Yes - University of Texas Southwestern Medical Center at Dallas

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Updated December, 2005 CURRICULUM VITAE Ronald Gary Victor, M.D. PROFESSIONAL EXPERIENCE : 1984-1985 Associate in Medicine, University of Iowa, College of Medicine 1986-1990 Assistant Professor of Medicine, Cardiology Division, UT Southwestern Medical Center 1990-1996 Associate Professor of Medicine with Tenure, Cardiology Division, UT Southwestern 1993-1994 Visiting Associate Professor in Molecular Cardiology, Johns Hopkins Medical School, Baltimore, Maryland January, 1997- Professor of Medicine, UT Southwestern (effective 9/1/97) December, 1997- Chief, Hypertension Division, UT Southwestern 1998-2000 Director, NHLBI Specialized Center of Research on Ischemic Heart Disease in Blacks October, 1999- Principal Investigator, Dallas Heart Study and Co-Director, Donald W. Reynolds Cardiovascular Clinical Research Center EDUCATION : 1970-1974 A.B., Cornell University, Ithaca, New York 1974-1978 M.D., Tulane University, New Orleans, Louisiana POSTGRADUATE TRAINING : 1978-1979 Internal Medicine Internship, University of California (UCLA), Los Angeles, CA 1979-1981 Internal Medicine Residency, UCLA, Los Angeles, CA 1981-1983 Cardiology Fellowship, Duke University, Durham, NC 1983-1984 Special Cardiovascular Research Fellowship, University of Iowa, Iowa City, IA

Transcript of Yes - University of Texas Southwestern Medical Center at Dallas

Page 1: Yes - University of Texas Southwestern Medical Center at Dallas

Updated December, 2005

CURRICULUM VITAE

Ronald Gary Victor, M.D.

PROFESSIONAL EXPERIENCE:

1984-1985 Associate in Medicine, University of Iowa, College of Medicine1986-1990 Assistant Professor of Medicine, Cardiology Division, UT

Southwestern Medical Center 1990-1996 Associate Professor of Medicine with Tenure, Cardiology

Division, UT Southwestern 1993-1994 Visiting Associate Professor in Molecular Cardiology,

Johns Hopkins Medical School, Baltimore, MarylandJanuary, 1997- Professor of Medicine, UT Southwestern (effective 9/1/97)December, 1997- Chief, Hypertension Division, UT Southwestern1998-2000 Director, NHLBI Specialized Center of Research on Ischemic

Heart Disease in BlacksOctober, 1999- Principal Investigator, Dallas Heart Study and Co-Director,

Donald W. Reynolds Cardiovascular Clinical Research Center EDUCATION:

1970-1974 A.B., Cornell University, Ithaca, New York1974-1978 M.D., Tulane University, New Orleans, Louisiana

POSTGRADUATE TRAINING:

1978-1979 Internal Medicine Internship, University of California (UCLA), Los Angeles, CA

1979-1981 Internal Medicine Residency, UCLA, Los Angeles, CA1981-1983 Cardiology Fellowship, Duke University, Durham, NC1983-1984 Special Cardiovascular Research Fellowship, University of

Iowa, Iowa City, IA11/83-1/84 Visiting Fellowship in Clinical Neurophysiology, University of

Uppsala, Uppsala, Sweden

BOARD CERTIFICATION:

1978 Federal Licensing Examination

1981 Diplomate, American Board of Internal Medicine

1984 Subspeciality of Cardiovascular Diseases

LICENSURE:

State       Status    Number  

1978 Louisiana Inactive 014692

1979 California Inactive C039033

1983 Iowa Inactive 233841986 Texas Active H1670

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HONORS AND AWARDS:

1974 Summa Cum Laude with Distinction, Cornell University1974 Phi Beta Kappa1974 Phi Kappa Phi1978 Tulane Medical School Owl Club President1978 Alpha Omega Alpha1984-88 NHLBI, Clinical Investigator Award 1986 Young Investigator Award, American College of Cardiology1987 NHLBI, FIRST Award1989-94 Established Investigatorship, American Heart Association1989 Harold Lamport Young Investigator Award, Cardiovascular Section,

American Physiological Society1991 American Society for Clinical Investigation1991 Pfizer Visiting Professorship in Cardiology1996 Award of Merit, American Heart Association, Dallas Division1998 Dallas Heart Ball Chair in Hypertension and Heart Disease 1999 Association of University Cardiologists2000 Hypertension Specialist, American Society of Hypertension2001Association of American Physicians2002Secretary, American Society of Hypertension2003Executive Council, Association of University Cardiologists2004Norman and Audrey Kaplan Chair in Hypertension2005Course Director, American Society of Hypertension Clinical Hypertension

Review Course2005 Humanitarian Award, Professional Barber & Stylists Committee2005 James Edward Smith Trailblazer Award, Texas Association of

Tonsorial Artists2005 Cardiovascular Distinguished Alumni Award, University of Iowa2005 Distinguished Alumnus Tulane University School of Medicine

Hypertension and Renal Center of Excellence2005 Best Doctors in Dallas 2005 “D” Magazine

CLINICAL APPOINTMENTS:

1984-1985 Attending Physician, University of Iowa Hospital1984-1985 Attending Physician, Iowa City Veterans Administration Hospital1986- Attending Physician, Parkland Memorial Hospital 1991- Attending Physician, Zale University Hospital2005- Attending Physician, St. Paul Hospital

CLINICAL ACTIVITIES:

Attending Physician, Internal Medicine, Parkland Memorial HospitalAttending Physician, Parkland Hypertension Clinic Hypertension Specialist, J. W. Aston Center Consultant, Zale University Hospital

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PROFESSIONAL SOCIETIES:

Association of American PhysiciansAmerican Society for Clinical Investigation, Member Association of University Cardiologists, Member American Society for Hypertension, Executive Council American Heart Association, Immediate Past President, Dallas Affiliate American Heart Association, Council on Basic Cardiovascular Sciences, Executive Committee, Newsletter Editor American Heart Association, Council on High Blood Pressure Research, FellowAmerican Federation for Clinical Research, MemberAmerican Physiological Society, Circulation Council MemberAmerican College of Cardiology, FellowSouthern Society for Clinical Investigation, MemberTexas Association of Tonsorial Artists (Honorary Member)

SELECTED VISITING PROFESSORSHIPS AND INVITED PRESENTATIONS:

1. Pfizer Visiting Professor in Cardiology, University of California at Davis,19912. "Neural Mechanisms of Cyclosporine-Induced Hypertension." Cardiology Grand

Rounds, Coumbia University College of Physicians and Surgeons, 1994.3. “The Sympathetic Nervous System Really Is Involved in Hypertension.” Lewis K.

Dahl Symposium, American Society for Hypertension Meeting, New York, 1995.

4. “Nitric Oxide and the Sympathetic Nervous System in Renal Parenchymal Hypertension,” American Society of Nephrology Meeting, San Antonio, 1997

5. “Obesity-Related Hypertension in African-Americans,” NHLBI Symposium on Heart Diseases in African-Americans, Harlem Hospital, New York, 1997

6. "The Ups and Downs of Blood Pressure in Patients with Chronic Renal Failure," Medicine Grand Rounds, University of Iowa, 1998

7. “Hypertension in African Americans: A Challenge for the 21st Century,.” Cardiology Grand Rounds, Johns Hopkins Medical Center, 1999.

8. “Hypertension in Chronic Renal Failure,” Nephrology Grand Rounds, University of Colorado, 2000.

9. “Taking the Clinical Investigator Off the Endangered Species List,” Michigan State University MD-PhD Visiting Professorship, 2000.

10. “NO Skeletal Muscle-Derived Relaxing Factor in Duchenne Muscular Dystrophy,”Keynote Speaker, Emory University Cardiology Fellows Research Day, 2000.

11. Isadore Rosenfeld Visiting Professorship, Medical College of Cornell University, 2000

12. “Neural Mechanisms of Hypertension in Chronic Renal Failure,” Keynote plenary lecture, International Society of Hypertension, Chicago, August, 2000.

13. “Hypertension in African Americans,” Cardiology Grand Rounds, Mid-America Heart Institute, Kansas City, 2001.

14. “Hypertension in Special Populations,” Texas ASH Chapter Symposium, December, 2001, Dallas

15. “Future of Hypertension Treatment Trials,” Preliminary session presentation, 2002 AHA meeting

16. “Synapsins, synaptic microvesicles, and sympathetically-mediated hypertension,” 2003 John H. Laragh Conference

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17. “Functional muscle ischemia as a cause of Duchenne muscular dystrophy,” invited presentation, invited presentation, 2003 AUC meeting

18. “Treating hypertension in African Americans,” invited faculty presentation, 2004 American Society of Hypertension meeting.

