11

When Engineers meet When Engineers meet BioscientistsBioscientists

Gary Wang 10/31/2009Gary Wang 10/31/2009

22

Greener?Greener?

Biotech

IT industry

33

Life Science? Bio-Tech? High-Life Science? Bio-Tech? High-Tech?Tech? May be subjective and will change over timeMay be subjective and will change over time

No “official” definitions of Life Science, Bio-Tech, and High-Tech No “official” definitions of Life Science, Bio-Tech, and High-Tech but according to North American Industry Classification System but according to North American Industry Classification System (NAICS) (NAICS)

44

Why? Why? (1)(1)

“80% products of Fry’s Electronics are not necessities of our life.”

-- Judy Wang, Family talk, 2006

“Daddy, next time when you come to my house, could you bring me a new toy?”

-- Derek Wang, Skype call, 2005

55

Why? Why? (2)(2)

High-tech Impact Biotech Impact

66

MotivationMotivation

2003 International Technology Roadmap 2003 International Technology Roadmap for Semiconductors (ITRS) clearly identifies for Semiconductors (ITRS) clearly identifies the integration of electrochemical and the integration of electrochemical and electrobiological techniques as one of the electrobiological techniques as one of the system-level design challenges that will be system-level design challenges that will be faced beyond 2009faced beyond 2009

Electrical engineering technologies and Electrical engineering technologies and microfluidics can be fully integrated to microfluidics can be fully integrated to provide advanced biochemical solutions.provide advanced biochemical solutions.

77

MotivationMotivation

88

What? What? (1)(1)

POCT (Point-of-Care Testing)

Learning BusinessLearning Business Learning TechnologiesLearning Technologies

Lab-on-a-chip technology Lab-on-a-chip technology may soon become an may soon become an important part of efforts to important part of efforts to improve global health improve global health particularly through the particularly through the development of point-of-development of point-of-care testing devices.care testing devices.

99

IVD (In Vitro Diagnostic) IVD (In Vitro Diagnostic) MarketMarket

1010

Continuous-Flow Continuous-Flow MicrofluidicsMicrofluidics

• “miniaturized total chemical analysis systems” (µTAS)

• the broader terms “microfluidics” and “lab-on-a-chip” are now often used in addition to µTAS.

1111

Digital MicrofluidicsDigital Microfluidics• electrowetting-on-dielectric (EWOD)

• EWOD refers to the modulation of the interfacial tension by applying an electric field

• Many advantages of EWOD architecture

• We are filing significant IP’s

1212

Very different business modelVery different business model Very diversified industry with Very diversified industry with

Fragmented marketsFragmented markets Longer development cycle & slower Longer development cycle & slower

pace pace Very different mindsetVery different mindset Not Silicon Valley friendlyNot Silicon Valley friendly

So? So? (1)(1)

1313

Different business modelDifferent business model

1414

Technology driven but Technology driven but conservative businessconservative business

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1515

Veterinary Diagnostic Veterinary Diagnostic EquipmentEquipment

Hematology analysisHematology analysis Automated hematology analyzersAutomated hematology analyzers Coagulation analyzersCoagulation analyzers Blood typing kits Blood typing kits

Biochemistry analysisBiochemistry analysis Biochemistry systemsBiochemistry systems Dry chemistry systemsDry chemistry systems Blood gas analyzersBlood gas analyzers Electrolyte analysisElectrolyte analysis Lactate metersLactate meters Glucose metersGlucose meters ImmunoassaysImmunoassays

Competitive immunoassaysCompetitive immunoassays Sandwich immunoassaysSandwich immunoassays Animal-site rapid immunoassaysAnimal-site rapid immunoassays

DNA testingDNA testing Bile acid tests and othersBile acid tests and others Urine test kitsUrine test kits RefractometersRefractometers

Blood pressure monitorsBlood pressure monitors Pulse oximetersPulse oximeters

Digital oximetersDigital oximeters CapnographyCapnography Vital signs monitorsVital signs monitors Anesthesiology equipmentAnesthesiology equipment

Anesthetic machines Anesthetic machines Breathing systemsBreathing systems VentilatorsVentilators Anesthetic agentsAnesthetic agents

RadiographyRadiography Digital radiographyDigital radiography Computed tomographyComputed tomography Dental radiographyDental radiography Peripherals and consumablesPeripherals and consumables

Diagnostic ultrasoundDiagnostic ultrasound Large animal reproductionLarge animal reproduction Small animal reproductionSmall animal reproduction Equine tendonEquine tendon CardiologyCardiology OphthalmologyOphthalmology Ultrasound systemsUltrasound systems Three dimensional ultrasoundThree dimensional ultrasound

Magnetic resonance imagingMagnetic resonance imaging Other imagingOther imaging

Gamma camerasGamma cameras Dermatology imagingDermatology imaging PACSPACS EndoscopesEndoscopes

LaparoscopesLaparoscopes Tract endoscopesTract endoscopes Gastroscopes Gastroscopes Bronchoscopes Bronchoscopes Thoracoscopes Thoracoscopes CystoscopesCystoscopes OtoscopesOtoscopes RhinoscopesRhinoscopes

1616

Longer development cycleLonger development cycle

Reboot is not an optionReboot is not an option Regulatory Regulatory

requirementsrequirements FDA, The European Medicines FDA, The European Medicines

Agency (EMEA) and PMDA (Japan)…Agency (EMEA) and PMDA (Japan)… Clinical trialsClinical trials GMP (Good manufacturing practice)GMP (Good manufacturing practice)

Regional Regional differences/protectionsdifferences/protections

X3 ?X3 ?

1717

Very different mindsetVery different mindset

Know-how?Know-how? Anti-big-companies?Anti-big-companies? Team work?Team work? More individual dependent?More individual dependent? More Self-centered?More Self-centered? Scientistic vs. Engineering?Scientistic vs. Engineering? Degree important?Degree important?

1818

Not Silicon Valley friendlyNot Silicon Valley friendly

Anti-high-tech altitude?Anti-high-tech altitude? Silicon Valley culture? Silicon Valley culture? Difficult to start from your garage?Difficult to start from your garage? Rational decision?Rational decision? Lack knowledge & appreciation of Lack knowledge & appreciation of

advanced IT technologies?advanced IT technologies?

1919

So? So? (2)(2)

2020

Roadkills?Roadkills? Set the right expectationsSet the right expectations Planning is the keyPlanning is the key DeterminationDetermination Reach outReach out Timing is rightTiming is right

Increasing demands on Increasing demands on multi-disciplined talents multi-disciplined talents

No Recession in IVD No Recession in IVD (2/6/2009 (2/6/2009 Kalorama Information)Kalorama Information)

Act now!Act now! Or “120” questionOr “120” question

2121

ConclusionConclusion