Discussion Amines

diisopropylamine

nicotine histamine pyrrolidine

pyrrole

Which is the strongest base?

Which is the weakest base?

lysine

Which is the most basic amino group in lysine? Why?

Which structure best represents lysine in living cells (physiological conditions)

Acetamides

Regiochemistry: Anti-Markovnikov

Stereochemistry: syn addition to double bond

How would you synthesis these starting materials?

Diazonium chemistry

& more

or

Retrosynthetic analysis

Synthesis plan

Formation of amide