19. “The Engima of Hypertension in African Americans,” Internal Medicine Grand Rounds, Loyola University, 2005

20. “Cutting Blood Pressure in Barbershops,” Invited presentation at the Texas Association of Tonsorial Artists Meeting

21. “Functional Muscle Ischemia as a Cause of Duchenne Muscular Dystrophy,” Cardiology Grand Rounds, University of Iowa, 2005

22. “A New Approach to Treating Hypertension in African American Men,” Medicine Grand Rounds, University of Iowa, 2005

SELECTED CLINICAL PRESENTATIONS:

1. “Left atrial myxoma,” Parkland Hospital Clinical Pathologic Conference, April, 1996.2. “Inhaled nitric oxide for mitral valve replacement in a patient with severe

pulmonary hypertension, UT SouthwesternCardiology Conference, March, 1997. 3. “Management for blood pressure problems in patients with chronic renal failure,”

Breckenridge Hospital Medicine Grand Rounds, Austin, Texas, May, 1997. 4. “Hypertension in Patients with Chronic Renal Failure,” Clinical Symposium,

American Society of Nephrology Meeting, November, 1999. 5. “Angiotensin converting enzyme inhibitors provide organoprotection in African

American hypertensives, clinical debate, American Society of Hypertension Meeting, May, 2000.

6. “Acute Severe Hypertension,” Parkland ED didactic series, 20027. “Hypertension and hypertensive emergencies,” Parkland ICU nurse interns, 2004

EDITORIAL BOARDS:

American Journal of Hypertension, 1999-presentAmerican Journal of Cardiology, 2004-presentHypertension, 1989-1996Circulation, 1993-1998Journal of Clinical Hypertension, 2003-Journal of Hypertension, 2002-

AD HOC SCIENTIFIC REVIEWER:

Journal of Clinical InvestigationCirculationNew England Journal of MedicineCirculation Research

SELECTED SESSIONS CHAIRED:

Cardiovascular Physiology/Pharmacology, 1994 AFCR Meeting Autonomic Control in Heart Failure and After Heart Transplant, 1994 AHA Meeting

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Sympathetic Neurotransmission, 1995 Biophysical Society Meeting Autonomic Control of the Circulation in Humans, 1998 AHA MeetingOrganoprotective Effects of ACE Inhibitors in African Americans, 2000 ASH MeetingBringing Preventative Cardiology to Minority Communities, 2002 ISHIB MeetingImplications of ALLHAT for clinical practice, 2003 ASH meetingClinical case presentations in difficult hypertension, 2003 ASH meeting

COMMITTEES:

UT Southwestern Medical Center

Nephrology Section Chief Search Committee, 1998-1999Institutional Animal Care and Research Committee (alternate), 1995-presentGeneral Clinical Research Center Advisory Board (alternate), 1996-present

National

Secretary, American Society of Hypertension, 2002-2005Counselor, Association of University Cardiologists, 2002-2005Consultant, University of Alabama Cardiovascular Training Grant, 2000-Consultant, Duke University Cardiovascular Training Grant, 2000-Member, NHLBI Specialized Centers of Research Study Section on Heart Disease in Blacks, 2000 Member, Veterans Affairs Merit Review Cardiovascular Study Section, 1997-2000. Member, Executive Council American Society of HypertensionMember, Executive Committee, AHA Council on Circulation, 1992-presentEditor, AHA Council on Circulation News Letter, 1996-2000 Ad Hoc Reviewer, NHLBI Program Project Grant Study Section, 1996

CURRENT GRANT SUPPORT:

A. R0-1s

1. HL44010Grantor: National Heart Lung and Blood InstituteTitle of Project: Neural Mechanisms of Cyclosporine-Induced Hypertension Role: RG Victor, Principal Investigator

Years 11-15 (7/02-6/06): Annual amount and dates: $200,000 requestedTotal amount of award: $1,000,000 requested

2. DA10064Grantor: National Institues on Drug Abuse Title of Project: Cocaine and Sympathetic Nerve Activity in HumansRole: RG Victor, Principal Investigator

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Years 09-13 (9/04-8/09): Annual amount and dates: $171,716 (9/1/99 - 8/31/00)Total amount of award: $866,229

B. Programmatic Grants

1. Donald W Reynolds Cardiovascular Clinical Research CenterGrantor: Donald W. Reynolds FoundationTitle of Project: Project 4: Barbershop-Based Intervention

for Controlling Hypertension in Black MenRole: RG Victor, Principal Investigator

Years 6-7 (10/04-9/06)Total amount of award: $2,600,000

2. HL06296 - Program Project GrantGrantor: National Heart, Lung, and Blood InstituteTitle of Project: Responses and Adaptations to ExerciseResearch Unit IV: Muscle Metabolism and Muscle Sympathetic Nerve ActivityRole: RG Victor, PPG Co-Director/Research Unit Director

Years 42-46 (7/02- 6/07)Annual amount and dates: $200,000 (7/97-12/98) Total amount of award: $1,000,000

SELECTED PREVIOUS GRANTS :

1. HL55988 - Ischemic SCORGrantor: National Heart Lung and Blood InstituteTitle of Project: NHLBI SCOR: Ischemic Heart Disease in BlacksResearch Unit III: Neural Mechanisms of Obesity-Related Hypertension in BlacksRole: RG Victor, SCOR Director/Research Unit III Director

Years 01-05 (10/95-9/00)Annual amount and dates: $615,433 (9/1/98 - 8/31/98)Total amount of award: $2,971,981

2.. Patient Care and Outcomes RFAGrantor: American Heart AssociationTitle of Project: Controlling Blood Pressure in an Urban Black Community Role: RG Victor, Principal Investigator

Years 01-03 (1/4/99 - 12/31/02):Annual amount and dates: $166,666 (1/1/99 - 12/31/00)Total amount of award: $500,000

3. Community Intervention TrialGrantor: Texas Higher Education Coordinating BoardTitle of Project: Efficacy of a Barbershop-Based Intervention for Controlling

Hypertension in Black Men

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Role: RG Victor, Principal Investigator

Years 01-02 (9/01-8/03):Annual amount and dates: $168,000 (9/01-8/02)Total amount of award: $336,000

ENDOWED CHAIRS

1. Dallas Heart Ball Chair in Hypertension and Heart Disease1999 - Total amount of gift: $500,000

2. Norman and Audrey Kaplan Chair in Hypertension

2004 - Total amount of gift: $500,000

CAREER DEVELOPMENT AWARDS

1. Individual National Research Service AwardGrantor: National Heart Lung and Blood Institute Title of Project: Carotid Baroreflex Modulation of the Somatic Pressor ReflexRole: RG Victor, Principal InvestigatorTotal amount of award and dates: $50,000(1983-1984) 2. Clinical Investigator Award #HL01886 Grantor: National Heart Lung and Blood InstituteProject Title: Vascular Beta-Receptors in Borderline HypertensionRole: RG Victor, Principal InvestigatorTotal amount of award and dates: $275,600 (3/84-12/88)3. FIRST Award, #HL38678Grantor: National Heart Lung and Blood InstituteProject Title: Reflex Sympathetic Discharge During Exercise in HumansRole: RG Victor, Principal InvestigatorTotal amount of award and dates: $349,623 (funds turned back in lieu of Program Project

funding) (6/87-5/92)4. Established Investigator Award Grantor: American Heart Association Project Title: Muscle pH, and Sympathetic Outflow During Exercise in

HumansRole: RG Victor, Principal Investigator Total amount of award and dates: $212,025 (7/89-6/94)5. Grant-In-Aid #86G-098Grantor: American Heart Association, Texas AffiliateProject Title: Beta Blockers and Exercise: Microneurographic Studies in HumansRole: RG Victor, Principal Investigator Total amount of award and dates: $54,221 (7/87-6/89)

CLINICAL TRIALS

Antihypertensive and Lipid Lowering to Prevent Heart Attack Trial Grantor: NHLBI

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Project Title: ALLHATRole: RG Victor, Center Director UT Southwestern Total Amount of award and dates: $3681/quarter (12/97-12/02)

MENTORSHIP OF POSTDOCTORAL AND CAREER DEVELOPMENT AWARDS

1. Individual National Research Service Award #HL08085 Grantor: National Heart Lung and Blood InstituteProject Title: Neural Mechanism of Cyclosporine-A Induced HypertensionRole: RG Victor, Sponsor (Trainee: B J Morgan PhD) Total amount of award and dates: $49,000 (6/89-5/91)2. International Research Fellowship AwardGrantor: NIH Fogarty FoundationProject Title: Sympathetic Regulation by Ventricular Afferents in HumansRole: RG Victor, Sponsor (Trainee: TN Jacobsen, MD)Total amount of award and dates: $58,500 (3/11/90-2/28/92)3. International Research Fellowship AwardGrantor: NIH Fogarty FoundationProject Title: Neural Control of Skeletal Muscle Metabolism in HumansRole: RG Victor, Sponsor (Trainee: J Hansen, MD) Total amount of award and dates: $50,000 (9/93-2/95)4. International Research Fellowship AwardGrantor: NIH Fogarty FoundationProject Title: Nitric Oxide and Sympathetic Activity in UremiaRole: RG Victor, Sponsor (Trainee: Mikael Sander, MD) Total amount of award and dates: $50,000 (9/94-9/96)5. Fellowship Award,Grantor: Muscular Dystrophy AssociationProject Title: Sympathetic Nerve and MetabolismRole: RG Victor, Sponsor (Trainee: GD Thomas, PhD) Total amount of award and dates: $53,000 (1/93-12/94)6. International Fellowship Award Grantor: University of Copenhagen PhD ProgramProject Title: Neural Mechanisms of Pregnancy-Induced HypertensionRole: RG Victor, Sponsor (Trainee, K Sander, MD) Annual Amount and Dates: $30,000 (10/1/96-9/30/97)Total amount of award and dates: $90,000 (10/96-9/99)7. Merck American College of Cardiology Research Fellowship PrizeGrantor: Merck Corp./American College of CardiologyProject Title: Sulfonylureas and Muscle Oxgenation in HumansRole: RG Victor, Mentor (Trainee, B Chavoshan, MD)Total Amount and Dates: $35,000 (7/97-6/98)8. Mentored Patient-Oriented Research career Development Award (K23) Grantor: NIHProject Title: Postmenopausal Hormone Replacement Therapy, Sympathetic Nerve

