TS Alliance Grant Analysis 1984-2010. TS Alliance Research Grants Programs Since 1984, the TS...
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Transcript of TS Alliance Grant Analysis 1984-2010. TS Alliance Research Grants Programs Since 1984, the TS...
TS Alliance Grant Analysis
1984-2010
TS Alliance Research Grants Programs
Since 1984, the TS Alliance has supported investigator-initiated research in the general areas of: Genetics of TSC Basic mechanisms of tumor growth Basic mechanisms of CNS manifestations of TSC Cognition Clinical trials Translational research Development of research tools
Funding Mechanisms
This has been accomplished through funding of: Predoctoral Student Awards Postdoctoral Fellowship Awards – Basic and Clinical Junior Investigator Awards Senior Investigator Awards Conference Awards
Research Grants Programs
During the period of 1984-2010 the TS Alliance has supported the following programs: Research Grant Awards Center Without Walls TS Alliance Rothberg Courage Awards TSC Drug Screening Program
Research Resources
In addition, the TS Alliance has supported the development of research tools and resources, including: TSC Patient Registry (N. Lenn) TSC1/2 Variation Database (S. Povey & R. Ekong) Seizure Tracker Clinical Trial Tool (L. & R. Moss) TSC Tissue Bank (Stein)
Analysis of TS Alliance Research Grant Programs
The following slides illustrate: Analysis of TS Alliance funds directed to each grant
mechanism (Conference, Predoctoral, Postdoctoral, Junior and Senior);
Analysis of TS Alliance funds directed to specific TSC research areas (Basic Mechanisms of CNS Manifestations, Basic Mechanisms of Tumor Growth, Genetics, Cognition, Clinical Trials, Research Tools, and Translational Research);
Distribution of funding across funding mechanisms for each research area;
Analysis of PIs who continue to be involved in TSC research and/or clinical care;
Funding of specific PIs by the TS Alliance, NIH and DoD; and Analysis of TS Alliance funding that was used to leverage
funding from NIH and DoD
Data for Analysis
Data for analysis was derived from: TS Alliance funding information from 1984-present NIH Reporter CDMRP Award Search
2%
33%
38%
27% 1%
Total Funding By Grant Mechanism
Conference Postdoctoral Junior Senior Predoctoral
2%
37%
30%
29%
2%
Type of Grant Award
Predoctoral Postdoctoral Junior Senior Conference
21%
28%4%
5%
37%
2%3%
TSC Research Funding Areas
Basic Mechanisms - CNS Basic Mechanisms Clinical Trials Cognition Genetics Research Tools Translational
11%
26%
47%
16%
Basic Mechanisms of CNS Manifestations of TSCPredoctoral Postdoctoral Junior Senior Conference
54%
18%
25% 4%
Basic Mechanisms of Tumor Growth in TSC
Predoctoral Postdoctoral Junior Senior Conference
33%
67%
Clinical Trials
Predoctoral Postdoctoral Junior Senior Conference
14%
29%
43%
14%
Cognition
Predoctoral Postdoctoral Junior Senior Conference
43%
32%
25%
Genetics
Predoctoral Postdoctoral Junior Senior Conference
20%
80%
Research Tools
Predoctoral Postdoctoral Junior Senior Conference
33%
33%
33%
Translational Research
Predoctoral Postdoctoral Junior Senior Conference
33%
67%
Clinical Trials
54%
18%
25%4%
Basic Mechanisms of Tumor Growth in TSC
Predoctoral Postdoctoral Junior Senior
11%
26%
47%
16%
Basic Mechanisms of CNS Manifestations of
TSC
14%
29%
43%
14%
Cognition
43%
32%
25%
Genetics
20%
80%
Research Tools
33%
33%
33%
Translational
Predoctoral Postdoctoral Junior Senior Conference0
20
40
60
80
100
120
PIs Still in TSC Research/Clinical Care(Percent of Funded PIs)
(19/34)(15/28)
(16/27)
(2/2) (2/2)
0
2,000,000
4,000,000
6,000,000
8,000,000
10,000,000
12,000,000
14,000,000
Funding for TSC Researchers
TS Alliance-PI TS Alliance-Lab NIH DoD
Henske
Yeung
Pericak-Vance
Northrup
Dabora
Crino
Kwiatkowski
Walker
SahinBissler
$8,694,741
$60,047,276
$6,859,075
TS Alliance Funding Leveraged to NIH and DoD
TS Alliance NIH DoD
Conclusions and Recommendations
TS Alliance-funded researchers have successfully leveraged funding from NIH and DoD for TSC.
The use of different funding mechanisms varies by research area, but significant funds have been invested in Postdoctoral and Junior Investigators across all research areas.
Providing funding for basic, translational, clinical research, clinical trials, and research tool development has served the TSC research community well.
Continued and increased flexibility in funding is needed to support not only young investigators, but also for Junior and Senior Investigators who provide expertise, experience and dedication to TSC research.