�þtB�N�� ���*N#�Kf./�êEP�d�¬���Æ�/¹ 40Á+Äp¥ÇK�

£�Æ� 1ì�tu�§¨� 2008�;61G�2307J2311� 11! å8\���gU¹ïá\Í×ï\�6UÕW®t�Æ�tud�� 2008�;40G�586J588. Ï S"!

1! Gueven N, Fukao T, Luff J, Paterson C, Kay G, Kondo N, Lavin MF. Regulation of the Atm promoter in vivo. Genes Chromosomes Cancer. 2006;45:61-71. IF 4.532

2! Matsukuma E, Kato Z, Omoya K, Hashimoto K, Li A, Yamamoto Y, Ohnishi H, Hiranuma H, Komine H, Kondo N. Development of fluorescence linked immunosorbent assay (FLISA) for high throughput screening (HTS) of interferon-gamma. Allergol Int. 2006;55:49-54.

3! Uehara R, Peng G, Nakamura Y, Matsuura N, Kondo N, Tada H. Human milk survey for dioxins in the

general population in Japan.Chemosphere. 2006;62:1135-1141. IF 2.739 4! Kaneko H, Matsui E, Shinoda S, Kawamoto N, Nakamura Y, Uehara R, Matsuura N, Morita M, Tada

H, Kondo N. Effects of dioxins on the quantitative levels of immune components in infants. Toxicol Ind Health. 2006;22:131-136. IF 0.731

5! Funato M, Shimozawa N, Nagase T, Takemoto Y, Suzuki Y, Imamura Y, Matsumoto T, Tsukamoto T, Kojidani T, Osumi T, Fukao T, Kondo N. Aberrant peroxisome morphology in peroxisomal beta-oxidation enzyme deficiencies. Brain Dev. 2006;28:287-292. IF 1.464

6! Kaneko H, Matsui E, Asano T, Kato Z, Teramoto T, Aoki M, Kawamoto N, Lian LA, Kasahara K, Kondo N. Suppression of IFN-gamma production in atopic group at the acute phase of RSV infection. Pediatr Allergy Immunol. 2006;17:370-375. IF 2.454

7! Kato Z, Asano T, Kondo N. Inosiplex affects the spectra of proton magnetic resonance spectroscopy in subacute sclerosing panencephalitis. J Child Neurol. 2006;21:177-178. IF 1.240

8! Kaneko H, Isogai K, Kondo M, Hosoi K, Asano T, Funato M, Kondo N. Autologous peripheral blood stem cell transplantation in a patient with relapsed pleuropulmonary blastoma. J Pediatr Hematol Oncol. 2006;28:383-385. IF 1.278

9! Teramoto T, Fukao T, Tomita Y, Terauchi Y, Hosoi K, Matsui E, Aoki M, Kondo N, Mikawa H. Pharmacokinetics of beclomethasone dipropionate in an hydrofluoroalkane-134a propellant system in japanese children with bronchial asthma. Allergol Int. 2006;55:317-320.

10! Kondo N, Katsunuma T, Odajima Y, Morikawa A. A randomized open-label comparative study of montelukast versus theophlline added to inhaled corticosteroid in asthmatic children. Allergol Int. 2006;55:287-293.

11! Kato T, Isogai K, Orii K, Kuratsubo I, Kondo N, Orii T, Suzuki Y. Portal hypertension in a patient with Hunter disease. J Inherit Metab Dis. 2006;29:686. IF 1.668

12! Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity. 2006;25:745-755. IF 19.266

13! Zhang G, Fukao T, Sakurai S, Yamada K, Michael Gibson K, Kondo N. Identification of Alu-mediated, large deletion-spanning exons 2-4 in a patient with mitochondrial acetoacetyl-CoA thiolase deficiency. Mol Genet Metab. 2006;89:222-226. IF 2.550

14! Shiozawa K, Goda N, Shimizu T, Mizuguchi K, Kondo N, Shimozawa N, Shirakawa M, Hiroaki H. The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97. FEBS J. 2006;273:4959-4971. IF 6.791

15! Orii KE, Lee Y, Kondo N, McKinnon PJ. Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A. 2006;103:10017-10022. IF 9.598

16! Kawamoto N, Kaneko H, Takemura M, Seishima M, Sakurai S, Fukao T, Kasahara K, Iwasa S, Kondo N. Age-related changes in intracellular cytokine profiles and Th2 dominance in allergic children. Pediatr Allergy Immunol. 2006;17:125-133. IF 2.454

17! Fukao T, Sakurai S, Rolland MO, Zabot MT, Schulze A, Yamada K, Kondo N. A 6-bp deletion at the splice donor site of the first intron resulted in aberrant splicing using a cryptic splice site within exon 1 in a patient with succinyl-CoA: 3-ketoacid CoA transferase (SCOT) deficiency. Mol Genet Metab. 2006;89:280-282. IF 2.550

18! Sukegawa-Hayasaka K, Kato Z, Nakamura H, Tomatsu S, Fukao T, Kuwata K, Orii T, Kondo N. Effect of Hunter disease (mucopolysaccharidosis type II) mutations on molecular phenotypes of iduronate-2-sulfatase: enzymatic activity, protein processing and structural analysis. J Inherit Metab Dis. 2006;29:755-761. IF 1.668

19! Kato Z, Saito K, Isogai K, Kondo N. Magnetic resonance imaging and spectroscopy in FCMD. J Ped Neurol. 2006;4:261-264.

20! Kato Z, Omoya K, Orii KE, Kondo N. Acute disseminated encephalomyelitis associated with enterovirus 71. Pediatr Infect Dis J. 2006;1:115-118. IF 3.086

21! Horikoshi H, Kato Z, Masuno M, Asano T, Nagase T, Yamagishi Y, Kozawa R, Arai T, Aoki M, Teramoto T, Omoya K, Matsumoto N, Kurotaki N, Shimokawa O, Kurosawa K, Kondo N. Neuroradiologic findings in Sotos syndrome. J Child Neurol. 2006;21:614-618. IF 1.240

22! Takahashi Y, Matsuda K, Kubota Y, Shimomura J, Yamasaki E, Kudo T, Fukushima K, Osaka H, Akasaka N, Imamura A, Yamada S, Kondo N, Fujiwara T.Vaccination and infection as causative factors in Japanese patients with rasmussen syndrome: Molecular mimicry and HLA class I. Clin Dev Immunol. 2006;13:381-387.

23! Tomatsu S, Sukegawa K, Trandafirescu GG, Gutierrez MA, Nishioka T, Yamaguchi S, Orii T, Froissart R,Maire I, Chabas A, Cooper A, Di Natale P,Gal A, Noguchi A, Sly WS. Differences in methylation patterns in the methylation boundary region of IDS gene in hunter syndrome patients: implications

for CpG hot spot mutations.Eur J Hum Genet. 2006;14:838-845. IF 4.003 24! Tomatsu S, Montano AM, Lopez P, Trandafirescu G, Gutierrez MA, Oikawa H, Nishioka T, Vieira MB,

Orii T, Noguchi A. Determinant factors of spectrum of missense variants in mucopolysaccharidosis IVA gene.Mol Genet Metab. 2006;89:139-149. IF 2.550

25! Sakurai S, Fukao T, Haapalainen AM, Zhang G, Yamada S, Lilliu F, Yano S, Robinson P, Gibson MK, Wanders RJA, Mitchell GA, Wierenga RK, Kondo N. Kinetic and Expression Analyses of Seven Novel Mutations in Mitochondrial Acetoacetyl-CoA Thiolase (T2): Identification of a Km Mutant and an Analysis of the Mutational Sites in the Structure. Mol Genet Metab. 2007;90:370-378. IF 2.550

26! Kondo M, Fukao T, Shinoda S, Kawamoto N, Kaneko H, Kato Z, Matsui E, Teramoto T, Nakano T, Kondo N. Lymphocyte responses to chymotrypsin- or trypsin V-digested �-lactoglobulin in patients with cow’s milk allergy. Allergy Asthma Clin Immunol. 2007;3:1-9.

27! Kato T, Kato Z, Kuratsubo I, Ota T, Orii T, Kondo N, Suzuki Y. Evaluation of ADL in patients with Hunter disease using FIM score. Brain Develop. 2007;29:298-305. IF 1.464

28! Ochiai T, Suzuki Y, Kato T, Shichino H, Chin M, Mugishima H, Orii T. Naturalhistory of extensive Mongolian spots in mucopolysaccharidosis type II(Huntersyndrome): a survey amond 52 Japanese patients. J Eur Acad Dermatol Venereol. 2007;21:1082-1085. IF 1.437

29! Takahashi N, Morita M, Maeda T, Harayama Y, Shimozawa N, Suzuki Y, Furuya H, Sato R, Kashiwayama Y, Imanaka T. Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein(ALDP/ABCD1) with naturally occurring missense mutations. J Neurochem. 2007;101:1632-1643. IF 4.451

30! Yamada K, Fukao T, Zhang G, Sakurai S, Ruiter JPN, Wanders RJA, Kondo N. Single-base substitution at the last nucleotide of exon 6 (c.671G >A), resulting in the skipping of exon 6, and exons 6 and 7 in human Succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene. Mol Genet Metab. 2007;90:291-297. IF 2.550

31! Haapalainen A, Merilinen G, Piril P, Kondo N, Fukao T, Wierenga R. Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase (T2): the importance of potassium and chloride ions for its structure and function. Biochemistry. 2007;46:4305-4321. IF 3.368

32! Yamada K, Fukao T, Suzuki H, Inoue R, Kondo T, Kondo N. Vitamin K-Deficient Intracranial Hemorrhage as the First Symptom of Cytomegalovirus Hepatitis with Cholestasis. Tohoku J Exp Med. 2007;212:335-339. IF 1.133

33! Funato M, Kaneko H, Matsui E, Teramoto T, Kato Z, Fukao T, Okusu K, Kondo N. Refractory osteomyelitis caused by bacille Calmette-Guerin vaccination: a case report. Diagn Microbiol Infect Dis. 2007;59:89-99. IF 2.448

34! Kondo N, Matsui E, Nishimura A. A genetic classification and a tailor-made medicine in allergic disorders. Korean Journal of Asthma, Allergy and Clinical Immunology. 2007;27:83-86.

35! Ohya Y, Watanabe H, Kojima N. Katsunuma T, Kondo N, Akasawa A. Impact of Pediatric Asthma and treatment on care-givers visiting specialist clinics in Japan. J Allergy Clini Immunol. 2007;119:S41-S42. IF 8.115

36! Tomatsu S, Montano AM, Gutierrez M, Grubb JH, Oikawa H, Dung VC, Ohashi A, Nishioka T, Yamada M, Tosaka Y, Trandafirescu GG, Orii T. Characterization and pharmacokinetic study of recombinant human N-acetyl galactosamine-6-sulfate sulfatase. Mol Genet Metab. 2007;91:69-78. IF 2.550

37! Montano AM, Tomatsu S, Gottesman GS, Smith M, Orii T.International Morquio A registry:clinical manifestation and natural course of Morquio A disease. J Inherit Metab Dis. 2007;30:165-174. IF 1.668

38! Tomatsu S, Vogler C, Montano AM, Gutierrez M, Oikawa H, Dung VC, Orii T, Noguchi N, Sly WS. Murine model(Galnstm(C76S)slu)of MPS IVA with a missense mutation at the active site cysteine conserved among sulfatase proteins. Mol Genet Metab. 2007;91:251-258. IF 2.550

39! Montaño AM, Sukegawa K, Kato Z, Carrozzo R, Di Natale P, Christensen E, Orii KO, Orii T, Kondo N, Tomatsu S. Effect of 'attenuated' mutations in mucopolysaccharidosis IVA on molecular phenotypes of N-acetylgalactosamine-6-sulfate sulfatase. J Inherit Metab Dis. 2007;30:758-767. IF 1.668

40! Kato Z, Yamagishi A, Kondo N. Interstitial deletion of 1q42.13-q43 with Duane retraction syndrome. J AAPOS. 2007;11:62-64. IF 0.983

41! Kato Z, Nakamura M, Funato M, Kuwabara H, Kondo N. Accidental etizolam ingestion in a child. Pediatr Emerg Care. 2007;23:472-473. IF 0.581

42! Uehara R, Nakamura Y, Matsuura N, Kondo N, Tada H. Dioxins in human milk and smoking of mothers. Chemosphere 2007;68:915-920. IF 2.739

43! Aoki M, Fukao T, Kaneko H, Mizunaga S, Mitsuyama J, Sawamura H, Seishima M, Kondo N. Clinical and bacteriological evaluation of the efficacy of piperacillin in children with pneumonia. J Infect Chemother. 2007;13:224-229.

44! Fukao T, Zhang G, Aoki Y, Arai T, Teramoto T, Kaneko H, Sugie H, Kondo N. Identification of Alu-mediated, large deletion-spanning introns 19-26 in PHKA2 in a patient with X-linked liver glycogenosis (hepatic phosphorylase kinase deficiency). Mol Genet Metab. 2007;92:179-182. IF 2.550

45! Matsuo N, Imamura A, Ito R, Sugawara K, Takahashi Y, Kondo N. The correlation between 1H-MR spectroscopy and clinical manifestation with tuberous sclerosis complex. Neuropediatrics.

