· Web view2012-2014 წლების განმავლობაში, USAID -ის...

2012 2014

2012-2014 , USAID - (., The Lancet, The New England Journal of Medicine, British Medical Journal, Evidence-Based Medicine , Circulation .) , -, , (., - WHO), , (., NICE) , , . , , .

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-Lactam Monotherapy vs -LactamMacrolide Combination Treatment in Moderately Severe Community-Acquired PneumoniaA Randomized Noninferiority Trial.

NicolasGarin,MD1,2; DanielGenn,MD3; SebastianCarballo,MD, DPhil1; ChristianChuard,MD4; GerhardtEich,MD5; OlivierHugli,MD, MPH6; OlivierLamy,MD7; MathieuNendaz,MD, MHPE1; Pierre-AugustePetignat,MD8; ThomasPerneger,MD, PhD9; OlivierRutschmann,MD, MPH10; LaurentSeravalli,MD3; StephanHarbarth,MD, MS11; Ar

JAMA Intern Med.2014;174(12):1894-1901. doi:10.1001/jamainternmed.2014.4887naudPerrier,MD1

http://archinte.jamanetwork.com/article.aspx?articleid=1910547

, - - , - , "JAMA Internal Medicine" - 2014 -. , , - , . , , , 2009- 2013 , . - , - - + . Legionella pneumophila - , . , -7 ( < 100/ -, > 90 .., < 38,0 C, < 24/ -, > 90% -, ).- 7 , 120 291- (41,2%) 97 289 (33,6%) ;- , , - Pneumonia Severity Index (PSI) - IV ( ) , , , , , PSI - I- III , ;- , 30 (7,9%, 3,1% -);- , , 90 .

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MESA Analysis Uncovers Link Between Persistent Asthma and Cardiovascular Disease.

Tattersall MC, Guo M, Korcarz CE, et al. Asthma predicts cardiovascular disease events: The Multi-Ethnic Study of Atherosclerosis (MESA). American Heart Association Scientific Sessions; November 17, 2014; Chicago, IL

http://www.medscape.com/viewarticle/834995.

(AHA) 2014 , , , , , - ( , , , , - / , , ) 60%- . - (MESA- Multi-Ethnic Study of Atherosclerosis) 6792 ( , 38% - ), 62 , . 156 , ( , ) . 511 , , , 6125 - .

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Identification of children at risk of influenza-related complications in primary and ambulatory care: a systematic review and meta-analysis

Peter J Gill, DPhil,Helen F Ashdown, MRCGP, DrKay Wang, DPhil, ProfCarl Heneghan, DPhil, Nia W Roberts, MSc Econ, ProfAnthony Harnden, FRCGP, Susan Mallett, DPhil

http://www.thelancet.com/journals/lanres/article/PIIS2213-2600(14)70252-8/fulltext

, "The Lancet Respiratory Medicine" - - ., , , .Medline-, Medline in Process -, Embase -, Science Citation index - CINAHL - , , , , . . 27 , 14 086 ., - :- ( - OR - 4,62), (OR - 4,33), (OR - 3,46), (OR - 2,39), (OR - 2,34) 2 (OR - 2,51);- , , , , , - ;- 1612 , - , , -, 2 . , - . , , , , , , , 2 , -. , , , , - .

Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis.

Anne K rtqvist, doctoral candidate, Cecilia Lundholm, statistician, Helle Kieler, associate professor, Jonas F Ludvigsson, professor, Tove Fall, associate professor, Weimin Ye, professor,

Catarina Almqvist, professor

http://www.bmj.com/content/349/bmj.g6979

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Adverse Respiratory Effect of Acute B-bloker Exposure in Asthma: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Daniel R. Morales, MBChB; Cathy Jackson, MD; Brian J. Lipworth, MD; Peter T. Donnan, PhD; Bruce Guthrie, PhD

http://journal.publications.chestnet.org/article.aspx?articleid=1767055#Acknowledgments

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A systematic review of associations between environmental exposures and development of asthma in children aged up to 9years

S Dick, A Friend,K Dynes,F AlKandari,E Doust,H Cowie,J G Ayres, ,S W Turner

http://bmjopen.bmj.com/content/4/11/e006554.full

"BMJ Open"- 2014 , , 9 . , , . , , , , , (., , ), , , , . 2013 , Medline-, Embase-, Cochrane Controlled Trials Register (CCTR) CINHAL - . : (, ), , / , ( , , ) , , ( , ) , ( ), (, ) , , , , . 9 , .