Activity, and Blood PressureRole: RG Victor, Mentor (Recipient, W Vongpatanasin, MD)Total Amount and Dates: $100,000/year (3/2002-2/2007)9. Mentored Patient-Oriented Research career Development Award (K25)

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Grantor: NIHProject Title: In Vivo Measurement of Myocardial LipidsRole: RG Victor, Mentor (Recipient, L Szczpeniak, PhD)Total Amount and Dates: $100,000/year (3/2002-2/2007)

PERSONNEL SUPERVISED

Faculty:Douglas R. Seals, Ph.D. (5/86-7/86)

American College of Sports Medicine Visiting Assistant ProfessorUniversity of ArizonaTucson, Arizona

Urs Scherrer, M.D. (9/87-8/89)Visiting Assistant Professor of Internal MedicinePoliclinique Medicale UniversitaireLausanne, Switzerland

Fetnat Fouad-Tarazi, M.D. (3/90-7/90)Visiting Professor of Internal MedicineThe Cleveland ClinicCleveland, Ohio

Teresa Lyson, M.D. Ph.D. (1/93-8/94) Assistant Instructor of Internal MedicineU.T. Southwestern Medical Center

Gail Thomas, PhD (1/96-present)Associate Professor of Internal Medicine/Hypertension U.T. Southwestern Medical Center

Weiguo Zhang, MD PhD (7/97-present)Assistant Professor, Internal Medicine/HypertensionU.T. Southwestern Medical Center

Nicola Abate, MD PhD (7/97-6/98)Research Assistant Professor of Medicine/HypertensionU.T. Southwestern Medical Center

Wanpen Vongpatanasin, MD (8/98-present)Associate Professor of Internal Medicine/HypertensionU.T. Southwestern Medical Center

Nina Radford, MD (9/98-6/2001Assistant Professor of Internal Medicine/HypertensionU.T. Southwestern Medical Center

Lidia Szczpeniak, PhD (11/2000-presentAssistant Professor of Internal Medicine/HypertensionU.T. Southwestern Medical Center

Shawna Nesbitt, MD (11/2001-presentAssociate Professor of Internal Medicine/HypertensionU.T. Southwestern Medical Center

Norman Kaplan, MD (11/97-present)Professor of Internal Medicine/HypertensionU.T. Southwestern Medical Center

David Leonard, MD (12/2004-present)Assistant Professor, Biostatistics and Internal Medicine

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U.T. Southwestern Medical Center

Research Fellows and Students (*who have obtained current academic appointments):Susan L. Pryor, M.D. (7/86-6/87)

Cardiology FellowU.T. Southwestern Medical CenterNHLBI Clinical Investigator

*Susan Fløistrup Vissing, M.D. (3/87-9/88)Visiting Research FellowUniversity of Copenhagen, DenmarkCurrent Academic Position: Scientist, Copenhagen Muscle Research Center

Diane Rotto (1/89-5/89)Predoctoral FellowU.T. Southwestern Medical Center

*Barbara Morgan, Ph.D. (6/88- 6/91)Postdoctoral FellowU.T. Southwestern Medical CenterCurrent Academic Position: Associate Professor with Tenure, Physical Therapy Dept., University of Wisconsin at Madison

Tage Jacobsen, M.D. (3/90- 8/93)Visiting Research Fellow, PhD candidateUniversity of Copenhagen, DenmarkFogarty International Research Fellow

Richard Converse, M.D. (6/90- 1/92)Cardiology FellowU. T. Southwestern Medical Center

David M. McMullen (6/90-8/92)Medical Student Research FellowU. T. Southwestern Medical Center

Charles Jost, MD (7/91-6/92)Cardiology FellowU.T. Southwestern Medical Center

*Gail Thomas, PhD (10/91-12/94)Postdoctoral FellowMuscular Dystrophy Association FellowshipU.T. Southwestern Medical Center Current Academic Position: Instructor of Medicine, UT Southwestern

*Jim Hansen, MD (1/92-5/96) Visiting Research Fellow, PhD candidate

University of Copenhagen, DenmarkFogarty Foundation FellowCurrent Academic Position: Scientist, Copenhagen Muscle Research Center

*Mikael Sander, MD (8/94-06/98)Visiting Research Fellow, PhD candidateUniversity of Copenhagen, DenmarkFogarty Foundation FellowCurrent Academic Position: Scientist, Copenhagen Muscle Research Center

Kirsten Sander, MD (9/94-06/98)Visiting Research Fellow, PhD candidate

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University of Copenhagen, DenmarkBahman Chavoshan, MD (7/96-11/99)

Cardiology FellowACC/Merck Fellow U. T. Southwestern Medical Center

*Temple Howell-Stampley, MD (7/96-06/97) Cardiology Research FellowU. T. Southwestern Medical CenterCurrent Academic Position: Assistant Professor of Internal Medicine/General Internal Medicine, U.T. Southwestern

*Wanpen Vongpatanasin, MD (7/96-06/98)Cardiology FellowU. T. Southwestern Medical CenterCurrent Academic Position: Assistant Professor of Internal Medicine/ Hypertension, U.T. Southwestern

Arunima Misra, MD (7/97-06/98)Cardiology FellowU.T. Southwestern Medical Center

Yasser Mansour, MD (7/98-7/2000)Hypertension Research FellowU.T. Southwestern Medical Center

Meryem Tuncel, MD (7/99-7/2002)Hypertension Research FellowU.T. Southwestern Medical Center

*Aamer Abbas, MD (7/99-7/2002)Clinical Hypertension Fellow/Reynolds Research FellowU.T. Southwestern Medical Center

Nali Spencer, MD (7/2000-7/2003)Clinical Hypertension FellowU.T. Southwestern Medical Center

Dileep Menon, MD (8/2004-present)Clinical Hypertension FellowU.T. Southwestern Medical Center

Jason Reingold (8/2002-7/2003)Doris Duke Student Fellow from Emory UniversityU.T. Southwestern Medical Center

Dan Martin (8/2002-7/2003)Doris Duke Student Fellow from Emory UniversityU.T. Southwestern Medical Center

Paul Hess (8/2003-6/2005)Doris Duke Student Fellow from Emory UniversityU.T. Southwestern Medical Center

Darin Bell (8/2003-8/2004)Doris Duke Student Fellow from Emory UniversityU.T. Southwestern Medical Center

John HollierMedical Student (9/2003-present) U. T. Southwestern Medical Center

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Faculty Associates:Jai-Ling Li, MD PhD (11/98-present)

Research Assistants/Nurses:

Troy Obergon (5/90-7/91)LeAnn Ermel (5/90-7/92)David Ernest (7/91-6/92)Richard Cooley (5/91-7/93)Tolgar Bakraktaroglu (6/93-8/94) Pernille Hansen (6/92-9/95)George Albright (6/96-9/98)

Willie Young (6/96-11/99)Debbie Arbique, RN (11/98-present)Gloria Griffin, LVN (11/2002-present)

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PUBLICATIONS:

A. INVESTIGATIVE REPORTS

1. Seethanathan P, E Dalferes, B Rhadhakrishnamurthy, R Victor, and GS Berenson: Glycosaminoglycans from ateroid and bovine duodenal mucosa and pancreas. Molecular and Cellular Biochemistry 8:177-193, 1975.

2. Victor RG, J Mainardi, and D Shapiro: Effects of biofeedback and voluntary control procedures on heart rate and perception of pain during the cold pressor test. Psychosomatic Medicine 40:216-225, 1978.

3. Victor RG, D Weipert, and D Shapiro: Voluntary control of systolic blood pressure during postural change. Psychophysiology 21:673-682, 1984.

4. Mark AL, RG Victor, C Nerhed, and BG Wallin: Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circulation Research 57:461-469, 1985.

5. Victor RG, and AL Mark: Interaction of cardiopulmonary and carotid baroreflex control of vascular resistance in humans. The Journal of Clinical Investigation 76:1592-1598, 1985.

6. Victor RG, DA Morgan, P Thoren, and AL Mark: High salt diet sensitizes cardio-pulmonary baroreflexes in Dahl salt-resistant rats. Hypertension 8:II-21, 1986.

7. Leimbach WM, Jr, BG Wallin, RG Victor, G Sundlof, and AL Mark: Microneurographic evidence for increased central sympathetic neural drive in patients with heart failure. Circulation 73:913, 1986.

