Medicine at the Benchtop and the Bedside: Course Guidelines
Robert H. Chow, MD PhD
USC-Caltech MD-PhD Program
Keck School of Medicine
• Seminar course for MD-PhD students• Purpose:
– to introduce a clinical problem and research related to that problem– to introduce the faculty and their research – to keep your mind active and curious during the
first two years of med school!
• Two students present – 2nd-yr student presents clinical problem– 1st-yr student presents research paper
• One or two faculty mentors
Medicine at the Benchtop and the Bedside
Friday, September 25, 2009Faculty facilitator: Dr. Robert ChowStudent facilitator: none
Friday, October 16, 2009Faculty facilitator/s: Dr. James Weiland and Dr. Rajat AgrawalStudent facilitators: TBA
Friday, October 23, 2009Faculty facilitator/s: Dr. Peter Jones and TBAStudent facilitators: TBA
Friday, October 30, 2009Faculty facilitator/s: Dr. Ellis Meng and Dr. Uttam SinhaStudent facilitators: TBA
Friday, November 20, 2009Faculty facilitator/s: Dr. Shelly Lu and TBAStudent facilitators: TBA
Friday, December 4, 2009Faculty facilitator/s: Dr. Andrea Armani and Dr. Jane EmersonStudent facilitators: TBA
Tentative Outline
Following this slide are two sets of slides which can serve as templates
for the student presentations
• The mentor(s) may decide that an alternative format is preferable, in which case follow the mentors’ guidelines
Template for Clinical PresentationFor Medicine at the Benchtop
and Bedside
Robert H. Chow
Zilkha Neurogenetic Institute
History of
• if there are juicy tidbits about the history of this clinical problem or the research…
Case Presentation
• Chief complaint
• History of presenting illness
• Physical Examination
• Pertinent laboratory findings
Clinical Presentation: Symptoms/Signs
• What is difference between a symptom and a sign?
• In detail, typical presenting symptoms and signs
Diagnosis
• Pathognomonic signs/symptoms
• Lab tests
• Possible springboard for the research part of this seminar
Differential Diagnosis• Here, you list and discuss other diagnoses
that should be considered for the presenting signs/symptoms
Natural history
• The clinical course of the disease/ illness when no treatment is given
• Possible springboard for research portion of seminar
Epidemiology
• Characteristics at population level
• Possible springboard for research portion of seminar
Etiology/Pathogenesis
• May review pertinent anatomy/ physiology here
• Possible springboard for the research part of this seminar
Therapy/Response
• Current approach to therapy
• Scientific basis of therapy (or lack thereof !) -- another springboard for the reseach part of the seminar
Other interesting aspects of the clinical problem
• Clinically relevant offshoots…
Template for Research Paper Presentation For Medicine at the Benchtop and Bedside
Robert H. Chow
Zilkha Neurogenetic Institute
Title of Article
Authors (at least the first and last)
Institutional Affiliation(s)
Major Hypothesis or Question
• Subhypothesis/ subquestion 1
• Subhypothesis/ subquestion 2
• Etc.
Background
• Short rationale or history of study of this hypothesis
Preparation
• Which animal/ tissue/ cell type used for the study• Any relevant details about the preparation,
particularly justification for using this preparation
Materials and Methods
• Method(s) used to perform study• Approach to analysis
Result 1
• Usually a figure clipped from paper
Result 2
• Another figure…
• It’s not necessary to review every figure in the paper, just the ones you want to focus on
• Etc.
Author’s Conclusions
• Summarize what the authors state is the important conclusion(s) of the paper
Critique of Paper
• Similar to review of submitted manuscript or grant proposal
• Evaluate the paper:– Author’s expertise– Validity of approach/ model/ methods– Quality of data– Validity of analysis– Validity of conclusions– Thoughts on how the study might have been improved--------------------------------------------------------------– Ideas on how to follow up on the findings of the paper…
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