WHENFRENCHTOUCHMEETSBEAUTY
When French touch meets beauty
PERFECTHA® is manufactured 100% in France by SINCLAIR PHARMA in its laboratory specialized in the research, development and manufacturing of Hyaluronic Acid (HA) dermal fillers, and ISO 13485 certified since 2007.
The biocompatibility and performance of the entire PERFECTHA® range have been clinically demonstrated. PERFECTHA® complies with all safety standards required by health authorities and has been CE marked since 2007. It is registered and launched in more than 70 countries around the world.
With more than 10 years of clinical use, 2.8 million syringes sold worldwide, PERFECTHA® has established itself among the leaders on the aesthetic market.
PERFECTHA®,MADE IN FRANCE BY SINCLAIR
When French touch meets beauty
PERFECTHA® IS A TAILOR - MADE RANGE OF
1 - Perfectha is intended for reconstructive purposes in the treatment, for instance, of facial lipoatrophy, or morphological asymmetry associated with the aging process or other underlying conditions. Perfectha is for intradermal and subcutaneous application and is implanted in the areas of the face and hands to fill skin depressions and also for the augmentation of tissue volume.
« MADE IN FRANCE » HA DERMAL FILLERS,
DESIGNED FOR WRINKLE CORRECTION, FACIAL CONTOURING AND VOLUME RESTORATION,
COMBINING EASE OF INJECTION
AND NATURAL AND LONG-LASTING RESULTS.1
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When French touch meets beauty
THE E-BRID TECHNOLOGY: A STATE OF
Use of high molecular weight and
high purity Sodium Hyaluronate
ENHANCED CROSS-LINKING
PROCESS
Elimination of impurities
1
2
3
ENHANCED CROSS-LINKING PROCESS
Microgel Particles
The Macromolecular Network is maintained
in the resulting microgel particles.
Free HA Macromolecular Network
BDDE
CROSS-LINKINGPARTICLE CREATION
+
2
RANGE OF FILLERS
When French touch meets beauty
THE ART MANUFACTURING PROCESS
CONTROLLEDMIXING PROCESS
Standardized pharmaceutical
grade sterilization
Extensive quality control
4
5 6
CONTROLLED MIXING PROCESS
Microgel particles
HA Polymer Solution Network
CONTROLLED MIXING
MULTI STRUCTURED CONNECTIVE NETWORKS
+
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4
RANGE OF FILLERS
When French touch meets beauty
MULTI-STRUCTURED CONNECTIVE NETWORKS
FEATURES BENEFITSBENEFITS FOR PATIENTS
Use of high quality, high molecular weight Sodium Hyaluronate
� Product with a high safety rating� Tolerance� Safe use
� Ensures coherent flow and ease of injection
� Lifting and volumizing effect
� Slows down the gel degradation process
� Slows down the gel degradation process
� Antioxidant effect
� Confers mobility to the microgel particles and thus ensures coherent flow and ease of injection
� Instant volumizing effect� Filled cutaneous depressions
� Better / healthier looking� Longer-lasting results
� Longer - lasting results
� Slows down the skin degradation process
� Less painful
� Low risk of adverse events
� Less painful
PURE GEL
RESILIENT MICROGEL NETWORKS
CREATES A PROTECTIVE FLUID ENVIRONMENT
PROVIDES BRIDGES BETWEEN NETWORKS
Degree of cross-linking
HA Polymer Solution Network
Interfacial Network
MACROMOLECULAR NETWORKA combination of both physical and chemical bonds leading to a strong cross-linked network.
HA POLYMER SOLUTION NETWORKPhysical network made of entangled HA chains. It is a soft solution.
INTERFACIAL NETWORK This interfacial network is created by the presence of entanglements between the outer region of the microgel particles and the neighbouring HA.
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When French touch meets beauty
No significant cytotoxicity3
OPTIMAL GEL CHARACTERISTICS
PERFECTHA® complies with safety standards for dermal fillers2. It is a non-cytotoxic product3 and proves to be a biologically safe product2.
CTL
S A F E T Y
PERFECTHA® is made of cross-linked hyaluronic acid gel of non-animal origin at a concentration of 20 mg/ml in phosphate-buffered saline.
