Excitabilidade Eltrica das Clulas
Eletrofisiologia: Pr-HistriaLuigi Galvani: 1737-1798
Excitabilidade Eltrica das ClulasOscilaes da diferena de potencial eltrico, em escala de tempo de ms, associadas transduo sensorial em receptores, transmisso de informaes em neurnios e clulas musculares e transmisso de informao entre clulas, nas sinapsesPotencial de ao Resposta tudo ou nadaPotencial gerador.
Excitabilidade: Repostas graduadas e potenciais de ao
Potencial de ao como resposta local, registrada no compartimento intracelular
POTENCIAL DE AO resposta local propagao
Potencial de ao: Circuito eltrico equivalente para a membranaCmgClgKicexgNai
Potencial de ao: Fenomenologia da resposta local
Excitabilidade: potenciais de ao
O Potencial de AoReverso da polaridadeLimiarPs-potencial
Potenciais de ao: Limiar
Potenciais de ao: Perodos refratrios
Mecanismos inicos da resposta local
Oscilaes da diferena de potencial eltrico nas clulas so determinados primariamente pela transferncia de carga pelo fluxo de ons atravs de canais[K]=110mM[Na+]=10mM[Na+]=135mM[K+]= 4mM--++
Gnese dos Potenciais de membrana (Medidas intracelulares no axnio gigante de lula)
Gnese dos Potenciais de membrana (Medidas intracelulares no axnio gigante de lula)
Mas a membrana permevel a vrios ons....Equao de Hodgkin-Katz-Goldman, considerados apenas os efeitos de ons monovalentes
Fixao de voltagem 10mmVcVmi
Correntes inicas que causam o potencial de ao em axnios
Condutncias dependentes de voltagem em axnios
Esquemas cinticos para os canais Canais para Na+Canais para K+FAFAI
Cinticas das condutncias: a potssio
Cinticas das condutncias: sdio
K(Vm,t)
INav
Relaes I-V
Sheet1
Na1000ka15
gca10Era-100
Vha-40
Nb1000kb5
gcb10Erb50
Vhb-100
A.C.Cassola v.0, 04/2000
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Page &P
Sheet1
6.53E-044.54E-05
9.11E-041.23E-04
1.27E-033.35E-04
1.77E-039.11E-04
2.47E-032.47E-03
3.45E-036.69E-03
4.80E-031.80E-02
6.69E-034.74E-02
9.32E-031.19E-01
1.30E-022.69E-01
1.80E-025.00E-01
2.49E-027.31E-01
3.44E-028.81E-01
4.74E-029.53E-01
6.50E-029.82E-01
8.84E-029.93E-01
1.19E-019.98E-01
1.59E-019.99E-01
2.09E-011.00E+00
2.69E-011.00E+00
3.39E-011.00E+00
4.17E-011.00E+00
5.00E-011.00E+00
5.83E-011.00E+00
6.61E-011.00E+00
7.31E-011.00E+00
7.91E-011.00E+00
8.41E-011.00E+00
8.81E-011.00E+00
9.12E-011.00E+00
9.35E-011.00E+00
9.53E-011.00E+00
9.66E-011.00E+00
9.75E-011.00E+00
9.82E-011.00E+00
9.87E-011.00E+00
9.91E-011.00E+00
9.93E-011.00E+00
9.95E-011.00E+00
9.97E-011.00E+00
9.98E-011.00E+00
9.98E-011.00E+00
9.99E-011.00E+00
9.99E-011.00E+00
9.99E-011.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
1.00E+001.00E+00
Vm(mV)
Po
Sheet2
Vm(mV)Po(V)G(V)IiVm(mV)Po(V)G(V)Ii
-1500.00065296530-3.26E-10-1500.00004539790-9.08E-11
-1450.00091105120-4.10E-10-1450.00012339460-2.41E-10
-1400.00127101630-5.08E-10-1400.00033535010-6.37E-10
-1350.00177295460-6.21E-10-1350.00091105120-1.69E-09
-1300.00247262320-7.42E-10-1300.00247262320-4.45E-09
-1250.00344745130-8.62E-10-1250.00669285090.0000000001-1.17E-08
-1200.00480475290-9.61E-10-1200.017986210.0000000002-3.06E-08