2007;38:126-129. IF 1.225 46! Ozeki M, Funato M, Kanda K, Ito M, Teramoto T, Kaneko H, Fukao T, Kondo N. Clinical improvement

of diffuse lymphangiomatosis with pegylated interferon alfa-2b therapy: Case report and review of the literature. Pediatr Hematol Oncol. 2007;24:513-524. IF 0.720

47! Funato M, Kaneko H, Ozeki M, Suzuki H, Orii K, Teramoto T, Fukao T, Kondo N. A positive Donath-Landsteiner test in paroxysmal cold haemoglobinuria. Eur J Haematol. 2007;79:462. IF 2.163

48! Aoyama Y, Asai K, Hioki K, Funato M, Kondo N, Kitajima Y. Herpes gestationis in a mother and newborn: immunoclinical perspectives based on a weekly follow-up of the enzyme-linked immunosorbent assay index of a bullous pemphigoid antigen noncollagenous domain. Arch Dermatol. 2007;143:1168-1172. IF 2.845

49! Fukao T, Kursula P, Owen EP, Kondo N. Identification and characterization of a temperature-sensitive R268H mutation in the human succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene. Mol Genet Metab. 2007;92:216-221. IF 2.550

50! Fukao T, Zhang G, Rolland M-O, Zabot M-T, Guffon N, Aoki Y, Kondo N. Identification of an Alu-mediated tandem duplication of exons 8 and 9 in a patient with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency. Mol Genet Metab. 2007;92:375-378. IF 2.550

51! Gobin-Limballe S, Djouadi F, Aubey F, Olpin S, Andresen BS, Yamaguchi S, Mandel H, Fukao T, Ruiter JP, Wanders RJ, McAndrew R, Kim JJ, Bastin J.Genetic basis for correction of very-long-chain acyl-coenzyme A dehydrogenase deficiency by bezafibrate in patient fibroblasts: toward a genotype-based therapy. Am J Hum Genet. 2007;81:1133-1143. IF 11.092

52! Kondo M, Fukao T, Omoya K, Kawamoto N, Aoki M, Teramoto T, Kaneko H, Kondo N. Protein-losing enteropathy associated with egg allergy in a 5-month-old boy. J Investig Allergol Clin Immunol. 2008;18:63-66. IF 1.254

53! Funato M, Kaneko H, Ozeki M, Kanda K, Fukao T, Kondo N. Anaphylactoid transfusion reactions associated with a positively charged white-cell reduction filter: a case report. Transfus Apher Sci. 2008;38:199-201. IF 0.970

54! Jin R, Kaneko H, Suzuki H, Arai T, Teramoto T, Fukao T, Kondo N. Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency. Int J Mol Med. 2008;21:233-238. IF 1.847

55! Bai CY, Matsui E, Ohnishi H, Kimata K, Kasahara K, Kaneko H, Kato Z, Fukao T, Kondo N. A novel polymorphism in the 5-lipoxygenase gene associated with bronchial asthma in Japanese children. Int J Mol Med. 2008;21:139-144. IF 1.847

56! Kondo M, Kaneko H, Fukao T, Suzuki K, Sakaguchi H, Shinoda S, Kato Z, Matsui E, Teramoto T, Nakano T, Kondo N. The response of bovine beta-lactoglobulin-specific T-cell clones to single amino acid substitutions of T-cell core epitope. Pediatric Allergy and Immunology. 2008;19:592-598. IF 2.454

57! Yamada K, Yamamoto Y, Uchiyama A, Ito R, Aoki Y, Uchida Y Nagasawa H, Kimura H, Ichiyama T, Fukao T, Kohno Y. A successfully treated case of neonatal herpes simplex type 1 infection complicated by hemophagocytic lymphohistiocytosis and acute hepatic failure. Tohoku J Exp Med. 2008;214:1-5. IF 1.133

58! Suzuki H, Kaneko H, Rong J, Kawamoto N, Asano T, Matsui E, Kasahara K, Fukao T, Kondo N. Induction of �1 and �2 gene expression in selective IgA deficiency. Molecular Medicine Report. 2008;1:395-399.

59! Yotsumoto Y, Hasegawa Y, Fukuda S, Kobayashi H, Endo M, Fukao T, Yamaguchi S: Clinical and molecular investigations of Japanese cases of glutaric acidemia type 2. Mol Genet Metab. 2008;94:61-67. IF 2.550

60! Funato M, Kaneko H, Ozeki M, Kanda K, Fukao T, Kondo N. Pediatric synovial sarcoma of the right masseter muscle: A case report and review of the literature. Int J Pediatr Otorhinolaryngol Extra. 2008;3:105-108. IF 0.851

61! Fukao T, Boneh A, Aoki Y, Kondo N. A Novel Single-Base Substitution (c.1124A>G) that Activates a 5-Base Upstream Cryptic Splice Donor Site within Exon 11 in the Human Mitochondrial Acetoacetyl-CoA Thiolase Gene. Mol Genet Metab. 2008;94:417-421. IF 2.550

62! Kuratsubo I, Suzuki Y, Shimozawa N, Kondo N. Parents of childhood X-linked adrenoleukodystrophy: High risk for depression and neurosis. Brain Dev. 2008;30:477-482. IF 1.464

63! Orii KE, Fukao T, Song X-Q, Mitchell GA, Kondo N. Liver-Specific Silencing of the Human Gene Encoding Succinyl-CoA: 3-Ketoacid CoA Transferase. Tohoku J Exp Med. 2008;215:227-236. IF 1.133

64! Taneichi H, Kanegane H, Sira MM, Futatani T, Agematsu K, Sako M, Kaneko H, Kondo N, Kaisho T, Miyawaki T. Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammagloblinemia. Clinical Immunology. 2008;126:148-154. IF 3.551

65! Purevsuren J, Fukao, T, Hasegawa Y, Fukuda S, Kobayashi H, Yamaguchi S. Study of deep intronic sequence exonization in a Japanese neonate with a mitochondrial trifunctional protein deficiency. Mol Genet Metab. 2008;95:46-51. IF 2.550

66! Kato Z, Stern JN, Nakamura HK, Kuwata K, Kondo N, Strominger JL. Positioning of autoimmune TCR-Ob.2F3 and TCR-Ob.3D1 on the MBP85-99/HLA-DR2 complex. Proc Natl Acad Sci U S A. 2008;105:15523-15528. IF 9.598

67! Kawamoto M, Matsui E, Kaneko H, Fukao T, Teramoto T, Kasahara K, Kondo N. IL-10 plays an important role as an immune-modulator in the pathogenesis of atopic diseases. Mol Med Reports. 2008;1:837-842.

68! Arai T, Kaneko H, Ohnishi H, Matsui E, Fukao T, Kawamoto N, Kasahara K, Kondo N. Hypothermia augments NF-kappa B activity and the production of IL-12 and IFN-gamma. Allergol Int. 2008;57:331-338.

69! Kimura T, Kato Z, Ohnishi H, Tochio H, Shirakawa M, Kondo N. Expression, purification and structural analysis of human IL-18 binding protein: a potent therapeutic molecule for allergy. Allergol Int. 2008;57:367-376.

70! Montaño AM, Tomatsu S, Brusius A, Smith M, Orii T. Growth charts for patients affected with Morquio A disease. Am J Med Genet A. 2008;146A:1286-1295. IF 2.440

71! Tomatsu S, Montaño AM, Ohashi A, Gutierrez MA, Oikawa H, Oguma T, Dung VC, Nishioka T, Orii T, Sly WS. Enzyme replacement therapy in a murine model of Morquio A syndrome. Hum Mol Genet. 2008;17:815-824. IF 7.806

72! Montaño AM, Oikawa H, Tomatsu S, Nishioka T, Vogler C, Gutierrez MA, Oguma T, Tan Y, Grubb JH, Dung VC, Ohashi A, Miyamoto K, Orii T, Yoneda Y, Sly WS. Acidic amino acid tag enhances response to enzyme replacement in mucopolysaccharidosis type VII mice. Mol Genet Metab. 2008;94:178-189. IF 2.550

73! Egawa K, Takahashi Y, Kubota Y, Kubota H, Inoue Y, Fujiwara T, Onodera O. Electroclinical features of epilepsy in patients with juvenile type dentatorubral-pallidoluysian atrophy. Epilepsia. 2008;49:2041-2049. IF 3.569

74! Matsukuma E, Kato Z, Orii K, Asano T, Orii K, Matsui E, Kaneko H, Kondo N. Acute mumps cerebellitis with abnormal findings in MRI diffusion-weighted images. Eur J Pediatr. 2008;167:829-830. IF 1.277

75! Teramoto T, Fukao T, Hirayama K, Asano T, Aoki Y, Kondo N. Escherichia coli O-157-induced hemolytic uremic syndrome: Usefulness of SCWP score for the prediction of neurological complication. Pediatr Int. 2008;50:1-3. IF 0.737

4X��ghiOj 1Zklmno 1! ��ræ��E8Ùb;PQ½h����T��¹��îVï(W��¥¦��/��X±�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f�§ÐU�VW��;¿� 16J18�z;83,000^_(24,000�30,000�29,000^_)

2! ��ræ��E8Ùb���"z���*N#;PQ½h����T��¹��îVï(W��¥¦��/��X±�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f�§

ÐU�VW��;¿� 16J18�z;10,600^_(3,400�3,800�3,400^_) 3! ��ræ��¿E�P(yÉõör�]�)���"z��E8Ùb;PQ½h����T��¹¥¦°N��R�¥¦°N�úµðbc3!&ÉU�VW©ªð��;¿� 15J18 �z;260 ^_(100�80�80^_)

4! ��ræ�;1-ud(!E]�]����k����� ���)���"z��E8Ùb;PQ½h¨���rÁ��X±�Ïp��;i¥��U�VWn���;¿� 17J19�z;6,500^_(2,300�2,200�2,000^_)

5! ��ræ��±�D(bâ�#]�)���"z��E8Ùb;PQ½h����T��¹×Þ�Èiyz��|��X±�S×�9�Y��Ýuê�íîË�u�O�b'�véU�VW��;

¿� 15J18�z;5,000^_(2,000�1,500�750�750^_) 6! ��ræ��E8Ùb;*Ð`KfJP±�ÎÞF1 ±ST��Ò� ÎÞF1 ±ST��¶·èYéW ÎÞ ±�Æ�KL�b"OTª��¶·X±;×ÎîVï(W��c�'�no#�ðvÕ�éY�´X�$�ðvé;¿� 17J21�z;105,000^_(21,000�21,000�21,000�21,000�21,000^_)

7! ��ræ��¹#À3;*Ð`KfJP±�ÎÞF1 ±ST��Ò� ÎÞF1 ±ST��¶·èYéW ÎÞ ±�Æ�KL�b"OTª��¶·X±;×ÎîVï(W���§¨��vévÕ�+��/f�ìp;¿� 17J21�z;95,000^_(19,000�19,000�19,000�19,000�19,000^_)

8! ��ræ��5�2�P(-Ð��Ò�� ��Ï��)���"z��E8Ùb;PQ½h����T��¹��îVï(W��¥¦��/X±�îVï(W���p¥�|Æ��¥��¥¦U�

VW��;¿� 18J20�z;12,000^_(4,000�4,000�4,000^_) 9! ��ræ��WOñ�(^�]�]�������� ���)���"z��E8Ùb;PQ½h����T��¹��îVï(W��¥¦��/X±�îUÏW��Æ�p¥vÕ�{�c#��

13p¥¥¦�¥5{�¦ç�KL�`Ûþ~&U�VW��;¿� 18J20 �z;6,600 ^_(2,000�2,000�2,500^_)

10! ��ræ��]�õ(O:]����)���"z��E8Ùb;PQ½h����T��¹��îVï(W��¥¦��/��X±�îVï(W���ÀÁ0�3¿^��/ñ�PÇK·�F D

E3·��/f�§Ð�Ë�²ú3²°Xø�ÂÃU�VW��;¿� 18J20 �z;12,500^_(4,000�4,000�4,500^_)

11! ��ræ��¿E�P(yÉõör�]�)���"z��E8Ùb;PQ½h¥¦°N��R�¥¦°N�úµðbc3!&ÉU�VW©ªð��;¿� 17J19�z;150(100�50^_)

12! ��ræ��fQ�¨(9:RT]�ãõ0�èYéJ)���"z��E8Ùb;PQ½h����T��¹�/STÂéª��X±�q×Î;×Y��KL�@�3Ë3Uà� QOLm�U�VW��;¿� 18J19�z;700(0�700^_)

13! ��ræ��E8Ùb;PQ½h����T��¹��îVï(W��¥¦��/��X±ôîVï(W�íW;WØ×Î�/0�q×Î;×Y�§Ð3bÊ�ý¿� 19J21 �z 51,000 ^_(24,000�27,000^_)