Non-detectable BDDE residual content
< 2 ppm
Low Endotoxin level
< 4 UI / ml ( routinely < 0.5 UI/ml )
Low Protein Load
< 6 µg / ml
1:4 DILUTION NO DILUTION1:2 DILUTION
Relative Cell Viability (%)
PERFECTHA® showed greater than 90% cell viability3.Cell toxicity was tested on fibroblast cell line. Cell viability was assessed neat and in 1/2 and 1/4 dilutions using 0.2g/ml HA filler.
References : 2- Technical file3- Park KY1, Kim HK, Kim BJ. Comparative study of hyaluronic acid fillers by in vitro and in vivo testing. J Eur Acad Dermatol Venereol. 2014 May;28(5):565-8.
JUVEDERM ULTRA-XC PERLANE® PERFECTHA DEEP ®
0%
20%
40%
60%
80%
100%
When French touch meets beauty
0.018 % adverse events5
PERFECTHA is devoid of
inflammatory effect4
References : 4- Koenig B., Analysis of IL-8 inducing potential from human effector cells. Evaluation of inflammatory potential of Perfectha product line by measurement of IL-8 release from adherent macrophages. Study Report, MMD, May 2016.5- Post-market survey from July 2012 to June 2016
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2.8 million syringes sold worldwide and a very low adverse event rate.
PERFECTHA® products were tested on adherent macrophages and induced a very low release of IL - 8 (specific mediators of inflammation), around 50 pg / ml, evidencing that the products are devoid of inflammatory effect4.
120000,00
STIMULUS
IL-8
[pg/
ml]
100000,0080000,0060000,0040000,00
20000,000,00
Lps 1 µg/ml100944,48
Lps 100 ng/ml49598,48
Lps 10 ng/ml17614,98
Lps 1 ng/ml5296,16
LPS : positive controle4
Dilution of hyaluronan filler4
IL-8
[pg/
ml]
1:2
50
1:4 1:8 1:16 1:32 1:64 1:128 1:256
PERFECTHA® COMPLEMENT
PERFECTHA® DEEP
PERFECTHA® DERM
PERFECTHA® SUBSKIN
When French touch meets beauty
References : 6- Talarico S. et al. Evaluation of the safety and efficacy of a new filler with hya-luronic acid for the treatment of nasolabial folds and lip contour; Surg. Cosmet. Dermatol.2010;2(2):83-67- Park KY1, Kim HK, Kim BJ. Comparative study of hyaluronic acid fillers by in
vitro and in vivo testing. J Eur Acad Dermatol Venereol. 2014 May;28(5):565-8.8- Da Costa et al. Durability of Three Different Types of Hyaluronic Acid Fillers in Skin: Are There Differences Among Biphasic, Monophasic Monodensified, and Monophasic Polydensified Products?; Aesthet. Surg. J. 2016, 1-9
Studies conducted on PERFECTHA® Derm evidenced that 86% of patients showed « much improved » and « very much improved » appearances one week after treatment, according to the Global Aesthetic Improvement Scale (GAIS). Moreover, they proved that filling effects last even after 6 months as excellent results remained in the nasolabial folds in 57% of the patients, and in the lips in 45%6.
E F F I C I E N C Y
L O N G L A S T I N G
Degradation rate in vitro7 (%)
Reduction rate in vivo in humans at 6 months8 (%)
50% 40% 79%
86% much improved and very much improved
appearances 6
PERFECTHA ®
DERMTEOSYAL®
GLOBAL ACTIONESTHELIS®
BASIC
PERLANE® PERFECTHA DEEP ®
JUVEDERM®
ULTRA-XC
86% much improved and very much improved
appearances 6
25% 12.5% 62.5%
The E-BRID Technology enables the presence of a higher number of covalent bonds which help to minimize the effects of hyaluronidase and oxidation in the body, thus slowing down the enzymatic degradation and allowing the gel to stay longer in the skin7.8. The HA Polymer Solution network acts as a protective environment also slowing down the gel degradation process.
Perc
enta
ge o
f sat
isfa
ctio
n %
100 %
90 %80 %
70 %
60 %
40 %
30 %
50 %
20 %
10 %
0 %
7 days 90 days 180 days
LIP CONTOUR
NASOLABIAL FOLD
When French touch meets beauty
All PERFECTHA® gels are among the most elastic on the market, making post-in jection results in terms of volume and lifting excellent9. Providing the practitioner an immediate effect, PERFECTHA® reduces the risk of overcorrection and gives the desired volume with a small amount of gel.