-1150.00669285090.0000000001-1.00E-09-1150.04742587320.0000000005-7.83E-08
-1100.00931595930.0000000001-9.32E-10-1100.1192029220.0000000012-1.91E-07
-1050.01295372750.0000000001-6.48E-10-1050.26894142140.0000000027-4.17E-07
-1000.017986210.00000000020.00E+00-1000.50.000000005-7.50E-07
-950.02492442660.00000000021.25E-09-950.73105857860.0000000073-1.06E-06
-900.03444519570.00000000033.44E-09-900.8807970780.0000000088-1.23E-06
-850.04742587320.00000000057.11E-09-850.95257412680.0000000095-1.29E-06
-800.06496916910.00000000061.30E-08-800.982013790.0000000098-1.28E-06
-750.08839967720.00000000092.21E-08-750.99330714910.0000000099-1.24E-06
-700.1192029220.00000000123.58E-08-700.99752737680.00000001-1.20E-06
-650.15886910490.00000000165.56E-08-650.99908894880.00000001-1.15E-06
-600.20860852730.00000000218.34E-08-600.99966464990.00000001-1.10E-06
-550.26894142140.00000000271.21E-07-550.99987660540.00000001-1.05E-06
-500.33924363120.00000000341.70E-07-500.99995460210.00000001-1.00E-06
-450.41742979350.00000000422.30E-07-450.99998329860.00000001-9.50E-07
-400.50.0000000053.00E-07-400.99999385580.00000001-9.00E-07
-350.58257020650.00000000583.79E-07-350.99999773970.00000001-8.50E-07
-300.66075636880.00000000664.63E-07-300.99999916850.00000001-8.00E-07
-250.73105857860.00000000735.48E-07-250.99999969410.00000001-7.50E-07
-200.79139147270.00000000796.33E-07-200.99999988750.00000001-7.00E-07
-150.84113089510.00000000847.15E-07-150.99999995860.00000001-6.50E-07
-100.8807970780.00000000887.93E-07-100.99999998480.00000001-6.00E-07
-50.91160032280.00000000918.66E-07-50.99999999440.00000001-5.50E-07
00.93503083090.00000000949.35E-0700.99999999790.00000001-5.00E-07
50.95257412680.00000000951.00E-0650.99999999920.00000001-4.50E-07
100.96555480430.00000000971.06E-06100.99999999970.00000001-4.00E-07
150.97507557340.00000000981.12E-06150.99999999990.00000001-3.50E-07
200.982013790.00000000981.18E-062010.00000001-3.00E-07
250.98704627250.00000000991.23E-062510.00000001-2.50E-07
300.99068404070.00000000991.29E-063010.00000001-2.00E-07
350.99330714910.00000000991.34E-063510.00000001-1.50E-07
400.99519524710.000000011.39E-064010.00000001-1.00E-07
450.99655254870.000000011.45E-064510.00000001-5.00E-08
500.99752737680.000000011.50E-065010.000000010.00E+00
550.99822704540.000000011.55E-065510.000000015.00E-08
600.99872898370.000000011.60E-066010.000000011.00E-07
650.99908894880.000000011.65E-066510.000000011.50E-07
700.99934703470.000000011.70E-067010.000000012.00E-07
750.99953204330.000000011.75E-067510.000000012.50E-07
800.99966464990.000000011.80E-068010.000000013.00E-07
850.99975968830.000000011.85E-068510.000000013.50E-07
900.99982779740.000000011.90E-069010.000000014.00E-07
950.99987660540.000000011.95E-069510.000000014.50E-07
1000.99991158080.000000012.00E-0610010.000000015.00E-07
1050.99993664330.000000012.05E-0610510.000000015.50E-07
1100.99995460210.000000012.10E-0611010.000000016.00E-07
1150.99996747060.000000012.15E-0611510.000000016.50E-07
1200.99997669140.000000012.20E-0612010.000000017.00E-07
1250.99998329860.000000012.25E-0612510.000000017.50E-07