8. Victor RG, DR Seals, and AL Mark: Differential control of heart rate and sympathetic nerve activity during dynamic exercise. The Journal of Clinical Investigation 79:508-516, 1987.

9. Aksamit PE, JS Floras, RG Victor, and PE Aylward: Paroxysmal hypertension due to sino-aortic baroreceptor denervation in man. Hypertension 9:309-314, 1987.

10. Mark AL, RG Victor, A Ferrari, DA Morgan, and P Thoren: Cardiac sensory receptors in Dahl salt-resistant and salt-sensitive rats. Circulation 75:I137-I140, 1987.

11. Victor RG, WN Leimbach, Jr, DR Seals, BG Wallin, and AL Mark: Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension 9:429-436, 1987.

12. Victor RG, and WN Leimbach, Jr: Effects of lower body negative pressure on sympathetic discharge to leg muscles in humans. Journal of Applied Physiology 63:2558-2562, 1987.

13. Floras JS, PE Aylward, RG Victor, AL Mark, and FM Abboud: Epinephrine

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facilitates neurogenic vasoconstriction in humans. The Journal of Clinical Investigation 81:1265-1274, 1988.

14. Scherrer U, SF Vissing, and RG Victor: Effects of lower body negative pressure on sympathetic nerve responses to static exercise in humans.Circulation 78:49-59, 1988.

15. Victor RG, LA Bertocci, SL Pryor, and RL Nunnally: Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans. The Journal of Clinical Investigation 82:1301-1305, 1988.

16. Morgan DA, P Thoren, EA Wilczynski, RG Victor, and AL Mark: Serotonergic mechanisms mediate renal sympathoinhibition during severe hemorrhage in rats. American Journal of Physiology 255:H496-H502, 1988.

17. Seals DR, RG Victor, and AL Mark: Plasma norepinephrine and muscle sympathetic discharge during rhythmic exercise in humans. Journal of Applied Physiology 65:940-944, 1988.

18. Victor RG, DA Rotto, SL Pryor, and MP Kaufman: Stimulation of renal sympathetic nerve activity by static contraction: evidence for mechanoreceptor-induced reflexes from skeletal muscle. Circulation Research 64:592-599, 1989.

19. Wallin BG, RG Victor, and AL Mark: Sympathetic outflow to resting muscles in arm and leg during isometric handgrip and post-handgrip muscle ischemia. American Journal of Physiology 256:H105-H110, 1989.

20. Victor RG, P Thoren, DA Morgan, and AL Mark: Differential control of adrenal and renal sympathetic nerve activity during hemorrhagic hypotension in rats. Circulation Research 64:686-694, 1989.

21. Victor RG, SL Pryor, NH Secher, and JH Mitchell: Effects of partial neuromuscular blockade on sympathetic nerve responses to static exercise in humans. Circulation Research 65:468-476, 1989.

22. Mitchell JH, DR Reeves, Jr, HB Rogers, NH Secher, and RG Victor: Autonomic blockade and cardiovascular responses to static exercise in partially curarized man. Journal of Physiology (London) 413:433-445, 1989.

23. Vissing SF, U Scherrer, and RG Victor: Relationship between sympathetic outflow and vascular resistance in the calf during perturbations in central venous pressure. Circulation Research 65:1710-1717, 1989.

24. Victor RG, and DR Seals: Reflex stimulation of sympathetic outflow during rhythmic exercise in humans. American Journal of Physiology 26:H2017-H2024, 1989.

25. Pryor SL, SL Lewis, RG Haller, LA Bertocci, and RG Victor: Impairment of sympathetic activation during static exercise in patients with muscle phosphorylase deficiency (McArdle's Disease). The Journal of Clinical Investigation 85:1444-1449, 1990.

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26. Scherrer U, SF Vissing, BA Morgan, P Hanson, and RG Victor: Vasovagal syncope after infusion of a vasodilator in a heart-transplant recipient. The New England Journal of Medicine 322:602-604, 1990.

27. Scherrer U, SF Vissing, BA Morgan, S Ring, PK Mohanty, P Hanson, and RG Victor: Cyclosporine-induced sympathetic activation and hypertension after heart transplantation. The New England Journal of Medicine 323:693-699, 1990.

28. Scherrer U, SL Pryor, LA Bertocci, and RG Victor: Arterial baroreflex buffering of sympathetic activation during exercise-induced elevations in arterial pressure. The Journal of Clinical Investigation 86:1855-1861, 1990.

29. Vissing S F, U Scherrer, and RG Victor: Stimulation of skin sympathetic nerve discharge by central command: differential control of sympathetic outflow to skin and skeletal muscle during static exercise. Circulation Research 69:228-238, 1991.

30. Vissing J, LB Wilson, JH Mitchell, and RG Victor: Static contraction reflexly increases adrenal sympathetic activity in rats. American Journal of Physiology 261:R1307-R1312, 1991.

31. Morgan BJ, T Lyson, U Scherrer, and RG Victor: Cyclosporine causes sympathetically-mediated elevations in arterial pressure in rats. Hypertension 18:458-466, 1991.

32. Jacobsen TN, Converse RL, and RG Victor: Contrasting effects of propranolol on sympathetic nerve activity and vascular resistance during orthostatic stress. Circulation 85:1072-1076, 1992.

33. Converse RL, Jacobsen TN, Fouad-Tarazi F, Obregon TM, Toto RD, and RG Victor: Paradoxical withdrawal of reflex vasoconstriction as a cause of hemodialysis-induced hypotension. The Journal of Clinical Investigation 90:1657-1665, 1992.

34. Converse RL, Jacobsen TN, Toto RD, Jost CMT, Cosentino F, Fouad-Tarazi F, and RG Victor: Sympathetic overactivity in patients with chronic renal failure. The New England Journal of Medicine 327:1912-1918, 1992.

35. Jacobsen RN, Morgan BJ, U Scherrer, SF Vissing, N Johnson, S Ring, PH Rhako, MT Olivari, P Hanson, and RG Victor: Relative contribution of cardiopulmonary and sinoaortic baroreflexes in causing sympathetic activation in the human skeletal muscle circulation during orthostatic stress. Circulation Research 73:367-378, 1993.

36. Lyson T, Ermel LD, Belshaw PJ, Alberg DG, Schreiber SL, and Victor RG: Cyclosporine A and FK506 induced sympathetic activation correlates with calcineurin-mediated inhibition of T cell signalling. Circulation Research 73:596-602,1993.

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37. Lyson T, McMullan DM, Ermel LD, Morgan BJ, and RG Victor: Mechnaism of cyclosporine-induced sympathetic activation and acute hypertension in rats. Hypertension 23:667-675, 1994.

38. Jost CMT, Agarwal R, Khair-El-Din T, Grayburn PA, Victor RG, and WL Henrich: Effects of cooler temperature dialysate on hemodynamic stability in "problem" dialysis patients. Kidney International 44: 606-612, 1993.

39. Jacobsen TJ, RA Lange, M-T Olivari, CW Yancy, VPH Horn, WS Ring, BJ Baldwin, Cooley RA, and RG Victor: Differential reflex control of forearm and calf resistance vessels by chemosenstive cardiac afferent activation. Journal of Applied Physiology 76: 1123-1129, 1994.

40. Thomas GD, Hansen J, and RG Victor: Inhibition of alpha-2 adrenergic vasoconstriction during contraction of glycolytic,not oxidative, rat hindlimb muscle. American Journal of Physiology 266: H920-H929, 1994.

41. Hansen J, Thomas GD, Jacobsen TN, and RG Victor: The muscle metaboreflex triggers parallel sympathetic activation in exercising and resting human skeletal muscle. American Journal of Physiology 266: H2508-H2514, 1994.

42. Hansen J, Jacobsen TN, and RG Victor: Is nitric oxide involved in the tonic restraint of central sympathetic outflow in humans? Hypertension 24: 439-

444, 1994.

43. Vissing SF, Scherrer U, and RG Victor: Increase of sympathetic discharge to skeletal muscle but not skin during mild lower body negative pressure in humans. Journal of Physiology (London) 481: 233-241, 1994.

44. Victor RG, Secher NH, Lyson T, and JH MItchell: Central command increases muscle sympathetic nerve activity during intense intermittent isometric exercise in humans. Circulation Research 76: 127-131, 1995.

45. Sander M, Hansen PG, and RG Victor: Sympathetically mediated hypertension caused by chronic inhibition of nitric oxide. Hypertension 26: 691-695, 1995.

46. Victor RG, Thomas GD, Marban E, and B O'Rourke: Presynaptic modulation of cortical synaptic activity by calcineurin. Proceedings of the National Academy of Sciences USA 92: 6269-6273, 1995.

47. Hansen J, Thomas GD, Harris S, Parsons WP, and RG Victor: Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscle. The Journal of Clinical Investigation 98: 584-596, 1996.

48. Thomas GD, Hansen J, and RG Victor: ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle. The Journal of Clinical Investigation 99: 26002-2609, 1997.