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Adenotonsillectomy reduces acute asthma exacerbations in children, study shows

Susan Mayor, London

http://www.bmj.com/content/349/bmj.g6575

, , 30% - , , - "The British Medical Journal" - , - . . , . , , , . , , . 3- 17 13 506 - , 2003- 2010 . "MarketScan" - (, , ) 27 012 , , . . , . , , :- 30,2% - , . , , 2% - ;- , (37,9-45.6% -);- , , , .- , 16,7% -, 21,5% -, 13,4% - 23,7% - . , , . , , , .

Increased incidence of inflammatory bowel disease in Qubec residents with airway diseases

Paul Brassard, Maria Vutcovici, Pierre Ernst , Valrie Patenaude, Maida Sewitch , Samy SuissaandAlain Bitton

http://erj.ersjournals.com/content/early/2014/11/18/09031936.00079414.1.abstract

"European Respiratory Journal" , , , . , .. 2001-2006 . 136 178 - 143 904 .- 100 000 23,1-, - 8,8- ;- - 26,2 17 , 100 000 ;- - , 27 55% - , ;- , 30% - - ;, , , , , , , - . , , , .

Sinusitis and Pneumonia Hospitalization After Introduction of Pneumococcal Conjugate Va ccine

Ann Lindstrand, MD, MPH ,Rutger Bennet, MD, PhDc,Ilias Galanis, MSc, Margareta Blennow, MD, PhD ,

Lina Schollin Ask, MD, Sofia Hultman Dennison, MD,Malin Ryd Rinder, MD, Ph, Margareta Eriksson, MD, PhD,Birgitta Henriques-Normark, MD, PhD , ke rtqvist, MD, PhD , andTobias Alfvn, MD, PhD

http://pediatrics.aappublications.org/content/early/2014/11/05/peds.2013-4177.abstract

, , "Pediatrics"- 2014 ., , 1 , , . Streptococcus pneumoniae . 1- 59 , 826 000 , , S.pneumoniae - , , 7% - . (PCV). , , (PCV7 PCV13) ., . 0-18 , , , , 2003- 2012 . :- 0- 2 , , 100 000 , 70 - 24 ;- , 450- 366-, 100 000 , 0- 2 , 250 - 212 - 2- 5 ;- ;- 0- 2 , , , , , 0-5 ; PCV7 PCV13 0- 2 , 66% -, - 19% -. , , PCV7 PCV13 . . - . .

Adult asthma increases dementia risk: a nationwide cohort study

Yi-Hao Peng ,Biing-Ru Wu ,Ching-Hua Su,Wei-Chih Liao ,Chih-Hsin Muo ,Te-Chun Hsia,Chia-Hung Kao

http://jech.bmj.com/content/early/2014/09/30/jech-2014-204445.abstract

, (11- ) 65 , - , , "Journal of Epidemiology and Community Health", 2014 30 . . , , . , 11 , 12 771 , (2001-2003 ), 51 084 , . 1,27-, , , , , . . , , , . , , , , , . ., , , . , .

Biomarker-based asthma phenotypes of corticosteroid response

Douglas C. Cowan, BMedSci, MBChB, MRCP, PhD D. Robin Taylor, MD, DSc, FRCP (Ed)

Laura E. Peterson, BA, Jan O. Cowan, Rochelle Palmay, Avis Williamson, Jef Hammel, MS, Serpil C. Erzurum, MD

Stanley L. Hazen, MD, PhD, Suzy A.A. Comhair, PhD

http://www.jacionline.org/article/S0091-6749(14)01521-8/fulltext

"The Journal of Allergy and Clinical Immunology - , . , , (ICSs) . , , , , . , (Feno) . Feno . ( , -Bromotyrosine(BrTyr)) . 18-75 46 , , , 40 , . , , , : 1 - - FEV1- 12% , (Asthma Control Questionnaire) 0,5 , , -5- () 2- , , FEV1- 20%- - PC20AMP.- , , ;- 28 , 82%-, 60%- , 58%-;- , , Feno- BrTyr- , (13,3-, P < .01) ;- , .

