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Transcript of 20 aznaurova
Personalized approach to treatment of endometriosis
Yana Aznaurova,CIEP «Medicine of the Future»
Endometriosis
• Endometriosis is a common and painful condition characterized by the existence of endometrial glands and stroma outside the uterine cavity (endometrial implant).
• Endometriosis present with severe symptoms such as chronic pelvic pain, pain with menstruation, pain during intercourse (dyspareunia) and dysmenorrhea
Significance
Endometriosis is one of the most enigmatic diseases:• the etiology and underlying pathophysiology is
still largely unknown• endometriosis impairs the quality of life of
women of reproductive age• in 30% leads to infertility
AnalogsHormone therapy Surgery Symptomatic
treatmentPersonalized
approach
Non-specific,
long-term, often lifetime
has many side effects
Does not eliminate the cause of the disease,
high probability of recurrence
"Operation of despair"
Short-term relief of symptoms,
does not cure the disease,
has side effects
Specificity
correction of intracellular damage,
low probability of recurrence
less side-effects
1 course of therapy+ IVF= $ 5500
1 operation + hormone therapy + IVF = $ 6700
1 course of therapy + IVF = $ 5250
1 biopsy + 1 genetic analysis + the cost of drugs = $ 760
Competitive advantages
• individual approach to treatment • effective targeted selection of drugs• lower economic cost of treatment • optimization of the making decision on the
treatment option for each patient
Scientific novelty
• Drug's prescribing is based on the genetic analysis of each patient
Current state
• Bioinformatic analysis of the main signaling pathways involved in pathogenesis of endometriosis in the article «Molecular aspects of development and regulation of endometriosis» in Reproductive Biology and Endocrinology Journal
• Perspective article about possibility of using Oncofinder software to implement the idea
Planned
• Creating a database of intracellular changes that underlie endometriosis
• Creating the medical protocol of personalized approach to diagnosis and treatment of endometriosis
• Obtaining a patent on intellectual property
Implementation stages
Biopsy
Microchipping
Targeting drugs selection
In-vitro validation
Resources
• The required sum of money (grant funds) - $ 220,000
• Scientific collaboration
Business model
Counseling CenterPotential customers
• Department of Obstetrics and Gynecology in Hospitals
• Reproductive centers• Fertility clinics
Genetic Testing
Personalized treatment
КомандаАзнаурова Я.Б.
ПМГМУ им. И.М.Сеченова
Румянцев С.А.
ФНКЦ ДГОИ им. Димы Рогачёва
Жуматаев М.Б.
ПМГМУ им. И.М.Сеченова
Гаража А.В.
ЦБРМ
Буздин А.А.
ИБХ РАН
Thank you for your attention!
Yana [email protected]
www.ScientistDoctor.com
Федеральный научно-клинический центр детской гематологии,
онкологии и иммунологии им. Димы Рогачёва