The Birth of Pharmanex• Director Medicinal
Chemistries, MERCK
• Identified need for quality control and standards in unregulated nutritional industry
• Achieved $50 million/yr in sales
• Purchased by Pharmanex in 1998 for $135 million
Over 125 PHD level ScientistsDisciplines including
• Botanists• Pharmacognosist• Natural Product Specialists• Medicinal, analytical and process
chemists
• Quality control specialists• Biochemists• Molecular biologist• Pharmacologists• Toxicologists
Pharmanex Scientific Advisory Board
Brilliant Minds Endorse...Brilliant Minds Endorse...• Lester Packer – Antioxidant Miracle. Father of
antioxidants. “This validates my life’s work.”
• James Rippe, MD - Tufts, Boston (Cardiologist)
• James Balch, MD – author The Prescription for Nutritional Healing - 8 million copies sold
• Koji Nakanishi – Columbia, Father of Ginkgo Biloba research
• Carl Dierassi – Stanford, birth control pill.
• Chi - Huey Wong – Scripps Institute, appointed to the National Academy of Sciences
Selection
To locate the botanicals with the most effective health-promoting properties, Pharmanex employs teams of experts from the United States and Asia. These teams conduct exhaustive research-compiling, reviewing, and summarizing historical use and current intelligence about a botanical's properties and health benefits. Pharmanex also conducts original research to identify new botanicals, coordinating with noted professionals at Purdue University, Kansas University, Columbia University, Scripps Research Institute, and Beijing University, among others. Only botanicals that pass extensive Pharmanex tests for authenticity, usefulness, and safety are considered.
Sourcing
Once Pharmanex decides to proceed with a particular botanical, a team investigates potential sources of the botanical and conducts exhaustive analyses on samples from each source. Sources may be domestic or international and may include Pharmanex cultivation areas in China and Chile. Pharmanex chooses a supplier based on the quality and concentration level of the active ingredient(s) present in samples from that source.
Structure
Using state-of-the-art analytical techniques and working in collaboration with respected universities and laboratories in both China and the United States, Pharmanex conducts structural analyses of the natural compounds present in the selected botanical. These analyses isolate and purify specific chemical structures in standardized extracts, a critical step in ensuring a safe and effective botanical.
Standardization
Wide variations in active ingredients are characteristic of any botanical. For example, when Pharmanex analyzes potential Ginkgo biloba leaves, studies reveal the concentrations of active components will vary by as much as 300% depending on season, climate, soil, method of harvest, storage conditions, and processing. Pharmanex optimizes the active ingredients of a product through strict, proprietary standardization processes (to at least one relevant marker molecule). Each capsule of a Pharmanex product contains the same amount of each active ingredient.
Safety
Pharmanex is leading the way in establishing strict standards to ensure the safety of its products. Scientists research and document the history of a product's use and safety. Pharmaceutical-grade tests for the presence of microbes, toxins, and heavy metals are carried out for all products. The active ingredient amount used is based on dosages found effective through clinical trials and is backed by published data on file at Pharmanex. Each product label details directions for use and contains appropriate warning information.
Substantiation
Pharmanex only makes product claims that have been substantiated through documented preclinical and clinical studies. Existing clinical data are reviewed, and when necessary, Pharmanex sponsors studies of its products. Data from some of these studies are subsequently submitted to major international journals for review. This adherence to scientific standards for substantiation helps make Pharmanex a leader in the natural healthcare product industry.
First Supplement with all 3 Certifications!
• NSF (www.nsf.org)– Exhaustive formulation & toxicology analysis– FDA, cGMP, NSF, ANSI compliance
• BSCG (www.bscgi.org)– Free from 80+ banned substances by IOC,
WADA, USADA, NFL, NCAA
• ConsumerLab.com (www.consumerlab.com)– Ingredient verification– Only MVMS to test and pass in 6 categories
Substantiation
As of 2004,
nine of the Pharmanex Products are now listed in the
Physician’s Desk Reference (PDR)
THE NEXT BIG THING
"The amount of ANTIOXIDANTS that you maintain in your body is directly
proportional to how long you will live.“
Dr. Richard Cutler, Director of the Anti-Aging Research Department of the National
Institute of Health(NIH), Wash D.C.
The fastest growing market is in
Health and Wellness which was $300 billion last year
and is projected to rise to
$1 trillion by the year 2010.
Baby boomers are 25% of the population and
represent 50% of the spending.
Fact
The Problem
Free Radicals are unstable molecules that
cause cell and DNA damage;
They are a by-product of metabolism.