14! ��ræ��E8Ùb;��"z���*N#;PQ½h��îVï(W��¥¦��/��X±�îVï(W�íW;WØ×Î�/0�q×Î;×Y�§Ð3bÊ�;¿� 19J21 �z;5,700^_(3,000;2,700^_)

15! ��ræ��±�D(bâ�#]�)���"z��E8Ùb;PQ½h×Þ�Èiyz��|��X±�S×�9�Y��Ýuê�íîË�u�O�b'�véU�VW��;¿� 19J21�z;1,250^_(500�750^_)

16! ��ræ�;E���(�[]����)���8Â��å?XL;PQ½h����T��¹#îô}Ö©ª��X±�éYÉ<�\��+STñQ4ÇK+ÇÃ+u�\\´8WXYZÐ(�

§ÐU�VW��;¿� 19J21�z;700^_(400�300^_) 17! ��ræ��Ïï�(ST]������);��"z��E8Ùb�PQ½h����T��¹¨

���rÁ��X±ôÏp��;i¥��U�VWn���ý¿� 20J22 �z;2,000 ^_(2,000^_)

18! ��ræ��å8\��;"���h����T��¹DU��(C)(2);éY�´ÐÐ�$UDFû+��k"#§¨ÉÊêmwKgUIVè�éW�Í\�ìp;¿� 17J18 �z;2,700 ^_(1,800;900^_)

19! ��ræ��EfD;"���h����T��¹DU��(C)(2);éY�´ÐÐ�$UDFû+��k"#§¨ÉÊêmwKgUIVè�éW�Í\�ìp;¿� 19�z;1,040^_

20! ��ræ���*N#;"���h��T��¹DU��(C)(2);îVï(W����'vwUDFÃK+KíF f�§Ð;¿� 17J18�z;3,000^_(1,900�1,100^_)

21! ��ræ��¹#À3;"���h����T��¹DU��(C)(2);}РÒ��véJ}Р;i¥UFU IgAáU¥ñ�ÉïUÇÄJ;¿� 18J19�z;3,500^_(2,100�1,400^_)

22! ��ræ��å?XL;"���h����T��¹DU��(C)(2);�UYÐrsb�¥�"#�'J�N 3�Ò$l�3\�;×�YZb�ñ��UJ;¿� 18J19�z;3,500^_(1,900�1,600^_)

23! ��ræ��àá��;"���h����T��¹Ç���(B);Ûg�0iãHacn¥UvwW*+lÒ�ñvéVWKL�DU��;¿� 17J18�z 3,400^_(2,000�1,400^_)

24! ��ræ��àáâ�;"���h����T��¹Ç���(B);��7ï�óá�YñÊÃKáï�9�«W<��/�DU��;¿� 17J18�z;3,400^_(1,400�2,000^_)

25! ��ræ��]�k1;"���h����T��¹Ç���(B);Àô����Þ��\סòYZÒ���$Î�ðvwUDFû}îVï(Wkìp;¿� 17J19�z;2,800^_(1,200�900�700^_)

26! ��ræ��V³6;"���h����T��¹Ç���(B);îYéVX\U�«ìpêmwK�$Î�ð[l�\´8WXYZ���;¿� 17J18�z;200^_(100�100^_)

27! ��ræ��)%t�#;"���h����T��¹Ç���(B);RS Í�ï\ ��"#no�ðvwUDFûtu0¶78�+Kí¥¦�/f�ìp;¿� 18J19�z;3,400^_(2,000�1,400^_)

28! ��ræ��E8�;"���h����T��¹Ç���(B);×ÎîVï(W���/fUá�òÎ/fUù m/fUÕW��=eüQÒe�vé;¿� 18J19�z;3,400^_(2,100�1,300^_)

29! ��ræ���WÀ�;"���h����T��¹Ç���(B);éY�´ÐÐ�$UDFû+�îVï(W�/k��×\ïW�¡U\´8WXYZ;¿� 18J19�z;3,100^_(1,800�1,300^_)

30! ��ræ��$%Ë#;"���h����T��¹Ç���(B);"½ð IgAáU¥��'vé3IgA ë´;\�ZÍ;¿� 19�z;1,700^_

31! ��ræ��àá��;����T��¹DU��(C)�t�lñdV{)no#Apb�¥��'U�/fU�VW��;¿� 20�z;1,400^_

32! ��ræ��]�k1;����T��¹Ç���(B)��$Î�ð�fUÕWÀô��� IL-18ÒÓ()3+���n�k�ìp;¿� 20�z;1,700^_

33! ��ræ��]�k1;¿� 20�z���������X�+TUÕW��T�MyD88�ZQïFbð�°«�ìpUmwKgh£üQîS�éW"#�éY�´�$�ÒÓvw;250^_

34! ��ræ��%=�;¿� 20 �z JST �W�p�st������îVï(W���/kñ�PÇK+�gU×YéW�×9Y-18()f�ìp;2,000^_

35! ��ræ�:t�«7;¿� 20�z]�`�+T(�����¼½¶·);1,060^_�

2Zpq�� 1! E8Ùb��*N#�¹#À3�Á��é�îVï(W�Ïc3íWà\UUvwWnoc#��1UvÕ�Ë�k«�/f�§Ð;¿� 17J18�z;300^_(300�0^_)�ICIH�W��<��頻��G

2! E8Ùb��*N#��Ýu78���0�UvwW��ëí�WïYìk�²ÊU�VWZÍ;¿� 18�z;0^_�ÁftuîVï(W�I

3! E8Ùb�¹#À3��*N#�)%t�#�îVï(WZ½9¡UUÕWîVï�YFbð IgE�1f�ÂÃ;¿� 17J18�z;700^_(700�0^_)�ICIH�+��[U�Y

4! E8Ùb��*N#�K}ð�tuîVï(W�����íW;WØ×Î�/ñ�PÇKno#±Ivw��;¿� 18J19�z;1,500^_(1,500�0^_)�]ßkÞȱICIH

3Zr��� 1! E8Ùb�n\���õöUïVíîn�;¿� 18J19�z;100^_�Áf×Y�:VW��YICIH

2! E8Ùb��*N#�¹#À3�Á��é�îVï(W�Ïc3íWà\UUvwWnoc#��1�vÕ�Ë�k«�/f�§Ð;¿� 17J20�z;300^_�ICIH�W��<��頻��G

3! E8Ùb�¹#À3�{)��;i¥�Ïcno#�1vÕ��'��Òe�vé�¿� 18J21�z;*Ð`KfJ�����G

5Xes�tuvwOj 1! E8Ùb�¹#À3��*N#�E8���]^�å8_6�+���=eñüQVWá�òÎË�Î�Ë�n~>f(pé)(F�Æ�);¿� 19�z

2! E8Ùb�å8\���]�k1�N_0P�7?�J�lbQ4MyD88�NUÕW Toll like receptor / Interleukin-18�ZQï�Fbð()f(pé)(-.F�Æ��);¿� 20�z

6Xx?@ 1Zxyz E8Ùb� 1! Áftu��I�X(¿� 18� 4 �¿� 20� 4 ) 2! Áftu��IrL2(�'4) 3! Áftu��IcÔ|1�PQl��(�'4) 4! Áftu��I�ð�(�'4) 5! Áftu��IcdÕlO2IO2(¿� 18� 5 �¿� 20� 5 ) 6! Áftu��IßjO2IO2(¿� 18� 5 �¿� 20� 5 ) 7! Áftu��I95ç>I�X(�'4) 8! Áftu��I95ç>InX(�'4) 9! ÁfîVï(W�I�X(�'4)

10! ÁfîVï(W�IcÔ|1�PQ�(�'4) 11! ÁfîVï(W�I|1�(�'4) 12! ÁfîVï(W�I-./0O2�(�¿� 19� 3 ) 13! ÁfîVï(W�I���AO2(�¿� 19� 3 ) 14! ÁfîVï(W�I�ð�(z���AO2(�¿� 19� 3 ) 15! ÁfîVï(W�IîUÏW��Æq×Î;×Y�ð�O2(�'4) 16! ÁftuîVï(W�I�X(�'4) 17! ÁftuîVï(W�I�X�(¿� 20� 12 �'4) 18! ÁftuîVï(W�I�/�0�q×Î;×YO2(�'4) 19! ÁftuîVï(W�I×ÎîVï(WO2(�'4) 20! ÁfJ�no�IÂL2(�'4) 21! ÁfJ�no�IcÔ|1�PQ�(�'4) 22! ÁfJ�no�I|1�(�'4) 23! Áftuno��InX(�'4) 24! Áfno#F/�IÂL2(�'4) 25! Áfno#F/�I�TO2(�¿� 19� 3 ) 26! Áftuãõ8IÂL2�¶��(�'4) å?XL� 1! Áf{)rsb��IÂL2(�'4) 2! ÁfJ�no�IÂL2(�'4) 3! Áftu��I95ç>InX(¿� 18� 4 �'4) 4! ÁfJ�no�IPQ�(¿� 18� 4 �'4) 5! Áftu��IrL2(¿� 20� 4 �'4) ¹#À3� 1! ÁfîVï(W�IrL2(�'4) 2! ÁfîVï(W8IÂL2(�'4) 3! Áftu��I95ç>InX(¿� 18� 4 �'4) 4! Áftu��IrL2(¿� 18� 4 �'4) å8\��� 1! Áftu*+�IÂL2(¿� 18� 4 �'4) 2! ÁfJ�no�IÂL2(¿� 19� 4 �'4) �*N#� 1! ÁfîVï(W�IrL2(�'4) 2! Áftu��IrL2(¿� 18� 4 �'4)

2Zx{| E8Ùb� 1! � 5¡i-tu�òÓî�Y8LI(¿� 19� 7 �úû) 2! � 18¡úûüýîô�õöñ#kWÂîÃ(¿� 19� 10 �úû) 3! � 241¡Áftu��I95ç>I(¿� 19� 10 �úû) 4! � 19¡úûüýîô�õöñ#kWÂîÃ(¿� 20� 10 �úû) 5! � 21¡ÁfîVï(W�I55§¨]I(¿� 21� 6 �úû)

3Z}~� E8Ùb� 1! Journal of Investigational Allergology & Clinical Immunology:=�O2(�'4) 2! ÁftuîVï(W�Iâ;=�O2�(�'4) 3! îVï(W�àá;=�`´(�'4) 4! International Review of Asthma:=�O2(�'4)

5! Allergy From the Nose to the Lungâ: Editorial Board(=�nX)(�'4) 6! îVï(î;=�O2�(�'4) 7! Pediatric Allergy for Clinicians: `´(�'4) å8\��� 1! Journal of Pediatric Neurology :Editorial Board(¿� 18� 1 �'4)

7Xx��$�����������%� E8Ùb� 1! 26th Symposium of the Collegium Internationale Allergologicum(2006.05, Malta, Molecular

Mechanism of Th1aTh2 Imbalance and Hygiene Hypothesis; ¨�) 2! KAAACI-WAO Joint Congress 2006 & the 9th WPAS(2006.11�b-�«Íï�ôGenetic factors and

environmental factors in allergyý¨��&�) 3! � 109 ¡Áftu��I(¿� 18 � 4  �¹Ç�"O^�Y�ÙÍ< 5ô0¶78�p¥¥¦ý¨�)

4! � 18¡ÁfîVï(W�I55§¨]I(¿� 18� 5 �9:�×ëXYZ�Y�ÙÍ< 7ôMãr=ô78¥5Uî�@ÉVWïý¨�)

5! � 23¡!��k�I]I(¿� 18� 8 �úû�F^%¨Hô�WSWØ×Î�/UvwW!��k��CNFw� –îVï(W��Yïì-ý¨�)

6! � 56¡ÁfîVï(W�I(¿� 18� 11 �9:���%¨ 10ôîVï(Wp¥UvwWno#3Ûþý¨�)

7! � 4¡«��@�è�QW(¿� 18� 1 �ÊË�F^%¨ô0¶78��WSWØ×ÎF/ìp� —QOLm�ñLæÇÄWý¨�)

8! � 2¡ Osaka IPOD Allergy Seminar(¿� 18� 2 �]��F^%¨ôU;Y\VW��Qï8 WòUô3FûîVï(WF/3Ë�ìpý¨�)

9! � 2¡tu0¶78��I(¿� 18� 3 �]��F^% ô̈tu0¶78�q×Î;×Y 2005ñÃïU`ÊÆìVWï� -cêý�#kW-ý¨�)

10! � 43¡úûüd��I��Z;<(¿� 18� 4 �úû�F^%¨ôý3ïì�îVï(WF/ñ#kW-�J�tuñýkÄ-ý¨�)

11! � 2¡�Étu�±��I(¿� 18� 5  ��É�F^%¨ôîVï(W�íW;WØ×Î�/321ãI�\U��<ý¨�)

12! � 11¡Ô9çdtuîVï(WeLI(¿� 18� 7 �9:�F^%¨ÅôîVï(W�u� QOL3Ë�m�ñLæÇÄWno3Ûþ��YïìWý¨�)