Mismatch between Asthma Symptoms and Spirometry: Implications forManaging Asthma in Children

Elizabeth D. Schifano, PhD, Jessica P. Hollenbach, PhD, Michelle M. Cloutier, MD

http://www.jpeds.com/article/S0022-3476(14)00650-7/abstract

, , - "The Journal of Pediatrics" - , , - . , 2008 - 2012 , 5-19 894 , , . , . 30%- , 32%, 33% 35% - - , -, - . - 1 - (FEV1) (FVC); , FEV1/FVC% - FVC% - , . 319 (36% -) , . 0,16 -. , , , , , . , , . .

Revised WHO classification and treatment of childhood pneumonia at health facilities

EVIDENCE SUMMARIES

http://apps.who.int/iris/bitstream/10665/137319/1/9789241507813_eng.pdf?ua=1

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Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

Janine Beale, Annabelle Jayaraman, David J. Jackson, Jonathan D. R. Macintyre ,Michael R. Edwards ,Ross P. Walton ,Jie Zhu ,Yee Man Ching ,Betty Shamji,Matt Edwards,John Westwick,David J. Cousins ,You Yi Hwang,Andrew McKenzie, Sebastian L. JohnstonandNathan W. Bartlett

http://stm.sciencemag.org/content/6/256/256ra134

" Science Translational Medicine" - , . , , , . -25- (IL-25) , . , in vitro , . 8 , IL-25 - , 10- , . 39 , 28 , IL-25 - . 10 , 60%- (17 ) IL-25 - . , , , IL-25 - , ., IL-25 . , , .

-

Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease

Kayleigh M Kew,Alieksei Seniukovich

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010115.pub2/abstract

, . -2 (LABA) , , . -2 , , , . , ("The Cochrane Airways Group Specialised Register of Trials (CAGR) , -, clinical.trials.gov, , . , , 12 , - , - , -2 - -2 . 43 30 000, - , , . , ( , - ). - , (18 , 1000 - 18 ) , , , ;- , , (9 1000 - 6 ), . , , , , 640 - , , , 320 ;- , (-, ) ;- ( ). , , . , - , .

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Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

Aida Semic-Jusufagic, MD,Danielle Belgrave, PhD,ProfAndrew Pickles, PhD,Aurica G Telcian, MD,Eteri Bakhsoliani, MSc,Annemarie Sykes, MD,ProfAngela Simpson, MD,ProfSebastian L Johnston, MD,ProfAdnan Custovic

http://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2814%2970096-7/fulltext

, , , - 17q21- . 11 . , , . , (- ) (Haemophilus influenzae and Streptococcus Pneumoniae) , , , . 1 7q21 . 916 , , ( ) , . , 2 . , ( ) . , 17q21 .

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Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial

DrPallavi Mandal, MRCP,James D Chalmers, MRCP,Catriona Graham, MSc,Catherine Harley, MRCP,Manjit K Sidhu, MRCP,Catherine Doherty, PhD,ProfJohn W Govan, DSc,ProfTariq Sethi, PhD,Donald J Davidson, PhD,ProfAdriano G Rossi, DSc,Adam T Hill, MD

http://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2814%2970050-5/abstract

, , . , , . , , . - , , , , , , . , . 18 - 79 , ( , ) , . , , , , . (80 ), , , 6 . , , - Leicester Cough Questionnaire(LCQ). . , LCQ , . , ( ., - 8 C- ). . , , .