49. Jacobsen TN, Grayburn PA, Snyder RW III, Hansen J, Chavoshan B, Landau C, Lange RA, Hillis LD, and RG Victor: Effects of intranasal cocaine on sympathetic

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nerve discharge in humans. The Journal of Clinical Investigation 99: 628-634, 1997.

50. Thomas GD, O'Rourke B, Sikkink R, Rusnak F, Marban E, and RG Victor: Differential modulation of cortical synaptic activity by calcineurin (phosphatase 2b) vs. phosphatases 1& 2a. Brain Research 749: 101-108, 1997.

51. Victor RG, Thomas GD, Marban E, and O'Rourke B: Mechanism of Ca2+. dependent inactivation of L-type Ca2+. channels in GH3 ; direct evidence against dephosphorylation by calcineurin. Journal of Membrane Biology, 156:53-61, 1997.

52. Ryuzaki M, Stahl LK, Lyson T, Victor RG, and VS Bishop: Sympathoexcitatory response to Cyclosporine A and baroreflex resetting. Hypertension 29:567-582, 1997.

53. Vissing SF, Secher NH, and RG Victor: Mechanism of cutaneous vasoconstriction during orthostatic stress. Acta Physiologica Scandinavica, 159:131-138, 1997.

54. Sander M, Hansen J, and RG Victor: The sympathetic nervous system is involved in the maintenance but not the initiation of L-NAME-induced hypertension. Hypertension, 30:64-70, 1997.

55. Bertocci LA, Jones JG, Malloy CR, Victor RG and Thomas GD. Oxidation of lactate and acetate in rat skeletal muscle: analysis by 13C-nuclear magnetic resonance spectroscopy. Journal of Applied Physiology, 83:32-39, 1997.

56. Thomas GD and RG Victor. Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle. Journal of Physiology London, 506:817-826,1997.

57. Thomas GD, Sander M, Lau KS, Huang PL, Stull JT and Victor RG. Impaired metabolic modulation of -adrenergic vasoconstriction in dystrophin-deficient skeletal muscle. Proceedings of the National Academy of Sciences USA,95:15090-15095,1998.

58. Dewey RB Jr., Rao SD, Holmburg SL, and Victor RG. Ergotamine/caffeine treatment of orthostatic hypotension in parkinsonism with autonomic failure. European Journal of Neurology, 5:593-599,1998.

59. Sander M, Chavoshan B and Victor RG. A large blood pressure-raising effect of acute nitric oxide inhibition in humans. Hypertension, 33:937-942, 1999.

60.Zhang W, Kowal RC, Rushank FR, Sikkink R, Olson EN and Victor RG. Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats. Circulation Research, 84:722-728, 1999.

61. Vongpatanasin W, Mansour Y, Chavoshan B, Arbique and Victor RG. Cocaine stimulates the human cardiovascular system via a central mechanism of action.

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Circulation,100:497-502, 1999.

62. Zhang W and Victor RG. Inhibition of calcineurin causes renal afferent activation in rats: a novel mechanism of cyclosporine A-induced hypertension. American Journal of Hypertension, 13:999-1004, 2000.

63. Zhang W, Li J-L, Hosaka M, Janz R, Shelton JM, Albright GM, Richardson JA, Südhof TC, , and Victor RG: Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings. Proceedings of the National Academy of Sciences USA, 97:9765- 9770, 2000.

64. Hansen J, Sander M, Hald CF, Victor RG, and Thomas GD: Metabolic modulation of sympathetic vasoconstriction in human skeletal muscle: role of tissue hypoxia.. Journal of Physiology London, 527: 387-396, 2000.

65.Sander M, Chavoshan B, Harris SA, Iannaccone ST, Stull JT, Thomas GD, and Victor RG: Functional muscle ischemia in neuronal NOS-deficient skeletal muscle of children with Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences USA, 97:13818-13823, 2000.

66. Thomas GD, Zhang W, and Victor RG: Impaired metabolic modulation of sympathetic vasoconstriction in rats with chronic myocardial infarction: role of reactive oxygen species. Circulation Research, 88:816-823, 2001.

67. Vongpatanasin W, Tuncel M, Mansour Y, Arbique D, and Victor RG: Transdermal estrogen replacement therapy decreases sympathetic discharge in postmenopausal women. Circulation, 103:2903-2908, 2001.

68. Abate NI, Mansour YH, Tuncel M, , Arbique D, Chavoshan B, Kizilbash A, Howell-Stampley T, Vongpatanasin W and Victor RG: Overweight and sympathetic overactivity in black Americans. Hypertension, 38: 379-383, 2001.

69. Wilson RP, Freeman A, Kazda M, Andrews TC, Berry L, Vaeth PAC, and Victor RG: Lay beliefs about high blood pressure in a low-to-middle income urban African American community: an opportunity for improving hypertension control. American Journal of Medicine, 112:26-30, 2002.

70. Victor RG and Talman WT: Comparative effects of clonidine and dihydroergotamine on venomotor tone and orthostatic tolerance in patients with severe hypoadrenergic orthostatic hypotension.American Journal of Medicine, 112: 361-368, 2002.

71. Tuncel M, Wang Z, Arbique E, Fadel PJ, Victor RG, and Vongpatanasin W: Mechanism of the blood pressure-raising effect of cocaine in humans. Circulation, 105:1054-1059, 2002.

72. Crandall CG, Vongpatanasin W, Victor RG: Mechanism of cocaine-induced hyperthermia in humans. Annals of Internal Medicine 2002;136:785-791.

73. Chavoshan B, Sander M, Sybert TE, Victor RG, and Thomas GD: Nitric oxide-

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dependent modulation of sympathetic control of skeletal muscle oxygenation in exercising human forearm. Journal of Physiology London, 540: 377-386, 2002.

74. Szczepaniak LS, Dobbins RL, Metzger GJ, Sartoni-D'Ambrosia G, Arbique D, Vongpatanasin W, Unger R, and Victor RG: Myocardial Triglyceride and Systolic Function in Humans: in vivo Evaluation by Localized Proton Spectroscopy and Cardiac Imaging. Magnetic Resonance and Medicine. 49:417-23, 2003.

75. Fadel PJ, Y Wong, W Vongpatanasin, A Abbas, R Haley, RG Victor, and GD Thomas: Reflex sympathetic activation is severely impaired during static exercise in patients with myophosphorlylase deficiency (McArdle’s Disease): Journal of Physiology London: 548:983-993, 2003.

76. Barman SM, Fadel PJ, Vongpatanasin W, Victor RG, and GL Gebber: Basis for the cardiac-related rhythm in muscle sympathetic nerve activity of humans.American Journal of Physiology: Heart Circulatory Physiology. 284:H584-97, 2003.

77. Fadel PJ, Orer HS, Barman SM, Vongpatanasin W, Victor RG, GL Gebber: Fractal properties of human muscle sympathetic nerve activity. American Journal of Physiology: Heart and Circulatory Physiology. 2004 Mar;286(3):H1076-87.

78. Vongpatanasin W, Taylor JA, Victor RG. Effects of cocaine on heart rate variability in healthy subjects. American Journal of Cardiology. 2004 Feb 1;93(3):385-8.

79. Spranger CB, Ries AJ, Berge CA, Radford NB, and RG Victor: Identifying gaps between guidelines and clinical practice in the evaluation and treatment of hypertension. American Journal of Medicine. 2004 Jul 1;117(1):14-8.

80. Victor RG, Haley RW, Willett D, Peshock RM, Vaeth PC, Leonard D, Basit M, Cooper RS, Iannachione VG, Visscher W, Staab J, and HH Hobbs for the Dallas Heart Study Investigators: The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health.American Journal of Cardiology. 2004; 93(12):1473-80.

81. Haley RW, Vongpatanasin W, Wolfe GI, Bryan WW, Armitage R, Hoffmann RF, Callahan TS, Charuvastra E, Shell WE, Marshall WW, and Victor RG. Blunted circadian variation in autonomic regulation of sinus node function in veterans with Gulf War syndrome. American Journal of Medicine 2004; 117(7):469-78.

82. Hollier J, Martin DF, Beel D, Li J-L, Chirachanchai MG, Menon DV, Leonard D, Wu X, Cooper RS, McKenzie C, Victor RG, and Auchus RJ. Epithelial Sodium channel (ENaC) allele T594M is not associated with hypertension or blood pressure response to amiloride. Hypertension, 2005 in press.

83. Dries DL, Victor RG, Rame JE, Cooper RS, Wu X, Zhu X, Leonard D, Ho SI, Wu Q, Post W, Drazner MH. Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. Circulation. 2005 Oct 18;112(16):2403-10.

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84. Drazner MH, Dries DL, Peshock RM, Cooper RS, Klassne C, Kazi F, Willett D, and Victor RG: African Americans have a markedly increased prevalence of left ventricular hypertrophy as compared to whites in the general population: the Dallas Heart Study. Hypertension, 2005; 46(1):124-9.

85. Victor RG, Leonard D, Vaeth PC, Hess P, Jones J, Freeman A, Wilson RP, and Haley R: Lay Health Beliefs and Uncontrolled Hypertension in African American Men: Race/Ethnicity- and Gender-Balanced Population Survey of Dallas County, Texas, submitted.

