Aerobic Exercise on LDL Oxidation: Implications on AtherogenesisMichael Rosenblat

Faculty Advisor: Dr. Drew Graham

KIN4400 Independent Research Study in KinesiologyUniversity of Guelph-Humber

Contents1) Introduction2) Results and Interpretation3) Summary

Contents1)Introduction2) Results and Interpretation3) Summary

Oxidative Stress and Atherogenesis

Muller et al. Antioxid Redox Signal 11: 1711, 2009.

Introduction•Purpose

▫Analyze the effect of aerobic exercise on OxLDL

▫Subsequent impact on atherogenesis

•Scope of Review▫Oxidative stress and endothelial function▫Aerobic exercise and redox status▫Aerobic exercise and atherosclerosis

Contents1) Introduction2)Results and Interpretation3) Summary

Sources of Endothelial O2.- Formation

Li et al. Am J Physiol Regul Integr Comp Physiol 287: R1014, 2004.

ROS in Physiology and Pathology

Li et al. Am J Physiol Regul Integr Comp Physiol 287: R1014, 2004.

ROS and Endothelial Dysfunction

Stephens et al. Atherosclerosis 202: 321, 2009.

Turrens. J Physiol 552: 335, 2003.

Mitochondrial ROS Generation

Antioxidant Production

Powers et al. Exp Physiol 88: 1, 2010.

Exercise on OxLDL

Ziegler et al. Arch Phys Med Rehabil 87: 265, 2006.

Exercise on Atherogenic Lesions

Atherogenic Diet Normal Diet + Exercise

Ramachandran et al. Atherosclerosis 178: 33, 2005.

Normal Diet

Contents1) Introduction2) Results and Interpretation3)Summary

Summary•ROS are significant in physiology and

pathology

•Aerobic exercise contributes to ROS formation and antioxidant production

•Aerobic exercise decreases plasma concentrations of OxLDL

•Aerobic exercise can help prevent and treat atherosclerosis

ReferencesLi J, Shah A. Endothelial cell superoxide generation: regulation and relevance for

cardiovascular physiology. Am J Physiol Regul Integr Comp Physiol 287: R1014-R1030, 2004.

Muller G, Morawietz H. Nitric oxide, NAD(P)H oxidase, and atherosclerosis. Antioxid Redox Signal 11(7): 1711-1731, 2009.

Powers S, Duarte J, Kavazis A, Talbert E. Reactive oxygen species are signaling molecules for skeletal muscle adaptation. Exp Physiol 95: 1-9, 2010.

Ramachandran S, Penumetcha M, Merchant N, Santanam N, Rong R, Parthasarathy S. Exercise reduced preexisting atherosclerotic lesions in LDL receptor knock out mice. Atherosclerosis 178: 33-38, 2005.

Stephens J, Khanolkar M, Bain S. The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease. Atherosclerosis 202: 321-329, 2009.

Turrens J. Mitochondrial formation of reactive oxygen species. J Physiol 552(2): 335-344, 2003.

Ziegler S, Schaller G, Mittermayer F, Pleiner J, Mihaly Jniessner A, Richter B, Steiner-Boeker S, Penak M, Strasser B, Wolzt M. Exercise training improves low-density lipoprotein oxidability in untrained subjects with coronary artery disease. Arch Phys Med Rehabil 87: 265-269, 2006.