Post on 25-Dec-2015
KOSThe microwave multifunctional
tissue processor you were waiting for
In a fraction of the time
• Tissue processing
• Decalcification
• Special stains
• Gross hardening
• Fixation
•Antigen retrieval (93°C to 120°C)
KOS
KOS: Smart and Fast
The first Icon driven HistoStation
• Multifunctional: 1 unit 6 applications
• Fast: Just plug-in and process
• Reliable: Sensors controlled
• Flexible: User programs / Favorites
• Safe: Sensors monitored
• Smart: Icons driven
KOS*
Multifunctional: ONE unit SIX major applications
• Fulfilling all requirements set by CAP/C.L.S.I.
• Ideal substitute for “kitchen type” microwave oven
• Fulfilling all requirements set by CAP/C.L.S.I.
• Ideal substitute for “kitchen type” microwave oven
Rapid Tissue processingSame day results for all tissue types.
• From 1 to 45 cassettes
• Ideal for transplant center
• Urgent biopsies
• Up to 3 mm thickness
• Safe. No xylene
• Ethanol – isopropanol only
Fast, unmatched tissue processing time
.
• 35 minutesFor transplant biopsies including fixation
• 75 minutesFor 2 mm biopsiesAdd 18 min fixation
• 140 minutesFor 3 mm biopsiesAdd 28 min fixation
Excellent H&E, IHC and FISHIn a fraction of the time
High Quality Slides
Breast Red-Labeled HER2-FISH, x800
Colonic BiopsyH&E, x400
AdenocarcinomaCytokaratin
CAM 5.2, x400
Breast, HER2IHC, x400
SMART . ICONS DRIVEN MENU
1) Select thickness.
2) Select number of cassettes.
3) Select reagents
4) Press GO
5) Press START.That’s all
Time left will be shown on the terminal
Bone Marrow processingSame day diagnosis for bone marrow trephine biopsies.
Decalcification + processing in less than 3 hours
EDTA.
Decalcification: 80 minutes
Processing: 60 minutes
Total time: 140 minutes
FORMIC ACID (10%).
Decalcification: 20 minutes
Processing: 60 minutes
Total time: 80 minutes
Rapid Bone decalcificationUp to 45 cassette – 60 Mega cassette
Hours, not days
Magnetic stirring plus microwave energyPositively influence the equilibrium
1. Select temperature, 2. Number of cassette, 3. Decalcifyng solution
Press GO
Special StainsUp to 16 slides
Up to 76% time saving for staining protocols
1) Select stains menu
2) Select specific stain
3) Follow step by step indications
4) Selected program is prestored ready to
use.
Antigen Retrieval Time At Temperature Protocols
Up to 80 slides
Dedicated Histomodules
4K, up to 4 cassette
45K, up to 45 cassette
16s, up to 16 slides
40s, up to 80 slides
Decal, up to 60 Megacassette
• Dedicated fixation histomodule up to 45 cassette
• Select time at temperature protocol to fulfill all requirements of standardization and documentation for CAP/ASCO for HER2/ER.
• Factory stored opitimized protocols at 37°C - 50°C guarantee consistent results
Fixation
• Dedicated GHK hardening module
• Efficient & rapid hardening in physiologic solution for a timely grossing
• Factory stored opitimized protocols at 50°C – 65°C guarantee consistent results
Gross Hardening
Glass Pressure Reactor-120°C
GPR-120°C
SuperHeating
Antigen Retrieval
(40 slides)
Dedicated Histomodules
Processing & Infiltration
Resin polymerization
KOS EM demo
KOS EM demo
• Better Quality and TAT (2-3 days vs same day diagnosis)
• Users were satisfied because fully supported during demo, installation and training (Competitors were won also because of this)
• KOS is not automatic but users understand that gives benefits in speed + quality and price
KOS
Packed with the latest microwave and sensor technology.Controlled by the most advanced, intuitive software.
State of the Art
Microwave is switched OFF if:
1.Cavity ventilation is compromised
2.Solvent in cavity is above Threshold
3.Humidity in cavity exceeds set value
4.Microwave leak is detected
Any protocol as Favorite
Last but not least…In 3 “stainful” colors to fit theatmosphere of your laboratory
Congo Red - GMS Green - Alcian Blue
KOS: 10 Good Reasons to Choose1. Not a modified kitchen applianceIndustrial engineered, laboratory grade, microwave unit designed
specifically for histology applications.
2. Easy-to-use• Why make things complicated? • Our icons driven user interface allows you to access information
quickly.• Basic user maintenance.
3. Optimized protocols• Factory stored for tissue processing, decalcification, fixation, gross hardening, special stains and EM• User’s defined protocols can be stored and, if required, included in a “Favorites” menu for easy retrieval.
