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8/13/2019 Lesson 3 Jezko Biotransformation of Drugs 1/48Biotransformation of drugsPharmDr. Pavol JekoCenter of Excellence PharmacyDepartment of Medicinal ChemistryCADD LaboratoryFaculty…
BIOTRANSFORMATION OF DRUGS PHASE I: OXIDATION Submitted by:STEFFI K. BABU 1st MPHARM (PHARMACEUTICS) JSSCP, OOTY PHASE I BIOTRANSFORMATION Conversion of drugs from one chemical…
Drug metabolism, prodrug biotransformation
1. Biotransformation(Metabolism) of Drugs 2. A. General properties1. Biotransformation is a major mechanism for drug elimination;• Results of biotransformation: – Production…
1.FACTORS AFFECTING BIOTRANSFORMATION OF DRUGS PRESENTED BY: HADIA ARSHAD 2. TYPES OF FACTORS • Chemical • Biological • Altered Physiological • Temporal • Route…
Phase I reactions Phase II reacions The effect of biotransformation on the biological activity of drugs: How the biological (pharmacological and toxic) activity of the metabolite
Biotransformation of the Analgesic-Antipyretic Drugs Metamizole and Aminopyrine by Genetically Polymorphic Enzymes Von der Fakultät für Lebenswissenschaften der Technischen…
Slide 1 Biotransformation of Drugs September 10, 2007 Frank F. Vincenzi Slide 2 Learning objectives: drug biotransformation Xenobiotic, endoplasmic reticulum & microsomes…
BIOTRANSFORMATION AND METABOLISM BIOTRANSFORMATION: Drugs being metabolized by enzymes and chemical reactions in the body before they are eliminated. Altered drug is known…
Biotransformation of drugs (Drug metabolism)(Drug metabolism) PharmDr. Pavol Ježko, PhD. Department of Pharmaceutical Chemistry Faculty of Pharmacy, Comenius University…
1 Mosul University College of pharmacy Lec 9 Biopharmaceutics Hepatic Elimination of Drugs The elimination of most drugs from the body involves the processes of both metabolism…
Biotransformation of drugs (Drug metabolism)(Drug metabolism) PharmDr. Pavol Ježko, PhD. Department of Pharmaceutical Chemistry Faculty of Pharmacy, Comenius University…
Slide 1SITES DRUG BIOTRANSFORMATION of HEPATIC METABOLISM undergo List of DRUGS Absorption Site Intestine & Colon Process Reductive Reaction SULFASALAZINE Slide 2 SITES…
I. Why is Biotransformation Necessary? Introduction: Lipophilic drugs pass through biological membranes; which contributes to the drug to reaching its site of action. Lipophilicity…
1. DR.VIJAYA KRISHNA Post graduate studentDepartment of Pharmacology GANDHI MEDICAL COLLEGEHyderabad, AP.01 AUG 2012 2. PLAN OF PRESENTATION• INTRODUCTION• DEFINITION•…
1.DR.VIJAYA KRISHNA Post graduate studentDepartment of Pharmacology GANDHI MEDICAL COLLEGEHyderabad, AP.01 AUG 20122. PLAN OF PRESENTATION• INTRODUCTION• DEFINITION•…
BIOTRANSFORMATION BIOTRANSFORMATION Guided by, K.charhate sir presented by, priyanka R Todkari M-PHARM(Q.A.) 1 CONTENT 1)INTRODUCTION. 2)FACTORS AFECTING BIOTRANSFORMATION…
Biotransformation Introduction Foreign and potentially toxic compounds absorbed into biological systems are generally lipophilic substances. They are therefore not ideally…
8/14/2019 Biotransformation BDS 1/32Dr.U.P.RathnakarDr.U.P.Rathnakar MD.DIH.PGDHMMD.DIH.PGDHMK.M.C. Mangalore.K.M.C. Mangalore.Fate of the drug8/14/2019 Biotransformation…
8/12/2019 biotransformation (1) 1/27 B I M M 1 1 8Drug Metabolism Most metabolic products are less pharmacologically activeImportant exceptions: Where the metabolite is more…