Nanomedicines for imaging and drug deliveryActivities of the BioNanoMaterials group
Jessica RosenholmProfessor in Pharmaceutical DevelopmentPharmaceutical Sciences LaboratoryÅbo Akademi University, Turku, Finland
Nanomedicine
”The application of nanotechnology to health”
Three scientific areas recognized by the ETP for
Nanomedicine:
1) Nanopharmaceutic(al)s (drug delivery systems...)
2) Nano-diagnostics (in vitro POC devices, in vivo
contrast agents...)
3) Regenerative medicine (tissue engineering,
stem cell therapy...)
theranostic agents
*) theranostics: simultaneous imaging and therapy enabling follow-up of the drug delivery process
19.1.2017 3Åbo Akademi University | Domkyrkotorget 3 | 20500 Åbo | Finland
Nanopharmaceuticals
Spatial control (targeting)Temporal control (drug release)
• Therapeutically active compounds:
• hydrophobic drugs, hydrophilicdrugs, biomolecules (e.g. peptides, proteins, nucleic acids)
• Sustained or controlled release
• Targeted drug delivery in vitro and in vivo (passive and active)
19.1.2017 4Åbo Akademi University | Domkyrkotorget 3 | 20500 Åbo | Finland
Nanodiagnostics
NPs as carriers for imaging agentsInherently detectable NPs
• Optically active materials:
• Carbon nanostructurs(nanodiamonds, carbon dots)
• UCNPs (upconvertingnanophosphors)
• Magnetically active materials:
• Iron oxides, Fe3O4 (SPIONs)
• Other metal oxides, MnO, Gd2O3
• NPs as carriers for molecularimaging agents
• Fluorophores (opt), rare earthmetal complexes (opt & mag)
Combined core activity & shell loading capacity: core@shell designs
Antibacterial”nanobiotics”
Theranosticnanomedicines
3D: Biofunctional scaffolds with cell-directed drug delivery for
tissue regeneration
2D: Personalized drug dosing
Printing of drug-loaded NPs as a nano-ink with a piezoelectric inkjet printer
Individualized dosing of poorlysoluble drugs
Sustained/controlled release
3D printed scaffolds providing stem cell guiding tools
Individually tailored structures combined with NPs for cell directed drug delivery
Printing of nanomedicines
The main objectives of the research group are to:
Develop mesoporous silica nanoparticle (MSN) based nanoformulations suitable for a broad range of cargo, e.g. drugs/biomolecules/imaging agents/sensor dyes…
Synthesize multifunctional composite nanostructures for improved bio-visibility (detectability in biological systems) and theranostic activity
Evaluate the potential and applicability of the developed nanomedical agents for in vitro and in vivo drug delivery and biomedical imaging together with our cross-disciplinary collaborators
Summary of activities of the BNM group
Novel materialsdevelopment
Nanoformulationdrugs/biomolecules/ diagnostic agents…
Evaluation of applicability
Flexible particle
design and wide
application areas
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