TS Alliance Grant Analysis

1984-2010

TS Alliance Research Grants Programs

Since 1984, the TS Alliance has supported investigator-initiated research in the general areas of: Genetics of TSC Basic mechanisms of tumor growth Basic mechanisms of CNS manifestations of TSC Cognition Clinical trials Translational research Development of research tools

Funding Mechanisms

This has been accomplished through funding of: Predoctoral Student Awards Postdoctoral Fellowship Awards – Basic and Clinical Junior Investigator Awards Senior Investigator Awards Conference Awards

Research Grants Programs

During the period of 1984-2010 the TS Alliance has supported the following programs: Research Grant Awards Center Without Walls TS Alliance Rothberg Courage Awards TSC Drug Screening Program

Research Resources

In addition, the TS Alliance has supported the development of research tools and resources, including: TSC Patient Registry (N. Lenn) TSC1/2 Variation Database (S. Povey & R. Ekong) Seizure Tracker Clinical Trial Tool (L. & R. Moss) TSC Tissue Bank (Stein)

Analysis of TS Alliance Research Grant Programs

The following slides illustrate: Analysis of TS Alliance funds directed to each grant

mechanism (Conference, Predoctoral, Postdoctoral, Junior and Senior);

Analysis of TS Alliance funds directed to specific TSC research areas (Basic Mechanisms of CNS Manifestations, Basic Mechanisms of Tumor Growth, Genetics, Cognition, Clinical Trials, Research Tools, and Translational Research);

Distribution of funding across funding mechanisms for each research area;

Analysis of PIs who continue to be involved in TSC research and/or clinical care;

Funding of specific PIs by the TS Alliance, NIH and DoD; and Analysis of TS Alliance funding that was used to leverage

funding from NIH and DoD

Data for Analysis

Data for analysis was derived from: TS Alliance funding information from 1984-present NIH Reporter CDMRP Award Search

2%

33%

38%

27% 1%

Total Funding By Grant Mechanism

Conference Postdoctoral Junior Senior Predoctoral

2%

37%

30%

29%

2%

Type of Grant Award

Predoctoral Postdoctoral Junior Senior Conference

21%

28%4%

5%

37%

2%3%

TSC Research Funding Areas

Basic Mechanisms - CNS Basic Mechanisms Clinical Trials Cognition Genetics Research Tools Translational

11%

26%

47%

16%

Basic Mechanisms of CNS Manifestations of TSCPredoctoral Postdoctoral Junior Senior Conference

54%

18%

25% 4%

Basic Mechanisms of Tumor Growth in TSC

Predoctoral Postdoctoral Junior Senior Conference

33%

67%

Clinical Trials

Predoctoral Postdoctoral Junior Senior Conference

14%

29%

43%

14%

Cognition

Predoctoral Postdoctoral Junior Senior Conference

43%

32%

25%

Genetics

Predoctoral Postdoctoral Junior Senior Conference

20%

80%

Research Tools

Predoctoral Postdoctoral Junior Senior Conference

33%

33%

33%

Translational Research

Predoctoral Postdoctoral Junior Senior Conference

33%

67%

Clinical Trials

54%

18%

25%4%

Basic Mechanisms of Tumor Growth in TSC

Predoctoral Postdoctoral Junior Senior

11%

26%

47%

16%

Basic Mechanisms of CNS Manifestations of

TSC

14%

29%

43%

14%

Cognition

43%

32%

25%

Genetics

20%

80%

Research Tools

33%

33%

33%

Translational

Predoctoral Postdoctoral Junior Senior Conference0

20

40

60

80

100

120

PIs Still in TSC Research/Clinical Care(Percent of Funded PIs)

(19/34)(15/28)

(16/27)

(2/2) (2/2)

0

2,000,000

4,000,000

6,000,000

8,000,000

10,000,000

12,000,000

14,000,000

Funding for TSC Researchers

TS Alliance-PI TS Alliance-Lab NIH DoD

Henske

Yeung

Pericak-Vance

Northrup

Dabora

Crino

Kwiatkowski

Walker

SahinBissler

$8,694,741

$60,047,276

$6,859,075

TS Alliance Funding Leveraged to NIH and DoD

TS Alliance NIH DoD

Conclusions and Recommendations

TS Alliance-funded researchers have successfully leveraged funding from NIH and DoD for TSC.

The use of different funding mechanisms varies by research area, but significant funds have been invested in Postdoctoral and Junior Investigators across all research areas.

Providing funding for basic, translational, clinical research, clinical trials, and research tool development has served the TSC research community well.

Continued and increased flexibility in funding is needed to support not only young investigators, but also for Junior and Senior Investigators who provide expertise, experience and dedication to TSC research.