Inhaled corticosteroids in children: effects on bone mineral density and growth

DrAnne L Fuhlbrigge, MD,ProfH William Kelly, PharmD


, , , . , ( 0.42 ) 12 ( 6 ). (The Chilhood Asthma Management Program) 5 12 , 1041 , 4 6 , . , , 1.3 2 1.2 . , , , . , , (, ). , , "" . ( D3- ) , . , , , .

Inhaled Steroids Do Not Prevent Wheezing in Children with Upper Respiratory Tract Infections

Katherine Bakes, MDreviewingClavenna A et al.Pediatrics2014 Mar

http://www.jwatch.org/na33764/2014/03/26/inhaled-steroids-do-not-prevent-wheezing-children-with

, - ""- , . () 1- 5 , 40 -. , 525 ( 2 ) 10 400 g . : , , . , - . 10 . 47 - 26- 10 , 21- - . , "" . , 46%- . , - 10- 60%-. .

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A Comparison of the Efficacy and Safety of Non-Steroidal Anti-Inflammatory Drugs versus Acetaminophen in Symptom Relief for the Common Cold: A Meta-Analysis of Randomized Controlled Trial Studies

Choi IK, Lee HK, Ji YJ, Hwang IH, Kim SY.

http://www.ncbi.nlm.nih.gov/pubmed/23904953

, - (PubMed-, Cochrane-, Embase-, CINAHL-, Kmbase- KoreaMed- ) , , . 61 5 . "" , , , . . , ., , , , - . , - - , . , , . , - .

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Risk factors for severe acute lower respiratory infections in children: a systematic review and meta-analysis

Jackson S, Mathews KH, Pulanic D, Falconer R, Rudan I, Campbell H, Nair H.


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General practitioners' prescribing behaviour as a determinant of poor persistense with inhaled corticosteroids in children with respiratory symptoms: mixed methods study

ed Klok, Ad A Kaptein, Eric Duiverman, Frank S Oldenhof, Paul L P Brand

http://bmjopen.bmj.com/content/3/4/e002310.long

. , (ICS) , . 7 , 19 . 2-12 134 , 1 . ICS- . , , ICS- , . , 51% (68 ) ICS -. .

" British Medical Journal " - -.

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A randomized, double-blind, placebo-controlled trial of oral montelukast in acute asthma exacerbation

Ali Bin Sarwar Zubairi, Nawal Salahuddin, Ali Khawaja, Safia Awan, Adil Aijaz Shah, Ahmed Suleman Haque, Shahid Javed Husain, Nisar Rao, and Javaid Ahmad Khan

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616955/

, , - , Aga Khan University - . 16 , . 100 , . . , .

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Asthma and COPD in the UK: Time to Ignite Change

http://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2814%2970173-0/fulltext

2011 , , . , 6 , , (NHS), 4,7 . , , , , , 2010 , . 2- 3- , .

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Cardiovascular Events After Clarithromycin Use in Lower Respiratory Tract Infections

Stuart Schembri, Peter A Williamson Philip M Short, Aran Singanayagam, Ahsan Akram, Joanne Taylor, Anika Singanayagam, Adam T Hill, James D Chalmers

http://www.medscape.com/viewarticle/781527_1

- - . : . : , 2009-2011 12- - ; , 2005- 2009 . - 1343 1631 , . . - ( , , ) (ST- , ST- ). - .: - 268 - , - 171 . - . : - . .

The Role of Inhaled Corticosteroids in Management of Asthma in Infants and Preschoolers


(ICS) , , " " " " , . . - ICS - .

PubMed.gov.- -

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HIV-Associated Obstructive Lung Diseases:Insights and Implications for the Clinician

Dr M Bradley Drummond, MD, Gregory D Kirk, MD


() - , 16-20%- . - , 55-75 -. - 21%- . , - - , .

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Efficacy of daily intranasal fluticasone propionate on ocular symptoms associated with seasonal allergic rhinitis

Paul Ratner, MD, Julius Van Bavel, MD, Dale Mohar, MD, Robert L. Jacobs, MD, Frank Hampel, MD, William Howland, MD, Ritu Karwal, MSc

http://www.annallergy.org/article/S1081-1206%2814%2900853-9/abstract

, , "Annals of Allergy, Asthma and Immunology"- . , . , , , -, , , 200 - , 14 , . , (Patient-rated reflective total ocular symptom score - rTOSS) , - rTOSS , . , , . , :- , , , ;- , rTOSS , , , ;- , , ;- , .