86. Reingold JS, McGavock JM, Kaka S, Tillery T, Victor RG, and Szczepaniak LS: Determination of Triglyceride in the Human Myocardium using Magnetic Resonance Spectroscopy: Reproducibility and Sensitivity of the Method.American Journal of Physiology: Endocrinology and Metabolism. 2005 Jun 21; [Epub ahead of print].

87. McGavock JM, Victor RG, Unger R, and Szczepaniak: Adiposity and the Heart, Revisited. Annals of Internal Medicine, 2005, Invited review, accepted for publication with minor revisions.

88. Hess P, Reingold JS, Jones J, Kim S, Raju J, Ruger E, Okoro C, Ogunji O, Mc Norton C, Fellman M, Clark S, Knowles P, Knowles PM, Leonard D, Wilson RP, Haley RW, Freeman A, Ferdinand KC, and Victor Ronald G.: Barbershops as hypertension detection, referral, and follow-up centers for African American men. In preparation.

B. THESIS,BOOK CHAPTERS,INVITED ARTICLES, MISCELLANEOUS (PARTIAL LIST)

1. Victor R: Operant conditioning of blood pressure. Undergraduate Honors Thesis, Cornell University, 1974.

2. Reeves J, and R Victor: Behavioral strategies for treating hypertension. In: Behavioral Medicine in General Medical Practice, P. Boudewyns, F. Keefe (eds.), Menlo Park: Addison-Wesley, pp. 166-188, 1982.

3. Victor R: Autonomic changes during the acute phase of acute myocardial infarction and ischemia. In: Acute Coronary Care 1986, R.M. Califf, G.S. Wagner (eds.), Martinus Nijhoff Publishers, pp. 3-18, 1985.

4. Mark AL, RG Victor, C Nerhed, DR Seals, and BG Wallin: Mechanisms of sympa-thetic nerve responses to static and rhythmic exercise: new insight from direct intraneural recordings in humans. In: The Sympathetic System, Alfred Benzon Symposium 23, p. 221, 1986.

5. Mark AL, BG Wallin, DR Seals, and RG Victor: Mechanism of contrasting pressor responses to static and dynamic exercise: New insights from direct intraneural recordings of sympathetic nerve activity in humans. In: Transactions, American

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Clinical and Climatological Assn. 98:98-104, 1986.

6. Victor RG, and LD Hillis: The heart in orthostatic hypotension (Editorial Comment). Journal of the American College of Cardiology 15:1343-1344, 1990.

7. Victor RG, and BJ Morgan: Baroreceptors and hypertension (Editorial Comment). Circulation 82(3):1057-1059, 1990.

8. Rostand SG, Brunzell JD, Cannon RO, and RG Victor: Cardiovascular complica-tions in renal failure (Invited Review). Journal of American Society for Nephrology 2:1053-1062, 1991.

9. Onyekwere OA, Morris H, Victor R, and FM Fouad-Terazi: Factitious anisocoria and orthostatic hypotension (Case Report). Cleveland Clinic Journal of Medicine 38: 229-233, 1991.

10. Seals D, and RG Victor: Control of muscle sympathetic nerve activity during exercise. In: Exercise and Sport Sciences Reviews, John O. Holloszy (ed.), Williams & Wilkins, pp. 313-349, 1991.

11. Jacobsen TN, Jost CMT, and Victor RG: Cardiovascular sensors: the bradycardic phase in hypovolemic shock. In: Blood Loss and Shock NH Secher, J Pawelczyk, and J Ludbook (eds.), Edward Arnold Publishers, pp. 47-59,1994.

12. Hansen J and RG Victor: Direct measurement of sympathetic activity: new insights into disordered blood pressure regulation in chronic renal failure (Invited Review). Current Opinion in Nephrology and Hypertension 3: 636-643, 1994.

13. Victor RG and Henrich W: Autonomic neuropathy and hemodynamic stability during dialysis. In: The Principles and Practice of Dialysis. Wl Henrich (ed.), Williams & Wilkins, 1994, pp. 196-208.

14. Victor RG and Hansen J: Alcohol and blood pressure: a drink a day...(Invited Editorial). The New England Journal of Medicine 332: 1782-1783, 1995.

15. Victor RG, CMT Jost, and RL Converse, Jr: Paroxysmal autonomic syncope. In: Disorders of the Autonomic Nervous System, G. Burnstock (ed.), Harwood Academic Publishers, pp. 287-309, 1995.

16. Victor RG and AL Mark: The sympathetic nervous system and human hypertension. In: Hypertension: Pathophysiology, Diagnosis, and Management, Second Edition, JH Laragh and B Brenner (eds.), Raven Press, New York , 1995, pp. 863-878.

17. Sander M and RG Victor: Hypertension after cardiac transplantation (Invited Review). Current Opinion in Nephrology and Hypertension 4:443-451, 1995.

18. Hansen J, Victor RG, and J H Mitchell: Control of regional sympathetic nerve activity during exercise: integration of studies in humans and animals. In The Autonomic Nervous System Volume 11: Central Nervous Control of Autonomic

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Function D Jordan (ed.), Harwood Academic Publishers, UK, 1996, in press, pp.189-223.

19. Mitchell JH and RG Victor: Neural control of the cardiovascular system: insights from muscle sympathetic nerve recordings in humans (Invited Review). Medicine and Science in Sports and Exercise, 28:S60-S69, 1996.

20. Sander M and RG Victor: Sympathetic neural mechanisms of cyclosporine-induced hypertension (Invited Review). American Journal of Hypertension, 9:121S-138S, 1996.

21. Thomas GD, Chavoshan B, Sander M and Victor RG. Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise. (Invited Editiorial) Journal of Applied Physiology 1825-26, 1998

22. Sander M and Victor RG. Neural mechanisms in nitric oxide deficient hypertension. Current Opinion in Nephrology and Hypertension. 8:61-73,1999 .

23. Victor RG and Radford NB. Resistant Hypertension. In: Cardiology Michael H. Crawford and John P. DiMarco (eds.), Mosby International Ltd., pp. 11.13-11.16, 2001.

24. Radford NB and Victor RG. Clinical evaluation of the hypetertensive patient. In: Cardiology Michael H. Crawford and John P. DiMarco (eds.), Mosby International Ltd., pp. 3.1-3.6, 2001.

25. Thomas GD , Zhang W, and Victor RG. Nitric oxide deficiency as a cause of clinical hypertension: novel therapeutic targets for refractory hypertension. Invited review,JAMA 285:2055-2057, 2001.

26. Augustyniak, R.A., M. Tuncel, W. Zhang, R.D. Toto, and R.G. Victor. Sympathetic overactivity as a cause of hypertension in chronic renal failure. J. Hypertens. 20(1): 3-9, 2002.

27. Tuncel, M., R.A. Augustyniak, W. Zhang, R.D. Toto, and R.G. Victor. Sympathetic nervous system function in renal hypertension. Curr. Hypertens. Rep. 4: 229-236, 2002.

28. Vongpatanasin W, Nesbitt S, and Victor RG. Resistant Hypertension. In: Cardiology Michael H. Crawford, John P. DiMarco, and Walter J Paulus (eds.), Mosby International Ltd., Edinburgh, 2nd edition, 2004, pp. 572-574.

29. Nesbitt S, Vongpatanasin W, and Victor RG. Initial Evaluation of the Hypertensive Patient. In: Cardiology Michael H. Crawford, John P. DiMarco, and Walter J Paulus (eds.), Mosby International Ltd., Edinburgh, 2nd edition, 2004, pp. 483-489.

30. Nesbitt S, Victor RG. Pathogenesis of hypertension in African Americans. Congestive Heart Failure. 2004;10.

31. Vongpatanasin W, Victor RG. “ Cocaine Overdose.” In Robertson D Ed., Primer of

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Autonomic Nervous System. 2nd Edition. Elsevier Academic Press, New York, NY, 2004, pp.370-371.

32. Victor RG. Arterial Hypertension (Chapter 63). In Cecil Textbook of Medicine, 22nd edition, L. Goldman and D Auseillo Eds, Saunders, Philadelphia, 2004, pp. 346-363.

32. Victor RG. Arterial Hypertension. In Cecil Textbook of Medicine, 23rd edition, L. Goldman and D Auseillo Eds, Saunders, Philadelphia, 2005 in preparation

33. Victor RG. Vascular Diseases and Hypertension. In Cecil Essentials of Medicine, 7th Edition, T Andreoli, C Carpenter, R Griggs, I Benjamin, Eds. Elsevier, 2005 in preparation

C. SELECTED ABSTRACTS

1. Victor RG, WN Leimbach, Jr, J Kempf, and AL Mark: Unloading of cardiopulmo-nary baroreflexes markedly increases muscle sympathetic outflow to the leg in humans. Federation Proceedings 45:156, 1986.

2. Victor RG, and WT Talman: Comparative effects of clonidine and ergotamine on venomotor tone in idiopathic orthostatic hypotension. Clinical Research 34:351A, 1986.

3. Victor RG, P Thoren, DA Morgan, and AL Mark: Differential control of adrenal vs renal sympathetic outflow during hemorrhagic hypotension in rats. Clinical Research 34:633A, 1986.