4. Fully compliantWe have always been concerned with Safety and Quality. Our laboratory
grade microwaves fully comply with CAP-C.L.S.I. Guidelines.
5. Full Tech supportWith over 70 years of combined histology experience our applications support
professionals have the answer to your questions.
6. Specimen safety• Focused infrared automatic temperature control with laser positioning.• Software controlled magnetic stirring for homogeneous temperature
distribution• Built-in re-generable charcoal filter on exhaust outlet
7. Lab safetySensors controlled operation. Built-in sensors will switch off microwave if:• Cavity ventilation is compromised• Solvent & Humidity in cavity is above threshold• Microwave leak is detected
8. Full documentationThrough a USB port, data from the built-in Logbook can be easily downloaded
for documentation Purposes (Q.A. - ISO 9001 - G.L.P.)
9. TV 7’ monitoring for easy observation of process in cavity.
10. Unique histomodule technology for easy, safe handling of solutions while preserving the pH of the solution throughout the procedure.
Milestone HistosBench top microwave
Dual multifunctional tissue processor
• Fixation and Tissue processing • Decalcification • Special stains
• Gross hardening
In a fraction of the time
• Processing performance
• Reagent efficiency
• Environmental sensitivity
• High quality results
HISTOS line
Histos Processing TimeThickness
35 min (+10 min fix.)
1.15 hr (+20 min fix.)
4.30 hr (+60 min fix.)
Simplicity
• NO need to change your grossing procedure
• NO need for special grossing tools
• Software driven procedures
• No cleaning cycles
Safety• Fixation with either formalin or Milestone’s FineFIX
• XYLENE free processing
• Exhaust fan
• Safety micro-switches
• Fume sensors
• Methods and process reports can be stored and exported
High throughputHistoprocessing of batches with up to 110 standard cassettes…
…and of batches with up to 16 Mega and 8 SuperMega
cassettes.
High throughput
The Proof ?
Is in the microscopic comparison
• Excellent results in a fraction of the time
• No compromise in regard to morphology and “staining”
expression
Quality equal or better than conventional histoprocessing for H&E, IHC,
FISH
Benefits Benefits Vs Conventional Vs Conventional systemssystems
• Fast processing and Same day results
• Flexibility in the processing
• Results equal or better than conventional
• Flexibility in workflow (no peaks)
• Dual processing and High throughput (110 Cass in 40-240 min)
• More healthy environment
• Cost saving (reagents and wax disposal)
Benefits Benefits for for all!all!
• Patient: - Same day results, less stress time
waiting for results
• Histologist: - Improved working conditions
- Work load with less peaks
• Pathologist: - “Same day” and high quality slides even for difficult tissues
• Administrator: - Reduced cost / cassette- Rapid turn around time
PRESENTING ’11 HistosLINE
Histos5
Histos3
• Microwave unit + single external retort (Wax module)
• Parallel processing, double productivity
• Up to 3mm thickness & 110 cassette
• No Vacuum
• Multifunctional
HISTOS3
The HISTOS3 is designed for small to medium size histology labs
•small to medium size biopsies
• Ideal for Transplant center
HISTOS3
• Microwave unit + double external retort (Dry module, Wax module)
• Parallel processing, double productivity
• Vacuum, 110 cassette
• Up to 7mm thickness
• Multifunctional
HISTOS5
HISTOS5 is designed for hospital laboratories
• high throughput processor for same day routine
• wide variety of tissues without compromising tissue block thickness.
• Multifunctional unit for Pathos users
HISTOS5
MILESTONE concept
Epitope Retrieval – Decalcification Fixation – Special Staining - Gross Hardening
…in a single unit!
MILESTONE multiple functions concept
Histos: direct access
Histos: Double processing
• Processing modules up to 110 cassette
• Fast protocol for urgent transplant biopsies (40’)
• Processing of samples up to 7mm thickness
• No xylene
• No proprietary reagents
• Excellent morphology, staining & IHC properties
Tissue processing
• Processing modules for 110 cassette
• Decal + processing in as little as 80minutes
• No proprietary reagents – Preset protocols
• Decalcification with either EDTA or acids
Decalcification
• Processing modules for up to 12 slides
• Save up to 76% of the time vs standard method
• Factory optimized stored methods guarantee consistent results
• No proprietary reagents
• No splashing, constant pH and temperature
Special Stains
Epitope Retrieval
• Processing modules for up to 120 slides
• Factory opitimized stored methods guarantee consistent results
• Standard methods at 98°C
• GPR up to 120°C
• No splashing, constant pH and temperature
• Whole organ hardening module
• Physiologic solution is the reagent
• Efficient & rapid hardening for a timely grossing
• Factory stored opitimized methods guarantee consistent results
Gross Hardening