Pac I Not I

γa γb

ST.

WAXY

Pac I Not I

γa γb

ST.

TaCOI1Pac I Not I

γa γb

ST.

TaDMC1

Pac I Not I

γa γb Waxy

Waxy

Loop

ST.

Pac I Not I

γa γb

ST.

MCS

αa

BstBI

βbβc

βd

(a)

(f)

(b)

(c)

(d)

(e)

(g)

Figure S1