Wednesday, 26 September 20137th CGO Workshop @ Berder
Proton Interaction Vertex Imaging With Silicon-Pixel CMOS Telescope For Carbon Therapy Quality Control
V. Reithinger1, J. Baudot2, S. Brons3, D. Dauvergne1, G. Dedes1, J. Krimmer1, C. La Tessa4, K. Parodi5,6
A.-L. Pequegnot1, R. Pleskac4, C. Ray1, I. Rinaldi5, M. De Rydt7, E. Testa1, M. Vanstalle4
1 Université Lyon 1 and CNRS/IN2P3/Institut de Physique Nucléaire de Lyon, UMR 5822, F-69622 Villeurbanne, France 2 Université Louis Pasteur and CNRS/IN2P3/IPHC , F-67037 Strasbourg, France
3 Heidelberg Ion Beam Therapy center (HIT), Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany4 GSI Helmholtzzentrum für Schwerionenforschung GmbH, Biophysics Division, D-64291 Darmstadt, Germany
5 University Clinic Heidelberg, Dep. Radiation Therapy and Radiation Oncology, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany6 Ludwig Maximilians University (LMU) Munich, Am Coulombwall 1, 85748 Garching, Germany
7 Instituut voor Kern- en Stralingsfysica, KU Leuven, Celestijnenlaan 200D, B-3001 Leuven, Belgium
CGO ws V. Reithinger – Proton Interaction Vertex Imaging for carbon therapy quality control 2
▸ Proton Interaction Vertex ImagingMethodsResultsConclusions and perspectives
▸ Context and principlePrevious results
Hadrontherapy : using ions (instead of photons)
[Amaldi et al.] [From IBA]
protontherapy IMRT
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▸ Proton Interaction Vertex ImagingMethodsResultsConclusions and perspectives
▸ Context and principlePrevious results
Need for an online ion range control during carbon-therapy treatments
Stoichiometric calibrationPatient positioning Morphologic changesMoving organsIonisation potentials ...
Uncertainties on
Why ?
Uncertainties on real ion range
How ?MC simulations :Carbon ions range
<correlated to>Nuclear reactions
● PET, Prompt gammas● Prompt protons
Imaging
Prompt protons
Emitted :● High production yield● In forward directionCharged particules :● Easily trackable
Vertex
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▸ Proton Interaction Vertex ImagingMethodsResultsConclusions and perspectives
Context and principle▸ Previous results
Previous results on PIVI with Monte Carlo simulations [Henriquet et al. PMB (2012)]
Simulated setup
Primary vs secondaries verticescontribution
Falloff Position (IPP)correleted with
incident ions energy
A millimetric resolution achievable
Considering a typical spot for active delivery
(105 – 106 carbon ions)
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Proton Interaction Vertex Imaging▸ MethodsResultsConclusions and perspectives
▸ Hardware & software
A CMOS sensor based protons trajectometer coupled with a software analysis tool
1 plane = 2 CMOS sensors
Proton trajectometer is made with 4 planes
Mimosa 26 :a High Energy Physics CMOS pixel sensor
fitted for PIVI
● Thickness : 50 μm● Dimensions : 2 x 1 cm2
● Pixels : 1152 x 576● Pitch : 18,6 μm● Resolution : ~3,2 μm (sigma_{pos}(MIP))● Integration time : 112 μs● Dead Time : negligible
Clustering
Tracking
Vertexing
Ion trajectory Proton track
vertex
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Proton Interaction Vertex ImagingMethods▸ ResultsConclusions and perspectives
▸ Vertices distributions versus energyNormalized vertices distributions versus angleComparison with MC simulationsEffect of secondaries vertices
Carbon ions range in PMMA [HIT 2011]
10°
PMMA10x10x25cm3
10cm hodoscope
beam4 ≠ energies
PMMA TARGET
y
z
Z [mm]
Co
un
ts
160 mm range
12C ions @ 310 Mev/u FWHM 3.8 mm
● Vertices distribution along target depthcorrelated tocarbon ions range
● 2D vertices distributionscorrelated both tocarbon ions rangebeam FWHM
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Proton Interaction Vertex ImagingMethods▸ ResultsConclusions and perspectives