H I G H L I F T I N G A N D V O L U M I Z I N G C A P A C I T Y
E A S Y T O I N J E C T
9- Internal data - Evaluation and comparison study of the G’ rheologi-cal properties of PERFECTHA® with the main competitors HA-based dermal fillers. This study was conducted internally on a TA Instruments DHR-2 rheometer with a 25mm parallel-plate geometry. Frequency sweep tests were performed on samples between 0.1 and 100 rad/s
at a 1% strain in order to match the gels Newtonian Plateau and using plate-plate geometry.10- Internal Data: Material: Brookfield Texturometer CT3-4500 with a TA51 probe. Extrusion speed: 12mm/s over distance of 15mm.
10
100
1000
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’ mod
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(Pa)
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BIPHASIC VOLUMIZERExtrusion force
(Newtons)
Measurement of injectability10
MONOPHASIC VOLUMIZER
PERFECTHA® SUBSKIN
22,5
8,08,7
Thanks to its specific technology, PERFECTHA® allows a smooth injection given the low extrusion force needed to inject the gel, and the addition of HA Polymer Solution which acts as a lubricant agent. Moreover, the controlled particle size of PERFECTHA® and its thin wall needle enable the gel to have a regular flow, reducing any possible discomfort during injection.
PERFECTHA® Subskin is as easy to inject as the
reference monophasic product and 2.5 times
easier than the reference biphasic product10
When French touch meets beauty
A TAILOR-MADE
� Superficial facial lines and skin depressions� Periorbital lines� Perioral lines
SUPERFICIAL DERMISDEPTH OF INJECTION
INDICATIONS
PERFECTHA®
COMPLEMENT
HA CONCENTRATION
VOLUMINIZING CAPACITY
VOLUME
NEEDLES & CANNULAS
20 mg / ml
0.5 ml
2 x 30 G1/2’’ needle 2 x 30 G1/2’’ needle
0.8 ml
+
20 mg / ml
+
SUPERFICIAL DERMIS
� Superficial facial lines and skin depressions� Forehead finelines
PERFECTHA®
FINELINES
When French touch meets beauty
RANGE OF FILLERSPERFECTHA®
DEEPPERFECTHA®
SUBSKIN
2 x 27 G1/2’’ needle
22G x 50mm needle+ 22G x 50mm cannula
21G x 50mm needle+ 21G x 50mm cannula
1 ml1 x 3 ml3 x 1 ml
20 mg / ml
+++
20 mg / ml
++++
DEEP DERMISSUBCUTANEOUS OR SUPRAPERIOSTEAL
� Deep facial lines and skin depressions� Lip volume� Nose� Nasolabial folds� Marionette lines� Oral commissures� Cheekbones and chin moderate augmentation
� Volume creation� Facial contours� Malar areas� Chin and cheeks� Nose bridge� Hands
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PERFECTHA®
DERM
2 x 30 G1/2’’ needle
1 ml
20 mg / ml
++
MID-DERMIS
� Medium facial lines and skin depressions� Glabellar lines� Lip contour
When French touch meets beauty
DIFFERENT PRODUCTS FOR DIFFERENT LAYERS
PERFECTHA® is a range of gels made of a 20mg/ml HA concentration. Each gel has the same HA concentration, however the cross-linking within each gel influences the rheological properties enabling a range of gels to be produced.
In particular, what differentiates PERFECTHA® gels is the particle size: the bigger the particles, the greater the volumizing effect, and the longer-lasting the results.
Each PERFECTHA® gel is unique and designed to best meet specific needs: depending on the treated areas, the volume needed and the depth of injection required, a different variant will be used.
Particle size
Resistance to enzymatic degradation
Volumizing capacity
+
+
+-
PERFECTHA® SUBSKIN
PERFECTHA® DEEP
PERFECTHA® DERM
PERFECTHA® DERM
PERFECTHA® DEEP
PERFECTHA® SUBSKIN
PERFECTHA® FINELINES
PERFECTHA® FINELINES
PERFECTHA® COMPLEMENT
PERFECTHA® COMPLEMENT
When French touch meets beauty
PERFECTHA® SUBSKIN : THE IDEAL VOLUMIZER
Be moldable, enabling you to shape your patients’ faces
Remain in place after injection
Perfectly restore or create volume, and redefine facial contours
Injection depth: Subcutaneous or Supraperiosteal
References : 11- J. Fares, A prospective study of evaluation of the results achieved with the application of PERFECTHA® Subskin, a new gel of hyaluronic acid non animal origin for malar and mental enhancement.
