Loring B. Rowell

• Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev. 1974

• How Are Blood Flow and Metabolism Matched?", Mayo Clinic, Rochester, MN, January, 1993.

• Cardiac Function in Hyperthermia and Hypoxemia”, Brisbane, Australia, August, 1996.

• Why Do We Require a Second Heart During Exercise? U. of W. Ontario, 2000

• Human Circulation: Regulation during physical stress. Oxford U. Press. 1986

• Human Cardiovascular Control. Oxford. 1993

• Handbook of Physiology: Section 12: Exercise: Regulation and Integration of Multiple Systems. APS. 1996

Academic History

1953 BS Springfield College, Springfield, Mass.Prof. Karpovich

1953 – 56 Science and Math teacher, Littleton High School Littleton/Franconia, N.H.

1962 Ph. D. University of Minnesota Minneapolis, Minn.

A Krogh 1874 – 1949U. of Copenhagen, DK

Ancel Keys F. Grande

U. Minnesota (LBR as student 1956-62)

Harvard U. England (Lovatt Evans)

Spain (beri beri research)

A Krogh 1874 – 1949U. of Copenhagen, DK

P.O. AstrandB. Saltin

E. AsmussenE. H-ChristensenMaurius Nielsen

B. SaltinB. NielsenF. Bonde-Petersen

Sweden

Krogh Institute(LBR sabbatical 1978-79)

A. KeysJ.T. ShepherdE. WoodY. Wang

Mayo Clinic(LBR 1960-1)

M. Visscher

H.L. TaylorA. KeysF. GrandeY. Wang

U. Minnesota(LBR 1956-62)

L. J. HendersonAncel Keys

H.L. Taylor

Harvard U

Cardiac output and its distribution among the organ

vasculatures

heart level, 5 Torr

foot level, 100 Torr

Central

Splanchnic, renal

Cutaneous

30 60 90 min

Heating Heating

Flow:volume interaction

Heating Heating

Stroke volume and the interaction between the heart and the peripheral vasculature

30 60 90

Time (min)

Right atrial pressure

Cardiac output(venous return)

Right atrial pressure

Cardiac output(venous return)

0

“Venous return curve” “Vascular function curve”

0 +

-

+

-

Gravity, the muscle pump,and reflex control

Overall control mechanisms: The exercise stimulus

Muscle chemoreflex: Zuntz 1889 , Wyss, Sheriff, O’Leary, Scher

University of Minnesota

University of WashingtonMedicine (Cardiology)

1962 - 70Physiology and Biophysics

(1970 - )

H.D. Patton, W. CrillE. MasoroG. L. BrengelmannA. ScherA.C. BrownO.A. SmithM. BinderJ. W. Woodbury

R. A. BruceJ. R. BlackmonJ.W. Kennedy

E. Strandness (Surg)W. Volwiler (GI)J. Short (Derm)J. Olerud (Derm)

Symposium on Alpine Crystallography