PANTHEON - UKCAB · PANTHEON • An NIHR programme grant for Applied Research: A comprehensive...
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PANTHEON • An NIHR programme grant for Applied Research: A comprehensive assessment of cost- effec?veness of HIV preven?on and tes?ng strategies, including HIV-self-tes?ng, among men who have sex with men (MSM) in the UK.
Transcript of PANTHEON - UKCAB · PANTHEON • An NIHR programme grant for Applied Research: A comprehensive...
PANTHEON
• AnNIHRprogrammegrantforAppliedResearch:
Acomprehensiveassessmentofcost-
effec?venessofHIVpreven?onandtes?ngstrategies,includingHIV-self-tes?ng,amongmenwhohavesexwithmen(MSM)intheUK.
Collaborators
• RoyalFree,UCL:AlisonRogers,AndrewPhilips• MRCCTU,UCL:SheenaMcCormack,DavidDunn
• LSHTM:PeterWeatherburn,CharlieWitzel• PHE:ValerieDelpech,TonyNardone
Programme
• Workstream1:– Feasibilitystudy– Processevalua?on
• Workstream2:SELPHItrial• Workstream3:Costeffec?venessanalysis
SELPHI
• Anevalua?onofHIVself-tes?nginEngland&Wales
• Recruitmentviasocialmediaandapps• Internetbaseddatabase– Par?cipantinforma?onandconsent– Selfreporteddata– Distribu?onofkits
RATIONALE
• PreviousandongoingstudiesofHIVself-tes?nghavegenerallybeensmallandqualita?ve.SELPHIisalarge,randomisedtrialwhoseprimaryaimistomeasuretheimpactofself-tes?ngonnewconfirmedHIVdiagnoseslinkedtoclinicalcare.
PrimaryObjec?ves
1. Istheonlinepromo?onandpostaldeliveryoffreeHIVself-testkits(withtes?ngreminders)feasibleandacceptable?
2. Willtheofferofasinglefreeself-testatenrolmentleadtotheconfirmeddiagnosisofprevalentHIVinfec?onsandentrytostandardHIVclinicalcare?
3. Amongsero-nega?vemenathighriskofacquiringHIVInfec?on,willtheofferofregularfreeself‑testswithtes?ngremindersresultinmorerapidconfirmeddiagnosisofanincidentHIVinfec?onandentryintostandardHIVclinicalcare?
SecondaryObjec?ves• ComparisonofthefollowingbetweenthosewhoreceivedfreeHIVself-
testandthosewhodidnot;– frequencyofHIVtes?ng– howindividualsaccesstes?ngop?ons(e.g.attes?ngwitha
healthcareprofessional,self-samplingorself-tes?ng)– frequencyofSTIscreening.
• ReportedusageofHIVself-tes?ngkits.• AcceptabilityofHIVself-tes?ng.• Assesspost-testlinkagewithcounsellingandtreatmentservicesincluding
a^endanceforconfirmatoryHIVtest• Assesstheextenttowhichdemographic,socio-economic,health-related
factors,sexualriskbehavioursusepredicttes?ngbehaviours• ExamineiftheofferofHIVself-testsinfluencesthefrequencyof
condomlesssex(eitherself‑reportorasreflectedinnewSTIdiagnoses).• Providedatatoinformkeyparametersforcost-effec?venessmodels.
Randomisa0onAschema
Randomisa0onAschema
Randomisa0onBschema
Randomisa0onBschema
BioSureHIVself-testkit• TheonlyCEMarkedSelfTestavailable,BioSureHIVSelf
Test(some?mesknownasaHIVhometest)isover99.7%accurateandallowsyoutodiscreetlydetermineyourHIVstatusata?meandaplacethatisconvenientforyou.
• TherapidHIVtestisextremelyeasytoperform,requiresonlya?nydropofblood,andgivesaclearandsimpletoreadresultinjust15minutes.
• ThepriceofasingleHIVSelfTestKitis£29.95(freeStandardUKdelivery)
h^p://hivseleest.co.uk/
PPI
• PPIlead:SimonCollins• CAB– Representa?vesfromUKCAB(12-17)– Representa?vesfromPROUD(2-3)
• Protocol&surveyreview– UKCAB– SELPHICAB
Timelines
• Ethicssubmission:October2016• Soerelease:early2017• Hardrelease:med2017• Followup:3years
