National Alliance for Medical Image Computing: NamicRandy L.
Gollub, MD, PhD
Training Core PI, MGH
This dataset in perspective
MIND Who?
Harvard/Massachusetts General Hospital
MIND MCIC Why?
A federally funded multi-site consortium created to advance our
understanding of schizophrenia by supporting the acquisition of
clinical, cognitive, genetic, morphometric, diffusion weighted and
functional neuroimaging data from schizophrenia patients and
matched controls using a common experimental protocol.
National Alliance for Medical Image Computing
http://na-mic.org
MIND What?
Reliability n =10 travelers to all 4 sites
Clinical n = 300+ Chronic and First Episode (FE) schizophrenics and
matched controls
FE subjects and matched controls have follow-up data at 1 year (n =
46)
National Alliance for Medical Image Computing
http://na-mic.org
MIND Reliability
T1, T2, DTI, and 4 fMRI task paradigms
Goal: calibrate for clinical study
National Alliance for Medical Image Computing
http://na-mic.org
MIND Reliability DTI
0, 700
Diffusion directions
MIND CICS
Over 300 subjects, Chronic and FE pts with matched controls
National Alliance for Medical Image Computing
http://na-mic.org
MIND MCIC DTI
Controls n = 138
MIND CICS DTI
Morphometric Scan parameters
T1 (Coronal, MPRAGE)
T2 (Coronal, TSE)
(MGH)
n/a
n/a
6
n/a
n/a
^FOV can be slid up to 18cm when needed for full brain
coverage
*1 NEX scan is performed, evaluated, repeated if necessary
dataspectrumphantom
DataSpectrum Phantom Protocol
T1 (Coronal, MPRAGE)
T2 (Coronal, TSE)
1.5 T (Siemens Sonata) Scan Parameters using CP Head Coil
T1 (Coronal, GRE)
T2 (Coronal, TSE)
Siemens 17cm protocol
T1 (Coronal, MPRAGE)
T2 (Coronal, TSE)
T1 (Coronal, GRE)
T2 (Coronal, TSE)
MIND CICS Preliminary Results
Morrow, et al International Congress on Schizophrenia Research,
2007
Morrow EM, Wallace S, Pacheco J, Bockholt J, White T, Ho B,
Kuperberg G, Magnotta V, Lim KO, Seidman L, Goff D, Andreasen N,
Schulz C, Fischl B, Gollub RL, Structural brain study across
lifetime of schizophrenia using computer automated quantification
of subcortical volumes in the MIND multisite study, International
Congress on Schizophrenia Research, 2007.
National Alliance for Medical Image Computing
http://na-mic.org
Freesurfer
Log normalized volume vs. age
1= Controls, 2= Chronic schizophrenia
Hippocampal volume is lateralized with a right greater than left
asymmetry noted within each site. Schizophrenic subjects have
comparable hippocampal asymmetry, but, are noted to have
consistently smaller hippocampal volumes bilaterally. Further work
is needed to discern whether there is an additional age or illness
duration effect on hippocampal volume that exceeds the normal age
effects.
National Alliance for Medical Image Computing
http://na-mic.org
For Marty and Andy with
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