Indisputable
30,000 Published Papers
Document the link
between
Free Radical Activity
and Disease
Eye HealthNIH Studies - .Age-Related Eye Disease Study Research Group (AREDS). A Randomized, Placebo-Controlled, Clinical
Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss. Arch Ophthalmol 2001;119:1417-1436.
Age-Related Eye Disease Study Research Group (AREDS). A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E and Beta Carotene for Age-Related Cataract and Vision Loss. Arch Ophthalmol. 2001;119:1439-1452.
Packer L. Antioxidant properties of lipoic acid and its therapeutic effects in prevention of diabetes complications and cataracts. Ann N Y Acad Sci 1994;738:257‑264.
Christen WG, Jr. Antioxidants and eye disease. Am J Med 1994;97 Suppl. 3A:14S-17S.
Eye Disease Case-Control Group. Antioxidant status and neovascular age-related macular degeneration. Arch Opthomol 1993;111(1):104-9.
Gerster H. Antioxidant vitamins in cataract prevention. Z Ernahrungswiss 1989;28:56-75.
Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA 1994;272:1413-1420.
Snodderly DM, Evidence for protecting against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr 1995;62:1448S-1461S.
Most of What Kills Us
Degenerative Diseases· Cancer· Heart Disease· Diabetes· Age Related Macular
Degeneration· Cataracts· The aging process itself!
“You’re not getting older, just your DNA”
(Headline from an article in Popular Science, August 2002, p.44)
Aging Symptoms
All Around Us
Sources:Sunlight, Stress, Toxins, Pollution,
X-rays, Radioactivity, Airline travel,
Medications
Metabolism – Calories & Oxygen (75K)
Smoking = 10 Billionfree radicals per cigarette!
The Solution
Antioxidants combat free
radicals to prevent cell damage and maintain health; we get
these from fruits, vegetables, and vitamin supplements
No one gets it
In a survey of 21,500 people, not a single person consumed a 100% of RDA for the 10 most important nutrients!
Did you eat 6-10 Servings* of Fruits and Vegetables Today?
*as recommended by the National Cancer Institute
June 19, 2002
“We recommend that ALL ADULTS take a multi-vitamin daily”
RDAs “Enough to prevent deficiency, but not enough to prevent disease”
You are now under doctors orders!
After decades, the American
Medical Association
does a 180º turn
After decades, the American
Medical Association
does a 180º turn
It is now Unanimous…
Which product?With so many choices, how do you know which Antioxidant supplements to buy?
How does a healthcare professional know what to recommend to their patients... and whether it works or not?
The Missing Link
The ability to MEASUREis the basis of SCIENCE
This has been the missinglink in the nutritional industry!
April 6, 1992
On Antioxidants vs. Free Radicals
…Antioxidants may one day revolutionize health care. …Screening people through a simple...test to assess how much damage free radicals have done to tissue, much as patients today are screened for high cholesterol.
Biochemist, William Pryor, director of theBiodynamics Institute at Louisiana State University
What if……
ANTIOXIDANT LASER SCANNER
“The Future” is NOW!
ANTIOXIDANT LASER SCANNER
MAKE NO MISTAKE:
There is nothing else like the
Protected by Patents
Key Patent issuedMarch 20, 2001
8 Patents Totalin the US,Europe and Asia
Global Exclusive Rights
acquired GlobalExclusive Rights
to this Technology from the U of U
for $110 Million....For the next 16 years!
Global Exclusive Rights
IT’S THE ONLY ONE OUT THERE.
This gives Pharmanex a
LEGAL MONOPOLY
Simple PhysicsA blue light laser is directed into the palm of your hand, and in about 3 minutes you see your total Antioxidant level... Non-invasively!
Site of Action
Only Pharmanex can measure at the
“Site of Action.” Cell Body:
Site of Action!
Blood and urine tests can be altered by a few meals.
It takes 4-6 weeks or longer for antioxidants to reach skin cells.
Brilliant Minds Endorse...Brilliant Minds Endorse...• Lester Packer – Antioxidant Miracle. Father of
antioxidants. “This validates my life’s work.”
• James Rippe, MD - Tufts, Boston (Cardiologist)
• James Balch, MD – author The Prescription for Nutritional Healing - 8 million copies sold
• Koji Nakanishi – Columbia, Discovered Ginkgo Biloba
• Carl Dierassi – Stanford, birth control pill.
• Chi - Huey Wong – Scripps Institute, appointed to the National Academy of Sciences
“Everyone should use the
Pharmanex Bio-Photonic
Scanner to learn their Optimal
Body Defense Score. Once you have your number, work to increase it and maintain it with a diet rich in fruits,
vegetables and vitamin supplements”
Lester Packer, PhD. UC Berkeley
As Quoted on CNN/Money.com
Everyone
Widely Acclaimed
•NBC
•CBS
•CNN Money
•Physician’s Desk Reference
•Logan College Of Chiropractic
•Much, much more.