4. Floras JS, PE Aylward, RG Victor, AL Mark, and FM Abboud: Epinephrine facili-tates neurogenic vasoconstriction in normal and borderline hypertensive subjects. Journal American College of Cardiology 7:112A, 1986.

5. Seals DR, SL Stringer, and RG Victor: Muscle chemoreflex control of sympathetic nerve activity during exercise in humans. Physiologist 29:110, 1986.

6. Victor RG, BG Wallin, J Kempf, and AL Mark: Does static exercise produce different sympathetic responses in the arm and leg? Circulation 74:II-71, 1986.

7. Victor RG, JC Connelly, KC McCoy, DM Rotto, and MP Kaufman: Reflex effects of chemically and mechanically sensitive muscle afferents on sympathetic nerve activity in cats. Circulation 74:II-71, 1986.

8.. Pryor SL, JH Mitchell, NH Secher, and RG Victor: Does central command increase sympathetic nerve activity in humans? Federation Proceedings 46:495, 1987.

9. Victor RG, and DR Seals: Muscle metaboreflex control of sympathetic nerve activity during exercise in humans. Clinical Research 35:244, 1987 (American Society for Clinical Investigation).

10. Victor RG: Control of sympathetic nerve activity during exercise in humans

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(Symposium). Medicine and Science in Sports and Exercise, 1987.

11. Pryor SL, RG Haller, SF Lewis, and RG Victor: Sympathetic activation is impaired during static exercise in McArdle's disease. Circulation 76:IV-60, 1987.

12. Victor RG, SL Pryor, RL Nunnally, and LA Bertocci: Sympathetic activation during exercise in humans is coupled to muscle cell pH. Circulation 76:IV-61, 1987.

13. Scherrer U, SF Vissing, L Urias, and RG Victor: Microneurographic evidence against cardiac baroreflex modulation of the exercise pressor reflex in humans. Clinical Research 36:545A, 1988, (American Society for Clinical Investigation).

14. Victor R, B Morgan, S Vissing, L Urias, P Hanson, and U Scherrer: Arterial baroreflex control of sympathetic activity in cyclosporine-hypertension after heart transplantation. Featured Research Session. Circulation 78:II-367, 1988.

15. Victor R, U Scherrer, S Vissing, B Morgan, L Urias, and P Hanson: Orthostatic stress activates sympathetic outflow in patients with heart transplants. Featured Research Session. Circulation 78:II-365, 1988.

16. Scherrer U, B Morgan, S Vissing, L Urias, P Hanson, and R Victor: Mechanism of pressor response to static exercise in heart transplant patients. Featured Research Session. Circulation 78:II-366, 1988.

17. Scherrer U, S Vissing, B Morgan, L Urias, P Hanson, and R Victor: Sympathetic activation in cyclosporine hypertension after heart transplantation. Hypertension 12:342, 1988.

18. Pryor SL, U Scherrer, and RG Victor: Reflex stimulation of sympathetic nerve activity by electrically-evoked tetanic muscle contraction in humans. FASEB Journal 3(3):A248, 1989.

19. Scherrer U, SL Pryor, L Urias, and RG Victor: Arterial baroreceptors greatly buffer sympathetic activation during static exercise in humans. FASEB Journal 3(3):A248, 1989.

20. Vissing SF, U Scherrer, L Urias, JM Johnson, and RG Victor: Do cardiac baroreflexes regulate vasoconstrictor outflow to skin during mild orthostatic stress in humans? FASEB Journal 3(3):A248, 1989.

21. Vissing J, LB Wilson, JH Mitchell, and RG Victor: Static muscle contraction reflexly increases adrenal sympathetic nerve activity in rats. FASEB Journal 3(3):A382, 1989.

22. Morgan BJ, U Scherrer, SL Pryor, C Kim, and RG Victor: Cyclosporine reflexly increases arterial pressure in rats. FASEB Journal 3(4):A1145, 1989.

23. Victor RG, SF Vissing, L Urias, and U Scherrer: Central motor command activates sympathetic outflow to skin during static exercise in humans. Clinical Research 37(2):524A, 1989.

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24. Victor RG, SL Pryor, LA Bertocci, SF Lewis, RG Haller, and RL Nunnally: Sympathetic nerve discharge is coupled to muscle cell pH during exercise. Acta Physiologica Scandinavica 136 (Suppl 584):43, 1989.

25. Vissing SF, and RG Victor: Central motor command activates sympathetic outflow to skin during static exercise. Acta Physiologica Scandinavica 136 (Suppl 584):44, 1989.

26. Scherrer U, J Rollins, R Tindall, BJ Morgan, and RG Victor: Does cyclosporine stimulate sympathetic outflow in humans? Circulation 80:II-89, 1989.

27. Victor RG, U Scherrer, BJ Morgan, S Vissing, S Ring, R Tindall, J Rollins, P Hanson, PK Mohanty, (intr. J.H. Mitchell): Hypertension after heart transplantation: ventricular deafferentation augments cyclosporine-induced sympathetic activation. Clinical Research 38:412A, 1990.

28. Pryor SL, S Strange, EA Richter, NJ Christensen, B Saltin, and RG Victor: Sympathetic discharge and norepinephrine spillover in humans. Clinical Research 38:413A, 1990.

29. Morgan BJ, C Kim, and RG Victor: The blood pressure raising effect of cyclosporine is caused by sympathetic stimulation of non-alpha 1 adrenergic receptors. FASEB 4:A957, 1990.

30. Victor RG, U Scherrer, FF Tarazi, TN Jacobsen, and R Toto: Reversible sympathetic activation in patients with chronic renal failure: a vasoconstrictor reflex arising in the failing kidney? Circulation 82:III-10, 1990.

31. Bertocci LA, U Scherrer, SL Pryor, and RG Victor: Does the exercise pressor reflex alleviate muscle hypoperfusion during static contraction? Circulation III-692, 1990.

32. Bertocci LA, U Scherrer, and RG Victor: Sympathetic nerve discharge to skeletal muscle attenuates muscle glycolysis during exercise. Circulation 84:II-269, 1991.

33. Victor RG, NH Secher, and JH Mitchell: Central command stimulates muscle sympathetic nerve activity during intermittent isometric exercise. Circulation 84:II-315, 1991.

34. Jacobsen TN, RA Lange, RL Converse, TM Obregon, and RG Victor: Differential control of forearm and calf vascular resistance during intracoronary injection of ionic contrast material. Circulation 84:II-556, 1991.

35. Lyson T, DM McMullen, LD Ermel, BJ Morgan, and RG Victor: Neural mechanism of cyclosporine-induced hypertension. Circulation 84:II-268, 1991.

36. Lyson T, BJ Morgan, LD Ermel, and RG Victor: Comparative effects of FK-506 and cyclosporine on sympathetic nerve activity and blood pressure. Hypertension 18:388, 1991.

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37. Converse RL, TN Jacobsen, F Fouad, RD Toto, TM Obregon, and RG Victor: Paradoxical withdrawal of sympathetic vasoconstriction during dialysis-induced

hypotension. Manuscript accepted as finalist for the Melvin Marcus Award in Integrative Physiology; Circulation 84:II-9, 1991.

38. Bertocci LA, JG Jones, WL Gitomer, PR Anderson, LD Ermel, T Lyson, RG Victor, and CR Malloy: 13 C MRS isotope analysis of substrate utilization by rat skeletal muscle after glycogen depletion: Medicine and Science in Sports and Exercise 24:S151, 1992.

39. Thomas GD, and RG Victor: Differential effects of sympathetic nerve stimulation on muscle blood flow during contractions of highly glycolytic versus highly oxidative rat skeletal muscle. 1992 APS Conference: Integrative Biology of Exercise. Physiologist 35:235, 1992.

40. Jacobsen TN, BJ Morgan, M-T Olivari, and RG Victor: Transplant-induced ventricular deafferentation does not impair forearm vasoconstriction during orthostatic stress. Circulation 86:I-367, 1992.

41. Jacobsen TN, B Morgan, C Jost, J Hansen, R Cooley, and RG Victor: Sympathetic activation during orthostatic stress in humans is caused mainly by arterial, not cardiac, baroreflexes. Circulation 86:I-776, 1993.

42. Jost CMT, CG Cigarroa, R Cooley, PA Grayburn, and RG Victor: Impaired peripheral vasodilator capacity in black men who chronically abuse cocaine. Circulation 86:I-678, 1992.

43. Lyson T, LD Ermel, PJ Belshaw, DG Alberg, SL Schreiber, and RG Victor: Is calcineurin the cellular target mediating cyclosporine-induced sympathetic activation? Hypertension 20:415, 1992.

44. Thomas GD, RG Victor: Skeletal muscle contractions abolishes alpha-2, but not alpha-1, mediated vasoconstriction. FASEB Journal 7:A858(4953), 1993.

45. Obregon TM, T Lyson, LD Ermel, PG Hansen, and RG Victor: Nitric oxide modulates cardiac vagal afferent inhibition of sympathetic nerve activity during hypovolemic hypotension. FASEB Journal 7:A532(3085).

