ISSN 0036-807529 OCTOBER 1993VOLUME 262NUMBER 5134
AMERICANASSOCIATION FOR THEADVANCEMENT OFSCIENCE
NEWS & COMMENT MW&
Is There Life After the SSC?
New Rules Squeeze EPA Scientists
No Way to Cool the Ultimate Greenhouse
New Sellafield Study Poses a Puzzle
EMF-Cancer Links: Yes, No, and Maybe
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RESEARCH NEWSHuman Embryo Cloning Reported 652
E 653New Protein Appears to BeLong-Sought Neural Inducer
Going for the Old: Ancient DNADraws a Crowd
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El Ninlo Metamorphosis Throws Forecasters 656
Lithium Hints at Possessed Stars
Nonlinear Codes Straighten Up-andGet to Work
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New Crater Age Undercuts Killer Comets M' 659
FRONTIERS IN NEUROSCIENCE
PERSPECTIVES
Singte MindM.Il . Posner:EX ::
Moieular Genetics of tNeuological:Diseases
jsJ.;B. Martin~rT M goati olbExcement ut Calum Signaling Innexcitable CellsX :t~~;0 ;0J. W. Putney Jr.
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ARTICLESThalam oal Oscllatns in the 679SleepingandAroused Brain
M. Steriade0.;A. M0cCormick. T. J SejnowskiNeurono mecaim fO~c8Recognition0? 0;f~K. TanhakaOida* Stress, Glumate, and 689Neu~rodegeeralv isorers f0t. f
J T Coylead .PuaiittfreProgaramed Ca11 Death and the 695Control f Call Survival:XLessons frm
McC.RfB. A. Bre,1.F. Burne,H. S. Colef, Y. Ishizaki, M. D. Jacobson
DEPARTMENTS
THIS WEEK IN SCIENCE
EDITORIALFrontiers in Neuroscience
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LETTERS 637NIH Support for Graduate Students: J. Hegde *
NCRR Funding Mechanisms: J. L. Vaitukaitis 9
Environmental Hazards: Real or Exaggerated?:M. D. Green; B. Weiss; D. Redfield * Carcinogeni-city Certification: P. Shubik * Excluded Gender?:D. Arnosti * Volcanology in Europe: F. Barberi eMesostructure Silicate Names: G. Stucky
SCIENCESCOPE
RANDOM SAMPLES
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BOOK REVIEWS 771Research and Relevant Knowledge, reviewed byD. A. Wilson * Galileo, Courtier, R. J. Blackwell *The Great Paleozoic Crisis, P. W. Signor * Atmo-spheric Remote Sensing by Microwave Radiometry,T. T. Wilheit * Vignettes * Books Received
INSIDE AAAS
PRODUCTS & MATERIALS
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mn Board of Reviewing Editors wGottfried SchatzJozef SchellRonald H. SchwartzTerrence J. SejnowskiEllen SolomonThomas A. SteitzMichael P. StrykerRichard F. ThompsonRobert T. N. TjianEmil R. UnanueGeerat J. Vermeij
Bert VogelsteinHarold WeintraubZena WerbGeorge M. WhitesidesOwen N. WitteWilliam A. WulfKeith Yamamoto
SCIENCE * VOL. 262 * 29 OCTOBER 1993
SCIENCE
653 & 713Noggin protein,identified as aneural inducer
John AbelsonFrederick W. AltDon L. AndersonMichael AshburnerStephen J. BenkovicDavid E. BloomFloyd E. BloomPiet BorstMichael S. BrownHenry R. BourneJames J. Bull
Kathryn CalameC. Thomas CaskeyDennis W. ChoiJohn M. CoffinPaul J. CrutzenRobert DesimoneNicole Le DouarinBruce F. EldridgePaul T. EnglundRichard G. FairbanksDouglas T. Fearon
Harry A. FozzardK. FriedrichTheodore H. GeballeMargaret J. GellerJohn C. GerhartRoger 1. M. GlassStephen P. GoffPeter N. GoodfellowCorey S. GoodmanStephen J. GouldIra Herskowitz
Eric F. JohnsonStephen M. KosslynMichael LaBarberaCharles S. Levings IllAlexander LevitzkiHarvey F. LodishRichard LosickDiane MathisAnthony R. MeansShigetada NakanishiRoger A. Nicoll
William H. Orme-Johnson I11Stuart L. PimmYeshayau PockerDennis A. PowersRalph S. QuatranoV. RamanathanDouglas C. ReesT. M. RiceErkki RuoslahtiDavid C. Rubie
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COVER