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Variation in treatment of acute childhood wheeze in emergency departments of the United Kingdom and Ireland: an international survey of clinician practice

Mark D Lyttle, Ronan O'Sullivan, Iolo Doull, Stuart Hartshorn, Ian Morris, Colin V E Powellbehalf of PERUKI

http://adc.bmj.com/content/100/2/121.abstract

"" , - , "Archives Disease in Childhood" - . , , , ., , . 2013 . , . , , , . 30 , 183 (81%) . 97% - , 40% - - . , , , . , :- 54% , 28% - ( ) 15% - ;- 48% , 16% - , . 148 (80%) .;- 170 , , 146 - , 21 - , 164 - , ;- , ;- 24% , . , , , , . , .

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Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials

Joanna Dobson, MSc, Prof Richard J Whitley, MD, Prof Stuart Pocock, PhD, Prof Arnold S Monto, MD

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)62449-1/abstract

"The Lancet" - - , . (2009 ), . , , . , / . Medline -, PubMed -, Embase -, (The Cochrane Central Register of Controlled Trials) , ,ClinicalTrials.gov-, , 2014 , , , , ., -, - 75 -, 2- , 5 . ( , , , 21,5 - ). . 9 4 328 . 2 402 -, 1926 . 66%, , , - - 68%. A , - A-H3N2.- :- , - , , , 97,5 -, , - 122, 7 - ;- , , , 48 - ;- ;- , (, ) , , , , , ;- , .

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Morphine or Ibuprofen for Post-Tonsillectomy Analgesia: A Randomized Trial

Lauren E. Kelly, PhD, Doron D. Sommer, MD, Jayant Ramakrishna, MD, Stephanie Hoffbauer, BHS, Sadaf Arbab-tafti, BHSc, Diane Reid, MD, Jonathan Maclean, MD, Gideon Koren, MD

http://pediatrics.aappublications.org/content/early/2015/01/20/peds.2014-1906

/ , . , , . , ( ). , , . , - , , . "Pediatrics" - . , 1- 10 91 , , , . , . (10-15 /-) , , (10 /-), (0,2-0,5 /-) , "McMaster Childrens Hospital and The Hospital for Sick Children" - . , -5 . .- , , 86%-, ;- , 68%-. , , , . , , . , . , , , , , , .

Effect of Corticosteroids on Treatment Failure Among Hospitalized Patients With Severe Community-Acquired Pneumonia and High Inflammatory Response

AntoniTorres,MD, PhD1,2,3,4; OriolSibila,MD, PhD5,6; MiquelFerrer,MD, PhD1,2,3; EvaPolverino,MD, PhD1,2,3; RosarioMenendez,MD, PhD3,7; JosepMensa,MD, PhD2,8; AlbertGabarrs,MSc1,2,3; JacoboSellars,MD, PhD1,2,3; Marcos I.Restrepo,MD, MSc9,10,11; AntonioAnzueto,MD, PhD9,10; Michael S.Niederman,MD12; CarlesAgust,MD, PhD1,2,3

"The JAMA Network" - , , - . . , 10-20% -, . , . , ., , -, - , (C- >150 /-). , , 5 , (), 0,5 /-, 12 - , . 36 - . ( , , , , 72 ) ( , , , , , 72-120 - ).- , , ( 8, 18 );- , ( , 10 15%- );- , (11 - 7- -). , , , , , , . , , .http://jama.jamanetwork.com/article.aspx?articleid=2110967

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Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma

Erick Forno, MD, MPH, Yueh-Ying Han, PhD, Radhika H. Muzumdar, MD, Juan C. Celedn, MD, DrPH

