Search results for Biotransformation of Drug Candidates by Non-CYP ... 2 Biotransformation in Drug Metabolism ¢â‚¬¢ Drug

Drug BiotransformationDepartment of Pharmacology Drug Biotransformation • Humans are exposed always to foreign compounds called xenobiotics, through the GIT, skin, lung,

1.Dr. Rahul Kunkulol , Asso. professor, Dept. Of Pharmacology 2. • The chemical modification of drugs with the overall goal of getting rid of the drug • Enzymes are typically…

SITES DRUG BIOTRANSFORMATION SITES DRUG BIOTRANSFORMATION of HEPATIC METABOLISM undergo List of DRUGS First-pass effect Absorption Site Intestine & Colon Process Reductive…

Biotransformation BIOTRANSFORMATION Dr.RENJU.S.RAVI MD OVERVIEW Definition Consequences Types Phase I/II in detail Enzyme Induction/Inhibition First Pass Metabolism Xenobiotics-…

Biotransformation BIOTRANSFORMATION Dr.RENJU.S.RAVI MD OVERVIEW Definition Consequences Types Phase I/II in detail Enzyme Induction/Inhibition First Pass Metabolism Xenobiotics-…

1. diaConjugation of salicylic acid 16.bin morphin steroids Dubin Johnson syndr. Ways of conjugation Sulfation – PAPS - sulfotransferases Sulfation – PAPS –

8172019 CS_K18 Drug Metabolism - Biotransformation 132 DRUG METABOLISM BIOTRANSFORMA TIONAznan Lelo Yunita Sari Pane De! Fara#olo$i %an Teraeuti# Fa#ulta e%o#teran…

Drug Metabolism By: Dr Mohsen Bebars Dr Mohsen Bebars Drug Metabolism Biotransformation ➢ It is a process of biochemical changes of drugs or xenobiotics in the body which…

Slide 1BIOTRANSFORMATION, Drug metabolism, detoxification Phase 2 conjugation Slide 2 su sulfation Glucuronidation (80%) Conjugation with amino acids glycosylation acetylation…

Ming-Jaw Don,5 and Ruei-Ming Chen1,2,6 1Brain Disease Research Center, Department of Anesthesiology, Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan 2Graduate

Biotransformation of Drug Candidates by Non-CYP Metabolic Pathways Jie Wang June 19 2012 2 Biotransformation in Drug Metabolism • Drug metabolism – Main function is to…

BD BIOSCIENCES FY’05 1st QUARTER REVIEWJie Wang Biotransformation in Drug Metabolism • Drug metabolism – Main function is to facilitate removal of compounds

PHARMACOKINETICS PHARMACOKINETICS BIOTRANSFORMATION Drug metabolism/drug inactivation/drug detoxification The chemical alteration of drug molecules by the body cells of patients…

PHARMACOKINETICS Part 3 BIOTRANSFORMATION Drug metabolism/drug inactivation/drug detoxification The chemical alteration of drug molecules by the body cells of patients to…

Biotransformation of drug Introduction to Biotransformation of drug (eg metabolism of phenytoin and codeine ) PRESENTED BY ADAM SHAHUL HAMEED M.TECH COMPUTATIONAL BIOLOGY…

In Vitro Biotransformation, Safety, and Chemopreventive Action of Novel 8-Methoxy-Purine-2,6-Dione Derivatives Małgorzata Anna Marć1 & Enrique Domínguez-Álvarez1,2…

Site of Action Dosage Effects Plasma Concen. Pharmacokinetics Pharmacodynamics Bound Free Free Bound LOCUS OF ACTION âRECEPTORSâ TISSUE RESERVOIRS SYSTEMIC CIRCULATION…

Gut, 1991,32,408-412 Biotransformation enzymes in human intestine: critical low levels in the colon? W H M Peters, L Kock, F M Nagengast, P G Kremers Abstract Biotransformation…

Slide 1 Pharmacodynamics Slide 2 Slide 3 BoundFree Bound LOCUS OF ACTION “RECEPTORS ” TISSUE RESERVOIRS SYSTEMIC CIRCULATION Free Drug Bound Drug ABSORPTION EXCRETION…

Slide 1 DRUG METABOLISM F. Keyhanfar Ph.D, D.I.C. Slide 2 METABOLISM (BIOTRANSFORMATION) ------------------------------------ Acetaminophen, NSAIDs inhibit cyclo-oxygenase…