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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo Yan Luo,1 Alexander R. Shoemaker,1 Xuesong Liu,1 Keith W. Woods,1 Sheela A. Thomas,1 Ron…
1. HTRF ® cellular-kinase assays: for the simple detection of phosphorylated kinases directly in the cell 2. HTRF ® Cellular kinase assays OBJECTIVE: Measurement of endogenous…
983Research Article Introduction AKT protein kinases have consensus kinase, regulatory, and PH (pleckstrin homology) localization domains (Song et al., 2005); the latter…
doi:10.3402/jev.v3.25657Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer The Harvard community has made this
The critical role of MAP-kinases and PI3K-Akt signaling pathways in inflammation and oxidative stress PhD Thesis Eszter Bognár Doctoral School leader: Balázs Sümegi PhD…
1 Dual targeting of aurora kinases with AMG 900 exhibits potent preclinical activity against acute myeloid leukemia with distinct post-mitotic outcomes Marc Payton1^, Hung-Kam…
Microenvironment and Immunology Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics JosephGCrompton123MadhusudhananSukumar1…
RESEARCH ARTICLE Open Access Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy Ryan Urak, Miriam Walter, Laura Lim, ChingLam…
1 Cross-talk between the receptor tyrosine kinases AXL and ERBB3 regulates invadopodia formation in melanoma cells Or-Yam Revach1 Oded Sandler1 Yardena Samuels1 and Benjamin…
OPEN AKT activation controls cell survival in response to HDAC6 inhibition M Kaliszczak1 S Trousil1 T Ali1 and EO Aboagye*1 HDAC6 is emerging as an important therapeutic…
Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2012 PI3K/AKT, MAPK and AMPK signalling: protein…
The role of PI3KAKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer Julius Semenasa Andreas Hedbloma1 Regina R Miftakhovaa1…
102 CANCER DISCOVERY JANUARY 2017 www.aacrjournals.org RESEARCH ARTICLE A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates…
PI3KAKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis Simon M. Schultze1,2, Brian A. Hemmings2, Markus Niessen1 and Oliver Tschopp1,* New therapeutic…
pubsacsorgjmc Published on Web 11162010 r 2010 American Chemical Society 8508 J Med Chem 2010 53 8508–8522 DOI: 101021jm100732t A Novel Pyrazolo15-apyrimidine Is a Potent…
RESEARCH ARTICLE Insulin regulates multiple signaling pathways leading to monocyte macrophage chemotaxis into the wound tissue Yan Liu1* Sandeep Dhall2 Anthony Castro2 Alex…
1 mTOR/RICTOR is the Ser473 Kinase for Akt/PKB in 3T3-L1 Adipocytes* Richard C. Hresko and Mike Mueckler§ From the Department of Cell Biology and Physiology, Washington…
Biophysical Journal Volume 103 December 2012 2389–2398 2389 Crosstalk and Competition in Signaling Networks Michael A Rowland† Walter Fontana§ and Eric J Deeds†‡*…
University of Groningen Implications of the cardiomyocyte stress response on protein homeostasis in atrial fibrillation Wiersma, Marit IMPORTANT NOTE: You are advised to…
Protein Kinases Primary elements in signal transduction - Phosphorylated residues by protein kinases: S, T, Y A Protein kinase can ⓟ hundreds of target proteins, thereby…