Overview of the Harvard Catalyst Imaging program
ClareTempany, MD; Ron Kikinis, MD;
Valerie Humblet, PhD
http://catalyst.harvard.edu April 9, 2009
Agenda
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• Harvard Catalyst
• Imaging Consortium
• Technology and Expertise
• IT Structure
• Why be a consultant ?
• Educational Opportunities
• Contact
Harvard Catalyst: The History and the Basics
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• GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued– BWH/MGH imaging cores (CT/AVD/GS)
• CTSA 2007(Roadmap initiative-EAZ)• HU- Response-Harvard Catalyst
– (PI Lee Nadler/Co-Director: Steve Freedman)– GCRC replaced by PCIR
• We are a pan-Harvard enterprise dedicated to improving human health by:– Creating Connections– Enabling research At the Cutting Edge of discovery– Nurturing clinical and translational researchers
National Effort in C/T Research
38 AHC/23 states
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• Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08
Source: http://www.ctsaweb.org/
Duke
Mayo Clinic
Cornell
J.Hopkins
UC Davis
Wash. U.
Northwestern
Emory U.
• Imaging programs-(Dan Sullivan/RSNA)
Institutions participating in Harvard CTSC
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Academic Healthcare Centers• Beth Israel-Deaconess Medical
Center• Brigham and Women’s Hospital• Massachusetts General Hospital• Children’s Hospital Boston
Specialty Hospitals and Institutes• Dana-Farber Cancer Institute• Forsyth Dental Institute• Joslin Diabetes Center• Massachusetts Eye and Ear
Infirmary• McLean Hospital• Schepens Eye Research Institute
Massachusetts Institutes of Technology
Harvard University• Faculty of Arts and Sciences• Harvard Business School• Harvard School of Dental Medicine• Harvard Divinity School• Graduate School of Design• Graduate School of Education• Kennedy School of Government• Harvard Law School• Harvard Medical School• Harvard School of Public Health• Harvard School of Engineering
Community Healthcare Institutions• Cambridge Health Alliance• HMS Department of Ambulatory
Care and Prevention at Harvard Pilgrim Healthcare
Red –Imaging Consortium
Year 01 total budget: $22,148,106
Harvard catalyst
• Programs (Selected list)
– Biomedical Informatics-Kohane– Community engagement– Design and Biostats– Dev of Novel CT methodologies-Vikas– Diversity/Health Disparities research– Ethics– Linkages-HL, HBS, Kennedy School etc– Pilot studies– Regulatory-BB– Research Education
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Harvard catalyst
• Programs– Translational Technologies and Resources
(TTR)-Gordon Williams (Imaging)– increases investigator awareness and utilization of
established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies.
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Pilot funds
• Eligibility:All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation.
• Funds:Pilot Grants will be awarded in the amount of $50,000, with an award period of one year.
• Deadlines:Letter of intent: May 13, 2009
Full application: June 12, 2009
• Contact:Harvard Catalyst Research Navigators617 432-7800
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Bruce Rosen, DirectorRandy Gollub, Co-DirectorGordon J. Harris, Site Co-Director
Robert Lenkinski, Site Co-DirectorNeil Rofsky, Site Co-Director
Clare Tempany, Site Co-DirectorRon Kikinis, Site Co-DirectorGordon Williams, PI for CTSC Translational Technologies
Stephan Voss, Site Co-DirectorSimon Warfield, Site Co-Director
Annick D. Van den Abbeele, Site Co-DirectorJeff Yap, Site Co-Director
Gordon J. Harris, Site Co-DirectorAnnick D. Van den Abbeele, Site Co-DirectorWilliam Hanlon, Core Manager
Valerie Humblet, Imaging LiaisonYong Gao, XNAT Engineer
Imaging Consortium Team
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Mission of the Imaging Consortium
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• Expand imaging in clincial research– To build infrastructure
• Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research
• IT framework
• Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging, techniques, capabilities and image processing capabilities in the Harvard environment.
Harvard Catalyst website
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• Access to resources and profiles
http://catalyst.harvard.edu/home.html
Image Consortium Consultation Service
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• Access to the consultation service:
http://catalyst.harvard.edu/home.html
Technologies and Expertise
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• Cancer imaging, MRI, PET, CT, fMRI, pediatric imaging, neuroimaging.
• Focused on assisting with planning and design of research proposals and/or methods for image analysis.
• Consultation is available for the preparation of a grant or IRB submission.
• We do not provide ongoing support for the implementation of new studies or the analysis of data from existing studies.
Imaging Consultation Service
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• Investigator fill webform on Catalyst website– Name, institution, nature research, reason for consult
• Medical Imaging Liaison – dispatches request to the imaging consortium– Follow-up with investigator
• Consultations discussed weekly• Designated consultant contacts investigator
Becoming an Imaging Consultant
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• Potential benefits of being an active collaborator:– Good framework for research– Research opportunities through collaborations– Meeting experts out of radiology– Networking with imaging cores outside of Boston
• Examples: – Standardization of physiologic monitoring system for fMRI– Development lingual nerve imaging (MGH-BIDMC)– Study of brain-development in premature infants (CHB-BWH-
MGH)– Liver inflammation– Cardiac conductivity study
Educational Opportunities proposal
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• Nanocourse: – Imaging 101 to increase knowledge about imaging
• More advanced classes for radiologists:– Tumor metrics– Radiation safety issues for IRB submission– Hands-on classes on data analysis– Imaging perfusion– Example: www.na-mic.org/Wiki/images/8/8b/Slicer3Training_ChangeTracker.ppt
XNAT-PACS-i2b2 Integration
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• IT Catalyst infrastructure:– i2b2: scalable computational framework to help
translation of genomic findings. – BIRN: XNAT imaging informatics platform: large
collections of images and study-specific metadata to be managed by image-driven clinical translational research groups.
– NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: slicer. Freesurfer.
XNATEnterprise
DataRepository
(CRC)
FileRepository
IdentityManagement
OntologyManagement
CorrelationAnalysis
De -Identification
Of dataNatural
LanguageProcessing
AnnotatingGenomicData #1
ProjectManagement
WorkflowFramework
AnnotatingGenomicData #2PACS PACS
i2b2 HIVE
Dr X Desktop Pediatric
rare disease
Dr YDesktop
Alzheimer
Dr ZDesktop
Chronic pain management Dr W
Desktop Quantitative
cancer biomarkers
XNAT-PACS-i2b2 Integration
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Slicer:Data
visualization analysis
Invitation
• Please consider getting involved– Info- Google Harvard catalyst– Pls sign up as a potential consultant today!– Pilot grants (est x2 application dates per year)– Watch your email- attend meetings
symposiums to meet new research colleagues
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