Personalized approach to treatment of endometriosis

Yana Aznaurova,CIEP «Medicine of the Future»

Endometriosis

• Endometriosis is a common and painful condition characterized by the existence of endometrial glands and stroma outside the uterine cavity (endometrial implant).

• Endometriosis present with severe symptoms such as chronic pelvic pain, pain with menstruation, pain during intercourse (dyspareunia) and dysmenorrhea

Significance

Endometriosis is one of the most enigmatic diseases:• the etiology and underlying pathophysiology is

still largely unknown• endometriosis impairs the quality of life of

women of reproductive age• in 30% leads to infertility

AnalogsHormone therapy Surgery Symptomatic

treatmentPersonalized

approach

Non-specific,

long-term, often lifetime

has many side effects

Does not eliminate the cause of the disease,

high probability of recurrence

"Operation of despair"

Short-term relief of symptoms,

does not cure the disease,

has side effects

Specificity

correction of intracellular damage,

low probability of recurrence

less side-effects

1 course of therapy+ IVF= $ 5500

1 operation + hormone therapy + IVF = $ 6700

1 course of therapy + IVF = $ 5250

1 biopsy + 1 genetic analysis + the cost of drugs = $ 760

Competitive advantages

• individual approach to treatment • effective targeted selection of drugs• lower economic cost of treatment • optimization of the making decision on the

treatment option for each patient

Scientific novelty

• Drug's prescribing is based on the genetic analysis of each patient

Current state

• Bioinformatic analysis of the main signaling pathways involved in pathogenesis of endometriosis in the article «Molecular aspects of development and regulation of endometriosis» in Reproductive Biology and Endocrinology Journal

• Perspective article about possibility of using Oncofinder software to implement the idea

Planned

• Creating a database of intracellular changes that underlie endometriosis

• Creating the medical protocol of personalized approach to diagnosis and treatment of endometriosis

• Obtaining a patent on intellectual property

Implementation stages

Biopsy

Microchipping

Targeting drugs selection

In-vitro validation

Resources

• The required sum of money (grant funds) - $ 220,000

• Scientific collaboration

Business model

Counseling CenterPotential customers

• Department of Obstetrics and Gynecology in Hospitals

• Reproductive centers• Fertility clinics

Genetic Testing

Personalized treatment

КомандаАзнаурова Я.Б.

ПМГМУ им. И.М.Сеченова

Румянцев С.А.

ФНКЦ ДГОИ им. Димы Рогачёва

Жуматаев М.Б.

ПМГМУ им. И.М.Сеченова

Гаража А.В.

ЦБРМ

Буздин А.А.

ИБХ РАН

Thank you for your attention!

Yana Aznaurovaaznaurova.endo@gmail.com

www.ScientistDoctor.com

Федеральный научно-клинический центр детской гематологии,

онкологии и иммунологии им. Димы Рогачёва