gp120

gp41

p17

RNAp24

env

gag

Reverse transcriptase (RT)

IntegraseProtease pol

genome

gp120

gp41

p17

RNAp24

env

gag

Reverse transcriptase (RT)

IntegraseProtease pol

genome

The HIV virus

Committee on Oversight and Government Reform. HIV/AIDS Today, 1(1):1, January 18, 2008

UNAIDS Global Report, 2012

UNAIDS Global Report, 2010

Percent of adults (15+) living with HIV who are female, Percent of adults (15+) living with HIV who are female, 19901990––20072007

0

10

20

30

40

50

60

70

Percent female (%)

Sub-Saharan AfricaGLOBALCaribbeanAsiaE Europe & C AsiaLatin America

1990‘91 ‘92 ‘93 ‘94 ‘95 ‘96 ‘97 ‘98 ‘99 ‘00 ‘01 ‘02 ‘03 ‘04 ‘05 ‘06 2007Year

5

The HIV/AIDS Epidemic in the U.S. through 2011

Kaiser Family Foundation. Black Americans and HIV/AIDS. Fact Sheet, March 2013

Kaiser Family Foundation. Black Americans and HIV/AIDS. Fact Sheet, March 2013

El-Sadr WM, Mayer KH, Hodder SL. AIDS in America -Forgotten but not gone. NEJM 362(11):969, 2010.

El-Sadr WM, Mayer KH, Hodder SL. AIDS in America - Forgotten but not gone. NEJM 362(11):968, 2010.

The HIV/AIDS Epidemic in California

California Department of Health Services, Office of AIDS, HIV/AIDS Case Registry Section, Dec 2012

The HIV/AIDS Epidemic in Los Angeles

County of Los Angeles Public Health. 2010 Annual HIV Surveillance Report, Jan 2011

County of Los Angeles Public Health. 2011 Annual HIV Surveillance Report

County of Los Angeles Public Health. 2011 Annual HIV Surveillance Report

County of Los Angeles Public Health. 2011 Annual HIV Surveillance Report

County of Los Angeles Public Health. HIV/AIDS Semi-Annual Surveillance Summary

County of Los Angeles Public Health. 2011 Annual HIV Surveillance Report

http://publichealth.lacounty.gov/dca/data/documents/2009MortalityReport.pdf

For males only –HIV not in top 10 causes of premature death of women

Group I: Acute infection

Group II: Asymptomatic infection

Group III: Persistent generalized lymphadenopathy

Group IV: Other diseases

CDC CLASSIFICATION OF HIV DISEASE

Group IV: Other diseasesSubgroup A: Constitutional diseaseSubgroup B: Neurologic diseaseSubgroup C: Secondary infectious diseaseSubgroup D: Secondary cancersSubgroup E: Other conditions

CDC CLASSIFICATION OF HIV DISEASE (continued)

APPENDIX B. Conditions included in the 1993 AIDS surveillance case definition (CDC)Candidiasis of bronchi, trachea, or lungs

Candidiasis, esophageal Cervical cancer, invasive *

Coccidioidomycosis, disseminated or extrapulmonaryCryptococcosis, extrapulmonary

Cryptosporidiosis, chronic intestinal (greater than 1 month's duration) Cytomegalovirus disease (other than liver, spleen, or nodes)

Cytomegalovirus retinitis (with loss of vision) Encephalopathy, HIV-related

Herpes simplex: chronic ulcer(s) (greater than 1 month's duration); or bronchitis, pneumonitis, or esophagitisHistoplasmosis, disseminated or extrapulmonary

Isosporiasis, chronic intestinal (greater than 1 month's duration) Kaposi's sarcoma

Lymphoma, Burkitt's (or equivalent term) Lymphoma, immunoblastic (or equivalent term)

Lymphoma, primary, of brain Mycobacterium avium complex or M. kansasii, disseminated or extrapulmonary

Mycobacterium tuberculosis, any site (pulmonary * or extrapulmonary) Mycobacterium, other species or unidentified species, disseminated or extrapulmonary

Pneumocystis carinii pneumonia Pneumonia, recurrent *

Progressive multifocal leukoencephalopathySalmonella septicemia, recurrent

Toxoplasmosis of brain Wasting syndrome due to HIV

Added in the 1993 expansion of the AIDS surveillance case definition.