Post on 20-Mar-2018
Tumour Lysis Syndrome
Section I: Scenario Demographics
Scenario Title: Tumour Lysis Syndrome (TLS)Date of Development: 24/02/2016 (DD/MM/YYYY)
Target Learning Group: Juniors (PGY 1 – 2) Seniors (PGY ≥ 3) All Groups
Section II: Scenario Developers
Scenario Developer(s): Donika Orlich (modified case Dysrhythmia secondary to hyperkalemia by Kyla Caners)
Affiliations/Institution(s): McMaster UniversityContact E-mail (optional): Donika.orlich@medportal.ca
Section III: Curriculum Integration
Section IV: Scenario Script
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Learning Goals & ObjectivesEducational Goal: To expose learners to a case of Tumour Lysis Syndrome with severe hyperkalemia,
hyperuricemia and hypocalcemia as its metabolic complications.CRM Objectives: 1) Demonstrate leadership by maintaining a global perspective and organizing team to
deliver multiple drug therapies2) Utilize resources appropriately by calling for help when indicated3) Demonstrate problem solving ability by implementing concurrent management
approach and avoiding fixation error4) Employ communication skills to obtain an immediate code status from a family
memberMedical Objectives: 1) Recognize hyperkalemia on ECG and initiate ED therapy
2) Investigate for the possibility of tumour lysis syndrome in the setting of recent chemotherapy for hematologic cancer by highlighting the importance of serum electrolyte levels and their distrubances, including hyperuricemia.
3) Considers indications for treatment of hypocalcemia in the ED setting4) Consults nephrology for dialysis
Case Summary: Brief Summary of Case Progression and Major EventsA 72-year-old male is brought in as a “code STEMI” to the resuscitation bay. He was recently diagnosed with ALL and had chemotherapy 3 days ago for the first time. The patient is severely hyperkalemic, which must be initially recognized and treated, hypocalcemic and hyperuricemic as a result of Tumour Lysis Syndrome and the metabolic derangements must be stabilized until emergent hemodialysis is arranged.
ReferencesPfennig CL, Slovis CM. (2013). Electrolyte disorders. In J. Marx, R. Hockberger & R. Walls (Eds.), Rosen's emergeny medicine - concepts and clinical practice. pp. (1636-51). Philadelphia, PA.:Saunders.Website: accessed on April 14, 2015: http://lifeinthefastlane.com/ecg-library/basics/hyperkalaemia/
Website: accessed on Feb 24, 2016: http://lifeinthefastlane.com/ccc/tumour-lysis-syndrome/
Tumour Lysis Syndrome
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A. Scenario Cast & RealismPatient: Computerized Mannequin Realism:
Select most important dimension(s)
Conceptual Mannequin Physical Standardized Patient Emotional/Experiential Hybrid Other: Task Trainer N/A
Confederates Brief Description of RoleWife: The wife arrives with the patient. The wife will stress the fact that he would not want
CPR or intubation unless the acute condition is reversible. She will ask the team leader directly “is this a reversible problem?”. The wife will then ask general questions (“what’s happening now?”) and will follow directions if asked to leave the bedside.
B. Required Monitors EKG Leads/Wires Temperature Probe Central Venous Line NIBP Cuff Defibrillator Pads Capnography Pulse Oximeter Arterial Line Other:
C. Required Equipment Gloves Nasal Prongs Scalpel Stethoscope Venturi Mask Tube Thoracostomy Kit Defibrillator Non-Rebreather Mask Cricothyroidotomy Kit IV Bags/Lines Bag Valve Mask Thoracotomy Kit IV Push Medications Laryngoscope Central Line Kit PO Tabs Video Assisted Laryngoscope Arterial Line Kit Blood Products ET Tubes Other: Intraosseous Set-up LMA Other:
D. MoulageNone required.
E. Approximate TimingSet-Up: 3 min Scenario: 15 min Debriefing: 30 min
Tumour Lysis Syndrome
Section V: Patient Data and Baseline State
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A. Clinical Vignette: To Read Aloud at Beginning of Case72M complaining of general weakness for 2 days. His wife called EMS and he was a STEMI patch to your hospital. He has been placed in the resuscitation bay.
B. Patient Profile and HistoryPatient Name: Geoff Brady Age: 72 Weight: 80kgGender: M F Code Status: DNRChief Complaint: Weak and dizzyHistory of Presenting Illness: Felt unwell since waking up this morning. Feels light headed with standing and like he “has no energy.” Nauseous. Has newly diagnosed ALL and had his first round of chemotherapy 3 days ago.Past Medical History: ALL Medications: Ramipril 5mg OD
HTN Crestor 20mg ODDyslipidemia Cisplatin
Allergies: PenicillinSocial History: Retired. Lives with his wife. No EtOH/smoking/illicit drug use.Family History: No hx CAD. All have diabetes.Review of Systems: CNS: Generally weak.
HEENT: Nil.CVS: No CP. No palps.RESP: No SOB.GI: Nausea.GU: NilMSK: Muscle cramps and paresthesia’s INT: Nil.C. Baseline Simulator State and Physical Exam
No Monitor Display Monitor On, no data displayed Monitor on Standard DisplayHR: 50/min BP: 92/65 RR: 16/min O2SAT: 97% RARhythm: Idioventricular T: 36.4oC Glucose: 12.7 mmol/L GCS: 13 (E3 V4 M6)General Status: Slightly diaphoretic. Looks unwell.CNS: A+Ox3. No focal neurologic deficits. No asterixis.HEENT: PERLA. 3mm.CVS: Normal S1/S2. No murmur.RESP: GAEB. No adventitious sounds.ABDO: Soft, NT.GU: Nil.MSK: Nil. SKIN: No rashes.