13! � 16¡-.78�IÁf�îÙî�I(¿� 18� 4 �9:��WUR��¢Ó¡ W3� &�) 14! � 14¡tu«îVï(W��I(¿� 18� 4 �yÖ�è¡��Y 2� &�) 15! � 235¡Áftu��I95ç>I(¿� 18� 5 �úû�F^%¨� &�) 16! � 15¡ Airway Club in Sendai(¿� 18� 9 �ÊË�I�%¨� &�) 17! � 15¡tu«îVï(W��I(¿� 18� 10 �*­�è¡��YH� &�) 18! � 38¡Áftu �¥�I��è�QW(¿� 18� 11 �yÖ�;Yò�Yè�QW11� &�) 19! � 43 ¡ÁftuîVï(W�I(¿� 18 � 11  �9:�F^%¨ 1ôf£�����3îVï(

W�°Yý&�) 20! ¿� 18�zÁf����Ihb{�A%?I(¿� 19� 1 �9:�ô{)��;i¥��ý¨

�) 21! � 15 ¡tu§¨k��îVï(W�����I(¿� 19 � 1  �9:��Y�ÙÍ< 2� 2010 �

�îVï(W�/jkô×ÎîVï(W�/ý¨�) 22! � 14¡]�tu��I�F�;e�I(¿� 19� 2 �]��F^%¨ôîVï(W�íW;WØ

×Î�/ñî�Õ�UÆìVWïý¨�) 23! US-Japan Asthma Summit 2007(¿� 19� 4 �9:�ôÁf��Ýu78ñ¤¥Gû'53ÄÅý

¨�) 24! � 110¡Áftu��I�T�I(¿� 19� 4 �:ª���%¨ 4 &�) 25! ÁfîVï(W8I�-¶�� ß��T%¨I(¿� 19 � 5  �ß��F^%¨ôîVï(WUv

wWíW;WØ×Î�/�ìp3bâý¨�) 26! � 7¡78 Early Intervention��I(¿� 19� 6 �9:�%¨ôîVï(WUvwWíW;W

Ø×Î�/�ìp3bâý¨�) 27! � 19¡ÁfîVï(W�I55§¨]I(¿� 19� 6 �ÇÈ��Y�ÙÍ< 1ôkÎîVï(W

�'53@�� tu�UvwWkÎîVï(W�'53@�ý¨�) 28! � 19¡ÁfîVï(W�I55§¨]I(¿� 19� 6 �ÇÈ�×ëXYZ�Y�ÙÍ< 8ô78

õ|�ñ�PÇK�/jk —0¶78��/���T�UmwÄý&�) 29! � 17¡-.78�IÁf�îÙî�I(¿� 19� 7 �9:�F^%¨ôîVï(Wp¥no#3

Ûþ��®¥ý¨�) 30! � 27¡2Q7Y¢rVY\(¿� 19� 8 �:ª��ô[{���'ý&�) 31! ¿� 19�zÁfgP���Y�ÙÍ<(¿� 19� 8 �úû�F^%¨ô×ÞîVï(W3Ë��

/jký¨�) 32! hfütu��I%¨I(¿� 19� 10 �hf�F^%¨ôîVï(W�íW;WØ×Î�/�+

Æì3bâý¨�) 33! � 17¡tu«îVï(W��I(¿� 19� 10 �9:�è¡��YE &�) 34! � 18¡úûüýîô�õöñ#kWÂîÃ(¿� 19� 10 �úû�ôúû]�U+Ô�3Kçá�

/��èYéW�ÛXW´í�$3��ý¨�) 35! � 241¡Áftu��I95ç>I(¿� 19� 10 �úû�F^%¨ &�) 36! � 57 ¡ÁfîVï(W�Ii5�T]I(¿� 19 � 11  �ÇÈ�×ëXYZ�Y�ÙÍ< 4ôî

UÏW��Æ�益3ªu¥ê�î��Wòïì�ý&�) 37! � 57 ¡ÁfîVï(W]I�Ii5�T]I(¿� 19 � 11  �ÇÈ��Y�ÙÍ< 2(English

session)îUÏW��3k«bX¥UvwW PharmacogenomicsôPharmacogenomics in treatment of atopic disease and drug hypersensitivityý±I)

38! The World Allergy Organizationjs 20th World Allergy Congress (WAC) (¿� 19� 12 �Bangkok�-.�I�Y�ÙÍ<ôSymposium -Genetics- Implications for Asthma and Allergyý&�)

39! The World Allergy Organization’s 20th World Allergy Congress (WAC) (¿�19� 12 �Bangkok�-.�I�Y�ÙÍ<,6Ý%¨ôSymposium –Genetic Evaluation of Allergic Diseases and Asthma –Japanese session: Genetic variations of interleukin 12 signaling and other cytokine genes in allergy and asthmaý¨�)

40! � 44 ¡ÁftuîVï(W�I©I(¿� 19 � 12  �wxy��Y�ÙÍ< 7ôîVï(W���"#Î�ðî��Wòý&�)

41! � 16¡tu§¨k��îVï(D�����I(¿� 20� 1 �rK�;Yò�Yè�QW2� &�) 42! � 30¡1Ôü��I�×ãõ�AI(¿� 20� 2 �1Ô�ôtu�îVï(W3Ë�@�� KE

�|�ô�LÄý¨�) 43! � 8¡×ÎîVï(W��I(¿� 20� 2 �9:�&�) 44! � 9¡×ÎîVï(W��I(¿� 20� 2 �9:�&�) 45! � 11¡�P��I�T�AI(¿� 20� 3 �úû�Dn%¨ôúû]��¤¥Ë¦ý�¨�) 46! � 5¡úûütu��I%¨I�îVï(Wè�QW�(¿� 20� 3 �úû�F^%¨ &�) 47! � 5¡tu«îVï(W��I(¿� 20� 4 �rK�è¡��Y\ &�) 48! � 61¡§¨îVï(W��I(¿� 20� 5 �]��F^%¨HôîVï(W�F/�+Æì3b

âý¨�) 49! The 1st Asthma Meeting in Tokyo(¿� 20� 5 �9:�Session2 (English) &�) 50! � 20¡ÁfîVï(W�I55§¨]I(¿� 20� 6 �9:��Y�ÙÍ< 9ôîVï(W��

�no#3"#Î�ý&�) 51! � 3¡úûtuîVï(W�78��I(¿� 20� 5  �úû�F^%¨ô W7É�îY8�<

ñ±W"#ÖÕ3Ë��C�()ý¨�) 52! � 20¡ÁfîVï(W�I55§¨]I(¿� 20� 6 �9:���è�QW1ôîVï(WUv

wWíW;WØ×Î�/�ìp3bâý¨�) 53! � 18 ¡-.78�IÁf�îÙî�I (¿� 20 � 7  �]� , Meet-the-professor 2

ôUnderstanding combination therapy for asthmaýChair) 54! � 11¡ Forum on Allergy in Nagoya(¿� 20� 10 �wxy ãLJ) 55! � 40¡Áftu �¥�I�T�I(¿� 20� 11 �wxy�F^%¨ &�) 56! 23rd International Scientific Forum(¿� 20 � 11  �9:�Lecture 3ôFood Allergy of

Childhoos-Pathogenesis and Strategy of Managementý¨�) 57! � 58¡ÁfîVï(W�Ii5�T�I(¿� 20� 11 �9:�F^%¨ &�)

58! � 4¡��78�COPD��I(¿� 20� 12 �]��F^%¨ôtu0¶78�F,3@É��J783�ZÃñ�LÄ�ý¨�)

59! � 45¡ÁftuîVï(W�I�T�I(¿� 20� 12 �9:��Y�ÙÍ< 7 ôîVï(W�'�"#Î�ðvéý&�)

60! � 45¡ÁftuîVï(W�I�T�I(¿� 20� 12 �9:���è�QW8 &�) å?XL� 1! The 10th International congress of inborn errors of metabolism(2006.09, Chiba, Mutation update

of human mitochondrial acetoacetyl-CoA thiolase (T2) deficiency; ¨�) 2! The 10th International congress of inborn errors of metabolism(2006.09, Chiba, Mutation update

of succinyl-CoA:3-ketoacid CoA transferase deficiency; ¨�) 3! � 11¡ß�{)rsb���I(¿� 20� 2 �ß��F^%¨ô�UYÐrs3Ë�b�¥ý¨�)

4! � 7¡9�rsb�¥�/��I(¿� 20� 7 �ÊË�F^%¨ô�UYÐrs3Ë�b�¥ý¨�)

5! � 10¡úû�;×�8W�î7Y¢r;Y\(¿� 20� 7 �úû�F^%¨ô$���yîY�Xî�¥�rsî�ÎW�\ý¨�)

6! 2008 Annual symposium of Society for the Study of Inborn Errors of Metabolism.(2008.09,ôCpG islands around exon 1 in succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene were hypomethylated even in human and mouse hepatic tissues where SCOT gene expression was completely suppressedý¨�)

7! 2008 Annual symposium of Society for the Study of Inborn Errors of Metabolism.(2008.09,ôA novel single-base substitution(c.1124A>G)that activates 5-base upstream cryptic splice donor site within exon 11 in the human mitochondrial acetoacetyl-CoA thiolase geneý¨�)

8! {��k�/�Y�ÙÍ<(¿� 20� 10 �úû��Y�ÙÍ<ôno#3�ý¨�) 9! � 45¡ÁftuîVï(W�I(¿� 20� 12 �ÇÈ��Y�ÙÍ< 10ôîVï�Y�Q_3Ë�±BíÒÓý¨�)

¹#À3� 1! � 18¡ÁfîVï(W�I55§¨]I(¿� 18� 5 �9:�ô}Р;i¥�§¨+b3�'�±Bý¨�)

2! � 56¡ÁfîVï(W�I©I(¿� 18� 11 �9:�ôk�îVï(W�DRðvwUDFû+��/f�ìpý¨�)

3! � 43 ¡ÁftuîVï(W�I(¿� 18 � 11  �9:�³W´��¡� 1ôk�îVï(W�DRðvw3��=eüQUÕW+��/fý¨�)

4! Pathogenesis of primary antibody deficiency Symposium for PID in Asia Riken RCAI(2008,12 Yokohama, ¨�)

5! � 45 ¡ÁftuîVï(W�I(¿� 20 � 12  �ÇÈ��X�Y�ÙÍ< 4� ô×ÎîVï(WF/�+ÇÃÆì.k�îVï(WUvwW+���=eüQ×Þ�m�ý¨�)

å8\��� 1! � 58¡ÁfîVï(W�Ii��T]I(¿� 20� 11 �9:��X�Y�ÙÍ< 17ôÀÁ���� Tgh�ZQïoTÒ�véUmwK TCR/peptide/HLA�ªÐéY�´ÐÐ�$vwý¨�)

2! � 38¡Áf���I©I��T�I(¿� 20� 12 �:ª�Symposium 12ôStructural basis of signaling via MyD88ý¨�)

�*N#� 1! � 56¡ÁfîVï(W�I(¿� 18� 11 �9:��Y�ÙÍ< 12ôp¥UïVÍ×ï\ ��íî3�dc#ý¨�)

2! � 18 ¡úûüýîô�õöñ#kWÂîÃ(¿� 19 � 10  �úû��Y�ÙÍ< 3ôçá�tu�/3tuãõý&�)

_ft�#� 1! � 45 ¡ÁftuîVï(W�I(¿� 20 � 12  �ÇÈ��Y�ÙÍ< 3ô���Ø3îVï(W��p¥3���UÂÃÄý¨�)

]�k1� 1! � 44 ¡ÁftuîVï(W�I(¿� 19 � 12  �wxy��Y�ÙÍ< 7ô"#Î�ðî��Wò�§¨ê�×Y�´U IL-18 ��ZQïoTÞéY�´X�$vwUDFû�kê�î��Wòý¨�)

_f1� 1! � 19¡ÁfîVï(W�I55§¨]I(¿� 19� 6 �ÇÈ��Y�ÙÍ< 3ôÆ[àWU��UÕWtuîVï(W���p¥U�®Wc#�ZÍý¨�)

w�)u� 1! � 19¡ÁfîVï(W�I55§¨]I(¿� 19� 6 �ÇÈ��X�Y�ÙÍ< 4ôÀô��ÞghdîS�éW"#��$Î�ðÒÓvw3§¨ÉÊê�ÆÇý¨�)

?�k`� 1! � 57¡ÁfîVï(W]I�Ii5�T]I(¿� 19� 11 �ÇÈ��X�Y�ÙÍ< 12ô]lîVï(Wö£}Ï p34�éY�´�$�vé3§¨ÉÊý¨�)

2! � 44 ¡ÁftuîVï(W�I(¿� 19 � 12  �wxy�³W´��¡� 1ô��=eüQ�KL�×ÎîVï(Wö£}ÏéY�´��$véý¨�)

%=�� 1! Joint Singapore Paediatric Congress & APAPARI Meeting 2008(2008.10, ô Expression,

Purification and Structural Analysis of Human IL-18 Binding Protein: A Potent Therapeutic Molecule for Allergyý¨� )