, . - "The Journal of Allergy and Clinical Immunology" - . , , -, , .- , 12 - 17 1429 , "National Health and Nutrition Examination Survey"-. 95 . :- , , FEV1- (1 ) FVC - ( ) , , (FEV1/FVC) , ;- , ;- - , , ;- , , FEV1/FVC 2% - , - 6% -, - 10% -.- - (., -, ). , , , , , . , . , , , .

http://www.jacionline.org/ar/S0091-6749(15)00099-8/fulltext

- :, , -

Association Between Use of -Blockers and Outcomes in Patients With Heart Failure and Preserved Ejection Fraction

Lars H.Lund,MD, PhD; LinaBenson,MSc; UlfDahlstrm,MD, PhD; MagnusEdner,MD, PhD; LeifFriberg,MD, PhD

http://jama.jamanetwork.com/article.aspx?articleid=1935124

, , , " The JAMA Network" - -. , (HFPEF), , , . , , . , , . , 67 , , 95 , 2005 2012 .19 083 ( 48%- ), , 8244 , 5496 - , , 2728 - , . , . , - , , .- , , 1 , , 80% -, - 79% -;- 5 , 45 42% - , - 41 45% -, , 1000 , , 177 191 .- , , , . .

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Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Japanese Patients 60 Years or Older With Atherosclerotic Risk FactorsA Randomized Clinical Trial

YasuoIkeda,MD; KazuyukiShimada,MD; TamioTeramoto,MD; ShinichiroUchiyama,MD; TsutomuYamazaki,MD; ShinichiOikawa,MD; MasahiroSugawara,MD; KatsuyukiAndo,MD; MitsuruMurata,MD; KenjiYokoyama,MD; NaokiIshizuka,PhD

http://jama.jamanetwork.com/article.aspx?articleid=1936801

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Anemia and Reduced Kidney Function as Risk Factors for New Onset of Atrial Fibrillation (From the Ibaraki Prefectural Health Study)

DongZhu Xu, MD, PhD, Nobuyuki Murakoshi, MD, PhD, Toshimi Sairenchi, PhD, Fujiko Irie, MD, PhD, Miyako Igarashi, MD, PhD, Akihiko Nogami, MD, PhD, Takuji Tomizawa, MD, PhD, Iwao Yamaguchi, MD, PhD, Kazumasa Yamagishi, MD, PhD, Hiroyasu Iso, MD, PhD, Hitoshi Ota, MD, PhD, Kazutaka Aonuma, MD, PhD

http://www.ajconline.org/article/S0002-9149%2814%2902077-3/abstract

, - . , - , "The American Journal of Cardiology" - -. 132 250 (40-79 ), 15 , , .13,8 , 1232 (0,93%) . - (eGFR 2 /) (34% - ) ;- , 50- 60 , 5 , , - ;- , 75 ., , , 75 -, , . , - 5 , / . , .."-" -.

Stroke Linked to Increased Cancer Risk

http://www.medscape.com/viewarticle/839931#vp_1

(International Stroke Conference, 2015) , , , , . , , , , , 2 , , , 1,4- (, ), , 3- . 1997-2001 , -, (The Vitamin Intervention for Stroke Prevention- VISP- Study) , 120 . 66 .- 2 , 3247 133 . (35.3%.). 18% - , 2013 . , , ;- , , - 1 1,2- , 2 - 1,4- ;- "" , , , , , - , , / ; , ; , / ;- - , , 50 , 2 , 1,4- , 50 . , - - , , . , , , . .

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treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and Mortality in Older Nursing Home Residents

AthanaseBenetos,MD, PhD1,2,3; CarlosLabat,BSc2; PatrickRossignol,MD, PhD2,3; RenaudFay,PharmD3; YvesRolland,MD, PhD4; FilippoValbusa,MD5; PaoloSalvi,MD, PhD6; MauroZamboni,MD, PhD7; PatrickManckoundia,MD, PhD8; OlivierHanon,MD, PhD9; SylvieGautier,MD1

80 , . , , , , , . "JAMA Internal Medicine" - , ., , , . - "The PARTAGE Study"- 1127 . (

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