Name of Drug General Action Specific Action Indications Contraindications Adverse Reaction Nursing Responsibilities

Clopidogrel75 mg 1 tab PO OD

Antiplatelet agents;Platelet aggregation inhibitors

Inhibits platelet aggregation by irreversibly inhibiting the binding of ATP to platelet receptors.

Therapeutic Effects: Decreased occurrence of atherosclerotic events in patients at risk.

Reduction of atherosclerotic events (MI, stroke, vascular death) in patients at risk for such events including recent MI, acute coronary syndrome (unstable angina/non-Q-wave MI), stroke, or peripheral vascular disease.

Contraindicated in: Hypersensitivity Pathologic bleeding

(peptic ulcer, intracranial hemorrhage)

Lactation.Use Cautiously in:

Patients at risk for bleeding (trauma, surgery, or other pathologic conditions)

History of GI bleeding/ulcer disease

Severe hepatic impairment

CNS: Depression, Dizziness, Fatigue, Headache. EENT: Epistaxis. Resp: Cough, Dyspnea. CV: Chest Pain, Edema, Hypertension. GI: GI Bleeding, Abdominal Pain, Diarrhea, Dyspepsia, Gastritis. Derm: Pruritus, Purpura, Rash. Hemat: Bleeding, Neutropenia, Thrombotic Thrombocytopenic Purpura.Metab: Hypercholesterolemia. MS: Arthralgia, Back Pain.

Misc: Fever, Hypersensitivity Reactions.

AssessmentAssess patient for symptoms of stroke,

peripheral vascular disease, or MI periodically during therapy.

Monitor patient for signs of thrombotic

thrombocytic purpura (thrombocytopenia, microangiopathic hemolytic anemia, neurologic findings, renal dysfunction, fever). May rarely occur, even after short exposure (<2 wk). Requires prompt treatment.

ImplementationDiscontinue clopidogrel 5-7 days before

planned surgical procedures. PO: Administer once daily without regard to

food.

Patient/Family TeachingInstruct patient to take medication exactly

as directed. Take missed doses as soon as possible unless almost time for next dose; do not double doses.

Advise patient to notify health care

professional promptly if fever, chills, sore throat, or unusual bleeding or bruising occurs.

Advise patient to notify health care

professional of medication regimen prior to treatment or surgery.