46. Jacobsen TN, RW Snyder II, RL Lange, PA Grayburn, and RG Victor: Intranasal cocaine decreases sympathetic nerve activity in humans. Circulation 88:446,1993.

47. Hansen J, TN Jacobsen, GD Thomas, RG Victor: Does the muscle metaboreflex trigger parallel sympathetic activation in exercising and resting skeletal muscle?. Circulation 88:446,1993.

48. Victor RG, E Marban, B O'Rourke: Does calcineurin mediate calcium-dependent inactivation of L-type calcium currents in GH3 cells. Biophysical Journal 66: A239,1994.

49. Hansen J, Jacobsen TN, Victor RG. Is nitric oxide involved in the tonic inhibtion of

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central sympathetic outflow in humans? Journal of Molecular and Cellular Cardiology 26 (6): LXI, 1994. Abstract presented at theanual meeting of the International Society for Heart Reserach, Copenhagen, Denmark, June 1994.

50. Hansen J, Jacobsen TN, Victor RG. Is nitric oxide involved in the tonic inhibtion of central sympathetic outflow in humans? Clinical Research 42: 257A, 1994. (American Society for Clinical Investigation).

51. Hansen J, Thomas G, Bayraktaroglu T, Lyson T, Bertocci L, Victor RG: Does reflex activation of symapathetic outflow to exercisng skeletal muscle exacerbate muscle hypoperfusion? Circulation 90: I-315, 1994.

52. Thomas G, Hansen J, Hansen P, Bertocci L, Victor RG: Sympathetic nerve stimulation attenuates intracellular acidosis and augments force during fatiguing hindlimb muscle contraction. Circulation 90: I-316,1994.

53. Thomas GD, Victor RG, Marban E, O'Rourke B: Differential modulation of cortical synaptic activity by calcineurin (phosphatase 2B) vs. phosphatases 1 and 2A. Biophysical Journal 68:A347, 1995.

54. Victor RG, Thomas GD, MArban E, O'Rourke B: Presynaptic modulation of cortical synaptic activity by calcineurin. Biophysical Journal 68:A347, 1995.

55. Sander M, Hansen PG, and Victor RG: Neurogenic hypertension caused by inhibition of nitric oxide synthase. American Journal of Hypertension 1995.

56. Sander M, Hansen PG, and Victor RG: Does inhibition of nitric oxide cause neurogenic hypertension? Circulation 92:1-3, 1995.

57. Sander K, Hansen J, Sander M, Gant N, and Victor RG: Sympathetic overactivity in pregnancy induced hypertension. Circulation 92:1-3, 1995.

58. Sander K, Hansen J, Sander M, and Victor RG: Magnesium-induced sympathetic activation in humans. Accepted for presentation at the 1996 American Heart Association Meeting, Circulation 94:I-545, 1996.

59. Hansen J, Sayad D, Thomas GD, Clarke G, Peshock RM, and Victor RG: Exercise-induced attenuation of alpha-adrenergic vasconstriction in humans. Accepted for presentation at the 1996 American Heart Association Meeting, Circulation 94:I-544, 1996.

60. Hansen J and Victor RG: Attenuation of reflex sympathetic vasoconstriction by skeletal muscle hypoxia in humans. Accepted for presentation at the 1996

American Heart Association Meeting, Circulation 94:I-545, 1996.

61. Abate N, Kizilbash A, Sander K, Howell-Stampley TS, Victor RG. Sympathetic neural activation in skeletal muscle correlates with abdominal obesity in healthy, young african-american women. American Journal of Hypertension 11:4, 1998.

62. Kizilbash AM, Abate NI, Peshcok RM and Victor RG. MRI evidence for obesity-

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related cardiac and vascular hypertrophy in young black women. American Journal of Hypertension 11:2A, 1998.

63. Victor RG, Abate NI, Kizilbash A, Howell-Stampley TS, Young WF, Pollock K, and RM Peshock: Obesity related sympathetic activation and left ventricular hypertrophy in young black women. Ethnicity and Disease 8: 282, 1998.

64. Vongpatanasin W and RG Victor: Cocaine stimulates central sympathetic outflow in humans. American Journal of Hypertension 11: 14A, 1998.

65. Victor R, Albright G, Morgan DA, Hosaka M, Sudhof T, and W Zhang: Impairment of CsA-induced sympathetic activation in knockout mice lacking synapsins. American Journal of Hypertension 11: 29A, 1998.

66. Zhang W, Albright GM, and RG Victor: Inhibition of calcineurin causes renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertension. American Journal of Hypertension 11: 148A, 1998.

67. Mansour Y, Abate N, Chavoshan B, Howell-Stampley T, Kizilbash A, Pollok K, Arbique D, and RG Victor: A major gender difference in the relation between adiposity and sympathetic activity in African-Americans. American Journal of Hypertension 12:108A, 1999.

68. Mansour Y, Vongpatanasin W, Armitage R, Hoffman R and RG Victor: Does sleep apnea explain overweight-related sympathetic overactivity in African American women? Circulation 100. 176A, 1999.

69. Victor RG: Calcineurin and pressure-overload cardiac hypertrophy. Invited presentation at AHA Heart Failure Meeting in Snowbird, Utah, August, 1999.

52. Zhang W, Kowal RC, Rusnak F, Sikkink RA, Olson EN, and RG Victor: Calcineurin inhibition does not prevent pressure-overload left ventricular hypertrophy in rat models. American Journal of Hypertension 12:34A, 1999.

71. Zhang WG, Li JL, Hosaka M, Janz R, Shelton JM, Albright GM, Richardson JA, Sudhof TC, and RG Victor: Impairment of cyclosporine-induced reflex sympathetic activation in synapsin-deficient mice. Hypertension 34:330, 1999.

72. Kazda M, Freeman A, Wilson R, and Victor RG: Non-medical beliefs about high blood pressure in an urban African-American community. Ethnicity and Disease 10:300, 2000.

73. Crandall C, Vongpatanasin W, and RG Victor: Cocaine alters thermoregulatory responses in humans. Abstract accepted for presentation at the 2001 American Heart Association Meeting.

74. Kara M, Mansour Y, Vongpatanasin W, Arbique D, and RG Victor: Dissociation between body weight and sympathetic nerve activity in African American men. Circulation 102: II-515, 2000.

28Does Home Remedy Use Constitute a Barrier to Controlling High Blood

Pressure in Urban African American Communities?

 Banks K1, Wilson RP2,

Freeman A1, Veath PAC1, Stevens F1, Waits R1, Victor

RG1

 UT Southwestern Medical

Center1 and Southern Methodist University2

Dallas, TX

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75. Vaeth PAC, Wilson WP, Andrews TA, Freeman AC, and RG Victor: Lay beliefs as a barrier to controlling hypertension in African Americans. American Journal of Hypertension 14:199A, 2001.

76. Borski CA, Victor RG, and NB Radford: Do physicians aggressively intensify medical treatment for hypertension? American Journal of Hypertension 14:201A, 2001.

77. Banks K, Wilson RP, Freeman AC, Vaeth PAC, Stevens F, Waits R, and RG Victor: Does home remedy use constitute a barrier to controlling high blood pressure in urban African American communities? Inter Soc Hyper Blacks, 2001.

78. Zhang W, Telemaque-Potts S, Anderson P, Wang Z, An J, Newgard CB, Victor RG. Adenoviral Leptin Gene Therapy For Obesity-Related Hypertension. Am J Hypertens 15: A1, 2002

79. Szczepaniak LS, Dobbins RL, Metzker GJ, Sartoni-D'Ambrosia G, Arbique D, Vongpatanasin W, Unger R, Victor RG: Fatty Heart Disease – Myocardial Steatosis in Humans: Am J Hypertens 15: A190, 2002

80. Fadel P.J., Wang Z., Tuncel M., Watanabe H., Abbas A., Arbique D., Vongpatanasin W., Haley R.W., Victor R.G., and Thomas G.D. Reflex sympathetic activation during static exercise is severely impaired in patients with myophosphorylase deficiency (in review). Experimental Biology, 2002.

81. Reingold J, Kim S, Razu J, Freeman A, Griffin G, Bailey C, Ferdinand K, and Victor RG: Cutting blood pressure in barbershops. Abstract accepted for oral presentation at the 2003 American Society of Hypertension Meeting.

82. Augustiniak R, Victor RG, and Zhang W: Are renal sympathetic nerves friend or foe in the progression of chronic renal disease? Abstract accepted for presentation at the 2003 American Society of Hypertension Meeting.

83. Hess PL, Reingold JS, Clark S, Ruger E, Ferdinand K, Freeman A, and Victor RG: Effectiveness of a barbershop-based intervention to improve the treatment and control of hypertension in African American men. Abstract presented at the 2004 American Society of Hypertension Meeting.

84. Li, J-L, Augustyniak RA, Zhang W, and Victor RG: Immunosuppresive doses of cyclosporine A cause chronic hypertension in mice. Abstract presented at the 2004 American Society of Hypertension Meeting.

85. Hess PL, Reingold JS, Clark S, Ruger E, Ferdinand K, Freeman A, and Victor RG: Cutting blood pressure in barbershops. 1st place prize for population science at the 2004 American Heart Association Meeting.

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