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L O N G L A S T I N G R E S U L T S U P T O 1 8 M O N T H S 1 1
E L A S T I C A N D V I S C O U S E N O U G H T O :
18 months Efficacity Results according to the Physician Evaluator Aesthetic Rating
2
60%
50%
40%
30%
20%
10%
0%4 8 12
MONTHS
Perc
enta
ge o
f Sat
isfa
ctio
n %
18
Very much improved
Much improved
Improved
No change
Worse
100% of patients rated as very much improved or improved11
When French touch meets beauty
FULL - FACE TREATMENT CASE STUDY
ASSESSMENT
Atrophy of the fat layers above the nasolabial fat pad which increases
the nasolabial line and induces convexity of the jawline.
Valérie – 42 years oldBEFORE
Valérie – 42 years oldAFTER
Cheek bones PERFECTHA® SUBSKIN 1 ml Subcutaneous Fanning
Deep dermis Fanning
Deep dermis Retrograde
Superficial dermis
Retrograde
Mid - dermis
Deep dermis
Retrograde
Multi-bolus
0.4 ml right0.2 ml left
0.4 ml right0.2 ml left
0.6ml
0.4 ml
1.8 ml
PERFECTHA® DEEP
PERFECTHA® DEEP
PERFECTHA® DERM
PERFECTHA® DEEP
PERFECTHA® FINELINES
TREATED AREA PRODUCT QUANTITY INJECTION
DEPTH TECHNIQUE
Preauricular
Nasolabialfolds
Lipcommissures
Marionette lines, jawline & chin
TREATMENT GOAL
Reduce the nasolabial folds by lifting the mid face laterally.
The procedures featured were performed by Dr. Iñigo de Felipe, Dermatologist, Barcelona, Spain.
When French touch meets beauty
NATURAL - LOOKING RESULTS
BEFORE
BEFORE
AFTER
AFTER
Treated areas:Glabellar lines CheeksNasolabial folds
Treated areas:Bridge of the noseTip of the noseNasolabial angle
Products used:PERFECTHA® DERM 0.5 ML PERFECTHA® SUBSKIN 1 MLPERFECTHA® FINELINES 0.4 MLPERFECTHA® DERM 1 ML
Products used:PERFECTHA® DEEP 0.3 MLPERFECTHA® DEEP 0.3 MLPERFECTHA® DEEP 0.3 ML
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Sécoura51 years old
Joseph32 years old
The procedures featured were performed by Dr. Iñigo de Felipe, Dermatologist, Barcelona, Spain.
When French touch meets beauty
BEFORE
BEFORE
AFTER
AFTER
Treated areas: Cheeks Nasolabial foldsJawline
Treated areas:CheekbonesTip of the noseNasolabial foldsJawline & zygomatic area
Products used:PERFECTHA® SUBSKIN 1.5 MLPERFECTHA® DEEP 0.6 MLPERFECTHA® SUBSKIN 0.8 ML
Products used:PERFECTHA® SUBSKIN 1 MLPERFECTHA® DEEP 0.3 MLPERFECTHA® DEEP 0.8 MLPERFECTHA® SUBSKIN 2 ML
NATURAL - LOOKING RESULTS
Edwige48 years old
Antonio41 years old
The procedures featured were performed by Dr. Iñigo de Felipe, Dermatologist, Barcelona, Spain.
When French touch meets beauty
PERFECTHA®
BY YOUR SIDE
� Injection technique videos� Case studies� Patient leaflets� Patient follow-up books � Waiting room video� Posters� Next visit reminders
www.perfectha.com
PERFECTHA® social networks are regularly updated with the latest information.
A C O M P L E T E S E T O F T O O L S T O S U P P O R T Y O U I N Y O U R D A I L Y P R A C T I C E
I N F O R M A T I O NP
ER
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www.perfectha.com
SINCLAIR PHARMA Office Village, Chester Business Park
Chester, CH4 9QZUnited Kingdom
PF-D
B3-0
3201
7-A
Sinclair Pharma, has been commited to skin expertise since 1971, and more recently to the development of a safe, minimally invasive and effective portfolio of aesthetic treatments including
PERFECTHA®.
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