Accepted by Scientific Community
• New York Academy of Sciences, Feb 2003• Oxygen Club of California, Feb 2003 and Feb 2004• FASEB/American Society of Nutritional Sciences - April 2003
and April 2004• Gordon Research Conference, Jan 2004• American College of Nutrition, October 2004
2005 American Business AwardsMOST INNOVATIVE PRODUCT
In the United States
ANTIOXIDANT LASER SCANNER
How do we RAISE our Antioxidant Score?
Eat Healthier4 Cups of Green Tea
50 Cups of Mangos
27 Cups of Green Peas
20 Small Apples
16 Large Potatoes
9 Cups of Cooked Rice
21 Slices of White Bread
14 Slices of Whole Wheat Bread
23 Cups of Pineapple
13 Medium Sized Bananas
65 Cups of Asparagus
30 Cups of Milk
10 Cups of Tomatoes
10 Tablespoons of Peanut Butter
59 Slices of Cheddar Cheese
11 ½ Cups of Peanuts
16 Cups of Squash
EVERY
DAY!
A better solution
OR TAKE LIFEPAK TWICE A DAY!
(Healthy eating and exercise are still a good idea)
Vitamin A,C, E, Selenium, ManganeseCopper, Zinc, Lutein
LycopeneAlpha-Lipoic Acid
Folic AcidPhytonutrients
QuercitinGrape Seed ExtractGreen Tea Extract
LifePak Antioxidants
A comprehensive, bioavailable nutritional wellness supplement
delivering the optimum amounts of all essential and
beneficial nutrients,
with Pharmaceutical-grade
testing and standardization.
What is LifePak?
NOT Just Another Multivitamin ....
“LifePak has been the subject of two clinical studies designed to assess the antioxidant benefits of the product – quite a significant fact when you consider that we know of NO other supplement companies that have sponsored clinical studies on their multivitamin products.”
“We applaud Pharmanex for their efforts in this regard.”
SupplementWatch rates LifePak #1!
SupplementWatch.com
Effect of LifePak Supplementation
19950
2685829463
33173
0
5000
10000
15000
20000
25000
30000
35000
40000
45000
Time (weeks)0 4 8 12
V. L
ow |
Low
| M
od.|
Hig
h
p < 0.01 p < 0.01
Individual Changes, Days 1-28
0
5,000
10,000
15,000
20,000
25,000
30,000
35,000
40,000
45,000
Day 1 Day 28
n = 25
#1 Product
Top Revenue Supplement in the World
Top Supplement certified banned substance
free by the USOC
Shipped directly to each customer
20% - 30% rewards program every month!
G3
Gac juice (Momordica cochinchinensis)
Cili juice
Siberian Pineapple
Chinese Lycium
Ingredients
With Highly Bio-Available Lipocarotenes™
Beta-Carotene (mg/g wet wt.)
48 76 79
718
0
100
200
300
400
500
600
700
800
Spinach Carrot Sw.Potato Gac aril
Ishida et al., J Agric Food Chem 52:274, 2004
10 x morethan carrots!
Zeaxanthin in Chinese Lycium (mg/g wet wt.)
18
800
0100200300400500600700800900
1000
Yellow Corn Ch.Lycium
40 x more thanyellow corn!
Vitamin C in Cili Fruit (mg/100g wet wt.)
30 45 71
2500
0
500
1000
1500
2000
2500
Mandarin Orange Kiwi Cili
60 x morethan oranges!
Lycopene (mg/g wet wt.)
31 41 54
2227
0
500
1000
1500
2000
2500
Tomato Watermelon Guava Gac aril
Ishida et al., J Agric Food Chem 52:274, 2004
70 x morethan tomatoes!
Pharmanex controls the world-wide production of
Gac
and
Cili
Recorded Benefits• Increases energy• Anti-aging properties• Promotes eye health• Strengthens Immune System• Fights cancer• Improves circulation• Regulates cholesterol• Promotes Prostate health• Facilitates optimal bioavailability of key nutrients• Promotes skin health• Promotes vascular health• Promotes would healing• Protects skin from UV damage• Fights heart disease• Prevents stroke• Stabilizes blood pressure• Promotes better digestion• Promotes prostate health• Bolsters immune system• Promotes liver health• Eases headaches• Promotes sexual health• Promotes vitality
ABSOLUTE PROOF
Free re-scan every 30 days
100% Money Back Guarantee!
Only Pharmanex can provide on-going measurement and motivation to every patient!
FINALLY SOMEONE PUTS THEIR MONEY WHERE THEIR MOUTH IS!