Salvador Dali's Raphaelesque Head Breaking (1951)portrays the logarithmic spirals of the rhinoceros horn,the dome of the Pantheon, and the contemplativeMadonna. Scientists are pushing the frontiers of neuro-science in all directions and may even enter into therealms of mathematics, architecture, and faith. This
RESEARCH ARTICLENeural Induction by the Secreted 713Polypeptide NogginT. M. Lamb, A. K. Knecht, W. C. Smith,S. E. Stachel, A. N. Economides, N. Stahl,G. D. Yancopolous, R. M. Harland
REPORTSLaser Ablation and the Production of 719Polymer FilmsG. B. Blanchet, C. R. Fincher Jr., C. L. Jackson,S. I. Shah, K. H. Gardner
Identification of Complex Aromatic 721Molecules in Individual InterplanetaryDust ParticlesS. J. Clemett, C. R. Maechling, R. N. Zare,P. D. Swan, R. M. Walker
The Effect of Changing Land Use on SoilRadiocarbonK. G. Harrison, W. S. Broecker, G. Bonani
Crustal Thickness on the Mid-AtlanticRidge: Bull's-Eye Gravity Anomalies andFocused AccretionM. Tolstoy, A. J. Harding, J. A. Orcutt
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The Manson Impact Structure: F 7294Ar/39Ar Age and Its Distal Impact Ejecta inthe Pierre Shale in Southeastern South DakotaG. A. Izett, W. A. Cobban, J. D. Obradovich,M. J. Kunk
Mississippian Fossils from Southern 732Appalachian Metamorphic Rocks and TheirImplications for Late Paleozoic TectonicEvolutionR. A. Gastaldo, G. M. Guthrie, M. G. Steltenpohl
Structure at 2.5 A of a Designed Peptide 734That Maintains Solubility of Membrane ProteinsC. E. Schafmeister, L. J. W. Miercke,R. M. Stroud
AAAS Board of Directors BE
special issue samples the variety in neuroscience. Seethe Editorial, the News story on page 653, the Re-search Article on page 713, and the section of Per-spectives and Articles beginning on page 673. [Trans-parency: Bridgeman/Art Resources, NY. Reproducedwith permission from Artists Rights Society, NY]
Analysis of a Nucleoprotein Complex:The Synaptosome of yb ResolvaseN. D. F. Grindley
Calcium Sparks: Elementary EventsUnderlying Excitation-Contraction Couplingin Heart MuscleH. Cheng, W. J. Lederer, M. B. Cannell
Microdomains with High Ca2+ Close to1P3-Sensitive Channels That Are Sensed byNeighboring MitochondriaR. Rizzuto, M. Brini, M. Murgia, T. Pozzan
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Alterations of a Zinc Finger-Encoding 747Gene, BCL-6, in Diffuse Large-Cell LymphomaB. H. Ye, F. Lista, F. L. Coco, D. M. Knowles,K. Offit, R. S. K. Chaganti, R. Dalla-Favera
Isolation of the Cyclosporin-Sensitive 750T Cell Transcription Factor NFATpP. G. McCaffrey, C. Luo, T. K. Kerppola, J. Jain,T. M. Badalian, A. M. Ho, E. Burgeon,W. S. Lane, J. N. Lambert, T. Curran,G. L. Verdine, A. Rao, P. G. Hogan
Nonuniform Probability of Glutamate 754Release at a Hippocampal SynapseC. Rosenmund, J. D. Clements, G. L. Westbrook
Functional Stoichiometry of ShakerPotassium Channel InactivationR. MacKinnon, R. W. Aldrich, A. W. Lee
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TECHNICAL COMMENTS c
Spatial Learning in Mutant Mice 760J. A. Deutsch; A. J. Silva, R. Paylor,J. M. Wehner, S. Tonegawa; S. G. N. Grant,T. J. O'Dell, K. A. Karl, P. L. Stein, P. Soriano,E. R. Kandel
Gravitational Separation in Polar Firn 763H. Craig; D. Raynaud, J. M. Bamola,J. Chappellaz, R. J. Delmas, C. Lorius, J. Jouzel,J. Schwander
2 Indicates accompanying featureF. Sherwood Rowland
Retiring President,Chairman
Eloise E. ClarkPresident
Francisco J. AyalaPresident-elect
Robert A. FroschFlorence P. Haseltinewilliamn A. Lester, Jr.
Alan SchriesheimJean'ne M. ShreeveChang-Lin TienWarren M. WashingtonNancy S. Wexler
William T. GoldenTreasurer
Richard S. NicholsonExecutive Officer
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