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1. Biotransformation(Metabolism) of Drugs 2. A. General properties1. Biotransformation is a major mechanism for drug elimination;• Results of biotransformation: – Production…

Biotransformation of drugs (Drug metabolism)(Drug metabolism) PharmDr. Pavol Ježko, PhD. Department of Pharmaceutical Chemistry Faculty of Pharmacy, Comenius University…

Biotransformation of drugs (Drug metabolism)(Drug metabolism) PharmDr. Pavol Ježko, PhD. Department of Pharmaceutical Chemistry Faculty of Pharmacy, Comenius University…

BIOTRANSFORMATION AND METABOLISM BIOTRANSFORMATION: Drugs being metabolized by enzymes and chemical reactions in the body before they are eliminated. Altered drug is known…

Biotransformation BIOTRANSFORMATION Dr.RENJU.S.RAVI MD OVERVIEW Definition Consequences Types Phase I/II in detail Enzyme Induction/Inhibition First Pass Metabolism Xenobiotics-…

Biotransformation BIOTRANSFORMATION Dr.RENJU.S.RAVI MD OVERVIEW Definition Consequences Types Phase I/II in detail Enzyme Induction/Inhibition First Pass Metabolism Xenobiotics-…

1.Dr. Rahul Kunkulol , Asso. professor, Dept. Of Pharmacology 2. • The chemical modification of drugs with the overall goal of getting rid of the drug • Enzymes are typically…

Biotransformation Xenobiotic metabolism “Essentials of Toxicology” by Klaassen Curtis D. and Watkins John B Chapter 6 Biotransformation Water soluble xenobiotics are…

PowerPointhydrolysis) Several routes of metabolism found in vivo May inactivate or bioactivate action Liver is the major site of metabolism Genetically variation with some

8172019 CS_K18 Drug Metabolism - Biotransformation 132 DRUG METABOLISM BIOTRANSFORMA TIONAznan Lelo Yunita Sari Pane De! Fara#olo$i %an Teraeuti# Fa#ulta e%o#teran…

1. diaConjugation of salicylic acid 16.bin morphin steroids Dubin Johnson syndr. Ways of conjugation Sulfation – PAPS - sulfotransferases Sulfation – PAPS –

BIOTRANSFORMATION OF DRUGS PHASE I: OXIDATION Submitted by:STEFFI K. BABU 1st MPHARM (PHARMACEUTICS) JSSCP, OOTY PHASE I BIOTRANSFORMATION Conversion of drugs from one chemical…

Drug metabolism, prodrug biotransformation

Cluj-Napoca, Romania and MINO R. CAIRA University of Cape Town, South Africa “ ” Edited by Drug Metabolism Current Concepts CORINA IONESCU I. Ha ieganu University of…

1 Mosul University College of pharmacy Lec 9 Biopharmaceutics Hepatic Elimination of Drugs The elimination of most drugs from the body involves the processes of both metabolism…

1.FACTORS AFFECTING BIOTRANSFORMATION OF DRUGS PRESENTED BY: HADIA ARSHAD 2. TYPES OF FACTORS • Chemical • Biological • Altered Physiological • Temporal • Route…

Drug Metabolism By: Dr Mohsen Bebars Dr Mohsen Bebars Drug Metabolism Biotransformation ➢ It is a process of biochemical changes of drugs or xenobiotics in the body which…

Slide 1SITES DRUG BIOTRANSFORMATION of HEPATIC METABOLISM undergo List of DRUGS Absorption Site Intestine & Colon Process Reductive Reaction SULFASALAZINE Slide 2 SITES…

Phase I reactions Phase II reacions The effect of biotransformation on the biological activity of drugs: How the biological (pharmacological and toxic) activity of the metabolite

8/13/2019 Lesson 3 Jezko Biotransformation of Drugs 1/48Biotransformation of drugsPharmDr. Pavol JekoCenter of Excellence PharmacyDepartment of Medicinal ChemistryCADD LaboratoryFaculty…