Post on 23-Feb-2016
description
Trifunctional Aminoamide Cellulose Derivative and its
Characterization
Outline• Objectives• Problem statement and motivation of
the study• Presuppositions from Literature• Methodology
Objectives• To illustrate how to use a couple of
techniques to confirm the structural of a newly synthesized material and its intermediate.
• To illustrate how to use a couple of techniques to characterize a final product and so provide some information for applications.
Problem statement and motivation of the study
• What are dendrimers?• “A dendrimer is a
molecule with a form like the branches of a tree.”[1]
• Dendrimers can be used in pharmaceutics, genetics, catalyst chemistry and superconductor currently or potentially. [2][1] Wikipedia[2] Sand, Anders. Dendrimers and Their Technical Applicability
Cellulose-based dendrimers
Zhang, Changde et al. Biomacromolecules (2006), 7(1), 139-145.
Presuppositions from Literature• Narrow molecular weight
distribution• The most exciting physical
property of dendrimers is the variation of their intrinsic viscosities with molecular weight. [6] It is found that, when the generation increases beyond a certain point, the intrinsic viscosity begins to decline, contrary to the behavior of linear polymers (Fig.4).
[6] http://www.dendritech.com/pamam.html
Methodology • Using 1H to confirm the structural of intermediate
product:• Using FT-IR to confirm and characterize the
structural of CMCBA and CMCBADMPDA:• Using NMR to confirm and characterize the
structural of CMCBA and CMCBADMPDA: • Using TGA to Characterize the Degree of
Substitution of CMCBA and CMCBADMPDA: • Using Intrinsic Viscosity to characterize the
conformation of CMCBADMPDA:• Using GPC-LS to characterize the MW and MWD of
CMCBADMPDA:
Using 1H to confirm the structural of intermediate product:
Using FT-IR to confirm and characterize the structural
Using NMR to confirm and characterize the structural of CMCBA
and CMCBADMPDA:
Using TGA to Characterize the Degree of Substitution
Using Intrinsic Viscosity to characterize the conformation
• CMC 5.62 dL/g, • CMCDMPDA 3.57 dL/g • CMCBADMPDA 0.39 dL/g
Using GPC-LS to characterize the MW and MWD of CMCBADMPDA:
Conclusions• The author got the “right ” product.• The product is of very low viscosity,
which is suitable for drug delivery.