1300.99998803290.000000012.30E-0613010.000000018.00E-07
1350.99999142510.000000012.35E-0613510.000000018.50E-07
1400.99999385580.000000012.40E-0614010.000000019.00E-07
1450.99999559750.000000012.45E-0614510.000000019.50E-07
1500.99999684550.000000012.50E-0615010.000000011.00E-06
Vm(mV)
I(Amp)
Peak Current
-1.50E+02
-1.50E+02
-1.45E+02
-1.45E+02
-1.40E+02
-1.40E+02
-1.35E+02
-1.35E+02
-1.30E+02
-1.30E+02
-1.25E+02
-1.25E+02
-1.20E+02
-1.20E+02
-1.15E+02
-1.15E+02
-1.10E+02
-1.10E+02
-1.05E+02
-1.05E+02
-1.00E+02
-1.00E+02
-9.50E+01
-9.50E+01
-9.00E+01
-9.00E+01
-8.50E+01
-8.50E+01
-8.00E+01
-8.00E+01
-7.50E+01
-7.50E+01
-7.00E+01
-7.00E+01
-6.50E+01
-6.50E+01
-6.00E+01
-6.00E+01
-5.50E+01
-5.50E+01
-5.00E+01
-5.00E+01
-4.50E+01
-4.50E+01
-4.00E+01
-4.00E+01
-3.50E+01
-3.50E+01
-3.00E+01
-3.00E+01
-2.50E+01
-2.50E+01
-2.00E+01
-2.00E+01
-1.50E+01
-1.50E+01
-1.00E+01
-1.00E+01
-5.00E+00
-5.00E+00
0.00E+00
0.00E+00
5.00E+00
5.00E+00
1.00E+01
1.00E+01
1.50E+01
1.50E+01
2.00E+01
2.00E+01
2.50E+01
2.50E+01
3.00E+01
3.00E+01
3.50E+01
3.50E+01
4.00E+01
4.00E+01
4.50E+01
4.50E+01
5.00E+01
5.00E+01
5.50E+01
5.50E+01
6.00E+01
6.00E+01
6.50E+01
6.50E+01
7.00E+01
7.00E+01
7.50E+01
7.50E+01
8.00E+01
8.00E+01
8.50E+01
8.50E+01
9.00E+01
9.00E+01
9.50E+01
9.50E+01
1.00E+02
1.00E+02
1.05E+02
1.05E+02
1.10E+02
1.10E+02
1.15E+02
1.15E+02
1.20E+02
1.20E+02
1.25E+02
1.25E+02
1.30E+02
1.30E+02
1.35E+02
1.35E+02
1.40E+02
1.40E+02
1.45E+02
1.45E+02
1.50E+02
1.50E+02
-3.26E-10
-9.08E-11
-4.10E-10
-2.41E-10
-5.08E-10
-6.37E-10
-6.21E-10
-1.69E-09
-7.42E-10
-4.45E-09
-8.62E-10
-1.17E-08
-9.61E-10
-3.06E-08
-1.00E-09
-7.83E-08
-9.32E-10
-1.91E-07
-6.48E-10
-4.17E-07
0.00E+00
-7.50E-07
1.25E-09
-1.06E-06
3.44E-09
-1.23E-06
7.11E-09
-1.29E-06
1.30E-08
-1.28E-06
2.21E-08
-1.24E-06
3.58E-08
-1.20E-06
5.56E-08
-1.15E-06
8.34E-08
-1.10E-06
1.21E-07
-1.05E-06
1.70E-07
-1.00E-06
2.30E-07
-9.50E-07
3.00E-07
-9.00E-07
3.79E-07
-8.50E-07
4.63E-07
-8.00E-07
5.48E-07
-7.50E-07
6.33E-07
-7.00E-07
7.15E-07
-6.50E-07
7.93E-07
-6.00E-07
8.66E-07
-5.50E-07
9.35E-07
-5.00E-07
1.00E-06
-4.50E-07
1.06E-06
-4.00E-07
1.12E-06
-3.50E-07
1.18E-06
-3.00E-07
1.23E-06
-2.50E-07
1.29E-06
-2.00E-07
1.34E-06
-1.50E-07
1.39E-06
-1.00E-07
1.45E-06
-5.00E-08
1.50E-06
0.00E+00
1.55E-06
5.00E-08
1.60E-06
1.00E-07
1.65E-06
1.50E-07
1.70E-06
2.00E-07
1.75E-06
2.50E-07
1.80E-06
3.00E-07
1.85E-06
3.50E-07
1.90E-06
4.00E-07
1.95E-06
4.50E-07
2.00E-06
5.00E-07
2.05E-06
5.50E-07
2.10E-06
6.00E-07
2.15E-06
6.50E-07
2.20E-06
7.00E-07
2.25E-06
7.50E-07
2.30E-06
8.00E-07
2.35E-06
8.50E-07
2.40E-06
9.00E-07
2.45E-06
9.50E-07
2.50E-06
1.00E-06
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Modelo de Hodgkin-HuxleyCondutncia a K+
Modelo de Hodgkin-HuxleyCondutncia a Na+Ativao (m)Inativao (h)
Modelo de Hodgkin-Huxley
Prmio Nobel de 1963Alan LLoyd Hodgkin1914-1998Andrew Fielding Huxley1917-John Carew Eccles1903-1997
Super-famlia dos canais dependentes de voltagem
Gating do Canal
Ativao Inativao
Filogenia dos KV
Canal para Na - filogenia
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