Post on 23-Jul-2020
IMAGING OF EXTRACELLULAR NANOVESICLE
EXOSOME IN MENTAL HEALTH
ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY AND MOLECULAR MEDICINE UNIVERSITY OF OULU, FINLAND
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DEPRESSION
BIPOLAR MOOD DISORDER
SCHIZOPHRENIA
DIAGNOSTIC ROLE
THERAPEUTIC ROLE
PROGNOSTIC ROLE
DIAGNOSTIC ROLEPSYCHIATRIC DISORDERS INCREASED miRs DECREASED miRs
SCHIZOPHRENIAmiR-497, miR-34a, miR-449a, miR-548d,
miR-564, miR-572, miR-652, let-7g, miR-181b, miR-219-2-3p, miR-1308
miR-195, miR-432, miR-31, miR-99b, miR-107, miR-134, miR-431, miR-433,
miR-487b
BIPOLAR MOOD DISORDER miR-29c -
DEPRESSION miR-132, miR-182, miR-107, miR-133a,
miR-148a, miR-425-3p, miR-494, miR-579, miR-589, miR-652, miR-941,
miR-200c, miR-381, miR-517b, miR-636,
miR-1243
DIAGNOSTIC ROLEPSYCHIATRIC DISORDERS INCREASED miRs DECREASED miRs
SCHIZOPHRENIAmiR-497, miR-34a, miR-449a, miR-548d,
miR-564, miR-572, miR-652, let-7g, miR-181b, miR-219-2-3p, miR-1308
miR-195, miR-432, miR-31, miR-99b, miR-107, miR-134, miR-431, miR-433,
miR-487b
BIPOLAR MOOD DISORDER miR-29c -
DEPRESSION miR-132, miR-182, miR-107, miR-133a,
miR-148a, miR-425-3p, miR-494, miR-579, miR-589, miR-652, miR-941,
miR-200c, miR-381, miR-517b, miR-636,
miR-1243
DIAGNOSTIC ROLEPSYCHIATRIC DISORDERS INCREASED miRs DECREASED miRs
SCHIZOPHRENIAmiR-497, miR-34a, miR-449a, miR-548d,
miR-564, miR-572, miR-652, let-7g, miR-181b, miR-219-2-3p, miR-1308
miR-195, miR-432, miR-31, miR-99b, miR-107, miR-134, miR-431, miR-433,
miR-487b
BIPOLAR MOOD DISORDER miR-29c -
DEPRESSION miR-132, miR-182, miR-107, miR-133a,
miR-148a, miR-425-3p, miR-494, miR-579, miR-589, miR-652, miR-941,
miR-200c, miR-381, miR-517b, miR-636,
miR-1243
PROGNOSTIC ROLE
SCHIZOPHRENIA Decreased miR-365 and miR-520c-3p after a 1-year treatment with risperidone
DEPRESSION 30 miRNAs differentially expressed after a 12-weeks treatment with escitalopram
DEPRESSION Increased miR-20b-3p, miR-133a, miR-145, miR-409-3p, miR-410,
miR-433, miR-485-3p decreased miR-331-5p after an 8-weeks treatment with different classes of drugs
BIPOLAR MOOD DISORDER Increased miR-134 from baseline after a 4-weeks treatment
PROGNOSTIC ROLE
SCHIZOPHRENIA Decreased miR-365 and miR-520c-3p after a 1-year treatment with risperidone
DEPRESSION 30 miRNAs differentially expressed after a 12-weeks treatment with escitalopram
DEPRESSION Increased miR-20b-3p, miR-133a, miR-145, miR-409-3p, miR-410,
miR-433, miR-485-3p decreased miR-331-5p after an 8-weeks treatment with different classes of drugs
BIPOLAR MOOD DISORDER Increased miR-134 from baseline after a 4-weeks treatment
PROGNOSTIC ROLE
SCHIZOPHRENIA Decreased miR-365 and miR-520c-3p after a 1-year treatment with risperidone
DEPRESSION 30 miRNAs differentially expressed after a 12-weeks treatment with escitalopram
DEPRESSION Increased miR-20b-3p, miR-133a, miR-145, miR-409-3p, miR-410,
miR-433, miR-485-3p decreased miR-331-5p after an 8-weeks treatment with different classes of drugs
BIPOLAR MOOD DISORDER Increased miR-134 from baseline after a 4-weeks treatment
PROGNOSTIC ROLE
SCHIZOPHRENIA Decreased miR-365 and miR-520c-3p after a 1-year treatment with risperidone
DEPRESSION 30 miRNAs differentially expressed after a 12-weeks treatment with escitalopram
DEPRESSION Increased miR-20b-3p, miR-133a, miR-145, miR-409-3p, miR-410,
miR-433, miR-485-3p decreased miR-331-5p after an 8-weeks treatment with different classes of drugs
BIPOLAR MOOD DISORDER Increased miR-134 from baseline after a 4-weeks treatment
NFBC 1986
471
50% MATERNAL SMOKING
ANALYSIS OF EXOSOME CONTENTS
& MATCHING WITH NEUROPSYCHIATRIC
DISORDERS AND ADDICTION
IMAGING OF EXOSOMES WITH HYPER-SPRECTAL
CAMERAS
IMAGING OF EXOSOMES BY MRI AND PET
PURIFICATION OF EXOSOMES
ELECTRON
MICROSCOPY
12 SAMPLES
PROTEIN ANALYSIS
12 SAMPLES
12 PILOT SAMPLES 6 SMOKING MOTHERS,
6 NON SMOKING MOTHERS
THANK YOU