²Øu±� 1! Joint Singapore Paediatric Congress & APAPARI Meeting 2008(2008.10�ôMolecular Analyses

Of Interaction Between Myd88-Adaptor- Like And The Other TIR Proteins In Toll-Like Receptor Signalingý¨� )

2! � 111 ¡Áftu��I�T�I(¿� 20 � 4  �9:ôMolecular analyses of protein-protein interactions of intra-cellular signaling in innate immunityý¨� )

@2M`� 1! � 48¡Áftu*+�I(¿� 18� 1 �-È�³W´��¡�ôno*+­���F ��/jký¨�)

2! 10th International Congress of Inborn Errors of Metabolism(2006.09, Chiba, -.�IDn%¨�ôMolecular and clinical aspects of peroxisomal diseaseý¨�)

3! 10th International Congress of Inborn Errors of Metabolism(2006.09, Chiba,ôA second case of PEX14 deficiency with prolonged survival and renal tubular dysfunctioný¨�)

4! � 49¡Áf{)rsb��I(¿� 19� 11 �E��³W´��¡�ô!#NXÙ\U�¢�W�$�ngh(a/f�'53´ÅY���rÁUmwÄý¨�)

8X}�>�p�Oj 1! àá���?NmëI��¸Á¹(¿� 18�z) 2! è­«²�?NmëI��¸Á¹(¿� 19�z) 3! ²Øu±: Young Investigator Award (� 111¡Áftu��I�T�I)(¿� 19�z) 4! ¹#À3�� 9 ¡tu��_On� tuDR��"O� tu�¨�îVï(W�������'vw3+��/f�ìp(¿� 20�z)

9X�x?@ E8Ùb� 1! ÁfîVï(W8I�X(�'4) 2! i-�������IL���X(¿� 18�19�z) 3! �Áf���Ð��o!I�(¿� 18�z) 4! Áf�T�GIF^��2�Ï�O2I�ðO2�-.X±O2IÜ'Ï�O2(¿� 17 ��19�z)

5! J�fJ�����GJ�ÂL2(¿� 19�z) 6! J�fJ�#õö8Itu������Ï�IÏ�2(¿� 17�19�z) 7! úûütuãõ8II�(�'4) 8! úûü �¥¥¦@�O2I¥¦°N�IO2(�¿� 19�z) 9! úûü �¥¥¦@�O2I�×�@��IO2(�¿� 19�z)

10! úûü¥¦°Nõöä°n��ðO2(�¿� 19�z) 11! úûüçá�/K�8LIO2(¿� 19�z) 12! úûüçá�/K�8LI"�I�I�(¿� 19�z) 13! úûü��I¥¦°NO2IO2(�¿� 19�z) 14! úûü��I�P��I�TO2I`´(�¿� 19�z) 15! úû¶¥¦°Nõöä°n�O2IO2(�'4) 16! J�fJúûü��ìpJ�Öð´;\éW��X±úû�]�çáUvwWf�ILO2(¿� 18

�z) 17! ÁftuîVï(W�I�X�(¿� 20� 12 �'4) å?XL� 1! úûütuãõ8I���X(�'4) 2! úûü¥¦°Nõöä°n��ð�����ð��(�'4) 3! úû¶ã�Gup�õöñ#kWIO2(O2�)(�'4) 4! úûütu­®�/8LIO2(�'4) 5! úû¶ãõ�/ÏLIO2(�'4) ¹#À3� 1! úûçátu­®�/Ð(�·ILO2(�'4) å8\��� 1! Ù\UY©àXq+I×Y¢ï�YR@� supervisor(¿� 18�z�'4) 2! Ù\UY©àXqö,+I×Y¢ï�YR@�%¨I%�(¿� 18�z�'4) �*N#� 1! pT÷°�·�pØUÉwK�ÝuõFZÍO2(¿� 20�z) 2! úûü}Ö���|O2(¿� 19�z�'4)

10X^�� 1! E8Ùb�iE�d�]�õ�Q2¶�E�r��N_s���*N#�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f�§ÐU�VW���¿� 17�zPQ½����T��¹ ��jÊÜ� 2"÷(E8R)�205J207(2006� 3 )

2! E8Ùb�å8\����fLÀ�îVï(W��cno#��'��/&É¥�c#�vé3íW;WØ×Î�/f�§ÐvÕ��k�ZÍ�¿� 17 �zPQ½����T��¹ ��jÊÜ� 2"÷(E8R)�208J210(2006� 3 )

3! �*N#�¹#À3�no#ij�¢¿ðvwvÕ�tu�'UvwW�×[U8�Y2eÐt}k��/&É¥�no#c#3íW;WØ×Î�/ìp�¿� 17�zPQ½����T��¹ ��jÊÜ� 2"÷(E8R)�226J228(2006� 3 )

4! E8Ùb�iE�d�]�õ�Q2¶�E�r��N_s���*N#�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f�§ÐU�VW���¿� 17�zPQ½����T��¹� ©]�"z��jÊÜ(E8R)�1J4(2006� 3 )

5! E8Ùb�å8\����fLÀ�îVï(W��cno#��'��/&É¥�c#�vé3íJ;JØ×Î�/f�§ÐvÕ��k�ZÍ�¿� 17�zPQ½����T��¹� ©]�"z��jÊÜ(E8R)�5J7(2006� 3 )

6! �*N#�¹#À3�no#ij�¢¿ðvwvÕ�tu�'UvwW�×[U8�Y2eÐt}k��/&É¥�no#c#3íW;WØ×Î�/ìp�¿� 17�zPQ½����T��¹�©]�"z��jÊÜ(E8R)�37J39(2006� 3 )

7! E8Ùb�¹#À3�E8��å?XL�a�>±�å8\���)%t�#�_f1�×Î�UÕWîQ¢�;9�W&É�ÏcÎX(îVï�Y)�§1�¥¦�¥Öf�§ÐU�VW��� ×ÎîVï�Y���ÉývÕ��³ÖI&ÉU�VW���¿� 17�zPQ½����T��¹���jÊÜ� 1"÷(5�2R)�90J92(2006� 3 )

8! E8Ùb�¹#À3�E8��å?XL�a�>±�å8\���)%t�#�_f1�×ÎîVï�Y���ÉývÕ��³ÖI&ÉU�VW���¿� 15 �zJ17 �zPQ½����T��¹ ©]��jÊÜ(5�2R)�22J24(2006� 3 )

9! E8Ùb�)%t�#�¹#À3��*N#�_f1���îVï(WUÌ®W�d��}c#��1U�VW��� RS Í×ï\ �­îVï(Wp¥UïVíîvÕ�EF�ñÊÃKîVï(W���¥Ö�¥¦f�§Ð�¿� 17�zPQ½����T��¹� ��jÊÜ� 1"÷(?_R)�41J43(2006� 3 )

10! E8Ùb�)%t�#�¹#À3��*N#�_f1�RSÍ×ï\ �­îVï(Wp¥UïVíîvÕ�EF�ñÊÃKîVï(W���¥Ö�¥¦f�§Ð�¿� 17�zPQ½����T��¹� ©]�"z��jÊÜ(?_R)�9J17(2006� 3 )

11! E8Ùb�)%t�#�¹#À3��*N#�_f1�RSÍ×ï\ �­îVï(Wp¥UïVíîvÕ�EF�ñÊÃKîVï(W���¥Ö�¥¦f�§Ð�¿� 15 �zJ17 �zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ©ª��jÊÜ(?_R)�12J16(2006� 3 )

12! àá���å?XL, ¹#À3, E8Ùb�Ataxia telangiectasia(Ûg�0iãHacn¥)��'U�V"#Î�ðvw�¿� 17�zP����T��¹ ¨���rÁ��X± ©]�"z��jÊÜ(1-R)�49J51(2006� 3 )

13! E8Ùb, _f1, �*N#, ¹#À3�����S×�9�Y�uz3��ÒÓ,îVï(WU�VWZÍ�¿� 17 �zPQ½����T��¹� ©]�"z��jÊÜ(±�R)�77J79(2006� 3 )

14! E8Ùb�úû]����� tu�UvwWîVï(WF/�;�îVï(WF/cÔXì�� ¿� 18 � 10  PQ½����� q×Î;×Y��KL�@�3Ë3Uà� QOL �m�U�VW��R(fQR)�210(2006� 10 )

15! å8\���E8Ùb�îVï(W��UvwWíW;WØ×Î¥¦��/fìp�KL� HLAÐÐ�$UDFÃKá�òÎ�8�J�k����J�fJÁf¥¦��8I¿� 17���îVï(W��¥¦��/���|X±jÊÜ(E8R)�14J19(2006� 3 )

16! ]�k1�E8Ùb�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f�§ÐU�VW���J�fJÁf¥¦��8I�¿� 17���îVï(W��¥¦��/���|X±jÊÜ(E8R)�87J103(2006� 3 )

17! E8Ùb�è­«²�vw���O�xM#�'}õs���fLÀ��*N#�àá���_f1�å8\���¹#À3�å?XL�yzþUp¥ÇK BCGþ`Æ��ì�IFNJ�+·�vwñ�LÄ��¿� 17 �zPQ½�����kÞ��/Ò��V(:;U8W ×�Y\©ª��X± ��jÊÜ(@�R)�105J107(2006� 3 )

18! ¹#À3�$%Ë#�¹� ��å?XL�E8Ùb�IgA áU¥��'3�cno#�vw�PQ½h� ¨���rÁ��X±� Ïp��;i¥��U�VWn���� ¿� 18�z�1¡RIL©I��Z;<(1-R)�6(2007� 1 )

19! E8Ùb�iE�d�]�� õ�Q2� ¶�E�r��N_s��5�2�P�82v7��*N#�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f�§ÐU�VW���

¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊI{£�(E8R)�1J3(2007� 2 )

20! E8Ùb�å8\���]�k1�îVï(W��cno#��'��/&É¥�c#�vé3íW;WØ×Î�/f�§ÐvÕ��k�ZÍ�¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊI{£�(E8R)�4(2007� 2 )

21! �*N#�no#ij�¢¿ðvwUvÕ�tu78UvwW�×[U8�Y2eÐt}k��/&É¥�no#c#3íW;WØ×Î�/ìp�¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊI{£�(E8R)�11(2007� 2 )

22! E8Ùb�å?XL��*N#�¹#À3�)%t�#�E8� ��_f1�îVï(W���p¥��¥��¥ÖU�VW���¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊI{£�(5�2R)�125(2007� 2 )

23! E8Ùb�å?XL�¹#À3��*N#�)%t�#�îUÏW��Æp¥3�����UFU���"�vwU�VW���¿� 18 �zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊI{£�(WOR)�143(2007� 2 )

24! E8Ùb�iE�d�]�� õ�Q2� ¶�E�r��5�2�P�82v7��*N#�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f�§ÐU�VW���¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ©]�"z��jÊÜ(E8R)�1J4(2007� 3 )

25! E8Ùb�å8\����fLÀ�îVï(W��cno#��'��/&É¥�c#�vé3íW;WØ×Î�/f�§ÐvÕ��k�ZÍ�¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ©]�"z��jÊÜ(E8R)�5J8(2007� 3 )

26! �*N#�no#ij�¢¿ðvwUvÕ�tu78UvwW�×[U8�Y2eÐt}k��/&É¥�no#c#3íW;WØ×Î�/ìp�¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ©]�"z��jÊÜ(E8R)�39J41(2007� 3 )

27! E8Ùb�iE�d�]�� õ�Q2� ¶�E�r��N_s��5�2�P�82v7��*N#�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f�§ÐU�VW���

¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ©ª��jÊÜ(E8R)�1J4(2007� 3 )

28! E8Ùb�å8\���îVï(W��cno#��'��/&É¥�c#�vé3íW;WØ×Î�/f�§ÐvÕ��k�ZÍ�¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ©ª��jÊÜ(E8R)�5J9(2007� 3 )

29! �*N#�no#ij�¢¿ðvw�vÕ�tu78UvwW�×[U8�Y2eÐt}k��/&É¥�no#c#3íW;WØ×Î�/ìp�¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ©ª��jÊÜ(E8R)�53J59(2007� 3 )

30! ¹#À3�$%Ë#�å?XL�E8Ùb�IgA áU¥��'3�cno#�vw� Ïp��;i¥��U�VWn����¿� 18�zP����T��¹� ¨���rÁ��X±� ©]�"z��jÊÜ(1-R)�41J43(2007� 3 )

31! E8Ùb�_f1��*N#�¹#À3�����S×�9�Y�uz3��ÒÓ�îVï(WU�VWZÍ� S×�9�Y��Ýuê�íîË�u�O�b'�véU�VW��� FU���

�S×�9�Y�uz�+�ðl�3Ýup�pTUïVíî�¿� 16 �zJ18 �z� PQ½����T��¹� ×Þ�È��Èi§ã�|��X±� ©ª��jÊÜ(±�R)�43J46(2007� 3 )

32! E8Ùb��*N#�¹#À3�)%t�#�E8� ��îVï(W���ÀÁ0�3¿^��/ñ�PÇK·�F DE3·��/f�§Ð�Ë�²ú3²°Xø�ÂÃU�VW���¿�

18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ©]�"z��jÊÜ(]�R)�20J24(2007� 3 )

33! E8Ùb�å?XL�%|p��N%� §��*N#�¹#À3�)%t�#�E8� ��_f1�îVï(W���p¥��¥��¥ÖU�VW���¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ©]�"z��jÊÜ(5�2R)�9J11(2007� 3 )

34! E8Ùb�å?XL�¹#À3��*N#�)%t�#�îUÏJ��Æp¥3�����UFU���"�vwU�VW���¿� 18 �zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ©]�"z��jÊÜ(WOR)�20J22(2007� 4 )

35! E8Ùb�iE�d�]�� õ�Q2� ¶�E�r��5�2�P�82v7��*N#�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f�§ÐU�VW���¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊÜ� PQ½��

��T��¹� ��îVï(W��¥¦��/��X±XPÞp`� � 1 "÷(E8R)�177J180(2007� 3 )

36! E8Ùb�å8\����fLÀ�îVï(W��cno#��'��/&É¥�c#�vé3

íW;WØ×Î�/f�§ÐvÕ��k�ZÍ�¿� 18�z� PQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊÜ� PQ½����T��¹� ��îVï(W��

¥¦��/��X±XPÞ� p`� 1"÷(E8R)�181J184(2007� 3 ) 37! E8Ùb�å?XL�%|p��N%� §��*N#�¹#À3�)%t�#�E8� ��_f1

�îVï(W���p¥��¥��¥ÖU�VW���¿� 18�zPQ½����T��¹���îVï(W��¥¦��/��X±� ��jÊÜ� PQ½����T��¹� ��îVï(

W��¥¦��/��X±XPÞ� p`� � 3"÷(5�2R)�161J163(2007� 3 ) 38! E8Ùb�å?XL�¹#À3��*N#�)%t�#�îUÏW��Æp¥3�����UF

U���"�vwU�VW���¿� 18 �zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊÜ� PQ½����T��¹� ��îVï(W��¥¦��/��

X±XPÞ� p`� � 3"÷(WOR)�210J212(2007� 3 ) 39! E8Ùb��*N#�¹#À3�)%t�#�E8� ��îVï(W���ÀÁ0�3¿^��/

ñ�PÇK·�F DE3·��/f�§Ð�Ë�²ú3²°Xø�ÂÃU�VW���¿�

18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊÜ� PQ½����T��¹� ��îVï(W��¥¦��/��X±XPÞ� p`� � 3"÷(]�R)�302J306(2007� 3 )

40! E8Ùb�a�>±�¹#À3�)%t�#��*N#��fLÀ�å?XL���ÒÓ$@ñ²VWtuU@VW¥¦°N�ZÍ(� 3j)��ßàU�VWZÍ�¿� 18�z� PQ½����T��¹� �kÞ��/Ò��V(:;W ×�Y\©ª��X±� ©]�"z��jÊÜ(@�R)�85J87(2007� 4 )

41! V� ³6�E8Ùb�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f§Ð�KL��$Î�ð�kU�VW���J�fJÁf¥¦��8I� ¿� 18�z��îVï(W��¥¦��/���|X±(Ç������`ÊX±)��jÊÜ(E8R)�42J45(2007� 7 )

42! Ohnishi H�Tochio H�Hiroaki H�Kato Z�Kondo N�Shirakawa M�Deposition�Protein Data Bank¢£�Accession number�2z5v ‘Solution structure of the TIR domain of human MyD88’ Date�(2007J07J19)

43! E8Ùb�îVï(W����/&É¥�c#�§Ð�íW;WØ×Î�/f�§ÐU�VW���¿� 18�zPQ½����T��¹� ��îVï(W��¥¦��/��X±�Y¢V¡U(E8R)�15J16(2007� 8 )

44! E8Ùb�iE�d�]�� õ�Q2� ¶�E�r��5�2�P�82v7��*N#�îVï(W�íW;WØ×Î�/0�q×Î;×Y�§Ð3bÊ�U�VW���¿� 19�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊI{£�(E8R)�165J167(2008� 1 )

45! E8Ùb�îVï(W�no£c�Ûþ£c�X3��ÂÃf�§Ð3íW;WØ×Î�/0�q×Î;×Y�§ÐUvÕ�©]�¿� 19 �zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊI{£�(E8R)�168(2008� 2 )

46! E8Ùb�å?XL��*N#�¹#À3�_ft�#�_f1�îVï(W���p¥��¥��¥ÖU�VW���¿� 19�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊI{£�(5�2R)�98(2008� 2 )

47! E8Ùb�a�>±��*N#�_ft�#�tu78 QOL���©]� q×Î;×Y��KL�@�3Ë3Uà� QOL�m�U�VW���¿� 19�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊI{£�(fQR)�73(2008� 2 )

48! E8Ùb�_ft�#�å?XL�¹#À3��*N#�]�k1�îUÏJ��Æp¥3�����UFU���"�vwU�VW���¿� 19�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� ��jÊI{£�(WOR)�8(2008� 2 )

49! E8Ùb��*N#�tu0¶78�·�F �·��/�P?�m�3ÂÃvÕ�0¶78U��VWno#vw� îVï(W���ÀÁ0�3¿^��/ñ�PÇK·�F DE3·��

/f�§Ð�Ë�²ú3²°Xø�ÂÃU�VW���¿� 19�zPQ½����T��¹���îVï(W��¥¦��/��X±� ��jÊI{£�(]�R)�204(2008� 2 )

50! E8Ùb�îVï(W�íW;WØ×Î�/0�q×Î;×Y�§Ð3bÊ��¿� 19 �z PQ½����T��¹ ��îVï(W��¥¦��/��X± ��jÊÜ� � 3"÷(E8R)�359J362(2008� 3 )

51! E8Ùb�å8\����fLÀ�îVï(W�no£c�Ûþ£c�X3��ÂÃf�§Ð3í

W;WØ×Î�/0�q×Î;×Y�§Ð�vÕ�©]�¿� 19 �z PQ½����T��¹ ��îVï(W��¥¦��/��X± ��jÊÜ� � 3"÷(E8R)�363J365(2008� 3 )

52! E8Ùb�a�>±��*N#�_ft�#�tu0¶78���©]�¿� 19�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� "z��jÊÜ� � 1 "÷(fQR)� 496J498(2008� 3 )

53! E8Ùb�å?XL��*N#�¹#À3�_ft�#�_f1�îVï(W���p¥��¥��¥ÖU�VW���¿� 19�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� "z��jÊÜ� � 2"÷(5�2R)�154J156(2008� 3 )

54! E8Ùb�_ft�#�]�k1�?�k`�îUÏJ��Æp¥3������FU���"�vwU�VW���¿� 19�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� "z��jÊÜ� � 2"÷(WOR)�200J202(2008� 3 )

55! E8Ùb��*N#�tu0¶78�·�F �·��/�P?�m�3ÂÃvÕ�0¶78U�VWno#vw�¿� 19�zPQ½����T��¹� ��îVï(W��¥¦��/��X±� "z��jÊÜ� � 2"÷(]�R)�309J311(2008� 3 )

11X^� 1! E8Ùb�o�þ}(3��)ê�+Kíî��Wòô3���/ý�'5ñ#kW�Acuatim

Forum in Gifu &�I 6(2006� 1  1Á) 2! $%ö/�úû]��������ìp��èYéW(i-j�uÊcÔ)������lìpÝ����� 37�54J55(2006� 1  1Á)

3! E8Ùb�¹#À3�k��]lîVï(Wô×�Ä�Vý×Þìpê��Á+¬(2006� 1  13Á)

4! E8Ùb�úû]������E8�³�úû+¬(2006� 1  20Á) 5! E8Ùb�Z�=p¥¥�¥¦Uúµ�xy+¬(2006� 2  9Á) 6! E8Ùb�ý3Çêî�íW�´-¥@�Kh¤� +~Ë�Õ¦�¥íV�X:W\\´;Yëï

(2006� 2  24Á) 7! E8Ùb�� 6 ¡×ÎîVï(W��I� îQ¢�;9�W&ÉU�VW���µ� �k�îVï(W�üZ��ñÇKk�á�òÎUÕ¥��=eñüQ�Medical Tribune(2006� 3  23Á)

8! E8Ùb��*N#�îVï(WÐXñno#=r1��:íV�X:W\�;\ 1(2006 � 3  28Á)

9! E8Ùb��*N#�îVï(WZc�no#Z�9¡U�ìp�úû]�tu�'�����ÙÓ´UHo��ú]�Ã�ë(2006� 4  1Á)

10! å?XL���Ýïì�úû+¬(2006� 4  4Á) 11! �fLÀ�tu8®Ëû�/fñvè��Á+¬(2006� 9  25Á) 12! ¹#À3�­®�/Uôíî� �4�çáqÀv�­ÄÅ�xy+¬(2006� 11  8Á) 13! E8Ùb�ËÌÛ�úû]�{��k��èYéW�Y¢V¡U(2006� 12 ) 14! E8Ùb�����'5UÂÃÄ�úû��Iq­Õ¥� 82�3J5(2007� 1  1Á) 15! E8Ùb�ª¶�4� i-³W\U 5C�úû8� �Á+¬(2007� 1  1Á) 16! E8Ùb��*N#�ýý�=®ï÷K´-¥��Kh¤�NHK� ×�Y\ ZERO(2007� 2 

13Á) 17! E8Ùb�úû]3�;�çá�/[\�úû8� úû+¬(2007� 2  16Á) 18! E8Ùb�yE���;ç­k�úû8� úû+¬(2007� 2  17Á) 19! E8Ùb��*N#�ô®[VWîVï(WñrÁâÕ�´-¥�8®8� �/Kh¤�ý�NHK´

�W�î¡�'r(2007� 3  8Á) 20! E8Ùb�çá�/��èYéWÔN�úû8� xy+¬(2007� 4  25Á) 21! E8Ùb�çá���;çv�ñ� úû]���� i-º� èYéWìÔ�úû8� �Á+¬(2007

� 4  25Á) 22! E8Ùb�úû]����èYéW�aôçá�/ñ¶kWý�úû+¬(2007� 4  25Á) 23! E8Ùb�úû]����� ��;çvS��¥���:íV�� 8îïé×<(2007� 4  25Á) 24! E8Ùb���;çvSU�/èYéWÔN�úû¢�� �­Kyí�(2007� 4  25Á) 25! E8Ùb�üçá�/@�8­ºIª�úû+¬(2007� 4  27Á) 26! E8Ùb�X±�56� �VXî<÷�n� K^k��n�J�fJ?NmëI� ÔÐ 50±�÷�

â� 50���ª¦�20J21(2007� 6 )

27! E8Ùb�úû],çá�/��èYéWñÔN�"�+¬(2007� 6  13Á) 28! E8Ùb�úû]�� çá�/��èYéWñÔN�"�X:W\(2007� 6  18Á) 29! E8Ùb���;ç� '��ÁÂïVK�ñ��Á+¬(2007� 7  9Á) 30! �fLÀ�îVï(W3Ë�@É�9: TBS;Ù�(2007� 8  20�24Á) 31! E8Ùb�#îô�õö� íW�U%¨�xy+¬(2007� 10  12Á) 32! ¹#À3�tuCÑ�/#kW� ��� ��ì­'5jÊ�úû+¬(2007� 10  12Á) 33! E8Ùb�çá�/§ãên���� ��Ø��Ð(ñ~&�úû+¬(2007� 10  18Á) 34! E8Ùb�úû]�U%&ìÔ� ü­l�¹� çá�Ð(ñ����Á+¬(2007� 10  18Á) 35! E8Ùb�çá���4sñèé� d�zbc�úû]������Á+¬(2007� 11  6Á) 36! E8Ùb�“�”�kJ��¥û¥� ��§ãKh¤� ���Á+¬(2007� 12  13Á) 37! E8Ùb�úû]U���çá���4sèéIñì,�"�½j(2007� 12  14Á) 38! E8Ùb�'5�ìêPQ���� ��§ãKh¤� @��Á+¬(2007� 12  15Á) 39! E8Ùb���§ã�«ñ��� úû]�=�Y�ÙÍ<��Á+¬(2007� 12  16Á) 40! �*N#�îVï(W���¥¦UmwK�d��}c#�vé�� 56¡ÁfîVï(W�Ii

5�T]I� Medical Tribune�40�16(2007� 1  4Á) 41! _f1��îVï(W��3no#±I�� LTC4S A-444CUlbñàÂ�=0¶78�²�

¾yÃ�� 19¡ÁfîVï(W�I55§¨]IF�� Medical Tribune�2�104(2007� 7  19Á)

42! E8Ùb�`Ûþ��kF � ÑñÂíû�úû��/'�ïì�úû8� úû+¬(2008 � 1  4Á)

43! E8Ùb�DR�����U¸�¹�úû8� úû+¬(2008� 1  8Á) 44! E8Ùb�DR�����ù°U�çL� ú]­���U¸�¹�úû8� �Á+¬(2008 � 1

  8Á) 45! E8Ùb�]�k1�îVï(W���"#Î�� �§¨U$ÛVWKE����µ3no#±

I��Medical Tribune�41�31(2008� 2  7Á)