Tumour Lysis Syndrome
Section VI: Scenario Progression
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Tumour Lysis Syndrome
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Scenario States, Modifiers and TriggersPatient State Patient Status Learner Actions, Modifiers & Triggers to Move to Next State1. Baseline StateRhythm: idioventricularHR: 50/minBP: 92/65RR: 20/minO2SAT: 97% RAT: 36.4oC
Diaphoretic, awake, answering questions. Feels dizzy.
Learner Actions- IV, O2, monitors- ECG- Blood work including trop, extended lytes, uric acid, lactate- Fluid bolus- Check cap sugar (12.7)- Administer calcium gluconate 1g (10-30ml) iv- ± ASA 160mg PO chew
ModifiersChanges to patient condition based on learner action- Calcium given HR 70, QRS narrows (change to sinus)- Fluid bolus BP 102/67
TriggersFor progression to next state- Calcium not given by 3 min 2. Arrest- Initial work-up complete and calcium given 4. VBG Back
2. ArrestRhythm AsystoleBP -/-RR 0O2SAT ?
Unresponsive with no vitals.
Learner Actions- Quality CPR- Calcium chloride 1-2 amps- NaHCO3 amps- Epinephrine amps- 1 amp D50 then insulin R 10 units iv
Modifiers- 7 minutes into case critical VBG back showing hyperkalemia
Triggers- Calcium given 3. NSR
3. NSRRhythm sinusHR 70BP 105/70RR 16O2SAT 97% RA
Awake and responding.
Learner Actions- Ventolin 20mg nebulized, 24 puffs, or 0.5mg IV- 1amp D50 then insulin R 10 units iv (if not yet done)- Repeat ECG- ± HCO3 amp- Call nephro re: dialysis
Modifiers- Ventolin given HR 90
Triggers- Two treatments for hyperK given and Nephro called 4. Blood Work Back- 12 minutes 4. Blood Work Back
4. VBG BackRhythm sinusHR 70BP 105/70
Awake, alert, no longer feels dizzy.
Learner Actions- Ventolin 20mg nebulized, 24 puffs, or 0.5mg IV- 1amp D50 then insulin R 10 units iv- Repeat ECG- ± HCO3 amp- ± Lasix 40mg iv (if still makes urine)- Call nephro re: dialysis
Modifiers- Given critical VBG result showing hyperkalemia as state starts- Ventolin given HR 90
Triggers- Two treatments for hyperK given and Nephro called 4. Blood Work Back-12 minutes 4. Blood Work Back
5. Blood Work Back
Patient still complaining of muscle crams, otherwise better.
Learner Actions- Recognize likely Tumour Lysis syndrome- IV NV bolus (goal u/o 2cc/h)- Allopurinol (600-800mg/d)- Rasburicase- ± Lasix 20mg IV (hyperK, volume overload, poor u/o)- IV Calcium gluconate (1-2g over 10 minutes)- Call MedOnc re admission- Call Nephro for dialysis
Modifiers- Given lab results showing hyperuricemia, hyperphosphatemia and hypocalcemia as state starts- If no treatment for hyperuricemia initiated, phone call from the “Lab” informing that the “Urate and calcium at a level that must be treated”,
Triggers- Considers or initiates a
Tumour Lysis Syndrome
Section VII: Supporting Documents, Laboratory Results, & Multimedia
Laboratory ResultsCritical VBG:pH 7.27PCO2 35PO2 45HCO3 20Lactate 2.5Na 142K 8.6Cl 105
Labs:Troponin: 5INR: 1.0WBC: 8Neuts: 1.0Hb: 140Plt: 300Urate 400 umol/L (high)Cr: 650 umol/L (high)PO4: 3.0 mmol/L (high)Ca: 1.98 mmol/L (low)
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Images (ECGs, CXRs, etc.) ECG 1: Hyperkalemia STEMI mimic(Source: http://lifeinthefastlane.com/ecg-library/basics/hyperkalaemia/)
ECG 2: NSR with no ST changes(Source: http://cdn.lifeinthefastlane.com/wp-content/uploads/2011/12/normal-sinus-rhythm.jpg)
Tumour Lysis Syndrome
Section VIII: Debriefing Guide
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General Debriefing Plan Individual Group With Video Without Video
ObjectivesEducational Goal: To expose learners to a case of Tumour Lysis Syndrome with severe hyperkalemia,
hyperuricemia and hypocalcemia as its metabolic complications.CRM Objectives: 1) Demonstrate leadership by maintaining a global perspective and organizing
team to deliver multiple drug therapies2) Utilize resources appropriately by calling for help when indicated3) Demonstrate problem solving ability by implementing concurrent
management approach and avoiding fixation error4) Employ communication skills to obtain an immediate code status from a
family memberMedical Objectives: 1) Recognize hyperkalemia on ECG and initiate ED therapy
2) Investigate for the possibility of tumour lysis syndrome in the setting of recent chemotherapy for hematologic cancer by highlighting the importance of serum electrolyte levels and their distrubances, including hyperuricemia.
3) Considers indications for treatment of hypocalcemia in the ED setting4) Consults nephrology for dialysis
Sample Questions for Debriefing1) What are the ECG changes associated with hyperkalemia?2) What are some mimics of ST elevation on an ECG?3) What lab abnormalities can be seen with tumour lysis syndrome? What causes each?4) What are symptoms of hypocalcemia? What is the risk in treating it?
Key MomentsIdentification of hyperkalemia on ECG.
Alteration of ACLS management to include copious calcium and HCO3 in context of hyperkalemia
Recognition of Tumor Lysis Syndrome as the cause of hyperkalemia and initiation of therapy aimed at hyperuricemia and symptomatic hypocalcemia.