Post on 11-Apr-2017
Aerobic Exercise on LDL Oxidation: Implications on AtherogenesisMichael Rosenblat
Faculty Advisor: Dr. Drew Graham
KIN4400 Independent Research Study in KinesiologyUniversity of Guelph-Humber
Contents1) Introduction2) Results and Interpretation3) Summary
Contents1)Introduction2) Results and Interpretation3) Summary
Oxidative Stress and Atherogenesis
Muller et al. Antioxid Redox Signal 11: 1711, 2009.
Introduction•Purpose
▫Analyze the effect of aerobic exercise on OxLDL
▫Subsequent impact on atherogenesis
•Scope of Review▫Oxidative stress and endothelial function▫Aerobic exercise and redox status▫Aerobic exercise and atherosclerosis
Contents1) Introduction2)Results and Interpretation3) Summary
Sources of Endothelial O2.- Formation
Li et al. Am J Physiol Regul Integr Comp Physiol 287: R1014, 2004.
ROS in Physiology and Pathology
Li et al. Am J Physiol Regul Integr Comp Physiol 287: R1014, 2004.
ROS and Endothelial Dysfunction
Stephens et al. Atherosclerosis 202: 321, 2009.
Turrens. J Physiol 552: 335, 2003.
Mitochondrial ROS Generation
Antioxidant Production
Powers et al. Exp Physiol 88: 1, 2010.
Exercise on OxLDL
Ziegler et al. Arch Phys Med Rehabil 87: 265, 2006.
Exercise on Atherogenic Lesions
Atherogenic Diet Normal Diet + Exercise
Ramachandran et al. Atherosclerosis 178: 33, 2005.
Normal Diet
Contents1) Introduction2) Results and Interpretation3)Summary
Summary•ROS are significant in physiology and
pathology
•Aerobic exercise contributes to ROS formation and antioxidant production
•Aerobic exercise decreases plasma concentrations of OxLDL
•Aerobic exercise can help prevent and treat atherosclerosis
ReferencesLi J, Shah A. Endothelial cell superoxide generation: regulation and relevance for
cardiovascular physiology. Am J Physiol Regul Integr Comp Physiol 287: R1014-R1030, 2004.
Muller G, Morawietz H. Nitric oxide, NAD(P)H oxidase, and atherosclerosis. Antioxid Redox Signal 11(7): 1711-1731, 2009.
Powers S, Duarte J, Kavazis A, Talbert E. Reactive oxygen species are signaling molecules for skeletal muscle adaptation. Exp Physiol 95: 1-9, 2010.
Ramachandran S, Penumetcha M, Merchant N, Santanam N, Rong R, Parthasarathy S. Exercise reduced preexisting atherosclerotic lesions in LDL receptor knock out mice. Atherosclerosis 178: 33-38, 2005.
Stephens J, Khanolkar M, Bain S. The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease. Atherosclerosis 202: 321-329, 2009.
Turrens J. Mitochondrial formation of reactive oxygen species. J Physiol 552(2): 335-344, 2003.
Ziegler S, Schaller G, Mittermayer F, Pleiner J, Mihaly Jniessner A, Richter B, Steiner-Boeker S, Penak M, Strasser B, Wolzt M. Exercise training improves low-density lipoprotein oxidability in untrained subjects with coronary artery disease. Arch Phys Med Rehabil 87: 265-269, 2006.