Insulin and Counterregulatory
Hormones - DKA
Ahmad Abid Abas 2
6th Year – IUMP 2013
Diabetic Ketoacidosis
• Due to :
Severe insulin deficiency.
Excess counter-regulatory hormones.– Epinephrine
– Glucagon
– Cortisol
– Growth Hormone
Role of Insulin• Required for transport of glucose into :
Muscle
Adipose
Liver
• Inhibits lipolysis.
• Growth, Potassium..
• Absence of Insulin .– Glucose accumulates in the blood.
– Liver• Uses amino acids for gluconeogenesis.
• Converts fatty acids into ketone bodies.– Acetone,Acetoacetate, ß-hydroxybutyrate
- Increase counter-regulatory hormones
Counterregulatory Hormones -DKAIncreases
Insulin Resistance
Activates glycogenolysis and gluconeogenesis
Activates Lipolysis
Inhibits Insulin
Secretion
Epinephrine X X X X
Glucagon X
Cortisol X X
Growth Hormone
X X X
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