12XTUVW Âà ©ªðUêË3í¥�ÂÃê=ëWóĹô9ëòë���µ3±{�gíWßà�m�­Ç�3Wó

�ãrñz�Ç�����Ç�tu�����UÂñ43ÄÃWý3êÂÃUÌVWó�ìUÃ�ÇK

Ãó

'5�´ÅY�Ë�@É� K]�´ÅYê��Ý�\áW\­�t=�÷K­ 2004� 4 ����(),ªUÕ¥�!�3Kó

]���4�ê�� 4�5J=�tu�'��]��êi���®âÄ�U 20Jh¹=�Wóiàáñ7ñWVWtu��§¨ïì®ëÆWh´3íW��iÄUõ�VWý3굨=�W­�îVï(

W����rsUåkÄÛþ� �3no#�Õ�í+Kí��ÙÓ´UñЯ� Ä|LÄÃWó

Ĺ�ÆÇ '4�íW�3>m�gíWab3i]ó�ìU�ý3ì��µñ�/UÙ°ðUÉÊVW U;

Y\VW��Qï8 Wò!ó'4�=����öí03 Û 1!3ie Û 2!3+¬j« Û 3!ñÛÏVWóÎç¥3çáUmwK^3K�����3Õ¥ÕÃ�����3bâÏñ��UÇÄÃWó

Y8Z�&]^ÍÎ�!_

1X���`a 1!8��Nrs3a�� [V\í�Wï$@k=�WHMGCoA reductase�°«=�WîªW\éòYÞk«�!mÊ=�

WÇ�­Tv¥3no#±I3���UÂÃÄZÍÇ��ìU!mÊp¥Òe�véó 2!��í�W<vw NÀ��UvwW��ñvwÇ��'ñ&�VW+ÇÃ�W7WñØÃÆÇ�1VWó

3!�Æp¥Òe CH-B BI��Æ!UvwW Impaired CTL proligeration�Òe�vé�� IDO��Æp¥UvwW��ó 4!�ghî�UW�\vÕ�¤ß�ÒeUÂÃÄ aÎ�ÉïñÊÃÄ�"#Î�ðØçïìî�UW�\vÕ�¤ß�ñÂÃó

5!�­ghUvwW�WU¢rÙW �WU¢rÙW���3�ÒÓU´kWíîñ�×vÕ��­þ��ÉïñÊÃÄZÍó

2Xbc �³� %�� §¨%�� §¨%��

��� � 78`ö ]2ño ¹?=a

Mitsuru Seishima Hiroyasu Ito Yousuke Osawa Hiromitsu Kanamori

3X��Fd�ef Ü !"!

1! ��� ��Á�yL�f8�Ì�8��N3Ë�"l��*u"=��ôZ�Ì�¦ïKý��9:��}��H;2006��173J176�

2! ��� ��yc��#, Á�yL�p(a)��*u"=���ôZ�Ì�¦ïKý��9:��}��H;2006��177J179.

3! ��� ���w�(, yc��#�Lp(a)��*u"=�.��N3�"l��9:��}��H;2006��187J189.

4! ��� ����� ���Ï�6=�ô�E§¨Z���� � 38ý�9:���Ü�;2006��168J180. 5! 2=�s���y©=�ÎMËôMicrobial Handbooký, �k Î;W�îYÎ�ê²�WICIH;

2007��5J76. 6! ��� �����/o�h���,A�8��N� Sï 12H��§¨Z�H��1�9:���kÆ8I

CIH;2008��237J245. 7! ¹?=a���� ���ÒÓZ���� 1/,A��®@�q×Îë¡´�¹@�;2008��163J165. 8! ¹?=a���� ����[W��� 1/,A��®@�q×Îë¡´�¹@�;2008��166J167. 9! �=4d���� ��-.�W7W�@Ô"n=��ØÉ�7ï�WUôZ��Dfý��=Ü�;2008��59J65.

10! 2=�s�]�Z�����Î��2e�I=�Ðæ� �¥ôØÉ�7ï ×�Y\ÎZ��ý�ErÆ8;2008��269J277.

Ü S"! íÇ

©è !"! 1! 8�À���8Wé�U8�U¢rYrsYZ�çè¹Aê�Ðfî��ü��� 2006 �;176 G�20

J26. 2! s��X�Z�ìåÃÌij�µ¶�Z�3ST� 2007�;35G�479J480� 3! �=4d��8Wé���8Í�òZ��F/�+Æì�Medical Technology� 2008�;36G�27J30. 4! �� sJ�§¨Z� Yearbook 2008 �_Z�=�§¨��V�:WF�� 2008�;140��167J169. 5! ]2ño�`�� ����06�N%4´�?-Ov��0:�UÕ¥üQ�3K��÷°�Í\�É

ïUvwWî�UW�\�ÞÒe�Minophagen medical review� 2008�;53�123J125. 6! ��� ��F�� F1õF(z F1õFUïï®WZ�3Q_�õö×Þ0�Ê|18IIj� 2008�;

3G�11J20.

©è S"! 1! Osawa Y, Nagaki M. Cyclooxygenase-2: its paradoxical roles in liver inflammation and fibrosis.

Hepatol Res. 2008;38:772-774.

Ï !"! 1! _M_t�h�� ���*}7�!�O#���ö3���� ����laïì¦KiÜÃ�¥�À�

*+ÒÓ�§¨��� 2006�;54G�325J328. 2! _M_t�·_���å8_`��KXd���� ��­Ù\U�¢�W��UvwW�Ý�}�ç�

�¥z"�3MN�;ØWéZ�:µ��ÌZÍ���Z�� 2006�;55G�639J643. 3! ]c��Ó�s��X�x�M`�,E3Ç#�Á�yL��y0L��fs7�h��±��=4d�

��� ��8[Y�QYU TP}ÏñÊÃK® Z��ZÍ �ÁÐ 7170�"wtNê�ÉÊ��/3Z�Ò��sk� 2006�;29G�603J607.

4! s��X��=4d�x�M`��?���t�3#�Á�yL��8]4�iEp¡���� ��y z��p�YZ���1fUÕW interleukin-8 (IL-8) �1�§¨ð²ÊUÂÃÄ���3k�� 2006�;55G�437J442.

5! ¢­vD�w847��=4d��8Wé���� ��}ÐüQ�Í\��Æ�ÉïUvwW ×U7×Y�la���8Í�ò� 2006�;37G�8J9.

6! w847�¢­vD�¡�CR�<�� â��=4d��8Wé���� ����8Í�ò£����}CCP}Ð�1�Q_�§¨8Í�ò� 2006�;18G�158J162.

7! w847�¢­vD�¡�CR�<�� â��=4d�£����� Cartilage Oligomeric Matrix Proteinuz��1���8Í�ò� 2006�;37G�76J77.

8! w847�¢­vD�¡�CR�<�� â��=4d���8Í�òU@VW�é²Vè�U�n´¡»3Èi�²úU�VWZÍ���~�}�¯°}��IFâ� 2006�;49G�923J924�

9! �c¤.�¥¦!§���+��OÏk���=4d�=�Ë3�A�� ¨�tÄ����-D�Zï7YÌñP�3ÇKå4��¥U@VW�7¢rY(Y�²ú�ZÍ�Á���â� 2007 �;14 G�77J80�

10! �_(#�1�y1�2=�s�':tv#�E[§O�-©³#�ª8v��ü�Ñ(6ÖÑ)h�ØÇK Haemophilis influenzae ñst@ø3VWiÀag�Z�tN;× \=�k« 2st�24�J�»cÔ=�j�ÂÃ�§¨��� 2007�;55G�611J618�

11! Á�yL��=4d�å8«y�E�¬v�­����h��±�78`ö��8Wé���� ��y"#�îÉ��²´òY�1U�VWDRðZÍ��/3Z�Ò��sk� 2007�;30G�499J503.

12! w847��=4d�¢­vD��8Wé���� ����8Í�òU@VW TNF-�ñ�ð3ÇKÎ�ð�«�/�Biotherapy� 2007�;21G�176J180�

13! w847�¢­vD��=4d�¡�CR�<�� â� ×U7×Yuzïì¦K��8Í�òU@VW×Y¢89��ë�§¨úµ���~¯â� 2007�;50G�633J634�

14! w847�¢­vD�¡�CR�<�� â��=4d���8Í�òU@VW�é²ïè�U�n´¡»3²úUÈiUÂÃÄ���8Í�ò�I� 2007�;38G�24J25�

15! w847�¢­vD��=4d�®8Wé���� ����8Í�òU@VW�é²ïè�U�n´¡»�ZÍ�§¨8Í�ò�I� 2007�;19G�164J169�

Ï S"!

1! Fujigaki H, Saito K, Lin F, Fujigaki S, Takahashi K, Martin BM, Chen CY, Masuda J, Kowalak J, Takikawa O, Seishima M, Markey SP. Nitration and inactivation of IDO by peroxynitrite. J Immunol. 2006;176:372-379. IF 6.068

2! Zhu Y, Saito K, Murakami Y, Asano M, Iwakura Y, Seishima M. Early increase in mRNA levels of pro-inflammatory cytokines and their interactions in the mouse hippocampus after transient global ischemia. Neurosci Lett. 2006;393:122-126. IF 2.085

3! Kawamoto N, Kaneko H, Takemura M, Seishima M, Sakurai S, Fukao T, Kasahara K, Iwasaki S, and Kondo N. Age-related changes in intracellular cytokine profiles and Th2 dominance in allergic children. Pediatr Allergy and Immunol. 2006;17:125-133. IF 2.454

4! Fujigaki H, Saito K, Fujigaki S, Takemura M, Sudo K, Ishiguro H, Seishima M. The signal transducer and activator of trenscription 1� and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: involvement of p38 mitogen-activated protein kinase and nuclear factor-�B pathways, and synergistic effect of several proinflammatory cytokines. J Biochem. 2006;139:655-662. IF 2.020

5! Goto N, Tsurumi H, Takemura M, Hara T, Sawada M, Kasahara S, Kanemura N, Yamada T, Shimizu M, Takahashi T, Tomita M, Seishima M, Takami T, Moriwaki H. Serum-soluble tumor factor receptor 2 (sTNF-R2) level determines clinical outcome in patients with aggressive non-Hodgkin’s lymphoma. Eur J Haematol. 2006;77:217-225. IF 2.163

6! Cen X, Nitta A, Ohya S, Zhao Y, Ozawa N, Mouri A, Ibi D, Wang L, Suzuki M, Saito K, Ito Y, Kawagoe T, Noda Y, Ito Y, Furukawa S, Nabeshima T. An analogue of dipeptide-like structure of FK506 increases GDNF expression through CREB activated by Hsp90/Akt signaling pathway. J Neurosci. 2006;26:3335-3344. IF 7.490

7! Niwa M, Nitta A, Yamada Y, Nakajima A, Saito K, Seishima M, Shen L, Noda Y, Furukawa S, Nabeshima T. An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-alpha

protects against methamphetamine-induced rewarding effects and sensitization. Biol Psychiatry. 2007;61:890-901. IF 8.456

8! Li Y, Takemura G, Okada H, Miyata S, Kanamori H, Maruyama R, Esaki M, Li L, Ogino A, Ohno T, Kondo T, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H. ANG II type 1A receptor signaling causes unfavorable scar dynamics in the postinfarct heart. Am J Physiol Heart Circ Physiol. 2007;292:946-953. IF 3.973

9! Li Y, Takemura G, Okada H, Miyata S, Maruyama R, Esaki M, Kanamori H, Li L,Ogino A, Ohno T, Kondo T, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H. Molecular signaling mediated by angiotensin II type 1A receptor blockade leading to attenuation of renal dysfunction-associated heart failure. J Card Fail. 2007;13:155-62. IF 3.067

10! Niwa M, Nitta A, Yamada Y, Nakajima A, Saito K, Seishima M, Shen L, Noda Y, Furukawa S, Nabeshima T. An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-alpha protects against methamphetamine-induced rewarding effects and sensitization. Biol Psychiatry. 2007;61:890-901. IF 8.456

11! Kanamori H, Takemura G, Li Y, Okada H, Maruyama R, Aoyama T, Miyata S, Esaki M, Ogino A, Nakagawa M, Ushikoshi H, Kawasaki M, Minatoguchi S, Fujiwara H. Inhibition of Fas-associated apoptosis in granulation tissue cells accompanies attenuation of postinfarction left ventricular remodeling by olmesartan. Am J Physiol Heart Circ Physiol. 2007;292:2184-2194. IF 3.973

12! Li L, Takemura G, Li Y, Miyata S, Esaki M, Okada H, Kanamori H, Ogino A, Maruyama R, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H. Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy. Lab Invest. 2007;87:440-455. IF 4.479

13! Takahashi K, Saito K, Masuda J, Fujigaki S, Takemura M, Ito H, Seishima M.Changes in neuronal protein expression in LP-BM5-infected mice. Neurosci Lett. 2007;422:114-118. IF 2.085

14! Aoki M, Fukao T, Kaneko H, Mizunaga S, Mitsuyama J, Sawamura H, Seishima M, Kondo N.Clinical and bacteriological evaluation of the efficacy of piperacillin in children with pneumonia. J Infect Chemother. 2007;13:224-229.

