PANTHEON

•  AnNIHRprogrammegrantforAppliedResearch:

Acomprehensiveassessmentofcost-

effec?venessofHIVpreven?onandtes?ngstrategies,includingHIV-self-tes?ng,amongmenwhohavesexwithmen(MSM)intheUK.

Collaborators

•  RoyalFree,UCL:AlisonRogers,AndrewPhilips•  MRCCTU,UCL:SheenaMcCormack,DavidDunn

•  LSHTM:PeterWeatherburn,CharlieWitzel•  PHE:ValerieDelpech,TonyNardone

Programme

•  Workstream1:– Feasibilitystudy– Processevalua?on

•  Workstream2:SELPHItrial•  Workstream3:Costeffec?venessanalysis

SELPHI

•  Anevalua?onofHIVself-tes?nginEngland&Wales

•  Recruitmentviasocialmediaandapps•  Internetbaseddatabase– Par?cipantinforma?onandconsent– Selfreporteddata– Distribu?onofkits

RATIONALE

•  PreviousandongoingstudiesofHIVself-tes?nghavegenerallybeensmallandqualita?ve.SELPHIisalarge,randomisedtrialwhoseprimaryaimistomeasuretheimpactofself-tes?ngonnewconfirmedHIVdiagnoseslinkedtoclinicalcare.

PrimaryObjec?ves

1.  Istheonlinepromo?onandpostaldeliveryoffreeHIVself-testkits(withtes?ngreminders)feasibleandacceptable?

2.  Willtheofferofasinglefreeself-testatenrolmentleadtotheconfirmeddiagnosisofprevalentHIVinfec?onsandentrytostandardHIVclinicalcare?

3.  Amongsero-nega?vemenathighriskofacquiringHIVInfec?on,willtheofferofregularfreeself‑testswithtes?ngremindersresultinmorerapidconfirmeddiagnosisofanincidentHIVinfec?onandentryintostandardHIVclinicalcare?

SecondaryObjec?ves•  ComparisonofthefollowingbetweenthosewhoreceivedfreeHIVself-

testandthosewhodidnot;–  frequencyofHIVtes?ng–  howindividualsaccesstes?ngop?ons(e.g.attes?ngwitha

healthcareprofessional,self-samplingorself-tes?ng)–  frequencyofSTIscreening.

•  ReportedusageofHIVself-tes?ngkits.•  AcceptabilityofHIVself-tes?ng.•  Assesspost-testlinkagewithcounsellingandtreatmentservicesincluding

a^endanceforconfirmatoryHIVtest•  Assesstheextenttowhichdemographic,socio-economic,health-related

factors,sexualriskbehavioursusepredicttes?ngbehaviours•  ExamineiftheofferofHIVself-testsinfluencesthefrequencyof

condomlesssex(eitherself‑reportorasreflectedinnewSTIdiagnoses).•  Providedatatoinformkeyparametersforcost-effec?venessmodels.

Randomisa0onAschema

Randomisa0onAschema

Randomisa0onBschema

Randomisa0onBschema

BioSureHIVself-testkit•  TheonlyCEMarkedSelfTestavailable,BioSureHIVSelf

Test(some?mesknownasaHIVhometest)isover99.7%accurateandallowsyoutodiscreetlydetermineyourHIVstatusata?meandaplacethatisconvenientforyou.

•  TherapidHIVtestisextremelyeasytoperform,requiresonlya?nydropofblood,andgivesaclearandsimpletoreadresultinjust15minutes.

•  ThepriceofasingleHIVSelfTestKitis£29.95(freeStandardUKdelivery)

h^p://hivseleest.co.uk/

PPI

•  PPIlead:SimonCollins•  CAB– Representa?vesfromUKCAB(12-17)– Representa?vesfromPROUD(2-3)

•  Protocol&surveyreview– UKCAB– SELPHICAB

Timelines

•  Ethicssubmission:October2016•  Soerelease:early2017•  Hardrelease:med2017•  Followup:3years