Vertices distributions versus energy▸ Normalized vertices distributions versus angleComparison with MC simulationsEffect of secondaries vertices
Tracker angle influence on statistic and reconstruction [GSI 2012]
10° to 50° 14cm
PMMA15(L) x 15(D) cm3
beam
12C @ 200MeV/u
z
y
PMMA TARGET
● Tracker anglecorrelated toreconstructed vertices yieldreconstruction artefacts (low angles)
Vertices yield vs tracker angle
Statistics for 1 pencil beam (106C - present setup)
20°
70 mm range
10°
20°
30°
40°
50°
5 trackers
2 trackers
1 tracker
CGO ws V. Reithinger – Proton Interaction Vertex Imaging for carbon therapy quality control 8
Proton Interaction Vertex ImagingMethods▸ ResultsConclusions and perspectives
Vertices distributions versus energyNormalized vertices distributions versus angle▸ Comparison with MC simulationsEffect of secondaries vertices
A reasonable agreement between experimental & MC simulation data
PMMA TARGET
70 mm range
10°
20°
30°
Experimental dataSimulation data
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Proton Interaction Vertex ImagingMethods▸ ResultsConclusions and perspectives
Vertices distributions versus energyNormalized vertices distributions versus angleComparison with MC simulations▸ Effect of secondaries vertices
A sensitive to secondaries vertices method
“Vertexing” method
Proton track
Ion tr
ajectory
Shorter segmentEstimatedvertex
PMMA TARGET
70 mm range
All verticesEstimated 1ary verticesEstimated 2ary vertices
30°
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Proton Interaction Vertex ImagingMethodsResults▸ Conclusions and perspectives
Conclusions
Ongoing work● Experiment with heterogenous target (QAPIVI collaborative project)
→ Analysis→ MC simulations
● Tests with large acceptance detector (F. Sauli et al.)
● Feasibility of PIVI technique in homogeneous targets→ First, studied with MC simulation [Henriquet et al. PMB (2012)]→ Then, we performed two experiments that are validating the principle→ The tracker angle influence on absolute vertices yields and reconstruction→ Reasonable agreement between experimental and simulated data
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Acknowledgments
Collaborations: ● IPNL-Lyon: M. Chevallier, G. Dedes, S. Deng, J. Krimmer, H. Mathez,
M. Pinto, C. Ray, V. Reithinger, E. Testa, Y. Zoccaratto● CREATIS-Lyon: N. Freud, J.M. Létang● GSI-Darmstadt: C. La Tessa, R. Pleczak, M. Vanstalle● HIT-Heidelberg: K. Parodi, I. Rinaldi, S. Brons● IPHC-Strasbourg: J. Baudot, M. Winter, C. Finck, M. Rousseau, R. Rescigno
Research program supported by:● PRRH ETOILE (CPER 2007-2013)● GDR MI2B (CNRS-IN2P3)● FP7 project ENVISION (2010-2013)● FP7 ITN project ENTERVISION (2011-2014)● Labex PRIMES (2012-2020)● INCA project QAPIVI (2011-2013)
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BACKUP SLIDES
2 experiments
TARGET
● PMMA (C5O2H8) 1.185g.cm-3
● Rectangular 10x10x25 cm3
[HIT 2011]● Cylinder 15Lx ¼(7,5R)
2 cm3
[GSI 2012]
BEAM● 12C6+ ions● 250 < E < 395 Mev/u
3.6 < FWHM < 4.3 mm
[HIT 2011]● 200 Mev/u
5 mm FWHM[GSI 2012]
TRACKER
● 8 CMOS sensors in 4 planes● 2 x 2 cm2 active area/plane● 10°
[HIT 2011] ● 10°< angle < 50°
[GSI 2012]
Plastic scintillator
● To detect protons crossing the tracker
● 7 x 7 cm2 active area● Used as CMOS trigger
(coincidence with hodoscope)
Beam hodoscope
● To detect incoming ions● Used as CMOS trigger
(coincidence with scintil.)
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BACKUP SLIDES
Protons Yield
Yie
ld [p
/C/m
sr]
Angle [degree]
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BACKUP SLIDES
Experiment correlation between Range & FallOff
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BACKUP SlidesClusters size
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BACKUP SlidesTracks resolution
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