The HIV virusIsosporiasis, chronic intestinal (greater than 1 month's duration) Kaposi's sarcoma...

58
gp120 gp41 p17 RNA p24 env gag Reverse transcriptase (RT) Integrase Protease pol genome gp120 gp41 p17 RNA p24 env gag Reverse transcriptase (RT) Integrase Protease pol genome The HIV virus

Transcript of The HIV virusIsosporiasis, chronic intestinal (greater than 1 month's duration) Kaposi's sarcoma...

  • gp120

    gp41

    p17

    RNAp24

    env

    gag

    Reverse transcriptase (RT)

    IntegraseProtease pol

    genome

    gp120

    gp41

    p17

    RNAp24

    env

    gag

    Reverse transcriptase (RT)

    IntegraseProtease pol

    genome

    The HIV virus

  • Committee on Oversight and Government Reform. HIV/AIDS Today, 1(1):1, January 18, 2008

  • UNAIDS Global Report, 2012

  • UNAIDS Global Report, 2010

  • Percent of adults (15+) living with HIV who are female, Percent of adults (15+) living with HIV who are female, 19901990––20072007

    0

    10

    20

    30

    40

    50

    60

    70

    Percent female (%)

    Sub-Saharan AfricaGLOBALCaribbeanAsiaE Europe & C AsiaLatin America

    1990‘91 ‘92 ‘93 ‘94 ‘95 ‘96 ‘97 ‘98 ‘99 ‘00 ‘01 ‘02 ‘03 ‘04 ‘05 ‘06 2007Year

    5

  • The HIV/AIDS Epidemic in the U.S. through 2011

  • Kaiser Family Foundation. Black Americans and HIV/AIDS. Fact Sheet, March 2013

  • Kaiser Family Foundation. Black Americans and HIV/AIDS. Fact Sheet, March 2013

  • El-Sadr WM, Mayer KH, Hodder SL. AIDS in America -Forgotten but not gone. NEJM 362(11):969, 2010.

  • El-Sadr WM, Mayer KH, Hodder SL. AIDS in America - Forgotten but not gone. NEJM 362(11):968, 2010.

  • The HIV/AIDS Epidemic in California

  • California Department of Health Services, Office of AIDS, HIV/AIDS Case Registry Section, Dec 2012

  • The HIV/AIDS Epidemic in Los Angeles

  • County of Los Angeles Public Health. 2010 Annual HIV Surveillance Report, Jan 2011

  • County of Los Angeles Public Health. 2011 Annual HIV Surveillance Report

  • County of Los Angeles Public Health. 2011 Annual HIV Surveillance Report

  • County of Los Angeles Public Health. 2011 Annual HIV Surveillance Report

  • County of Los Angeles Public Health. HIV/AIDS Semi-Annual Surveillance Summary

  • County of Los Angeles Public Health. 2011 Annual HIV Surveillance Report

  • http://publichealth.lacounty.gov/dca/data/documents/2009MortalityReport.pdf

    For males only –HIV not in top 10 causes of premature death of women

  • Group I: Acute infection

    Group II: Asymptomatic infection

    Group III: Persistent generalized lymphadenopathy

    Group IV: Other diseases

    CDC CLASSIFICATION OF HIV DISEASE

  • Group IV: Other diseasesSubgroup A: Constitutional diseaseSubgroup B: Neurologic diseaseSubgroup C: Secondary infectious diseaseSubgroup D: Secondary cancersSubgroup E: Other conditions

    CDC CLASSIFICATION OF HIV DISEASE (continued)

  • APPENDIX B. Conditions included in the 1993 AIDS surveillance case definition (CDC)Candidiasis of bronchi, trachea, or lungs

    Candidiasis, esophageal Cervical cancer, invasive *

    Coccidioidomycosis, disseminated or extrapulmonaryCryptococcosis, extrapulmonary

    Cryptosporidiosis, chronic intestinal (greater than 1 month's duration) Cytomegalovirus disease (other than liver, spleen, or nodes)

    Cytomegalovirus retinitis (with loss of vision) Encephalopathy, HIV-related

    Herpes simplex: chronic ulcer(s) (greater than 1 month's duration); or bronchitis, pneumonitis, or esophagitisHistoplasmosis, disseminated or extrapulmonary

    Isosporiasis, chronic intestinal (greater than 1 month's duration) Kaposi's sarcoma

    Lymphoma, Burkitt's (or equivalent term) Lymphoma, immunoblastic (or equivalent term)

    Lymphoma, primary, of brain Mycobacterium avium complex or M. kansasii, disseminated or extrapulmonary

    Mycobacterium tuberculosis, any site (pulmonary * or extrapulmonary) Mycobacterium, other species or unidentified species, disseminated or extrapulmonary

    Pneumocystis carinii pneumonia Pneumonia, recurrent *

    Progressive multifocal leukoencephalopathySalmonella septicemia, recurrent

    Toxoplasmosis of brain Wasting syndrome due to HIV

    Added in the 1993 expansion of the AIDS surveillance case definition.