15! Niwa M, Nitta A, Yamada Y, Nakajima A, Saito K, Seishima M, Noda Y, Nabeshima T. Tumor necrosis factor-alpha and its inducer inhibit morphine-induced, Rewarding effects and sensitization. Biol Psychiatry. 2007;62:658-668. IF 8.456

16! Ogino A, Takemura G, Kanamori H, Okada H, Maruyama R, Miyata S, Esaki M, Nakagawa M, Aoyama T, Ushikoshi H, Kawasaki M, Minatoguchi S, Fujiwara T, Fujiwara H. Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling. Am J Physiol Heart Circ Physiol. 2007;293:2271-2280. IF 3.973

17! Kimura A, Sakurai T, Tanaka Y, Hozumi I, Takahashi K, Takemura M, Saito K, Seishima M, Inuzuka T. Proteomic analysis of autoantibodies in neuropsychiatric systemic lupus erythematosus patient with white matter hyperintensities on brain MRI. Lupus. 2008;17:16-20. IF 2.248

18! Shinohe R, Sato M, Takemura M, Shimizu K, Koishi H , Tanaka R, Saito K, Seishima M. Cytokine profiles in mice with arthritis induced by anti-type II collagen monoclonal antibody plus lipopolysaccharide. Jpn J Clin Chem. 2008;37:53-62.

19! Kajita K, Mune T, Ikeda T, Matsumoto M, Uno Y, Sugiyama C, Matsubara K, Morita H, Takemura M, Seishima M, Takeda J, Ishizuka T. Effect of fasting on PPARgamma and AMPK activity in adipocytes. Diabetes Res Clin Pract. 2008;81:144-149. IF 1.823

20! Sakashita F, Osada S, Takemura M, Imai H, Tomita H, Nonaka K, Takahashi T, Seishima M. The effect of p53 gene expression on the inhibition of cell proliferation by paclitaxel. Cancer Chemother Pharmacol. 2008;62:379-385. IF 2.568

21! Maruyama R, Goto K, Takemura G, Ono K, Nagao K, Horie T, Tsujimoto A, Kanamori H, Miyata S, Ushikoshi H, Nagashima K, Minatoguchi S, Fujiwara T, Fujiwara H. Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2008;295:H1599-607. IF 3.973

22! Nakagawa M, Takemura G, Kanamori H, Goto K, Maruyama R, Tsujimoto A, Ohno T, Okada H, Ogino A, Esaki M, Miyata S, Li L, Ushikoshi H, Aoyama T, Kawasaki M, Nagashima K, Fujiwara T, Mintoguchi S, Fujiwara H. Mechanisms by which late coronary reperfusion mitigates post infarction cardiac remodeling. Circ Res. 2008;103:98-106. IF 9.721

23! Okada H, Takemura G, Li Y, Ohno T, Li L, Maruyama R, Esaki M, Miyata S, Kanamori H, Ogino A, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H. Effect of a long-term treatment with a low dose granulocyte colony-stimulating factor on post-infarction process in the heart. J Cell Mol Med. 2008;12:98-106. IF 6.807

24! Taguchi A, Hara A, Saito K, Hoshi M, Niwa M, Seishima M, Mori H. Localization and spatiotemporal expression of IDO following transient forebrain ischemia in gerbils. Brain Res. 2008;1217:78-85. IF 2.218

25! Chousa M, Ito H, Saito K, Takahashi K, Takemura M, Takahashi T, Tomita E, Seishima M. The measurement of serum ceruloplasmin is useful for diagnostic differentiation of immune thrombocytopenic purpura. Clin Chim Acta. 2008;389:132-138. IF 2.601

26! Ito H, Ando K, Ishikawa T, Nakayama T, Taniguchi M, Saito K, Imawari M, Moriwaki H, Yokochi T,

Kakumu S, Seishima M. Role of Valpha14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of Valpha14+ NKT cells promotes the breakage of CTL tolerance. Int Immunol. 2008;20:869-879. IF 3.290

27! Sudo K, Yamada Y, Saito K, Shimizu S, Ohashi H, Kato T, Moriwaki H, Ito H, Seishima M. TNF-alpha and IL-6 signals from the bone marrow derived cells are necessary for normal murine liver regeneration. Biochim Biophys Acta. 2008;1782:671-679. IF 4.041

4X��ghiOj 1Zklmno 1! ��ræ����� ����"z��®8Wé�!�O#;"���h������¹DU��(B)�

2 ��Q� LC/MS ñÊÃKÀÁ������'vw�\í<U�VW��;¿� 17J19 �z;14,400^_(5,500�5,200�3,700^_)

2! ��ræ��®8Wé;¿� 18�zúû]�`�+T���*+��UvwW+Kí��()c#3ÇÄ� Indoleamine-2,3-dioxygenaseU�VW��;¿� 18�z;1,200^_

3! ��ræ���=4d���"z����� ��®8Wé, "���h������¹DU��(C)�\éòYUÕWÇ�­Tvp¥�Ø7X�<�vé3no#Z�ñÊÃK¥�f�§Ð;¿� 18J19�z;3,500^_(1,800�1,700^_)

4! ��ræ��]2ño;"���h������¹Ç���(B)���÷°UvwW\¢�YVWX�ZQï��gh�õS1ÒeU�VW��;¿� 19J20 �z;3,300 ^_(1,800�1,500 ^_)

5! ��ræ��78`ö;¿� 20�zúû]�`�+T��gh÷°UvwWU8�U¢rYrs()�vé3���ê��/ÉÊ;¿� 20�z;1,050^_

6! ��ræ��¹?=a;¿� 20�zúû]�`�+T��Ð�­UvwW�WU¢rÙW�ÒÓðíì�U�'�ðZÍ;¿� 20�z;1,050^_

2Zpq�� íÇ

3Zr��� 1! ��� �, ®8Wé��ãr§¨Z�ij�\í<U�VW��;¿� 18�z;500^_�ICIH�×îYÎí�W

2! ®8Wé: +�ìpÉñ×\ñÊÃK§¨��í�W<vwU�VW��;¿� 18�z;100^_: 9VICIH

3! ��� ��ë�;�Y�mÊÒevw;¿� 19�z;1,819^_��)�k¯ 4! ��� �, 78`ö�Q�Ïî DS×�WskvÕ�[îZÏî Figsk�DRðZÍ;¿� 19�z;180^_�����kÞ¯

5Xes�tuvwOj íÇ

6Xx?@ 1Zxyz ��� �� 1! Áf§¨Z���IÂL2(�'4) 2! Áf§¨��IÂL2(�'4) 3! Áf§¨Z�Àa��IÂL2(�'4) 4! Áfa���IÂL2(�'4) 5! Áf§¨"#��IÂL2(�'4) 6! Áf§¨Z���I�T�|�O2(�'4) 7! Áf§¨Z���I�InO2(�'4) 8! i--Ð]���Z��ILnX(95���ë�¡´)(�¿� 18�) 9! Áf§¨Z���I�InO2(�'4)

10! Áf§¨��I-./0O2(¿� 19� 4 �'4)

2Zx{| íÇ

3Z}~� ��� �� 1! �/3Z�Ò��sk;=�O2(�¿� 18�)

7Xx��$�����������%� ��� �� 1! <°¨±§¨Z������GD¹ ¿� 18 �zt²*Çn2n÷�%¨I(2007 � 2  �9:�÷�%¨ôî�8��N��ðÒÓ3��3��®¥ý¨�)

2! õö×Þ0�ÊI��¶�ÔЩI(2007� 10 �úû���%¨ôØéÙ8¡´�YÎ�W<3×`ý¨�)

78`ö� 1! � 43¡Áfg��I��¶�©I(2006� 10 �úû��Y�ÙÍ<ôÎ �­Ïca[{c#3íW��UÂÃÄ�KE�LÅý��YÎU9�YUÕWÜÝ�;i�Í\�Éï�ìpý�

¨�) 2! õö×Þ0�ÊI� ��¶�ÔÐ÷��Y�ÙÍ<(¶Ó<ì%&)(2007 � 10  �úû��Y�ÙÍ<ô ×�Èi�È�êBì3ÄÃWï�ýJôõö×Þ�è³ý§¨��Ð�ïìõö×Þñ#kWJ¨�)

®8Wé� 1! The 11th Meeting of International society for Tryptophan research(2006.06, Tokyo, Physiological

significances of tryptophan-kynurenine pathway metabolism. In CNS Opening remark: What is the new in the kynurenine pathway in CNS.–In the past, present and future; Speaker)

2! The 6th Korea-Japan Gerontologist Joint Meeting(2006.06, Korea, Oxidative stress, inflammation and aging: The physiological significance of cerebral indoleamine-2,3-dioxygenase following transient cerebral ischemia in gerbil; Speaker)

3! Áf§¨��I95��¶�©I(2006� 6 , wxy¶, �Y�ÙÍ<ô�'ñ´kW§¨��Z�� New Marker TNF-�3Ë���"#ñéW�¡U3ÇK§¨��í�W<vwý¨�)

4! Recent advances in kynurenine pathway metabolism in CNS. ISTRY 2006, (2006.07, Tokyo, Significance of IDO in CNS : Inhibition of increased indoleamine-2, 3-dioxygenase activity exacerbates neuronal cell death in various CNS disorders; Panelist)

5! � 1¡§¨Z�����I(2006� 8 , 9:, �Y�ÙÍ<� §¨Z�S���ôc­�ÃÄdK« : §¨Z�S�����e�ý¨�)

8X}�>�p�Oj 1! 78`ö�È8�D�,_uv��E}§�5�� r��8Wé�*µ«7�?-Ov�MPM����� ��The 5th JSH Single Topic Conference Young Investigator Award (¿� 18�z)

2! ��� ��t²*Çn2n(¿� 19�z) 3! 78`ö�%fÙs�yc��#�È8�D�,_uv��8Wé��=4d�*µ«7�?-Ov���� ��The 6th JSH Single Topic Conference Best Poster Award (¿� 19�z)

4! I¶â7�?�·#��O+ó#��� �#�¡O�¸�_M_t�å8_`��KXd�78`ö���� ��� 33¡Áf�¹Z��I YIA(Young Investigator’s Award)^kn(¿� 20�z)

5! ¹?=a��=����E1t�¹8!#�V� 6º���� ��»�¨v�8ÏO_�� 12¡Áf�;i�T�I YIA(Young Investigator’s Award)^kn(¿� 20�z)

6! ¹?=a��=���_�"«��E}"�_=�s�¹8!#�V� 6º�8ÏO_���� ��»�¨v�� 30¡�­Z��IÇ�¸Án(¿� 20�z)

9X�x?@ 1! úûü�z0��ðO2(úûü)(�'4) 2! úû¶�z0��ðO2(úû¶)(�'4)

3! úûü��I§¨Z��z0�O2IO2(úûü��I)(�'4) 4! §¨Z�S�stO2IO2�(PQ½h)(�¿� 19� 6 ) 5! F ST���|O2IO2(J�fJúûü<¼²èYéW)(�'4)

10X^�� 1! ��� ��®8Wé�!�O#�2��Q� LC/MSñÊÃKÀÁ������'vw�\í<U�VW���¿� 18�z"���h������¹DU��(B)����µjÊÜ(2006� 3 )

2! ��� ���8Wé�!�O#�2��Q� LC/MSñÊÃKÀÁ������'vw�\í<U�VW���¿� 19�z"���h������¹DU��(B)����µjÊÜ(2007� 3 )

3! !�O#���� ���8Wé��=4d�\éòYUÕWÇ�­Tvp¥�Ø7X�<�vé3no#Z�ñÊÃK¥�f�§Ð�¿� 18 �z"���h������¹DU��(C)����µjÊÜ(2006� 3 )

4! �=4d���� ���8Wé�\éòYUÕWÇ�­Tvp¥�Ø7X�<�vé3no#Z�ñÊÃK¥�f�§Ð�¿� 19�z"���h������¹DU��(C)����µjÊÜ(2007� 3 )

11X^� 1! ��� ��o�%2�\UV\»Ì��úû+¬(2006� 2  24Á)

12XTUVW Âà ��±{ê¹øUí÷Ä°ÇáW\î¡�ÇK ­�¥��3ï¥1ÇÄÃK��ñ´8îÇK3³

®3Wó}�p¹UÂÃÄê����Tñ��Uô�°Ç�ÞVWÕ�ÁÂÇíw3¸íìíí��

Tn�2nô�¥�iÐðUê��UTÇK3ÂÃÇ�Wó

'5�´ÅY�Ë�@� °J»�KL���§ã3�ÖUÃïUú¾ðí����U[WïñKÄWï­�£íÄÅ=�Wó

Ĺ�ÆÇ ��deê±úU®KW­�íW�ûu%&vÕ�ucÔ3�j���ñDØðU`Ã�ú¾ðí�

�ñ�PÇKÃó